Revolutionising Care

Leading hospital in Cyprus offers Digital Breast Tomosynthesis

YGIA Polyclinic’s Radiology Department has been operating for 27 years and its staff is actively involved in ongoing clinical research and training to ensure the best possible services to all patients. A year ago, it embarked on setting up a breast imaging unit equipped with state-of-the-art technology, culminating in the installation of the Hologic Selenia Dimensions DBT system.  
Dr. Annie Papoutsou, Head of the X-ray Department gives us the full picture.

How has your hospital expanded in recent years?
In 2007, after major renovations and an extension of its building facilities, the YGIA Polyclinic private hospital boosted its capacity to 152 beds, extended the number of operating theatres to 12, established and extended the capabilities of its Clinical Laboratory Department, Radiology Department (X-ray, Mammog, Fluoroscopy, MRI, CT, Ultrasound), produced a multi-dynamic Intensive Care Unit (ICU), Obstetrics & Gynecology, and Pediatrics Departments. Furthermore, from mid June 2012, a state-of-the-art Cardio-Vascular Catheterizations Centre was established at the hospital offering the only 24-hour acute percutaneous coronary intervention (PCI) service in Cyprus. Moreover, the hospital has a range of fully equipped ambulances working 24 hours in order to be able to best respond to emergencies.

What type of equipment is used by your department?
Most of our X-ray rooms use the latest DR digital detectors providing superior quality images almost instantly, and are linked to an enterprise-wide fully integrated RiS/PACS.
Last year we organized a breast imaging unit, equipped with the latest technology, FFDM Hologic Selenia Dimensions, a GE ultrasound  with strain and shearwave elastography and a Hitachi ultrasound with high frequency  linear probe.
In our department we performed  more than 90,000 exams yearly.
What was the rationale for selecting the Hologic Selenia Dimensions system?
The decision was based on the special features offered by the Selenia Dimensions; these include:

  • 2D imaging or combo mode (2D+3D) imaging in the same  compression.
  • Exceptionally sharp  images with minimal dose.
  • Streamlined workflow.
  • Ergonomic design for comfort and  ease of operation.
  • We believe that it offers the best technology available.

What are the advantages of Digital Breast Tomosynthesis?
The use of Digital Breast Tomosynthesis in breast screening enables us to find more invasive cancers than conventional 2D mammography alone.
The masses, distortions and asymmetric densities are better visualized with the Selenia Dimension.
But also it can reduce the costs associated with unnecessary recalls and it can reduce the incidence of negative biopsies.

Has the number of exams been affected by the adoption of DBT?      
Since the installation the number of mammography exams has increased up to 50%.
The recalls rate has decreased and also additional views have decreased.

When did you decide to acquire the C-View software and what are the benefits?
C-View software was installed from the first  day of the equipment installation, giving us the possibility of eliminating the need for conventional 2D exams after 6 months. The combined tomosynthesis and C-View exam makes lower patient radiation dose possible. Tomosynthesis exams with C-View software offer a patient dose similar to a 2D  only exam with  superior clinical performance for all breast types.

You are also using the Affirm biopsy device –what is the typical biopsy procedure followed in your department?
Up until now we are using the Affirm stereotactic biopsy device and in the next few days we are going to install the Affirm stereotactic tomosynthesis biopsy device to target lesions seen only with tomosynthesis. The typical biopsy procedures followed in our department are the biopsy under  the stereotactic  guidance and hookwire localization for subtle masses clusters of microcalcifications and architecture distortion.

What  do you see as the next step for improving the performance of your department?
Installing I-view with the contrast media.
I-View is a contrast-enhanced mammography technique that may be a viable alternative to breast MRI in performing contrast agent breast imaging. It offers certain advantages over MRI, including reduced cost and shorter procedure times. The imaging combination of contrast enhanced 2D imaging (CE2D) along with a 3D tomo scan, gives additional information beyond a CE2D examination alone, and may allow localization and morphologic evaluation of an enhancing lesion, further increasing the value of the CE2D procedure.

Imaging centre boosts patient care services in Sicily

With investments in two new, top-of-the-line DR solutions plus the innovative Portal, the imaging centre owned by Dr. Francesco Fiumara offers a higher level of healthcare service in Sicily, Italy.
Established in 1986, the Centro di Diagnostica per Immagini Dr. Francesco Fiumara is today recognized as the best diagnostic centre in the eastern region of Sicily, and is contributing to enhancing the level of healthcare services in the area. As a private clinic fully dedicated to diagnostic imaging, and accredited by the Italian National Healthcare System, it must offer first-rate services while controlling costs. Agfa HealthCare’s solutions have been key in helping the clinic achieve this goal.

Spread over two floors and 1,200 m2 of a building in Santa Teresa di Riva, some 40 km from Messina, Sicily, the diagnostic imaging clinic carries out diagnostic imaging and medical examinations for about 150 patients every day. The clinic strives to offer patients high-quality services, delivered with competence and compassion. This is reflected in the extended 8 am to 8 pm opening hours, the team of 14 specialists in a total staff of 40, and the use of the most advanced imaging technologies: including digital radiography, mammography, CT, ultrasound and MRI.

The clinic was already a customer of Agfa HealthCare; based on this positive experience, in 2015 it installed the DX-D 800 and DX-D 300 direct radiography (DR) systems. These have supported the clinic to increase and improve its radiology services as well as to reduce patient radiation dose. The clinic also implemented Agfa HealthCare’s Portal solution, giving patients the ability to remotely access and share their own exams.

A broad range of high-quality, dedicated exams
The centre performs a broad range of digital exams. One of the four radiography rooms contains a DR system specifically for mammography, while another is used for dental radiography. The last two rooms house the two new Agfa HealthCare DR systems, used for skeletal imaging, and for digestive and urogenital imaging using contrast media.

The DX-D 300 is installed in the skeletal radiography room; its fully-motorized arm easily accommodates a number of configurations, making it ideal for orthopedic studies. The remote-controlled DX-D 800 can handle general radiography and fluoroscopy, and has a detachable, tethered detector for portable exposures. “We only needed one investment to handle a broad range of applications,” says Dr. Fiumara, owner of the centre. The system is used for functional examinations such as barium enemas and esophagus tests.

Increased efficiency and faster throughput
“Diagnostic radiography has become a strategic service for our clinic to offer. We began working with Agfa HealthCare on this project in 2009, installing the IMPAX RIS/PACS solution, which was continuously updated in the following years. With these tools, we could already increase the efficiency of our imaging workflow and archive all patient exams in our database.”

The centre was one of the first in Sicily to adopt digital radiology. “We installed our first Agfa HealthCare computed radiography (CR) system, the DX-S, in 2012,” says Dr. Fiumara. “Our CR solution was a big innovation in efficiency and quality compared to conventional radiography. The challenge was to keep up a high standard of image quality while simultaneously reducing examination time and – consequently – patient waiting times.”

Once the clinic had experienced the quality of Agfa HealthCare’s technology and support services, Dr. Fiumara was keen to continue this partnership. “Working with Agfa HealthCare makes us feel confident for the future.”

“We considered several aspects when we were looking at the Agfa HealthCare DR solutions,” confides Dr. Fiumara. “Reducing exam time was a significant attraction, but so were the high resolution and the MUSICA image processing software. So we chose both the DX-D 300 and DX-D 800.”

“With these two DR solutions we have increased the number of exams we can perform every day, and at the same time we have enhanced our imaging reputation.”

The agreement with Agfa HealthCare includes full 24-hour service with a local engineer for any hardware problems and remote support for the software. “We have a single point of contact, so if something goes wrong I can directly speak to the technical contact and have an immediate solution,” continues Dr. Fiumara. Expertise in operations and workflow is another advantage; he says: “The specialized knowledge of the local technical and commercial Agfa HealthCare team is very valuable and helps us identify specific needs.”

Reducing patient dose
“As we learned more about dose reduction, we started to look for dose reduction potential in all our radiography systems. This became our strategic objective.”

The clinic’s four digital radiology systems and CT system all feature very low levels of radiation dose. “The I-Dose system in the CT device, for example, reduces dose by 60%. That’s the highest reduction we have reached so far with our devices.”

“Patients today are better informed and ask questions about patient dose. We are proud to offer not only an efficient and high-level radiology service, but also the safest in our area,” continues Dr Fiumara.

A Portal to better patient care and satisfaction

To further expand its patient services, Dr. Fiumara implemented the Agfa HealthCare Portal solution, which gives patients access to information from different sources inside and outside the hospital. This overview of information and actions can help enhance operational efficiency while improving the overall patient experience. “Integrating the Portal with the RIS/PACS solution means patients can access their exams and get an online consultation, instead of needing to return to the clinic just for this. It also speeds up a therapy.”

Patients can look at their own images, results and other aggregated information; and can share them in a secure way with a caregiver or another doctor. By empowering and satisfying patients, the Portal will also support the clinic to increase patient loyalty and to attract new patients.

“With our Agfa HealthCare solutions, we can offer a higher-quality service to patients, with low downtime,” concludes Dr. Fiumara. “We have increased the number of exams we conduct, whilst reducing our costs. Our partnership with Agfa HealthCare puts us in a better position for further growth.”

*DX-D 800 is not available in the US and Canada

Disaster medicine: French lessons in the age of terror

It is now clear that casualties after the November 2015 terror attacks in Paris were reduced by a superbly conceived and coordinated response.
While 130 people died in the tragedy, another number deserves attention, too. As many as 302 people were wounded, several seriously. They were triaged, treated on site and then shifted to hospital. Of these, two died during transport and another two in the first 10 days after admission. In other words, the casualty rate in the aftermath of terror was less than 1.5%.

by Ashutosh Sheshabalaya and Antonio Bras Monteiro

Plan Blanc – a collaborative blueprint for disaster medicine
Much of the credit for such an achievement goes to France’s ‘Plan Blanc’ (White Plan), created to respond to disasters. In Paris, the White Plan was activated within an hour after the first incident, namely the bomb explosions at the Stade de France. It mobilized some 40 hospitals, 200 operating rooms, 22,000 beds and 100,000 health professionals.
The White Plan is essentially a collaborative blueprint for disaster medicine. Although its conceptual roots go back several decades, November 2015 was the first time it was put to use.
The White Plan effectively places the entire French hospital system on a war footing, with the ability to pool resources on demand. It establishes a lean/quick-response command, control, communication and information system, mobilizing and synchronizing hospital/clinic bed and staff availability to anticipated victim inflows, postponing chronic surgeries and interventions while readying operating rooms, and providing rolling plans for augmenting resources – both human and material. The White Plan also establishes a specialized unit for informing families and communicating with the media.

No surprise about French leadership
According to us, France is among the world’s best prepared countries to deal medically with the aftermath of a terrorist attack. This laurel should be no surprise, given that the concept of ‘disaster medicine’ (médecine de catastrophe) was developed in the 1980s by three French physicians – René Noto, Alain Larcan and Pierre Huguenard. The French Society of Disaster Medicine/Société Française de Médecine de Catastrophe (SFMC) was founded in 1983.

Emergency medicine versus disaster medicine
Both emergency medicine and disaster medicine deal with the kind of challenges seen in Paris: gunshot wounds, blast wounds caused by explosions with organ and tissue damage, contusion and embolisms, multiple penetrations, pulmonary damage, and last but not least, shock.
The key difference between the two, however, involves the subject for medical attention. In emergency medicine, the subject is an individual patient, while disaster medicine deals with a group of patients. Disaster medicine begins on site and, given extreme constraints in human resources and equipment, is devoid of any element of personal medical care. It also uses specialized equipment, such as portable ultrasound and minimalist lightweight stretchers, while first responders are trained to improvise – for instance, carrying patients by their arms and legs. All this was evident in Paris.

Specialized military medical practices
What also was seen in Paris was a full range of specialized techniques. Some of these are derived direct from military medicine – hemorrhage control with tourniquets, hypotensive resuscitation and hypothermia prevention.
Another battlefield practice deployed in Paris (and debated subsequently by clinicians in many other countries) was to let the blood pressure of thoracic primary blast injury victims fall to levels which avoided exsanguination, but not below that required to maintain perfusion.

Anticipating frictions
Although considerable attention was paid to the White Plan, other Plans too rolled into place in the immediate aftermath of the first attack in Paris. Taken together, they highlight how potential conflicts on roles and responsibilities, jurisdiction etc. between different sets of professionals, in a period of extreme personal and systemic stress, had been anticipated, with interdisciplinary protocols already in place to minimize confusion between the police, the fire brigade, ambulance drivers, physicians and other hospital staff as well as the media and the public.
The police, for example, provided perimetric security and crowd control, taking charge of  clearing and organizing pathways to and from incident scenes. The fire brigade was responsible for victim search and extraction as well as certain types of emergency first aid. Though based in principle at field stations, doctors and nurses attended on site as and when required to the severely wounded, conducting triage and handing over patients for transport to ambulance drivers. On their part, specialist Red Cross teams had set up counselling services for victims and their families by midnight – in other words, within just 2-3 hours of the attacks.
The impact of such preparation cannot be under-estimated. In many cases, it allowed BRI special police forces to ignore pleas for help from victims, without disrupting their conscience or composure. Knowing that qualified medical professionals would shortly be taking responsibility for the wounded, the armed intervention teams instead concentrated on their job – to neutralize the terrorists.
All this, it must be underlined, was undertaken in the face of anticipated dislocations due to a strike by thousands of medical professionals protesting a health reform bill in the French Parliament on the very same day as the terrorist attacks. The strike was subsequently called off.

Other plans also implemented
The Alpha Red Plan is designed to deal with extreme emergencies at multiple sites. It sets up an ad-hoc, quick-operational chain of command which pools the full range of emergency services. These include public and private ambulances, the fire brigade and civil protection as well as the Red Cross – to provide evacuation and support. Hospitals outside the region are also placed on standby, if required.
In an interview with the ‘New England Journal of Medicine’, France’s Director-General for Health, Benoit Vallet, said that he had activated emergency protocols in areas outside Paris, including a request for helicopters to be on standby to transport victims. Vallet also noted that military hospitals treated some of the victims: “[Their] surgeons’ experience in war surgery was, unfortunately, exactly what was needed.”
The Red Plan focuses on pre-hospital care in the field. It is based on the principle of extracting and grouping the injured in a field medical facility, triaging them and then providing care on a need basis. Care is based on prioritizing treatment to what is strictly necessary for survival, managing extreme pain and transporting victims without worsening their condition.
Indeed, a key factor behind the success of the Paris response in November was the pre-hospital system. Within an hour of activation of the Red Plan, eight coordinating units dispatched 45 medical teams – each consisting of a doctor, a paramedical assistant and a driver – to six incident sites.

Lessons from France: the US case
The lessons from the French response to terror are being studied in many parts of the world. One of the first questions being asked is whether other countries would have managed as well.

Such a topic seems to be particularly charged in the US, for several reasons.
A key hurdle is that it is not easy to compare the US and French disaster response systems. The US system is built around mainly private hospitals, and is bottom-up and decentralized, while the French system is based largely on public sector hospitals, and is top-down and centralized.
Nevertheless, critics of hospital disaster preparedness in the US complain that decentralization simply means far too many federal initiatives, which leaves considerable scope for confusion about  lines of authority and responsibility in a crisis.

The US National Disaster Medical System
The point organization for overseeing a US federal medical response to disaster is the National Disaster Medical System (NDMS). NDMS is staffed by more than 8,000 civilian volunteer medical personnel. It is tasked with supplementing medical professionals and equipment should local medical resources become overwhelmed. It also has the responsibility to move injured patients to areas unaffected by a disaster.
NDMS was originally under the Department of Health and Human Services (HHS) but was moved as a result of the 9-11 terror attacks to the Federal Emergency Management Agency (FEMA), which is part of the Department of Homeland Security.
After Hurricane Katrina in 2005, amidst allegations of mismanagement, NDMS was removed from FEMA and sent back to HHS, where it now remains parked within the Office of Preparedness and Emergency Operations (OPEO). OPEO is responsible for developing operational plans, analysis and training to respond to public health emergencies and acts of terror.

HHS versus Homeland Security: Turf wars and more
It is evident that there is room for considerable conflict between OPEO and NDMS’s original parent, FEMA. One of the supra-entities tasked with overseeing a disaster response is The National Response Framework, a multi-agency initiative run by FEMA for the Department of Homeland Security.
As Beltway insiders know, the rivalry between Homeland Security and HSS is considerable.

In 2005, a then-confidential report prepared for the Secretary of Homeland Security evaluated US disaster medical readiness. The 103-page report found that “the nation’s medical leadership works in isolation, its medical response capability is fragmented and ill-prepared to deal with a mass casualty event and … HHS lacks an adequate medical support capability for its field operating units.”

NDMS was specifically targeted, as lacking the medical leadership and oversight “to effectively develop, prepare for, employ, and sustain deployable medical assets,” relying on an overtaxed volunteer network and experiencing “critical shortfalls in doctrine, training, logistics support and coordination” with other emergency responders and federal agencies.

ER capacity shortfalls in the US ‘truly alarming’
The impact of such inter-departmental rivalry and the seriousness of the allegations drew the attention of a Congressional Committee a few years later. The Committee chose a very specific target, namely emergency room (ER) capacity in cities considered to be at greatest risk of a terror attack.
Its findings, released in May 2008, were described as “truly alarming”. The hospitals surveyed did not have “sufficient ER capacity to treat a sudden influx of victims from a terrorist bombing.” The situation in Washington DC and Los Angeles were described as being “particularly dire.”
Aside from capacity, the Congressional investigation also revealed what appeared to be “a complete breakdown in communications between the Department of Homeland Security and the Department of Health and Human Services.” When the Committee requested information on hospital emergency surge capacity, “neither department was able to produce a single document.”

In France, some ironies too
There are several lessons to be learned from the French response to the November 13 terror attacks. The most salutary one brims with irony.
The French ‘system’, in the Anglo-Saxon mind, is believed to be statist, bureaucratic, top-heavy and inflexible. The White Plan response in November was based largely on the Parisian APHP, Assistance Publique – Hôpitaux de Paris, Europe’s largest hospital system.
Many critics have questioned the concept of the APHP, particularly its enormous size, as “an obstacle to adaptation in a rapidly changing technological, medical, and social context.” However, the rapid response of the APHP after the Paris terror attacks negates such criticism.
According to APHP Director General Martin Hirsch: “We sensed … that the size of the [APHP] could be an advantage in times of disaster. This advantage has now been demonstrated. No lack of coordination has been identified. No leakage or delay has occurred. No limit was reached.”
“At no time during the emergency was there a shortage of personnel.”

The authors
Ashutosh Sheshabalaya and Antonio Bras Monteiro
SolvX Solutions
Email: office@solvx.com

SolvX provides security and risk consulting services out of offices in Europe, the Middle East and Asia

The rise and rise of superbugs – are only industrialized countries to blame?

In April 2011, the World Health Organization (WHO) warned that indiscriminate use of antibiotics was giving rise to resistant ‘superbugs’ which could render the drugs useless. Three years later, it warned about the arrival of a ‘post-antibiotic era.’ In autumn 2014, US officials termed antibiotic resistance a threat to national security.
However, awareness of this challenge has been present for decades. In the early 1990s, ‘Newsweek’ dramatically highlighted the threat in a cover story titled ‘End of the Miracle Drugs.’ A few months later, ‘Time’ magazine followed up with a feature on the ‘Revenge of the Killer Microbes.’

Bug resistance too knows no frontiers
The Centers for Disease Control and Prevention (CDC) has estimated that resistant bacteria lead to 23,000 deaths in the US every year. In Europe, the ‘British Medical Journal’ has urged authorities to harmonize antibiotic prescribing practices in order to tackle resistance. In spite of little effect on patients’ recovery times, an EU-funded study called GRACE identified wide variations in antibiotic use. For coughs, for example, antibiotic prescribing by physicians ranged from 20% in some countries to 90% in others.
Nevertheless, according to a report in the ‘The New York Times’ at the end of 2014, efforts to crack down on “inappropriate antibiotic use in the United States and much of Europe have been successful,” with prescriptions dropping from 2000 to 2010. Such a drop has, however, been “more than offset” by growing use in the developing world, according to ‘The Times’.
Indeed, like bugs themselves, drug-resistant bugs seem to know no frontiers.

Large emerging markets drive global drug sales
The ‘Times’ reports that sales of antibiotics for human consumption worldwide rose by 36% in the 2000-2010 period, with more than three-fourths of this increase accounted by the BRICS group of major emerging markets (Brazil, Russia, India, China and South Africa).
Such findings have been endorsed by an authoritative study, published in September 2015 by the Center for Disease Dynamics, Economics and Policy (CDDEP). The CDDEP report,  which has drawn up a global Resistance Map for antibiotics, found sharp growth in resistant bacteria in developing countries, notwithstanding much lower per capita use of antibiotics.

India: highest risk case
The respected journal ‘New Scientist’ has recently also covered the CDDEP report, singling out culprits as countries with growing wealth – “especially India,”… “where more people are demanding antibiotics for minor infections.”
Indeed, the CDDEP highlights the case of E. coli in contaminated water or food, where India shows the world’s highest rates of resistance to nearly every available drug. Other problems in India include MRSA, where isolates have shown prevalence rising sharply, from 29% in 2009 to 47% in 2014 and Klebsiella pneumoniae, which can cause fatal lung infections. In 2014, 57 per cent of Klebsiella pneumoniae samples tested in India were resistant to carbapenems, an antibiotic used as a last resort. By comparison, the figure six years ago was virtually zero.

Resistant bacteria and infants
Antibiotic resistance has an especially dramatic impact on Indian infants. According to the ‘New York Times’ article in December 2014, bacterial infections resistant to most known antibiotics led to the death of more than 58,000 newborns in India compared to the previous year. The head of Sir Ganga Ram Hospital, one of India’s top medical facilities, stated that such infections were unheard of just five years previously. “Now, close to 100 percent of the babies referred to us have multi-drug resistant infections,” he lamented.
Ironically, due to high rates of infant mortality, the Indian government has been encouraging women, sometimes with financial incentives, to deliver babies in hospitals. The programme seems to have worked. Within a decade, the share of babies born in hospitals has more than doubled to over 80%.
However, the government has spent little to increase hospital capacity. As a result, maternity wards are overcrowded, sometimes with two or three women per bed. Apart from overcrowding, many hospitals are unhygienic. A UNICEF survey of 94 district hospitals and health centres in the Indian state of Rajasthan found 78% lacked soap at hand-washing sinks, while 67% of toilets were unsanitary.

The impact of bacterial resistance is, however, not just confined to newborns. Resistant bacteria cost the life of Uppalapu Shrinivas, one of India’s most famous musicians, at the age of 45.
Indeed, according to Dr. Timothy R. Walsh, a professor of microbiology at Cardiff University, India is creating a “tsunami of antibiotic resistance that is reaching just about every country in the world.”

NDM1: New Delhi’s global export
Researchers have already tracked superbugs with the so-called NDM1 (New Delhi metallo-beta lactamase 1) genetic code, first identified in India. NDM1 makes bacteria resistant to almost all antibiotics, including carbapenems – the drug of last resort.
The first report about NDM1 was published in ‘Lancet Infectious Diseases’ in April 2011, and made headlines due to the fact that this was the same time when the World Health Organization warned about superbugs.
The ‘Lancet’ study was sponsored by the EU and reported that NDM1 was found in about one fourth of water samples in New Delhi, the Indian capital. The authors speculated that, since many Americans and Europeans travelled to India and Pakistan for elective medical procedures, it was likely the superbug gene could eventually spread worldwide.

Since then, NDM1 has been found in Europe, the Middle East, Japan and the United States. 
Meanwhile, back in India, what worries public health experts is “that the NDM 1 gene appears to have spread to germs that cause cholera and dysentery, two common and dangerous ailments in India.” In other words, it may be no exaggeration to say that the drug resistance problem is about to explode.

From toilet deficits to untreated sewage
The roots of the problem are complex. Bacteria spread relatively easily in India, since an estimated half of Indians defecate outdoors. Meanwhile, much of the sewage generated by the other half, who use toilets, is also left untreated. The result is expected: Indians have some of the world’s highest rates of bacterial infections – and resistance.
Cardiff University microbiologist Dr. Walsh says up to “95% of adults in India and Pakistan” carry bacteria that are resistant to ‘last-resort’ antibiotics such as carbapenems. By comparison, only 10% of adults in the Queens area of New York carry such bacteria.

The answer to no sanitation: use antibiotics, preventively
Ironically again, rather than building better infrastructure for sanitation, the response in India to growing bacterial infections has been to resort indiscriminately to antibiotics, which are often sold without a prescription. According to the December 2014 report in ‘The New York Times’, Indians collectively take more antibiotics than any other group of people.
Together, the lack of sanitation and overcrowding in hospitals may well have catalysed the superbugs. Doctors across India too have lent the crucial helping hand by responding to the hospital sanitation crisis through doling out antibiotics. In the Indian State of Haryana, for example, almost every baby born in hospitals in recent years has been injected with antibiotics – “whether they showed signs of illness or not,” Dr. Suresh Dalpat, deputy director of child health told ‘The New York Times’.
Completing the circle is the fact that the resistant bacteria, created by indiscriminate use of antibiotics, find their way into hospital sewage. As mentioned, much of this is untreated and dumped into canals and pits in nearby communities, leading to the infection of pregnant women, the delivery of ill infants – and more antibiotics.

A perfect storm
Though some Indian health experts believe drug-resistant bacteria to be largely confined to hospitals, some of India’s top neonatologists suspect the bacteria have begun “thriving in communities and even pregnant women’s bodies.”
“India has a perfect storm,” says Dr. Ramanan Laxminarayan, author of the CDDEP report. “You put all the things together and it’s this gigantic petri dish of experimentation that is resulting in highly pathogenic strains.”

Nevertheless, rushing to blame India alone (or India and other developing nations) for the growing drug resistance may not be helpful, or entirely accurate. Carbapenemases like NDM-1 have also been discovered elsewhere. For example, Klebsiella pneumoniae carbapenemase (KPC), currently the most common carbapenemase, was detected in the US in 1996 and has since spread worldwide. In addition, enterobacteriaceae which produce KPC have recently been reported as becoming common in the US.

Drug industry in India adds to the problem
In India, nevertheless, yet another growing area of concern seems to be loose compliance with regulations by Indian manufacturers of antibiotics. In early 2011, ‘Scientific American’ reported high levels of antibiotic resistance in bacteria downstream from a waste-water treatment plant in the southern Indian State of Andhra Pradesh.
Citing findings by a Swedish-led research team, the article noted that drugs in the effluent water from the plant were “sometimes equivalent to the high doses that are given therapeutically.” The antibiotic-rich water originated from the plants of 90 bulk drug manufacturers in the region.

The next wave: animal antibiotics in India
The other area for attention does not concern human use of antibiotics. Their overuse in chicken, pig and cattle farms in the US has also provoked the growth of resistant strains. Research has not only shown that “as much as half of antibiotic prescriptions in the United States are unnecessary,” but also that an estimated 80 percent of antibiotic sales remain directed at animals. 
In Europe, unlike the US, antibiotics for animal growth have been banned since 2006. However, their use in medicated feeds continues. This, in turn, fuels resistance to antibiotics, and not just through animals. One study in Poland discovered high levels of resistant bacteria in gardens, orchards and forest soils, largely due to manure from antibiotic-fed animals.

Unfortunately, India does not seem to be heeding such lessons. Its booming economy has led to rapid growth of industrialized animal husbandry, where antibiotic use is widespread. A science group in New Delhi found antibiotic residues in 40 percent of chicken samples.

Why the chronic shortage of anesthesiologists?

We are all aware that there is a dearth of physicians both in primary healthcare and several hospital specialities in the West, an escalating problem that is particularly acute in the case of anesthesiologists. In some European countries this situation is at least partially the result of poor planning and under-investment in medical education, coupled with aggressive attempts to recruit medical professionals overseas, but there are other factors involved that must be addressed before we can hope to consider approaches that could alleviate the problem.
A major contributing factor is that today’s anesthesiologists are not only active in the operating theatre: their expertise is required during patient evaluation prior to surgery, and in critical care and pain management post-surgery. And not only has medical research augmented the number of surgical procedures that are now possible, but Europe’s increasing numbers of senior citizens, who are the most likely to suffer from non-communicable and chronic diseases, are the main beneficiaries of these innovative approaches. Inevitably this results in the demand for anesthesiologists exceeding the supply.
Another factor is that the generation of predominantly male anesthesiologists who focussed on their careers and were prepared to work in the evenings, at night and during weekends and holidays, severely limiting the time they could spend with their families, are retiring and being replaced by younger specialists who are legally entitled to work fewer hours per week and are also aware that social changes in recent decades, allowing both genders to enjoy satisfactory careers, require them to contribute practically (as well as financially) at home.
There is also a shortage of surgeons in Europe but this problem is not so acute as with anesthesiologists. Sadly this may well be because of the greater prestige enjoyed by practitioners of the former specialization, a situation which should surely be an anachronism. It is to be hoped that the primary goal of all medical professionals is to help their patients but until all specialisms are equally valued and respected for their essential contribution to patient care, some will continue to attract fewer recruits than others. There could even be a long-term solution to the problem if physicians themselves, including anesthesiologists, would value and respect non-medical healthcare professionals as they deserve. Surely the ever evolving technologies available in critical care settings and the relevant training offered could allow specialized anesthesia nurses to be trusted to administer anesthesia for certain procedures and patients, as well as sedation and pain relief, without requiring direct supervision from on high?

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Mobile health – a potentially disruptive technology ?

Mobile health or mHealth has recently become one of the fastest growing and potentially disruptive segments of healthcare technology. Some typical mHealth segments include medication reminders, remote patient monitoring and wellness management. Key challenges faced by mHealth include data storage and management, network availability and maintenance, compatibility and interoperability. The single biggest issue however is considered to be security and privacy – in terms of access control, infrastructure integrity and data anonymity.

M&A, drug costs and mHealth shake up US healthcare
In December 2015, consultants PricewaterhouseCoopers (PwC) said that mHealth ranked just behind mergers & acquisitions (M&A) and the escalating costs of prescription drugs as a key factor shaking up US healthcare.
PwC noted that one reason for such an impact was mHealth’s status as a late starter. Smartphones and apps have been relatively underutilized by the healthcare industry, and playing catch-up has catalysed an ultra-fast pace of growth. The consulting firm noted that 71% of US adults now own a web-enabled smartphone or wireless device and users with health or fitness apps doubled from 16% to 32% in 2015 compared to the year before.
Other figures endorse the enthusiasm about mHealth.
93% of US clinicians now believe that mHealth apps can improve patient’s health, according to a GreatCall survey on their rising popularity. This is well above a level of just 52% in 2013, according to a survey cited by US telecoms carrier Qualcomm. That report also noted that another 16% percent also noted ‘that the use of mobile technology will dramatically change the way that healthcare is delivered in the future.’

Europe and mHealth
The picture is more nuanced in other parts of the world.
In Europe, for example, Pew Research figures show smartphone penetration is roughly equal to US levels in northern countries such as Sweden, Denmark and the Netherlands, as well as on the other side, in Spain. The levels are 60-70% in Germany and the UK and 50% in France. These three, together, account for 45% share of the European mHealth market.
There also are some major differences between European countries in the mHealth climate, as another recent report, by Germany’s r2G, shows. As a result, usage of ePrescription varies dramatically, from 0 all the way to 100%. In Europe, regulatory differences can indeed have profound implications for mHealth. For example, ‘remote treatment of patients is prohibited’ in Germany, ‘whereas in Spain telemedicine is encouraged.’
In spite of being Europe’s largest economy, Germany remains a major challenge. According to a report from FTI Consulting, ‘only 28% of German hospitals have a clear strategy’ on digital healthcare. In spite of this, a proposed new law on eHealth ‘does not even mention the opportunities’ provided by mHealth (or personalized medicine). In effect, Europe has some way to go before it approaches mHealth benchmarks in the US, where doctors in several states can ‘bill health insurance companies for the costs of email-based consultations,’ according to a survey by A.T Kearney.

India among most mHealth-ready
Overall, revenues in the global mHealth market are expected to rise annually at a rate of 33.5% between 2015 and 2020, based on forecasts in an Allied Market Research report. Leading the pack will be the Asia-Pacific, with a growth rate estimated by Allied at more than 35%.

India is a special case for several reasons. Although Pew reports penetration of just 17% in the country in 2015, India recently overtook the US to become the second largest market for smartphones, after China (where penetration is much higher, at 58%).
Indeed, the speed of growth in the Indian market has surprised experts. As recently as August 2015, researchers IDC were forecasting that India would surpass the US in smartphone sales, in 2017.
India is in fact considered as one of the most mHealth-ready markets, in spite of a per capita income which is still among the world’s lowest. A survey in 2012 by PwC and the Economist Intelligence Unit (EIU) explained the reasons for the paradox: ‘In developed markets, mHealth is perceived as disrupting the status quo, whereas in emerging countries it is seen as creating a new market, full of opportunities and growth potential…. Consumers are more likely to use mobile devices and mHealth applications, and more payers are willing to cover the cost of mHealth services.’ The report notes that the pace of adoption of mHealth ‘will likely be led by emerging markets that rank highest among ten countries on a score of mHealth maturity.’

Demand driven by both business and consumers
The Indian case in the PwC/EIU survey illustrates one of the salient features for mHealth, everywhere. mHealth technology is both B2B (business-to-business) as well as B2C (business-to-consumer). Indeed, it is consumers who are pulling mHealth, in both developing and industrialized countries. This is probably less for cost than for reasons of access ( anywhere, anytime’ diagnosis, monitoring and treatment). The title of the PwC/EIU report underscores such an observation: ‘Consumers, it says, ‘are ready to adopt mobile health faster than the health industry is prepared to adapt.’

4 million downloads a day
Overall, the near-frenzied enthusiasm for mHealth is illustrated by figures from German consultant R2G. Even in 2014, it says there were over four million downloads of mHealth apps every day.
The number is expected to keep growing. By 2017, it’s predicted that 50% of smartphone users will have downloaded mobile health apps.

Hospitals and mHealth
In spite of the incipient mHealth consumer boom, heavy-hitters in industry are also marshalling their mHealth strategies.
Hospitals and health plans see mHealth as a tool to contain costs and enhance efficiency, and enhance healthcare safety and quality too. A growing number of top hospitals have begun to incorporate mHealth – the use of mobile technology devices and smartphones for healthcare purposes – to connect patients and clinicians, improve care coordination and reduce avoidable, costly hospital readmissions.

In the US, one driving force for mHealth consists of reforms imposing penalties on hospitals for avoidable readmissions. Although hospital readmissions fell from 19% in 2011 to 17.5% in 2013, more can clearly be done. According to Kaiser Health News’, 2,225 hospitals paid 227 million dollars in penalties during 2013 for high hospital readmission rates.
The reforms have provided strong incentives to implement mHealth systems – for example, to track cardiac rhythms, glucose levels and vital signs, and to identify health issues in time so as to prevent repeat trips.
Evidence for this kind of direct benefit from mHealth is provided by the prestigious Mayo Clinic, who report that use of a smartphone app during cardiac rehabilitation can reduce hospital readmissions by a factor of three. Mayo researchers found that only 20 percent of cardiac patients who used the app visited the emergency department or were readmitted to the hospital within 90 days, compared with 60 percent of those who did not use it.

The role of mHealth in increasing efficiency is apparent from Canada’s Ottawa Hospital. The Hospital and IBM have launched a mobile-enabled platform to streamline workflow and create a circle of care’ around patients. Care providers have 24/7 access to patient information, collaboration tools and available hospital resources via a custom mobile app, which has enhanced process efficiency, leading to more accurate discharge scheduling and reducing over-occupancy rates from levels of 110 percent.

European hospitals are also enthused about mHealth. In Britain, the National Health Service is encouraging remote medical monitoring and mobile health access as part of the country’s digital healthcare revolution, according to a report in The Telegraph’. The programme, which focuses on greater efficiency in providing medical services, includes use of wearables, video link consultations, e-prescription and connected clothing. Its objective is to make virtual healthcare ubiquitous within five years and save the NHS up to 5 billion pounds over a decade.

The pharmaceutical industry and mHealth
The pharmaceutical industry, too, has got into mHealth, with hundreds of mobile apps providing information on drugs, drug interactions and enabling patients to track usage. A study by Avella Specialty Pharmacy found apps focusing on HIV medication significantly boosted adherence. Despite this, it has ‘lagged in mHealth app development and adoption,’ due to concerns about liability and the need to follow strict regulatory compliance.
There are three other reasons for the lack of success. Pharma company app portfolios are not globally available. It is also built around their core products, rather than market demand. In addition, there is no cross-referencing, or a common and recognizable design providing a corporate identity.

Profiling mHealth apps
At present, some sources estimate that there are over 100,000 mobile health apps that have been developed. 85% of the apps are for wellness, while the remaining 15% (or 15,000) are directed at medical purposes. Even though a late starter, as many as 42% of mHealth apps available in major stores have a paid business model.

Nevertheless, the bulk of mHealth apps are forced to struggle.
A November 2015 survey of the global market by R2G found that 62% of app vendors attained less than 5,000 downloads per year for their entire mHealth app portfolio. 11% percent reached over 100,000 downloads. Just 2% had 1 million-plus downloads. Of the latter, about half had been in the business before 2010.
R2G said that as many as 60% of developers of mHealth apps were dissatisfied with the market reception for their apps. Many also found that the performance of the apps fell short of their goals.
The survey also reported that over half mHealth app developers were technology companies, and they viewed the presence of medical professionals on their team as a priority. In terms of targeted customers, patients with chronic conditions were most common, accounting for 48% of apps. Hospitals are the second biggest target, with 32% of developers focusing on them.
Another finding of interest was the fact that the most successful vendors were more likely to develop apps for hospitals as opposed to patients. This may be one of the strongest indicators that the mHealth apps industry still has to mature, and that there is much more to come. During the same month as the R2G survey, New York University School of Medicine released another mHealth report. The study found that though consumers frequently downloaded mHealth apps they ‘don’t necessarily use them a lot.’
For consumers at least, there is much more to explore in mHealth.