Researchers presenting a preclinical study at the 2017 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) demonstrated the efficacy and optimal dose for targeted photodynamic therapy (tPDT) to treat prostate cancer before and during surgery. Prostate-specific membrane antigen (PSMA) was targeted with an anti-PSMA antibody radiolabeled with the tracer indium-111 (111In) and coupled with specialized photosensitizers that cause cell destruction upon exposure to near-infrared (NIR). The combined formula is 111In-DTPA-D2B-IRDye700DX.
“Coupling the photosensitizer to an imaging agent that targets PSMA on the tumour surface makes it possible to selectively and effectively destroy prostate tumour remnants and micrometastases while surrounding healthy tissues remain unaffected,” said Susanne Lütje, MD, PhD, lead author of the study from the Department of Radiology and Nuclear Medicine at Radboud University Medical Center in Nijmegen, the Netherlands, and the Clinic for Nuclear Medicine at University Hospital Essen, Germany.
This technique optimizes prostate cancer care by allowing visualization of tumours prior to surgery, by providing real-time guidance to surgeons in the operating room, and by priming tumours for photodynamic therapy when surgery isn’t enough or risks damage to sensitive structures.
A gamma probe is used to detect PSMA-expressing tumour cells. Photosensitizers can then be activated with light in the near-infrared wavelength, which causes them to emit fluorescence, or oxygen radicals, that damage PSMA over-expressing tumour tissues.
Study results showed effective localization of the drug at the site of tumours, as well as effective imaging and photodynamic therapy via near-infrared exposure in mice. Further study in humans is needed before this procedure could be made available for prostate cancer patients.
“In the future, this novel approach to prostate cancer could significantly improve the effectiveness of treatment, reduce recurrent disease and ultimately prolong survival and protect quality of life for patients,” said Lütje.
Society of Nuclear Medicine and Molecular Imaging