A major international clinical trial has overturned four decades of standard cardiac care, finding that beta-blockers provide no benefit for most heart attack survivors with preserved heart function. The REBOOT study, involving over 8,500 patients, could reshape treatment guidelines worldwide.
The Society of Nuclear Medicine and Molecular Imaging has unveiled a comprehensive digital platform designed to streamline patient access to radiopharmaceutical clinical trials. The Global Radiopharmaceutical Trial Finder utilises artificial intelligence to match patients, physicians, and researchers with relevant studies across multiple international registries, addressing critical gaps in clinical trial participation rates.
A groundbreaking diagnostic test measuring brain blood flow dynamics has demonstrated superior accuracy in detecting Alzheimer’s disease compared to traditional markers, achieving a 96% diagnostic performance rate. The non-invasive cerebrovascular test offers hope for earlier, more accessible dementia screening whilst challenging conventional amyloid-focused diagnostic approaches.
Researchers at the University of Minnesota Twin Cities have demonstrated a groundbreaking process that combines 3D printing, stem cell biology, and lab-grown tissues for spinal cord injury recovery. The innovative approach uses microscopic channels to guide neural regeneration, offering new hope for treating complete spinal cord injuries.
Researchers have developed PathoPlex, a new multiplexed imaging technology capable of mapping over 140 proteins within cells at subcellular resolution. The framework identified kidney stress-related protein patterns in people with type 2 diabetes before clinical signs of disease appeared, potentially accelerating both diagnosis and treatment timelines.
Researchers have achieved a milestone in xenotransplantation by successfully transplanting a genetically modified pig lung into a brain-dead human recipient, where it remained viable and functional for nine days without hyperacute rejection or infection, according to research published in Nature Medicine.
A comprehensive investigation reveals sophisticated networks of editors, authors, and brokers systematically scamming the scientific publishing system at unprecedented scale. The research exposes coordinated fraud operations that have infiltrated major journals and publishers, with fraudulent publications growing exponentially faster than legitimate science.
OHSU scientists have developed OmicsTweezer, a powerful machine learning tool that uses advanced deep learning and optimal transport techniques to analyse cell type composition in human tissues. The breakthrough technology addresses long-standing batch effect challenges in cancer research, potentially improving therapeutic target identification and patient outcomes across multiple cancer types.
Researchers have developed a third-generation CRISPR technique that modifies gene expression by removing methylation marks rather than cutting DNA sequences. The approach uses catalytically dead Cas9 proteins fused to demethylating enzymes, offering a potentially safer alternative to conventional gene editing for treating inherited blood disorders including sickle cell disease and β-thalassemia.
In an interview, Dr Zheng-Yi Chen reveals how his team’s single-dose CRISPR therapy successfully restored hearing and balance in adult mice with DFNA41 genetic deafness, marking a potential breakthrough for treating progressive hearing loss in humans.
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