A multicentre trial has demonstrated that patients receiving stem cell transplants from unrelated donors with multiple genetic mismatches can achieve survival rates comparable to those with better-matched donors when using post-transplant cyclophosphamide prophylaxis.
Scientists at the University of Cambridge have created three-dimensional embryo-like structures that produce blood stem cells through a naturally occurring developmental process, eliminating the need for supplementary growth factors. The innovation, termed ‘hematoids’, mimics human embryonic blood development and could transform approaches to regenerative medicine and disease modelling.
A groundbreaking stem cell repository has been established using blood samples from over 100 individuals selected for their extreme genetic risk profiles for Alzheimer’s disease. The IPMAR resource will enable researchers worldwide to study how genetic variants contribute to the neurodegenerative condition in laboratory models.
Scientists have discovered two populations of stem cells in the retina with strong regenerative properties, according to a new study published in Science Translational Medicine. The research team identified human neural retinal stem-like cells (hNRSCs) that can differentiate into light-sensing cells, offering a potential source of stem cells for regenerative eye therapies.
New research reveals how delaying inflammatory signalling can dramatically increase the number of blood stem cells formed during embryonic development, potentially aiding efforts to produce these cells in the laboratory.
April 2024
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