A groundbreaking stem cell repository has been established using blood samples from over 100 individuals selected for their extreme genetic risk profiles for Alzheimer’s disease. The IPMAR resource will enable researchers worldwide to study how genetic variants contribute to the neurodegenerative condition in laboratory models.
A major NHS study has demonstrated that pharmacogenomic testing can be successfully integrated into routine clinical practice, with genomic data seamlessly incorporated into electronic health records to guide safer prescribing decisions. The PROGRESS programme showed that 95% of patients carried actionable genetic variants related to common medications, leading to prescription adjustments in over a quarter […]
A pioneering five-year research programme to develop the foundational tools for synthesising human genomes has launched with £10mn funding from Wellcome. The ambitious Synthetic Human Genome project, led by Professor Jason Chin at the MRC Laboratory of Molecular Biology, aims to unlock transformative biotechnology applications and accelerate targeted cell-based therapies.
Scientists at the San Raffaele Telethon Institute for Gene Therapy have unlocked a remarkable biological window – a fleeting period immediately after birth when circulating blood stem cells become uniquely accessible for genetic modification directly within the body. This discovery could transform treatment approaches for devastating genetic blood disorders, offering hope without the invasive procedures […]
Researchers at Children’s Hospital of Philadelphia and Penn Medicine have successfully treated an infant with a rare genetic disease using a bespoke CRISPR gene editing therapy, marking a watershed moment in personalised genomic medicine.
Researchers have developed a novel RNA-based gene editing system capable of inserting entire therapeutic genes, addressing limitations of current CRISPR technology for diseases with multiple mutations.
University of Chicago researchers have developed a groundbreaking imaging technology that visualizes the spatial organization of genetic material in three dimensions, without relying on conventional optical instruments. This technique, called volumetric DNA microscopy, works by tagging DNA and RNA molecules and allowing neighboring tags to interact, creating a molecular network that encodes their relative positions […]
Scientists have created the first comprehensive map showing how human DNA is mixed and passed down through generations, offering new understanding of genetic diversity and its relationship to fertility and evolution.
UCLA Health study demonstrates significant impact of genetic diagnostics on treatment decisions and specialist referrals in complex neurodevelopmental cases, pointing towards more personalised medical approaches.
A groundbreaking RNA-based technology allows therapeutic genes that are too large for conventional delivery methods to be successfully transported into cells, offering new hope for treating muscular dystrophies and other genetic disorders caused by mutations in large genes.
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callan emery / Midjourney
callan emery / Midjourney
Children’s Hospital of Philadelphia