Archive for category: Research

Non-autoimmune diabetes discovered in African children challenges type 1 classification

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A landmark multi-country study has uncovered compelling evidence that the majority of children and young adults clinically diagnosed with type 1 diabetes across sub-Saharan Africa actually have a previously unrecognised non-autoimmune form of insulin-deficient diabetes. The research fundamentally challenges current diabetes classification systems and could change treatment approaches for young people with diabetes in Africa […]

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Schematic illustration of the iPSC cell-derived airway and alveolus chips.Ryuji Yokokawa, et. al. Kyoto University, Nature Biomedical Engineering https://doi.org/10.1038/s41551-025-01444-2

New lung-on-chip technology with iPS cells reveals distinct immune responses for flu and COVID-19

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Scientists have developed groundbreaking airway and alveolus chip models using induced pluripotent stem cells, revealing how SARS-CoV-2 and influenza trigger dramatically different immune responses in upper versus lower respiratory regions. The research offers new insights into COVID-19 pathology and potential therapeutic targets.

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Associate Professor Elliot Long, Murdoch Children’s Research Institute

Phoenix sepsis criteria fail to detect 95% of hospitalised children

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A large-scale prospective study across Australia and New Zealand has revealed that the internationally recognised Phoenix sepsis criteria identify fewer than 5% of children hospitalised with suspected sepsis, raising significant concerns about diagnostic accuracy and patient safety in paediatric emergency medicine.

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Bill Gates

Global protein study reveals new biomarkers for Alzheimer’s disease

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A landmark international collaboration has created one of the world’s largest protein datasets, analysing 250 million protein measurements from over 35,000 biofluid samples to identify novel biomarkers for Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative conditions that affect 57 million people globally.

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callan emery / Midjourney

DNA-guided prescribing shows major clinical impact in NHS trial

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A major NHS study has demonstrated that pharmacogenomic testing can be successfully integrated into routine clinical practice, with genomic data seamlessly incorporated into electronic health records to guide safer prescribing decisions. The PROGRESS programme showed that 95% of patients carried actionable genetic variants related to common medications, leading to prescription adjustments in over a quarter […]

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Professor Heyo K. Kroemer, Charité Executive Board Chairman and Bernd Montag, Siemens Healthineers Chief Executive sign the strategic cooperation agreement.

Siemens Healthineers partners with Charité for preventive medicine research

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Germany’s leading medical technology company Siemens Healthineers has announced a strategic cooperation agreement with Charité – Universitätsmedizin Berlin to develop innovative preventive medicine concepts, with an initial focus on cardiovascular disease prevention through advanced imaging and artificial intelligence technologies.

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The new implantable device for chronic pain management is small and flexible.© The Zhou Lab at University of Southern California

Wireless implant breakthrough offers personalised chronic pain relief

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Researchers at the University of Southern California have developed a revolutionary wireless implant that could transform chronic pain management for millions of patients. The ultrasound-induced wireless implantable (UIWI) stimulator combines artificial intelligence with flexible bioelectronics to deliver personalised spinal cord stimulation without requiring batteries or invasive surgical procedures.

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Researchers have discovered a molecular fingerprint called the “traumome”

Scientists identify ‘traumome’ targets for rapid emergency trauma treatment

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Researchers have discovered a molecular fingerprint called the “traumome” that becomes accessible within minutes of severe injury. The breakthrough could enable targeted treatments to be delivered directly to trauma sites, with the potential to significantly advance emergency trauma care for patients with life-threatening injuries.

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The BMJ has uncovered substantial data integrity concerns surrounding ticagrelor

BMJ investigation reveals AstraZeneca’s billion-dollar heart drug built on flawed data

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A damning BMJ investigation has blown open a scandal at the heart of modern cardiology, revealing how AstraZeneca’s billion-dollar blockbuster ticagrelor may have reached patients through manipulated data, missing evidence, and phantom investigators in clinical trials that regulators failed to properly scrutinise.

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Researchers identify how gut bacteria-specific immune cells breach the blood-brain barrier and trigger neuroinflammation through molecular mimicry, offering new therapeutic targets.

Gut bacteria immune cells attack brain in autoimmune discovery

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Scientists have discovered a novel mechanism by which immune cells targeting gut bacteria can infiltrate the brain and cause neuroinflammation through molecular mimicry. The research reveals how intestinal inflammation promotes the migration of microbiota-specific T cells into the central nervous system, where they mistakenly attack brain proteins.

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