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Archive for category: E-News

E-News

kirigami-inspired stent

Stents inspired by paper-cutting art designed to deliver drugs to GI tract

, 29 June 2021/in E-News, Featured Articles /by panglobal
kirigami-inspired stent

The kirigami-inspired stent

Inspired by kirigami, the Japanese art of folding and cutting paper to create three-dimensional structures, MIT engineers and their collaborators have designed a new type of stent that could be used to deliver drugs to the gastrointestinal tract, respiratory tract, or other tubular organs in the body.

The stents are coated in a smooth layer of plastic etched with small “needles” that pop up when the tube is stretched, allowing the needles to penetrate tissue and deliver a payload of drug-containing microparticles. Those drugs are then released over an extended period of time after the stent is removed.

This kind of localized drug delivery could make it easier to treat inflammatory diseases affecting the GI tract such as inflammatory bowel disease or eosinophilic esophagitis, says Giovanni Traverso, an MIT assistant professor of mechanical engineering, a gastroenterologist at Brigham and Women’s Hospital, and the senior author of the study.

“This technology could be applied in essentially any tubular organ,” Traverso says. “Having the ability to deliver drugs locally, on an infrequent basis, really maximizes the likelihood of helping to resolve patients’ conditions and could be transformative in how we think about patient care by enabling local, prolonged drug delivery following a single treatment.”

Sahab Babaee, an MIT research scientist, is the lead author of the paper, which appears in Nature Materials.

Stretchable stents

Inflammatory diseases of the GI tract, such as IBD, are often treated with drugs that dampen the body’s immune response. These drugs are usually injected, so they can have side effects elsewhere in the body. Traverso and his colleagues wanted to come up with a way to deliver such drugs directly to the affected tissues, reducing the likelihood of side effects.

Stents could offer a way to deliver drugs to a targeted portion of the digestive tract, but inserting any kind of stent into the GI tract can be tricky because digested food is continuously moving through the tract. To make this possibility more feasible, the MIT team came up with the idea of creating a stent that would be inserted temporarily, lodge firmly into the tissue to deliver its payload, and then be easily removed.

The stent they designed has two key elements – a soft, stretchy tube made of silicone-based rubber, and a plastic coating etched with needles that pop up when the tube is stretched.

“The novelty of our approach is that we used tools and concepts from mechanics, combined with bioinspiration from scaly-skinned animals, to develop a new class of drug-releasing systems with the capacity to deposit drug depots directly into luminal walls of tubular organs for extended release,” Babaee says. “The kirigami stents were engineered to provide a reversible shape transformation: from flat, to 3D, buckled-out needles for tissue engagement, and then to the original flat shape for easy and safe removal.”

In this study, the MIT team coated the plastic needles with microparticles that can carry drugs. After the stent is inserted endoscopically, the endoscope is used to inflate a balloon inside the tube, causing the tube to elongate. As the tube stretches, the pulling motion causes the needles in the plastic to pop up and release their cargo.

“It’s a dynamic system where you have a flat surface, and you can create these little needles that pop up and drive into the tissue to do the drug delivery,” Traverso says.

For this study, the researchers created kirigami needles of several different sizes and shapes. By varying those features, as well as the thickness of the plastic sheet, the researchers can control how deeply the needles penetrate into the tissue. “The advantage of our system is that it can be applied to various length scales to be matched with the size of the target tubular compartments of the gastrointestinal tract or any tubular organs,” Babaee says.

GI drug delivery

The researchers tested the stents by endoscopically inserting them into the oesophagus of pigs. Once the stent was in place, the researchers inflated the balloon inside the stent, allowing the needles to pop up. The needles, which penetrated about half a millimetre into the tissue, were coated with microparticles containing a drug called budesonide, a steroid that is used to treat IBD and eosinophilic esophagitis.

Once the drug-containing particles were deposited in the tissue, the researchers deflated the balloon, flattening out the needles so the stent could be endoscopically removed. This process took only a couple of minutes, and the microparticles then stayed in the tissue and gradually released budesonide for about one week.

Depending on the composition of the particles, they could be tuned to release drugs over an even longer period of time, Traverso says. This could make it easier to keep patients on the correct drug schedule, because they would no longer need to take the drug themselves, but would periodically receive their medicine via temporary insertion of the stent. It would also avoid the side effects that can occur with systemic drug administration.

The researchers also showed that they could deliver the stents into blood vessels and the respiratory tract. They are now working on delivering other types of drugs and on scaling up the manufacturing process, with the goal of eventually testing the stents in patients.

  • See how the stent works: https://youtu.be/dEnTRa5ts9o
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GammaDelta Therapeutics GDX012

GammaDelta Therapeutics receives FDA clearance of IND application for GDX012, a novel allogeneic variable delta 1 gamma-delta T cell cancer therapy

, 29 June 2021/in E-News /by panglobal

FDA also granted orphan drug designation to GDX012 for the treatment of Acute Myeloid Leukaemia

 

GammaDelta Therapeutics GDX012

 

GammaDelta Therapeutics has received US FDA clearance for the Investigational New Drug (IND) application for the Company’s allogeneic variable delta 1 (Vδ1) gamma-delta (γδ) T cell therapy, GDX012, to be investigated as a treatment for haematological malignancies. The FDA also granted orphan drug designation to GDX012 for the treatment of Acute Myeloid Leukaemia (AML).

Dr. Paolo Paoletti, CEO of GammaDelta Therapeutics, commented: “The clearance of our IND application for GDX012 marks an important step for our company in establishing a portfolio of innovative allogeneic cell therapies. The unique properties of Vδ1 γδ T cells will be evaluated for the first time in a clinical study for patients with AML. This important milestone results from our efforts to establish a robust pipeline of cellular immunotherapies derived from our proprietary platforms and processes for the isolation and expansion of Vδ1 γδ T cells from both blood and tissues for targeting haematological malignancies and solid tumours.”

GammaDelta plans to initiate a Phase 1 clinical trial for patients with measurable residual disease (MRD) positive AML. Expected to begin later in 2021 as a multicentre study in the US, the trial will evaluate safety, tolerability and anti-leukemic activity of GDX012.

GammaDelta Therapeutics is advancing its novel T cell platform under an ongoing collaboration with Takeda Pharmaceutical Company formed in 2017.

Changing treatment paradigm for AML

Dr. Michael Koslowski, Head of R&D and Chief Medical Officer of GammaDelta Therapeutics, said: “Although progress has been made in the treatment of AML, the median overall five-year survival rate for patients diagnosed with AML remains under 30 percent. With the development of GDX012 we are aiming to change the treatment paradigm for AML and potentially other haematologic malignancies. The unique biological characteristics of Vδ1 γδ T cells offer a first-in-class Vδ1 γδ T cell therapy for AML, where the development of cell therapies has been historically limited due to the lack of specific targets.”

Dr. Chris Arendt, Oncology Therapeutic Area Unit Head of Takeda, commented: “The progression of GammaDelta Therapeutics’ platform technology underscores the potential of γδ T cells and the power of the innate immune system. Through collaboration with pioneers like GammaDelta Therapeutics, we hope to advance next-generation cell therapies and to maximise off-the-shelf treatments in the battle against hard-to-treat cancers.”

GammaDelta has developed proprietary technologies to generate both blood-and tissue-derived allogeneic immunotherapies based on Vδ1 γδ T cells for the treatment of haematologic malignancies and solid tumours. Both platforms have enabled the creation of highly active and selective non-engineered and genetically engineered allogeneic cell therapies, which demonstrate cellular activity and tumour cell killing capacity. Vδ1 γδ T cells are a unique subset of T cells that specifically recognise and are activated by molecular patterns of dysregulation on cancer cells. The non-MHC-restricted activity of Vδ1 γδ T cells makes them a unique cell type for the development of fully allogeneic, “off-the-shelf” cell therapies.

  • For further information and to view a video on the science behind GammaDelta’s proprietary technologies, visit: https://gammadeltatx.com/the-science/
https://interhospi.com/wp-content/uploads/sites/3/2021/06/gamma_delta_web.jpg 1042 1392 panglobal https://interhospi.com/wp-content/uploads/sites/3/2020/06/Component-6-–-1.png panglobal2021-06-29 10:58:362021-06-29 10:58:36GammaDelta Therapeutics receives FDA clearance of IND application for GDX012, a novel allogeneic variable delta 1 gamma-delta T cell cancer therapy
wound material resistant to bacteria

New material to treat wounds can protect against resistant bacteria

, 29 June 2021/in E-News /by panglobal
wound material resistant to bacteria

Researchers at Chalmers University of Technology, Sweden, have developed a new material that kills bacteria and could potentially prevent infections in wounds – a specially designed hydrogel, that works against all types of bacteria, including antibiotic-resistant ones. The active substance in the new bactericidal material consists of antimicrobial peptides, small proteins which are found naturally in our immune system. Photo: Anna-Lena Lundqvist/Chalmers

Researchers at Chalmers University of Technology, Sweden, have developed a new material that prevents infections in wounds – a specially designed hydrogel, that works against all types of bacteria, including antibiotic-resistant ones. The new material offers hope for combating a growing global problem antibiotic-resistant bacteria.

The World Health Organization describes antibiotic-resistant bacteria as one of the greatest threats to global health. To deal with the problem, there needs to be a shift in the way we use antibiotics, and new, sustainable medical technologies must be developed.

“After testing our new hydrogel on different types of bacteria, we observed a high level of effectiveness, including against those which have become resistant to antibiotics,” says Martin Andersson, research leader for the study and Professor at the Department of Chemistry and Chemical Engineering at Chalmers University of Technology.

Research and development of the material has been ongoing for many years at Martin Andersson’s group at Chalmers, growing in scope along the way, with a particular focus on the possibilities for wound care. Now, the important results are published as a scientific article in the journal ACS Biomaterials Science & Engineering.

wound patch has antibacterial properties

In recent years, foundational research into the antimicrobial peptide hydrogel has run in parallel with commercial development of the innovation through the spin-off company Amferia AB. The company has developed an antibacterial patch, which is expected to be commercialised soon. Photo: Anna-Lena Lundqvist/Chalmers

The main purpose of the studies so far has been to explore new medical technology solutions to help reduce the use of systemic antibiotics. Resistant bacteria cause what is referred to as hospital-acquired infection – a life-threatening condition that is increasing in incidence worldwide.

Mimicking the natural immune system

The active substance in the new bactericidal material consists of antimicrobial peptides, small proteins which are found naturally in our immune system.

“With these types of peptides, there is a very low risk for bacteria to develop resistance against them, since they only affect the outermost membrane of the bacteria. That is perhaps the foremost reason why they are so interesting to work with,” says Martin Andersson.

Researchers have long tried to find ways to use these peptides in medical applications, but so far without much success. The problem is that they break down quickly when they come into contact with bodily fluids such as blood. The current study describes how the researchers managed to overcome the problem through the development of a nanostructured hydrogel, into which the peptides are permanently bound, creating a protective environment.

“The material is very promising. It is harmless to the body’s own cells and gentle on the skin. In our measurements, the protective effect of the hydrogel on the antimicrobial peptides is clear – the peptides degrade much slower when they are bound to it,” says Edvin Blomstrand, Doctoral Student at the Department of Chemistry and Chemical Engineering at Chalmers, and one of the main authors of the article.

“We expected good results, but we were really positively surprised at quite how effective the material has proven,” adds Martin Andersson.

According to the researchers, this new material is the first medical device to make successful use of antimicrobial peptides in a clinically and commercially viable manner. There are many varied and promising opportunities for clinical application.

Start-up company Amferia takes the research from lab to market

In recent years, foundational research into the antimicrobial peptide hydrogel has run in parallel with commercial development of the innovation through the spin-off company Amferia AB.

The material and the idea, which is currently developed as an antibacterial wound patch, has generated interest around the world, attracting significant investment and receiving several awards. The company is working intensively to get the material to market so that it can benefit wider society.

Before the new material can benefit hospitals and patients, clinical studies are needed, which are ongoing. A CE marking of the material is expected to be completed in 2022.

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covid-19 virus

Researchers identify why Covid-19 patients develop life-threatening blood clots

, 25 June 2021/in Corona News, E-News /by panglobal

covid-19 virus

 

Scientists have identified how and why some Covid-19 patients can develop life-threatening blood clots, which could lead to targeted therapies that prevent this from happening.

The work, led by researchers from RCSI University of Medicine and Health Sciences, is published in the Journal of Thrombosis and Haemostasis.

Previous research has established that blood clotting is a significant cause of death in patients with Covid-19. To understand why that clotting happens, the researchers analysed blood samples that were taken from patients with Covid-19 in the Beaumont Hospital Intensive Care Unit in Dublin.

They found that the balance between a molecule that causes clotting, called von Willebrand Factor (VWF), and its regulator, called ADAMTS13, is severely disrupted in patients with severe Covid-19.

When compared to control groups, the blood of Covid-19 patients had higher levels of the pro-clotting VWF molecules and lower levels of the anti-clotting ADAMTS13. Furthermore, the researchers identified other changes in proteins that caused the reduction of ADAMTS13.

“Our research helps provide insights into the mechanisms that cause severe blood clots in patients with Covid-19, which is critical to developing more effective treatments,” said Dr Jamie O’Sullivan, the study’s corresponding author and research lecturer within the Irish Centre for Vascular Biology at RCSI.

He added: “While more research is needed to determine whether targets aimed at correcting the levels of ADAMTS13 and VWF may be a successful therapeutic intervention, it is important that we continue to develop therapies for patients with Covid-19. Covid-19 vaccines will continue to be unavailable to many people throughout the world, and it is important that we provide effective treatments to them and to those with breakthrough infections.”

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EHA logo

Study presented at EHA21 looks at Pfizer/BioNTech SARS-COV-2 vaccine impairment in immunosuppressed patients

, 22 June 2021/in Corona News, E-News /by panglobal

EHA logo

The European Hematology Association held their virtual congress from 9-17 June – it remains online until 15 August here. Many studies were presented, key among them was one titled: Humoral Response to the Pfizer/BioNTech BNT162b2 Vaccine Is Impaired in Patients Receiving CAR-T or High-Intensity Immunosuppressive Therapy.

In the study the researchers evaluated the efficacy and safety of the Pfizer/BioNTech BNT162b2 vaccine – approved for the prevention of SARS-CoV-2 infection – in patients that underwent hematopoietic cell transplantation (HCT) and chimeric antigen receptor (CAR)-T therapy. They prospectively followed 79 vaccinated patients who were actively treated at the Tel Aviv Sourasky Medical Center and monitored the safety profile and the humoral immune response to the vaccine.

They note that although the vaccine is recommended for immunosuppressed patients, its efficacy and safety in patients undergoing immunologic cell therapy have not been well-documented.

In their study they found that: “Overall, the vaccine was well-tolerated and all adverse events resolved within a few days except for one secondary graft rejection, which is still under investigation. We observed that only 36% of patients who received CAR-T therapy developed a humoral antibody response compared with 81% of patients who underwent allogeneic HCT. In addition, patients with B cell aplasia and those who received the vaccine shortly after infusion of cells were less likely to develop antibodies. Taken together, these data demonstrate that the humoral response to the BNT162b2 vaccine is significantly impaired in patients receiving CAR-T , as opposed to those after allogeneic HCT who had a good response.”

EHA21 Virtual Congress

This study presentation and others can be accessed at the EHA21 Virtual Congress. The education and scientific program of the congress focuses on clinical practice, recent advances, new data and views from different stakeholders and international organizations. Registration is open until 1 August and the sessions are online until 15 August.

 

 

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doctor

WHO’s Council on the Economics of Health for All issues brief on equitable health innovation

, 9 June 2021/in E-News, Featured Articles /by panglobal

Leading economists and health experts call for a health innovation ecosystem governed by “the common good”

surgery

The WHO Council on the Economics of Health for All, which comprises leading economists and health experts from across the globe, has called on governments, the scientific and medical community and private sector leaders to re-design the health innovation ecosystem toward delivering health technologies for the common good.

In the Council’s first brief, its members called on the public and private sectors to work collaboratively to deliver needed vaccines, therapeutics, diagnostics, and other essential health supplies that are available equitably to those who can benefit.

The Council Brief recommends both immediate and long-term action, urging all stakeholders to work towards creating a health innovation ecosystem characterized by purpose-driven and symbiotic public-private partnerships that put the common good front and centre.

“Mobilizing money to throw at solutions that fail to address the underlying causes of longstanding structural problems will not be sufficient,” according to the Council Brief. “We all must look forward towards re-imagining health innovation as part of a new economic ecosystem that can deliver Health for All.”

Deep change is needed

The Council has made clear that just patching up the existing system will not work. Deep change is needed on how intellectual property rights are governed to drive collective intelligence, how corporate governance is structured, and how the benefits of public investments are shared to avoid the current dynamic of sharing risks but privatizing rewards.

To build an inclusive end-to-end health innovation ecosystem able to deliver the appropriate medical technologies required to achieve Health for All equitably, the following building blocks are critical:

  • Creating purpose-driven innovation through a mission-oriented approach;
  • Reshaping knowledge governance to nurture collective intelligence;
  • Reforming corporate governance to be more long-term and purpose-oriented;
  • Building resilient manufacturing capacity and infrastructure;
  • Introducing conditionalities for public investments to build symbiotic public-private partnerships;
  • Strengthening the capacity of the public sector on both the supply and demand side.

Growing calls for urgent action

In the short-term, the Council, in its brief, adds its voice to the growing calls for urgent action in four areas:

  • Available vaccine doses should be redistributed immediately, not as acts of charity, but as a shared imperative for pandemic control and inclusive, equitable and sustainable access.
  • Technology transfer and building manufacturing capacity must be supported and financed, not as the responsibility or property of any single actor, but as a collective responsibility towards building health greater health security and resilience in all regions, governed as common goods.
  • Knowledge should not be kept as privatized intellectual property under monopoly control but considered collective rewards from a collective value creation process to be openly shared and exchanged.
  • Existing mechanisms set up to address the above aspects, including COVAX, ACT-Accelerator, and the Covid Technology Access Pool, should be utilized and strengthened, not as an approach to fix market failures, but as turning points for creating market-shaping approaches.”

The Council’s brief came ahead of the G7 Leaders’ Summit under the U.K.’s Presidency, which aims to build back better from the COVID-19 pandemic, including by strengthening resilience against future pandemics; and following the Seventy-fourth World Health Assembly and the G20 Global Health Summit co-hosted by Italy and the EU earlier this month.

The Council, which was established by the World Health Organization in November 2020, is chaired by noted economist Professor Mariana Mazzucato, Professor of the Economics of Innovation and Public Value and Founding Director in the Institute for Innovation and Public Purpose at University College London.

Its patron is H.E. Sanna Marin, Prime Minister of Finland.

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Crohns mouse model

Researchers create bioengineered organism that could diagnose Crohn’s disease flareups

Research, 19 May 2021/in E-News /by panglobal
Jeff Tabor, associate professor of bioengineering in Rice’s Brown School of Engineering

Jeff Tabor, associate professor of bioengineering in Rice’s Brown School of Engineering (Credit: Jeff Fitlow/Rice University)

In an important step toward the clinical application of synthetic biology, Rice University researchers have engineered a bacterium with the necessary capabilities for diagnosing a human disease.

The engineered strain of the gut bacteria E. coli senses pH and glows when it encounters acidosis, an acidic condition that often occurs during flareups of inflammatory bowel diseases like colitis, ileitis and Crohn’s disease.

Crohns mouse model

Rice University researchers engineered a strain of the gut bacteria E. coli to detect gastrointestinal acidosis. The organism produces fluorescent molecules that allow researchers to see it with standard optical equipment. Under normal conditions (left) it produces molecules that glow red. When it encounters acidic conditions (right), it glows green, and the brightness of the glow reflects the level of acidity. (Image courtesy of Jeff Tabor/Rice University)

Researchers at the University of Colorado (CU) School of Medicine used the Rice-created organism in a mouse model of Crohn’s disease to show acidosis activates a signature set of genes. The corresponding genetic signature in humans has previously been observed during active inflammation in Crohn’s disease patients. The results are available online in the Proceedings of the National Academy of Sciences.

Colours that show up in the toilet

Study co-author Jeffrey Tabor, whose lab engineered the pH-sensing bacterium, said it could be reprogrammed to make colours that show up in the toilet instead of the fluorescent tags used in the CU School of Medicine experiments.

“We think it could be added to food and programmed to turn toilet water blue to warn patients when a flareup is just beginning,” said Tabor, an associate professor of bioengineering in Rice’s Brown School of Engineering.

Over their 3.5 billion-year history, bacteria have evolved countless specific and sensitive genetic circuits to sense their surroundings. Tabor and colleagues developed a biohacking toolkit that allows them to mix and match the inputs and outputs of these bacterial sensors. The pH-sensing circuit was discovered by Rice Ph.D. student Kathryn Brink in a 2019 demonstration of the plug-and-play toolkit.

pH sensor

PNAS study co-authors Sean Colgan, the director of the CU School of Medicine’s mucosal inflammation program, and Ian Cartwright, a postdoctoral fellow in Colgan’s lab, read about the pH sensor and contacted Tabor to see if it could be adapted for use in a mouse model of Crohn’s disease.

“It turns out that measuring pH within the intestine through noninvasive ways is quite difficult,” said Colgan, the Levine-Kern Professor of Medicine and Immunology in the CU School of Medicine.

So Brink spent a few weeks splicing the necessary sensor circuits into an organism and sent it to Colgan’s lab.

“Normally, the pH in your intestines is around seven, which is neutral, but you get a lot of inflammation in Crohn’s disease, and pH goes to something like three, which is very acidic,” Tabor said.

Colgan and colleagues have studied the genes that are turned on and off under such conditions and “needed a tool to measure pH in the intestine to show that the things they were observing in in vitro experiments were also really happening in a live animal,” Tabor said.

Biological tool

“Colonizing this bacterial strain was the perfect biological tool to monitor acidosis during active inflammation,” Colgan said. “Correlating intestinal gene expression with the bacterial pH sensing bacteria proved to be a useful and valuable set of biomarkers for active inflammation in the intestine.”

Tabor said he believes the pH-sensing bacterium could potentially be advanced for human clinical trials in several years.

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more nurses leads to shorter patient stays

More nurses lead to shorter hospital stays, less readmissions and fewer patient deaths

Research, 19 May 2021/in E-News /by panglobal

Australian study shows that savings made from shorter stays are double the cost of hiring more staff

more nurses lead to fewer patient deaths

 

 

 

 

 

 

 

 

 

 

 

 

 

A study across 55 hospitals in Queensland, Australia suggests that a recent state policy to introduce a minimum ratio of one nurse to four patients for day shifts has successfully improved patient care, with a 7% drop in the chance of death and readmission, and 3% reduction in length of stay for every one less patient a nurse has on their workload.

The study of more than 400,000 patients and 17,000 nurses in 27 hospitals that implemented the policy and 28 comparison hospitals is published in The Lancet. It is the first prospective evaluation of the health policy aimed at boosting nurse numbers in hospitals to ensure a minimum safe standard and suggests that savings made from shorter hospital stays and fewer readmissions were double the cost of hiring more staff.

Despite some evidence that more nurses in hospitals could benefit patient safety, similar policies have not been widely implemented across the globe, partly due to an absence of data on the long-term effects and costs, as well as limited resources. In recent years, Scotland, Wales, and Ireland have mandated numbers of patients per nurse, but strategies to improve nursing levels remains debated worldwide.

Study fills data gap

“Our findings plug a crucial data gap that has delayed a widespread roll-out of nurse staffing mandates. Opponents of these policies often raise concerns that there is no clear evaluation of policy, so we hope that our data convinces people of the need for minimum nurse-to-patient ratios by clearly demonstrating that quality nursing is vital to patient safety and care,” says lead author, Professor Matthew McHugh of the University of Pennsylvania School of Nursing, USA.

In 2016, 27 public hospitals in Queensland were required to instate a minimum of one dedicated nurse for every four patients during day shifts and one for every seven patients for night shifts on medical-surgical wards.

The research team collected data from those 27 Queensland hospitals that instated ratios and from 28 other hospitals in the state that did not, at baseline in 2016 and at follow-up in 2018 (two years after the policy was implemented). Only nurses in direct contact with adult patients in medical-surgical wards were included – data from patients in birthing suites and psychiatric units were not assessed in the study.

Researchers used patient data to assess demographics, diagnoses, and discharge details for patients, as well as length of hospital stay. These data were then linked to death records for 30 days following discharge, and to readmissions within seven days of discharge.

The researchers sent an email survey to nurses in each hospital to ask about the numbers of bedside nurses and patients on their most recent shift. The responses were used to establish the numbers of nurses per patient and then averaged across wards and hospitals. Responses were received from 8,732 nurses (of a possible 26,871) at baseline in 2016, and 8,278 (of a possible 30,658) in 2018.
more nurses leads to shorter patient stays

The study includes baseline data for 231,902 patients (142,986 in hospitals that implemented the policy and 88,916 in comparison hospitals), and for 257,253 patients (160,167 in hospitals that implemented the policy and 97,086 in comparison hospitals) after the policy was brought in.

Comparison hospitals had no change in staffing, with six patients per nurse in 2016 and the same ratio (1:6) in the follow-up period in 2018. Intervention hospitals averaged five patients per nurse at baseline in 2016, with a reduction to four per nurse after the policy implementation.

Patient deaths

To compare the changes in outcomes in the intervention and comparison hospitals over time, the researchers estimated the odds of dying within 30 days of admission and of being readmitted within seven days of discharge, and the additional length of stay, after adjusting for factors such as patient age, sex, existing health conditions and hospital size. They found that the chance of death rose between 2016 and 2018 by 7% in hospitals that did not implement the policy, and fell by 11% in hospitals that did implement the policy.

Readmissions

The chances of being readmitted increased by 6% in the comparison hospitals over time, but stayed the same in hospitals that implemented the policy. Between 2016 and 2018, the length of stay fell by 5% in the hospitals that did not implement the policy, and by 9% in hospitals that did.

Nurse workloads

Further analyses found that when nurse workloads improved by one less patient per nurse, the chance of death and readmissions fell by 7%, and the length of hospital stay dropped by 3%.

Using their modelling to predict figures that would have been expected without the policy in place, the researchers estimated that there could have been 145 more deaths, 255 more readmissions and 29,222 additional days in hospital in the 27 hospitals that implemented the policy between 2016 and 2018.

Financial impact of employing more nurses

To calculate the financial impact of the staffing policy, the researchers used state data to estimate the cost of funding the 167 extra staff needed to reduce workload by one patient per nurse at approximately $33,000,000 (AUD) in the first two years. Based on Australian health economic data, they further estimated that preventing readmissions and reducing lengths of stay resulted in an approximate saving of $69,150,858 in the 27 hospitals across the two years following the mandate.

“Part of the reluctance to bring in a minimum nurse-patient ratio mandate from some policy-makers is the expected rise in costs from increased staffing. Our findings suggest that this is short-sighted and that the savings created by preventing readmissions and reducing length of stay were more than twice the cost of employing the additional nurses needed to meet the required staffing levels – a clear return on investment. Often, policy-makers are concerned about whether they can afford to implement such a policy. We would encourage governments to look at these figures and consider if they can afford not to,” says Professor Patsy Yates of the Queensland University of Technology School of Nursing, Australia.

Study limitations

The authors note that there are a number of limitations associated with the study. Hospitals in the research were not randomly assigned to comparison or intervention groups, as only 27 hospitals in the state were mandated to follow the policy. Furthermore, the hospitals included in both groups were not matched for size or patient demographics and health conditions, although this is accounted for in adjusted analyses.

Access the study: Effects of nurse-to-patient ratio legislation on nurse staffing and patient mortality, readmissions, and length of stay: a prospective study in a panel of hospitals. The Lancet. May 11, 2021. https://doi.org/10.1016/S0140-6736(21)00768-6

https://interhospi.com/wp-content/uploads/sites/3/2021/05/nurse7.jpg 1701 1134 panglobal https://interhospi.com/wp-content/uploads/sites/3/2020/06/Component-6-–-1.png panglobal2021-05-19 08:07:492021-05-19 08:07:49More nurses lead to shorter hospital stays, less readmissions and fewer patient deaths
covid-19 vaccination

COVID vaccines: some fully vaccinated people will still get infected – here’s why

, 18 May 2021/in Corona News, E-News /by panglobal

covid-19 vaccination

 

By Tara Hurst  
Lecturer, Biomedical Science, Birmingham City University

 

The development of several COVID vaccines in less than a year has given us all hope of a release from the pandemic. Now the goal has shifted to ensuring widespread vaccine coverage is achieved as quickly as possible around the globe.

However, it is unlikely that any of the vaccines will be 100% effective at stopping transmission or infection. There is a small risk that some fully vaccinated people will get infected. This is known as a “breakthrough infection” – and it’s entirely expected.

It is important to realise the limitations of vaccines. No vaccine offers full protection to everyone who receives it. The measles vaccine has been highly effective at preventing infection, leading to the virus being nearly eradicated in some countries.

Yet there are infections reported even in populations with widespread vaccination. These infections occur not only in the unvaccinated; there are cases of breakthrough infections in fully vaccinated people.

The seasonal flu vaccine offers protection from the circulating viruses. But the circulating flu viruses vary, and vaccinated people may still get ill but have less severe illness.

This is possibly because different arms of the immune response produce different defences, namely antibodies, which are Y-shaped proteins that lock onto germs and neutralise them, and T cells, which find and destroy infected cells. Antibodies are typically raised against the more variable proteins on the surface of the virus, while the more consistent proteins inside the virus are targeted by the T cells. T cells are important for limiting the severity of illness.

For SARS-CoV-2 (the virus that causes COVID-19) there is anecdotal evidence, including from Seychelles, of breakthrough infections, but little has yet been published in scientific journals. A recent report in the New England Journal of Medicine described two COVID-19 cases following vaccination, with both showing mild symptoms that resolved within one week.

And a study from Stanford University, which is yet to be reviewed by other scientists, describes 189 post-vaccination COVID cases out of 22,729 healthcare workers, but attributes at least some of these to partial vaccination. Vaccination will probably make the disease less severe should such breakthroughs occur.

Several explanations

There are several possible explanations for breakthrough infections. The human immune response is encoded in our DNA and varies from person to person. This variability helps us to respond to an array of germs. But the effectiveness of these responses is also variable. This could also be due to several things, including poor health, medication or age.

The ageing immune system does not respond to new antigens (foreign substance that causes your immune system to produce antibodies against it) and vaccines as well as younger immune systems. For one COVID vaccine, there was a measurable difference in the concentration of neutralising antibodies in the elderly compared with younger adults. Some of the elderly participants had no neutralising antibodies at all after both doses of the vaccines.

Another reason for breakthrough infections is due to viral variants that escape immune detection and flourish even in vaccinated people. A virus, especially an “RNA virus” such as SARS-CoV-2, is expected to mutate and give rise to variants, some of which may be more easily transmitted. These variants may also be more or less effectively neutralised by the immune system since the mutations could alter the parts of the virus that are recognised by antibodies and T cells.

A new SARS-CoV-2 variant identified in India (B16172) is thought to make the virus more transmissible and this is a cause for concern in light of the COVID crisis unfolding there. Despite the absence of scientific studies, there are many reports in the media of frequent breakthrough infections and the B16172 variant is blamed, but this has yet to be proved.

In the one study, done on post-vaccine infections with SARS-CoV-2 in California, there was no significantly higher risk of infection due to the variants circulating in that region. Despite the evidence that the vaccines work well against the variants, the rapid increase in the proportion of cases in the UK that are due to B16172 as compared to the dominant Kent strain (B117) has meant that it has been raised to a variant of concern by Public Health England.

While widespread vaccination remains the pandemic end game, it bears mentioning that this is unlikely to prevent all infections. Those who develop COVID after vaccination will probably have a milder illness, and so the risk of breakthrough infections should not deter us from using the current vaccines. Further study into the causes of breakthrough SARS-CoV-2 infections could help scientists to refine COVID vaccines or the schedule of booster doses.

  • This article is republished from The Conversation under a Creative Commons license.
https://interhospi.com/wp-content/uploads/sites/3/2021/05/covid_vaccine_web.jpg 1134 1701 panglobal https://interhospi.com/wp-content/uploads/sites/3/2020/06/Component-6-–-1.png panglobal2021-05-18 11:21:252021-05-18 11:21:25COVID vaccines: some fully vaccinated people will still get infected – here’s why
brain-to-text BCI

Brain-to-text: Researchers develop brain-computer interface that turns neural signals into typed text in real time

Research, 13 May 2021/in E-News /by panglobal
brain-to-text BCI

Thoughts turned into text: Two implanted electrode arrays record the brain activity produced by thinking about writing letters. This information is then collected and processed in real-time by a computer, which converts that data into words on a screen. Courtesy Shenoy lab & Erika Woodrum (artist)

 

Scientists have developed a brain-computer interface (BCI) which for the first time enables neural signals associated with handwriting to be decoded and turned into text in real time.

This breakthrough in BCI technology has the potential to enable paralysed or paraplegic individuals – unable to write or speak – to communicate in writing, at speed, in real time.

The study was published in Nature, May 12.

The researchers developed an intracortical BCI that decodes attempted handwriting movements from neural activity in the motor cortex and translates it to text in real time, using a recurrent neural network decoding system.

They tested the device in a participant with paralysis which in essence enabled him to type without using his hands. By thinking about handwriting letters, the researchers were able to decode the neural signals with an algorithm which turned the letters into typed text on a screen in real time.

The study participant typed 90 characters per minute – more than double the previous record for typing with such a BCI. However, previous studies had not used decoded neural handwriting signals. They had instead used thought-controlled cursor movements on a virtual keyboard.

Neural signals associated with handwriting

Study coauthor Krishna Shenoy, a Howard Hughes Medical Institute (HHMI) investigator at Stanford University and his team have in recent years been studying neural activity associated with speech in an effort to reproduce it. However, they had not considered trying to decode neural signals associated with handwriting, says Frank Willett, an HHMI research specialist and neuroscientist in Shenoy’s group.

First, the participant was asked to copy letters that were displayed on the screen, which included the 26 lower-case letters along with some punctuation: “>” which was used as a space and “~” which was used as a “full stop.” At the same time, implanted electrodes recorded the brain activity from approximately 200 individual neurons associated with handwriting that responded differently while he mentally “wrote” each individual character. After a series of training sessions, the BCI’s computer algorithms learned how to recognize neural patterns corresponding to individual letters, allowing the participant to “write” new sentences that hadn’t been printed out before, with the computer displaying the letters in real time.

“This method is a marked improvement over existing communication BCIs that rely on using the brain to move a cursor to ‘type’ words on a screen,” said Willett, the study’s lead author. “Attempting to write each letter produces a unique pattern of activity in the brain, making it easier for the computer to identify what is being written with much greater accuracy and speed.”

Level of flexibility

This system also provides a level of flexibility that is crucial to restoring communication. Some studies have gone as far as attempting direct thought-to-speech BCIs that, while promising, are currently limited by what is possible through recordings from the surface of the brain which averages responses across thousands of neurons.

“Right now, other investigators can achieve about a 50-word dictionary using machine learning methods when decoding speech,” said Dr. Shenoy. “By using handwriting to record from hundreds of individual neurons, we can write any letter and thus any word which provides a truly ‘open vocabulary’ that can be used in almost any life situation.”

Although it is still relatively early days for this technology, it offers the potential to help those who have completely lost the ability to write and speak.

In the future, Dr. Shenoy’s team intends to test the system on a patient who has lost the ability to speak, such as someone with advanced ALS. In addition, they are looking to increase the number of characters available to the participants (such as capital letters and numbers).

The participant is part of a clinical trial, called BrainGate2, which is being conducted by a collaboration of internationally recognized laboratories, universities, and hospitals working to advance brain-computer interface technologies.

 

Reference

Willett, F.R., Avansino, D.T., Hochberg, L.R. et al. High-performance brain-to-text communication via handwriting. Nature 593, 249–254 (2021). https://doi.org/10.1038/s41586-021-03506-2

https://interhospi.com/wp-content/uploads/sites/3/2021/05/bci.png 584 816 panglobal https://interhospi.com/wp-content/uploads/sites/3/2020/06/Component-6-–-1.png panglobal2021-05-13 12:42:292021-05-13 12:42:29Brain-to-text: Researchers develop brain-computer interface that turns neural signals into typed text in real time
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