Chinese researchers have developed a revolutionary hybrid microscope that simultaneously captures brain blood flow and neuronal activity across the entire mouse cortex with unprecedented detail. The LiTA-HM system achieves subcellular resolution over a 6mm field of view, opening new frontiers in neurovascular coupling research and brain-computer interface development.
A landmark multi-country study has uncovered compelling evidence that the majority of children and young adults clinically diagnosed with type 1 diabetes across sub-Saharan Africa actually have a previously unrecognised non-autoimmune form of insulin-deficient diabetes. The research fundamentally challenges current diabetes classification systems and could change treatment approaches for young people with diabetes in Africa […]
Artificial intelligence could unlock the full potential of therapeutic and assistive exoskeletons by enabling autonomous operation, reducing dependence on therapists and caregivers. However, researchers emphasise that richer patient data and more accurate digital twins are essential before these technologies can achieve widespread clinical deployment and revolutionise rehabilitation outcomes.
Researchers at the University of the Basque Country have developed a groundbreaking microfluidic device that efficiently extracts platelet-rich plasma (PRP) from whole blood using gravity sedimentation, achieving significantly lower platelet activation rates than conventional centrifugation methods whilst maintaining high purity levels.
Scientists have developed groundbreaking airway and alveolus chip models using induced pluripotent stem cells, revealing how SARS-CoV-2 and influenza trigger dramatically different immune responses in upper versus lower respiratory regions. The research offers new insights into COVID-19 pathology and potential therapeutic targets.
A large-scale prospective study across Australia and New Zealand has revealed that the internationally recognised Phoenix sepsis criteria identify fewer than 5% of children hospitalised with suspected sepsis, raising significant concerns about diagnostic accuracy and patient safety in paediatric emergency medicine.
A pioneering music therapy programme embedded within NHS mental health dementia wards has demonstrated feasibility and acceptability in a groundbreaking study that could transform care for some of the most vulnerable patients in the health system. The MELODIC intervention achieved high treatment adherence rates while showing no increase in distress symptoms or safety incidents.
A comprehensive meta-analysis reveals that patients prescribed anti-obesity medications experience substantial weight regain starting eight weeks after discontinuing treatment, with the rebound effect continuing for an average of 20 weeks before stabilising. The research highlights critical challenges in long-term weight management strategies.
A revolutionary digital assessment that measures brain chemistry in just three minutes has been validated against direct neuroimaging for the first time, offering new possibilities for early detection of cognitive decline and dementia. The breakthrough research demonstrates that a self-administered computerised test can accurately reflect levels of acetylcholine, a crucial neurotransmitter whose decline signals cognitive […]
A landmark international collaboration has created one of the world’s largest protein datasets, analysing 250 million protein measurements from over 35,000 biofluid samples to identify novel biomarkers for Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative conditions that affect 57 million people globally.
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Ryuji Yokokawa, et. al. Kyoto University, Nature Biomedical Engineering https://doi.org/10.1038/s41551-025-01444-2 