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40th
In February last year, the US Food and Drug Administration (FDA) cleared the first medical device which uses artificial intelligence (AI) to provide clinical decision support for stroke. The Viz.AI Contact application uses an AI algorithm to identify a suspected stroke and notifies a specialist more quickly than was previously possible. Faster treatment, in turn, lessens the extent of a stroke or its progression. Subsequent FDA clearances and a recent decision to formalize regulations for such evaluations are likely to stimulate further innovation and acceptance of AI devices.
Saving time
Viz.AI Contact analyses CT images of the brain and sends a text notification by smartphone or tablet to a vascular neurologist or a neuro-interventional specialist, should a large vessel occlusion (LVO) be suspected. The algorithm automatically notifies the specialist at the same time that a review of the images is being conducted by a first-line provider. This is faster than the usual standard of care where patients wait for a radiologist to firstly review CT images and then notify a neurovascular specialist.
Retrospective study and real world data
Viz.AI, Inc., which developed the Contact application, submitted a retrospective study of 300 CT scans. This compared the performance of the image analysis algorithm and notification functionality against two trained neuro-radiologists.
Real-world evidence from a clinical study demonstrated quicker notification of a neurovascular specialist, in cases where blockage of a large vessel in the brain was suspected. In more than 95 percent of cases, the automatic notification was faster, saving an average of 52 minutes (with a range of between 6 and 206 minutes).
De Novo premarket review
The Viz.AI application was reviewed by the FDA through its De Novo premarket review process, a regulatory pathway for new types of medical devices that carry low to moderate risk, but lack a legally marketed predicate device to base a determination of equivalence. The FDA action creates a new regulatory classification, allowing other devices with the same medical imaging intended to obtain marketing authorization by 510(k) notification. One of the first areas to benefit from Viz.Ai will be AI or computer-aided triage devices, whose potential in fields such as emergency medicine is likely to be vast. Viz.AI, Inc., itself is developing Viz ICH, which uses AI to automatically detect intra-cerebral hemorrhages and triage the patient directly to the neurosurgeon on call.
Decision support for breast cancer screening
Nine months after FDA approval of Viz.AI, at the 2018 Radiological Society of North America (RSNA) annual meeting in November, Siemens Healthineers showcased the AI-based features of syngo.Breast Care, a mammography solution. syngo.Breast Care aims to provide interactive decision support for breast cancer screening.
Transpira, Siemens’ mammography reading software, is based on deep learning techniques, with training provided via over 1 million images. As a result, syngo.Breast Care’s AI-based algorithms evaluate and interpret individual lesions as well as 2-D mammograms and 3-D tomosynthesis. The system also sorts and scores cases on a 10-point scale, based on radiologist preferences of risk factors such as lesions, micro-calcifications and other abnormalities.
Siemens Healthineers aims to integrate interactive decision support into syngo.Breast Care, and reduce radiologists’ workload for the interpretation of mammograms. This has become especially challenging, given rapid growth in the use of techniques such as 3-D breast tomosynthesis.
Small firms also in play
Smaller firms have also targeted this area. ICAD’s ProFound AI, for example, also leverages AI to detect cancer in breast tomosynthesis. The software, which was FDA cleared less than a month after syngo.Breast Care was unveiled, examines every image in a tomosynthesis scan, detects malignant soft tissue densities and calcifications.
Profound AI estimates a ‘Certainty of Finding’ for each detection and, like the classification system in syngo.Breast Care, assigns Case Scores to each case to represent confidence that a detection or case is malignant. The scores are represented on a scale from 0 to 100 percent, with higher scores indicate high confidence levels in malignancy. This, in turn, is expected to improve detection, lead to fewer patient recalls and save mammographers time in reading images. This makes it geared toward screening, although it can evidently be used for diagnostic studies.
AI at inflection point
The above examples demonstrate that the use of AI is now close to an inflection point in terms of clinical decision support tools. These will provide physicians usable interactive and dynamic pathways which move beyond decision support to true evidence-based decision making, along with personalized care recommendations.
To many experts, AI seems to have been the missing link for tools that assist radiologists in improving appropriateness of follow-up recommendations for incidental findings, and thereby to enhance adherence to guidelines available at point of care. One of the consequences of such AI-assisted tools will be to reduce the variability in follow-up recommendations, as well as unnecessary imaging studies.
Diagnosis and decision support versus analysis and detection
Maximum attention to AI in imaging is currently on diagnosis and decision support. AI in areas such as quantitative analysis and assisted detection can be considered a spin-off from automation, which has been around for a longer period of time, but reinforced more recently by machine learning.
Automated quantification tools are now sufficiently mature and routinely accepted in the market. AI algorithms are used to make measurements from imaging exams and perform calculations which were previously manual and time-consuming. AI-driven quantitative analysis tools also are being used in data analytics for data mining electronic medical records, billing systems, patient scheduling and even in stand-alone scanners. Mined data range from radiation dose used by particular technologists for specific protocols to predictive analytics that pinpoint spikes in demand by day and time, and schedule back-up staff in the radiology department.
By contrast, the application of AI (and even automation) in medical fields such as computer-aided diagnosis and clinical decision support is very recent, and is likely to be some time before they become commonplace. The principal focus on AI use for image diagnosis is where timing is crucial – such as a heart attack or stroke (e.g. Viz.AI Contact). Closely related areas include tools to reduce review time for complex exams, and help triage patients needing more immediate care or other kinds of back-up.
Other new AI imaging applications
One exciting new entrant into AI in imaging is IcoMetrix, from Belgium’s IcoBrain. This FDA-cleared algorithm analyses CT scans to characterize traumatic brain injury, using deep learning to quantify the severity of such typically qualitative indicators of brain injury as hyperdense volumes, compression of the basal cisterns and midline brain shift.
Another FDA-cleared device is Cardio AIMR, which analyses MR images for cardiovascular blood flow. Its developer, Arterys, also has other AI tools to measure and track liver lesions and lung nodules, accelerate display of medical images, and interface with the common desktop Google Chrome browser to display mammograms.
The challenge of integration
Although the FDA is clearing the way for follow-on AI products, there are concerns that the process is constrained to highly specific medical imaging diagnostic reviews. Some radiologists are questioning the viability of new AI software systems, if they require scores of different contracts and integration into a hospital or enterprise imaging system – which would be a problem not only for hospital IT departments but also for legal review.
One of the ways forward is by reconfiguring approaches to enterprise imaging by streamlining workflow. Some vendors are developing bridges between different AI applications. One of the immediate goals is to have AI imaging dovetail into picture archive and communication systems (PACS) as well as vendor neutral archives. For example, Viz.ai software is designed to receive DICOM images directly from any CT scanner to a local virtual machine (VM) behind a network’s firewall.
Major firms nurture start-ups
Leading healthcare technology vendors are also starting to actively partner with smaller companies to provide a combination of in-house and third-party apps via a web-based AI app store platform. One good example of this is Siemens’ Digital Ecosystem, which offers an online menu of apps from Siemens and its partner, including some offering AI-enabled technology. Similar AI app store initiatives are also being taken by other vendors.
At RSNA 2018, where Siemens showcased syngo.Breast Care, IBM Watson said it would begin to partner with AI vendors to offer products on its new AI Marketplace, by offering standardized application programming interfaces (API) for building or integrating third party software and making it available through the IBM Cloud. Smaller vendors have seized such opportunities. French imaging agent vendor Guerbet, for instance, is working with IBM Watson Health to develop AI software to support liver cancer diagnosis and care.
IBM had initially planned to develop and launch its own AI solutions across the healthcare spectrum. However, it had to cope not only with delays in commercializing its own AI products, but small and nimbler start-ups, such as viz.AI getting ahead in obtaining FDA clearance. The biggest setback was MD Anderson ending its partnership on cancer imaging with IBM.
Other major players are also treading similar paths. GE Healthcare’s Edison platform is designed to help accelerate the development and adoption of AI and other new technologies, with clinical partners using Edison to develop and test algorithms and mate them to Edison applications and smart devices. On its part, at RSNA 2018, Philips Healthcare also launched its IntelliSpace Discovery 3.0 visualization and analysis platform to prepare patient data to train and validate deep learning algorithms. The platform is designed specifically to support imaging research.
FDA to formalize De Novo rules
Developments in AI-enabled clinical decision support, like broader AI healthcare applications, are likely to pick up after the FDA decided to formally establish regulations for the De Novo classification process in December 2018. Although the De Novo process is part of the Food and Drug Administration Modernization Act, the FDA Safety Innovation Act and the 21st Century Cures Act, it is currently not covered by any specific regulations. If finalized, the proposed rules are intended to provide clarity and transparency on the De Novo classification process.
St Helier Hospital in the London Borough of Sutton – part of the Epsom and St Helier University Hospitals NHS Trust – has one of the largest renal medicine departments in the UK, and relies on FUJIFILM SonoSite pointof- care ultrasound (POCUS) systems to improve care and patient safety.
Dr Pritpal Virdee, a senior registrar in the department, explained: “We have a very busy renal department offering a wide range of services to people with kidney conditions, including coordination of the South West Thames Renal and Transplantation Unit. We use POCUS throughout the department for both patient assessment and ultrasound-guided interventions – such as line or drain insertions, aspirations, biopsies – performing over 1,000 procedures every year.”
Better for clinicians and patients
“Ultrasound allows you to visualise the target and surrounding structures during these procedures, making them faster and safer. We use POCUS extensively for patient management – for example, during cannulation or when assessing where to position an anaesthetic or pleural drain – or taking biopsies. The systems give you much more confidence when carrying out these procedures, as you can see exactly where you are placing the needle, and that you are not going to cause any damage from positioning them incorrectly. This helps you to reassure the patients as well, especially during kidney biopsies. Physician satisfaction has increased significantly in the department since adopting POCUS for these techniques, as we are much happier with the quality of work that we are now able to perform.”
Investigating the unknown
“POCUS is the ideal partner for quickly scanning a patient with unknown aetiology; I often use the systems for looking at renal patients that come in with acute kidney problems; if there is a delay to get a formal ultrasound examination, I can easily perform a scan myself. In this way, I can identify whether there is an obstruction or dilation of the kidney as soon as possible. It’s also useful for investigating the bladder, as sometimes the bladder scanners can be unreliable. I can simply select the appropriate probe and have a look; it’s really helpful in streamlining the process and providing a better clinical picture.”
“We also have a programme of medical insertion of peritoneal dialysis (PD) catheters under ultrasound guidance, which is quite unusual, and clinicians from other renal departments are now coming here to train in the procedure. This is another key area that POCUS is able to significantly improve as, without ultrasound guidance, there’s a high risk of perforating the bowel or causing injury to another structure. Having a good view of the peritonea shows you exactly what you are aiming for, and we now only perform this procedure with ultrasound.”
Ultrasound is a necessity
“We have always used SonoSite ultrasound systems in the department and have recently acquired two of the latest generation X-Porte systems. Buying the extra systems was a necessity, as we now use ultrasound for so many of our procedures. These instruments offer exceptional image quality and, crucially, they are very straightforward to operate; you can get a clearer view much quicker making each procedure even easier. When we first purchased the systems, we received a brief demo on how to operate them, and everyone started happily using them straightaway. This user-friendliness has been very popular with clinical staff, and the X-Portes have rapidly become our primary POCUS systems in our procedure rooms. This has allowed us to move our older systems onto the wards, which is very convenient as the department is spread over quite a large area. We are always open to learning about new ultrasound applications and, as the physicians here develop more specific interests, we will likely use the built-in tutorials that are supplied with the systems to further develop our skills.”
No turning back
“The X-Porte certainly gives us a level of detail that we’ve never seen before; you can easily visualise tiny blood vessels, or observe any bleeding that occurs during a biopsy procedure – it’s incredible. I have been working with ultrasound since 2010 and, when we first acquired the new instruments, it still took a little time to get used to the resolution available. Until you’ve used a system like the X-Porte, you don’t realise what can be achieved with ultrasound, but we wouldn’t go back now,” Pritpal said.
A hospital or healthcare facility can be composed of dozens of departments. A catheterization lab, commonly referred to as cath lab or EP lab, is instrumentally vital to one of the busiest departments, cardiology. Hybrid OR’s are equipped with diagnostic imaging technology to give physicians visual access to chambers and arteries of the heart. In these areas, physicians perform life-saving procedures including coronary artery bypass graft surgery, balloon angioplasty, congenital heart defect closure, stenotic heart valves, and pacemaker implantations.
These acute procedures would not have been practicable without the appropriate technology to facilitate the imaging process. Cath lab operations are dependent on medical displays, as these monitors allow physicians to visualize a patient internally and perform the necessary procedure. In a single medical procedure, up to 4-6 monitors can be utilized at any time for enhanced visibility.
Although many monumental advancements have been made in the efficiency of cath labs, the dependence on X-rays for imaging has persisted through every upgrade. From purchasing analogue or digital modalities to choosing a single or bi-plane system, there are endless customization possibilities. Typically, the rooms are equipped with an image intensifier, C-arm, X-Ray tubes, and several displays.
Advantageously, the digital age ushered in an era of improvements to imaging technology, which emitted less radiation, and displayed visual clarity. The adoption of CRT monitors in the cath lab inherently changed how labs ran.
In the early cath labs, all information was conveyed through film. The X-rays, produced high-doses of radiation and low-quality images, which were printed on 16-mm or 35-mm film. Then, radiologists spent many hours of the day in darkrooms to process images, and ample storage space was wasted holding boxes of film.
With the implementation of picture archiving and communication systems (PACS), the transition from analogue to digital technology was concretized. PACS is an all-in-one program that provides electronic storage, retrieval, distribution, and presentation of radiology images.
In the cath lab, there are typically four to six CRT or LCDs in use. One image is always utilized for monitoring physiological attributes like a patient’s heart rate or blood oxygen level. Following CRT displays was the adaptation of LCD monitors. Many physicians upgraded to these monitors since they are slimmer, more portable, and offer higher resolution images.
“We are witnessing yet another transition in Cath Lab, Hybrid OR monitors as many physicians are upgrading from CCFL HD displays to ultra-high-definition 4K/8MP technology” says Michael Thomas Director of Business Development & Marketing at Ampronix. Many healthcare facilities have upgraded or are currently in the process of upgrading their medical displays to this resolution. These monitors provide a level of visibility previously unknown to physicians. During critical surgeries and procedures, increased clarity and sharper details can mean the difference between saving or losing a life.
These 4K/8MP large medical-grade displays are considered to be the new “gold standard” for surgical applications, allowing multiple screens to be viewed on a single monitor while taking up a minimal amount of space. When a 4K/8MP display is combined with a video manager, it can become customizable with a variety of layout options and editing tools like magnification. The design is easier to use and provides a higher resolution, making its adoption an easy choice as it facilitates precise procedures and minimally invasive surgeries.
Although the advancement of this technology has improved patient care, the transition made could prove to be detrimental and may demand considerable attention. With four to six displays in the cath lab previously, there are preventative measures in place that guarantee a backup option should a monitor burn out. In critical imaging procedures like angioplasty, mere seconds without visibility become crucial moments, and a single display makes cath labs extremely susceptible to all the risks associated.
To solve this issue, some displays are equipped with a secondary back-up monitor that folds out, if needed. However, this is a sacrifice that presents limited visual acuity. When this situation unravels, the entire procedure must be halted and the patient sutured up, as technicians attempt to remedy the problem.
Furthermore, any display failure amounts to an entire cath lab rendered obsolete until a replacement or repair solution is provided. Unfortunately, the turn around time for either of those protocols can take over a week.
THE SOLUTION
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technology questions and concerns
Over recent decades, the field of telemedicine has been witness to periods of great promise, relative stasis as well as overstretch and false starts.
However, there is one telemedicine application which has seen steady, consistent growth. This is emergency telemedicine, where application development, especially teleconsultation and teleradiology, has synchronized with increasing demand for A&E as well as the forward march of telecoms technology.
From the outset, the benefits of telemedicine were self-evident in emergency care in settings such as ski resorts, highway or rail accidents, and after natural disasters. Telemedicine enabled trauma specialists to interact with overtaxed field personnel on site, to gauge the severity of injuries and provide clinical assessments on treatment or evacuation. This aspect of telemedicine was spun out off one of its first movers, the military.
Telemedicine and travel
The roots of ‘serious’ telemedicine practice can be considered to date to the 1990s. Nevertheless, medical practitioners were aware of the enormous possibilities it afforded well before this.
In the 1930s, luxury liners used marine radio-telephones to communicate with physicians about urgent cases on board. Travellers were again the core target market for the first teleradiology consultations, conducted in the 1960s by Dr. Kenneth Bird, who used a two-way/interactive television system that connected Massachusetts General Hospital to Boston’s Logan Airport to provide emergency medical care.
1994: A&E referrals fall at Belfast hospital
Among the earliest case studies on modern emergency telemedicine is a 12-month review of a 1994 link between the Royal Victoria Hospital in Belfast and a minor treatment centre (MTC) in South Westminster, London. Over the study period, the telemedicine link was actively used in only about 0.5% of cases. However, the number of patients referred to a GP fell dramatically as did those referred to A&E. Another interesting observation was an increase in confidence of the nursing staff at the Westminster MTC.
Wembley study compares outcomes, radiologists vs. teleradiologists
At the beginning of 1996, Wembley Community Hospital in London established a minor accident treatment service (MATS), supported by an advanced telemedical link to Central Middlesex Hospital. The system was run by emergency nurse practitioners based on a set of clinical protocols which consisted of prompts advising the use of telemedicine.
Two years later, a paper evaluated six months activity at the MATS, covering all patients seen – a total of 2,843, with 150 teleconsultations. After an interval of three months, 99 per cent of telemedical and 95 percent of non-telemedical cases were followed up. Interestingly, while no further problems had arisen with the telemedical group, 26 of the non-telemedicine group had consulted their GP for the same problem. Another interesting finding was that A&E teleconsultants interpreting radiographs performed better than the consultant radiologist who subsequently interpreted the original films.
Head CT scans
Similar efforts were also made in the US and continental Europe. Other than minor injuries support, another application area with near-universal acceptance in A&E practice consisted of the transmission of head CT scans to a tertiary neurosurgical centre, in order to obtain an immediate expert opinion.
Economic impact of emergency telemedicine
By the late 1990s, rather than convenience alone, the first arguments about the economic impact of emergency telemedicine had begun to appear. A 1997 paper from Hong Kong found a significant reduction in unnecessary transfers, alongside a decrease in adverse events occurring during transfer. Another study from Austria during the same year concluded that though teleradiology for CT scans was more expensive than transferring the physical scans by taxi, it was considerably quicker, and much less expensive than transferring the patient.
Growing ER costs drive US interest in telemedicine
The acceleration of growth in mobile telecoms quality onwards from the late 2000s, along with sharp falls in cost, has intensified the case for emergency telemedicine. Alongside, increased demographic pressure on emergency rooms due to an ageing population and ER staff shortfalls have strengthened this further.
ER figures have been used to make the case for emergency telemedicine in the US. 130 million people visit ERs each year, up 36 percent from 97 million in 1995. In spite of this, the number of ERs in the US dropped by 11 percent over the period.
One leading healthcare provider, Cardinal Health, estimates that the average costs of a telehealth visit at USD 40-50, compared to USD 922 for an emergency room visit and that telemedicine could eliminate nearly 1 in 5 ER visits, which corresponds in numbers to almost two-thirds of those discovered to be non-urgent. Cardinal Health also states that 20% of ER visits require follow-up care for similar conditions, while only 6% of telehealth visits do. This echoes the spirit of the findings of the Wembley Community Hospital MATS study in 1996, mentioned previously.
Waiting times and demographic pressures
The problems with emergency medical care are similar in Britain. A&E waiting times have increased substantially over recent years, with many National Health Service (NHS) units failing to meet a four-hour standard for admission and discharge at national level. The number of people going to A&E has also risen substantially. In 2016/17 there were 23.4 million attendances at A&E departments – the equivalent of 63,000 attendances each day on average, and since 2011/12, this has been growing by 1.7 per cent each year – or the equivalent of an extra 5,100 each day.
These pressures have been exacerbated by closures. One in six A&E departments are being closed or downgraded, which corresponds to 33 casualty departments in hospitals in 23 areas of the UK.
The scourge of unnecessary visits
Unnecessary visits to A&E account for 16% of the total in England, but go over 50% in areas such as Durham and Darlington. From time to time, the media has a field day, citing lists from health officials about people going to A&E with broken false nails, splinters in their fingers, emergency contraception, as well as shaving and paper cuts.
The situation is similar in the US, where over 30% of visitors discover their case is not urgent – after being attended to. Some studies have estimated that 14 to 27 percent of ER visits could be treated at facilities like retail clinics or urgent care centres, with potential savings of USD 4.4 billion.
Telehealth to ‘redesign’ emergency medicine ?
A 2017 study from the University of Warwick calls for using telehealth to “redesign” emergency medical services. It chooses best of breed cases from different continents to make three cases:
• Specialists in underserved communities
• Pre-ambulance triage
• Ambulance-based triage
Providing patient access to remote specialists in underserved communities
In its early stages, emergency telemedicine applications were motivated by the need to provide more timely diagnosis and care to patients in underserved communities, in other words those lacking hospitals with full-time emergency medicine teams.
The Warwick study cites the Western Australia Emergency Telehealth Service (ETS, which comprises over 70 regional and remote hospital EDs as a “prominent example of this type of telehealth initiative.” The WA ETS makes specialist emergency medicine physicians available via videoconferencing to support regional hospital-based clinicians with the diagnosis and treatment of acute emergency patients. Another example in the Warwick study is the Cumbria and Lancashire Telestroke Network in Britain. This remote teleconsultation service connects 15 stroke consultants to provide ‘out-of-hours’ advice from their homes to hospital sites.
More recently, conclusive evidence about some of the above advantages has been obtained from another study at the University of Iowa’s Carver School of Medicine. The study found that telemedicine-equipped rural emergency departments provided patients with access to a clinician six minutes sooner than those in hospitals without the technology, regardless of whether or not telemedicine was used to intermediate the interactions. However, when telemedicine was used, as happened in 42% of the interactions, the door-to-provider time was shortened by nearly 15 minutes. This, according to lead author Nicholas Mohr, MD, an emergency physician and associate professor at the University, could change outcomes for patients with conditions like “severe trauma, stroke, myocardial infarction.”
Pre-ambulance triage, via teleconsultation with probable primary care patients
The second application highlighted by the Warwick researchers consists of pre-ambulance triage, via a system called ETHAN (Emergency Telehealth and Navigation). This was developed by the Houston (Texas) Fire Department in 2014, and combines teleconsultation, social services and alternative transportation. Its aim is to reduce the numbers of primary-care related patients being transported directly to the ED via fire-engine (although it could apply equally to ambulance). Apart from reducing ED patient loading, ETHAN makes substantial cost savings by eliminating unnecessary fire engine/ambulance journeys – estimated at USD 2500 per trip.
ETHAN equips EMS units with a Tablet to respond to patient initiated calls. Patients are connected via secure videoconferencing software to a hospital-based emergency physician who makes a diagnosis based on vital signs measured on scene by the field crew. After outlining treatment options, the physician then makes a final decision on whether the patient should be brought to the ED by fire engine/ambulance or via taxi, or taken by the latter to a primary care facility, or instructed on home care.
There is, however, little homogeneity in pre-ambulance triage, either in the US or elsewhere. In 2013, a systematic review of 120 publications by The Norwegian Knowledge Centre for the Health Services found that there was “a lack of scientific evidence about the effects of validated pre-hospital triage systems,” and called for further research.
Ambulance-based Triage
It has long been recognized that in-ambulance triage and care for an acute emergency patient during transportation to the ED, impact positively on patient outcomes, especially with time-critical conditions such as myocardial infarction and stroke. In several respects, Europe can be considered to be ahead of the US in this application. In Tucson (Arizona), a citywide ambulance telemedicine network, was shut down in 2011 due to budgetary problems and problems of reliability with the WiFi network.
On its part, the Warwick study reports on an ambulance-based telemedicine triage system with real-time bidirectional audio-video communication, carried out in Brussels. In 90 per cent of cases, preliminary pre-hospital diagnosis was formulated and was in agreement with in-hospital diagnoses. Failures, as had been the case in Arizona, resulted mainly from limited mobile connectivity.
April 2024
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+31 85064 55 82
info@interhospi.com
PanGlobal Media IS not responsible for any error or omission that might occur in the electronic display of product or company data.
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