• News
    • Featured Articles
    • Product News
    • E-News
  • Magazine
    • About us
    • Digital edition
    • Archived issues
    • Media kit
    • Submit Press Release
  • White Papers
  • Events
  • Suppliers
  • E-Alert
  • Contact us
  • Subscribe newsletter
  • Search
  • Menu Menu
International Hospital
  • AI
  • Cardiology
  • Oncology
  • Neurology
  • Genetics
  • Orthopaedics
  • Research
  • Surgery
  • Innovation
  • Medical Imaging
  • MedTech
  • Obs-Gyn
  • Paediatrics

Archive for category: E-News

E-News

Age is not a risk factor for complications after surgery among older patients

, 26 August 2020/in E-News /by 3wmedia

Among older patients, frailty and cognitive impairment before surgery are associated with developing complications after surgery, but age is not, a new study suggests.
In addition to frailty, depressive symptoms and smoking were also associated with developing postoperative complications following elective surgery, according to the systematic review.
Researchers at St. Michael’s Hospital also found that a patient’s American Society of Anesthesiologists status, which evaluates the physical health of a patient before surgery and is traditionally assessed as a risk factor for postoperative complications, was not associated with postoperative complications in older patients.
“The fact that age and ASA status were not risk factors for postoperative complications is somewhat surprising, because these are the factors a clinician would typically look at when assessing a patient’s risk of developing complications after surgery,” said Dr. Jennifer Watt, lead author of the study.
The review examined 44 existing studies including more than 12,000 patients 60 years and older and reporting on postoperative outcomes including complications, postoperative mortality, length of hospitalization, functional decline and whether patients were discharged home or to another hospital or long-term care facility.
Due to significant differences in the design and reporting methods of the included studies, the authors were unable to report on the level of risk for specific postoperative complications, or their severity.
The researchers found that across all studies, 25 per cent of older patients experienced some complications following elective surgery.
“Older adults are a diverse group of patients whose risk of postoperative complications is not solely defined by their age, comorbidities or the type of surgical procedure they receive,” said Dr. Watt. “This study highlights how common postoperative complications are among older adults undergoing elective surgery, and the importance of geriatric syndromes, including frailty, in identifying older adults who may be at risk.”
The review did not examine why frailty was associated with negative outcomes following surgery, but the authors hypothesize that frailty and not older age was associated with postoperative complications because frailty represents a patient’s biological age as opposed to their chronological age.
The authors also noted that there are proven interventions for a number of the risk factors identified in the review. Interventions aimed at improving a patient’s nutrition, physical fitness and cognition have been found to improve frailty in older patients, and smoking cessation interventions before surgery have been associated with a lower risk of postoperative complications, according to the review.
St. Michael’s Hospitalwww.stmichaelshospital.com/media/detail.php?source=hospital_news/2018/0112

https://interhospi.com/wp-content/uploads/sites/3/2020/06/logo-footer.png 44 200 3wmedia https://interhospi.com/wp-content/uploads/sites/3/2020/06/Component-6-–-1.png 3wmedia2020-08-26 14:36:192020-08-26 14:36:40Age is not a risk factor for complications after surgery among older patients

Prosthetic arms can provide controlled sensory feedback

, 26 August 2020/in E-News /by 3wmedia

Losing an arm doesn’t have to mean losing all sense of touch, thanks to prosthetic arms that stimulate nerves with mild electrical feedback.
University of Illinois researchers have developed a control algorithm that regulates the current so a prosthetics user feels steady sensation, even when the electrodes begin to peel off or when sweat builds up.
“We’re giving sensation back to someone who’s lost their hand. The idea is that we no longer want the prosthetic hand to feel like a tool, we want it to feel like an extension of the body,” said Aadeel Akhtar, an M.D./Ph.D. student in the neuroscience program and the medical scholars program at the University of Illinois. Akhtar is the lead author of a paper describing the sensory control module, published in Science Robotics, and the founder and CEO of PSYONIC, a startup company that develops low-cost bionic arms.
“Commercial prosthetics don’t have good sensory feedback. This is a step toward getting reliable sensory feedback to users of prosthetics,” he said.
Prosthetic arms that offer nerve stimulation have sensors in the fingertips, so that when the user comes in contact with something, an electrical signal on the skin corresponds to the amount of pressure the arm exerts. For example, a light touch would generate a light sensation, but a hard push would have a stronger signal.
However, there have been many problems with giving users reliable feedback, said aerospace engineering professor Timothy Bretl, the principal investigator of the study. During ordinary wear over time, the electrodes connected to the skin can begin to peel off, causing a buildup of electrical current on the area that remains attached, which can give the user painful shocks. Alternately, sweat can impede the connection between the electrode and the skin, so that the user feels less or even no feedback at all.
“A steady, reliable sensory experience could significantly improve a prosthetic user’s quality of life,” Bretl said.
The controller monitors the feedback the patient is experiencing and automatically adjusts the current level so that the user feels steady feedback, even when sweating or when the electrodes are 75 percent peeled off.
The researchers tested the controller on two patient volunteers. They performed a test where the electrodes were progressively peeled back and found that the control module reduced the electrical current so that the users reported steady feedback without shocks. They also had the patients perform a series of everyday tasks that could cause loss of sensation due to sweat: climbing stairs, hammering a nail into a board and running on an elliptical machine.
“What we found is that when we didn’t use our controller, the users couldn’t feel the sensation anymore by the end of the activity. However, when we had the control algorithm on, after the activity they said they could still feel the sensation just fine,” Akhtar said.
Adding the controlled stimulation module would cost much less than the prosthetic itself, Akhtar said. "Although we don’t know yet the exact breakdown of costs, our goal is to have it be completely covered by insurance at no out-of-pocket costs to users."
The group is working on miniaturizing the module that provides the electrical feedback, so that it fits inside a prosthetic arm rather than attaching to the outside. They also plan to do more extensive patient testing with a larger group of participants.

University of Illinois Urbana-Champaignnews.illinois.edu/view/6367/643862

https://interhospi.com/wp-content/uploads/sites/3/2020/06/logo-footer.png 44 200 3wmedia https://interhospi.com/wp-content/uploads/sites/3/2020/06/Component-6-–-1.png 3wmedia2020-08-26 14:36:192020-08-26 14:36:27Prosthetic arms can provide controlled sensory feedback

Philips and Hologic announce global partnership agreement to provide integrated imaging solutions for women’s health

, 26 August 2020/in E-News /by 3wmedia

Partnership will allow hospitals easier access to integrated suites of diagnostic imaging modalities, advanced informatics and services for comprehensive breast screening and diagnosis

Royal Philips and Hologic, Inc. announced on March 2nd a global partnership agreement to offer care professionals integrated solutions comprising diagnostic imaging modalities, advanced informatics and services for screening, diagnosis and treatment of women across the world. The collaboration combines Hologic’s innovative mammography technologies and Philips’ leading portfolio of ultrasound, MRI, CT, and X-ray systems, advanced informatics and broad range of services, including maintenance, upgrade, training and operational performance management services.

“No two women are alike, and we are teaming up with care providers and leading industry partners to support the delivery of a tailored, seamless breast care experience for women,” said said Rob Cascella, CEO Diagnosis & Treatment businesses for Royal Philips. “That is why I am very pleased to announce our new partnership with Hologic for mammography. This partnership allows us to offer a complete set of innovative diagnostic imaging systems, software and services to our customers, including Hologic’s market-leading mammography solutions for breast screening and diagnosis of women in need of care.”

“Hologic believes in enabling doctors with superior technology that improves women’s health through early detection and treatment,” said Pete Valenti, Hologic’s Division President, Breast and Skeletal Health Solutions. “Our market-leading mammography solutions perfectly complement Philips’ portfolio, making Hologic the right industry partner for this first-of-its-kind collaboration. Now, through the partnership, Hologic can join Philips when engaging with customers on projects that were not previously possible for the two companies alone. It’s a win for everyone involved, including the customers and patients we serve.”

In breast care, Philips offers advanced imaging for ultrasound (e.g. Philips Affinity with Anatomical Intelligence for Breast), MRI (e.g. Philips Ingenia digital MRI with Compressed SENSE to speed up exam times), and PET/CT (e.g. Philips Vereos fully digital PET/CT), supported by intelligent image analysis, quantification, information management and workflow tools. Under the agreement, Philips will be able to offer select products from Hologic’s breast health portfolio as part of multi-modality deals for hospitals and health systems. This will include Hologic’s new 3DimensionsÔ mammography system, the fastest, highest resolution breast tomosynthesis system in the industry, as well as other technologies for breast screening and interventional radiology [1,2].

The multi-year, non-exclusive global partnership agreement allows for customized regional implementation to best meet the individual needs of each customer. The financial details of the agreement were not disclosed.

To learn more about the 3Dimensions system and its comprehensive range of features, which are compatible with all Hologic 3D MammographyTM systems, visit 3DimensionsSystem.com. Hologic featured its full breast health portfolio, including the new 3Dimensions system, at the 2018 European Congress of Radiology (ECR) in Vienna.

Philips also showcased its full suite of solutions for diagnosis and treatment at ECR 2018. For more information about Philips’ presence at ECR 2018, including its virtual reality MR experience, visit www.philips.com/ecr.
[1]           Hologic Data on file
[2]           Pending FDA approval and/or commercial availability

https://interhospi.com/wp-content/uploads/sites/3/2020/06/logo-footer.png 44 200 3wmedia https://interhospi.com/wp-content/uploads/sites/3/2020/06/Component-6-–-1.png 3wmedia2020-08-26 14:36:192020-08-26 14:36:35Philips and Hologic announce global partnership agreement to provide integrated imaging solutions for women’s health

Existing cancer medication offers potential to treat Huntington’s disease

, 26 August 2020/in E-News /by 3wmedia

A drug already used to treat certain forms of cancer may also be an effective therapy for Huntington’s disease, according to a new study. The same study also increases our understanding of how this drug, and other medications like it, may offer hope for other neurodegenerative diseases like Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), and Parkinson’s disease.
Huntington’s disease is a devastating, inevitably fatal disease, with no medications that slow or stop disease progression. In this study, mice with the equivalent of Huntington’s disease became more mobile, recovered from neurodegeneration, and lived longer after being treated with bexarotene. The same research builds on a 2016 study where La Spada and his team showed that the drug KD3010 is an effective treatment for Huntington’s disease in mice and in human patient neurons made from stem cells.
Senior author Al La Spada, MD, PhD, said the study results are exciting not just because these drugs worked, but because of how they worked. “It’s not just the response from the drugs, but the mechanistic pathways these drugs are targeting,” said La Spada, director of the forthcoming Duke Center for Neurodegeneration and Neurotherapeutics. “These pathways are relevant to other neurodegenerative disorders and potentially the aging process, itself in addition to Huntington’s disease.”
Bexarotene and KD3010 function by activating PPARδ, a transcription factor that keeps neurons functional in two ways: by keeping mitochondria healthy and active, and by helping neurons remove dysfunctional proteins. Mice–and humans–with Huntington’s disease have problems activating PPARδ. When La Spada and colleagues treated Huntington’s mice with bexarotene or KD3010, they observed improved mitochondrial health in neurons, as well as increased removal of damaging misfolded proteins.
The same factors of impaired mitochondrial function and protein misfolding are recognized as increasingly important in diseases like Alzheimer’s disease, Parkinson’s disease, and ALS.
The study doesn’t mean that patients with Huntington’s disease or other conditions should rush to get bexarotene or KD3010. Further research needs to determine how to use these drugs in human patients. Bexarotene can have difficult side effects at high dosages, and optimal doses aren’t known, while KD3010 has only been tested in human subjects for type II diabetes.
Instead, future therapies for Huntington’s disease and other neurodegenerative conditions may take a cue from HIV treatments and involve a “cocktail” approach of combined medications. Lead author Audrey Dickey, PhD, found that, taken together, bexarotene and KD3010 produced better results in cells even when given at lower doses.
“With this approach, we could minimize side effects with lower doses of each compound, even when together the treatments provide a higher effect than either one alone,” said Dickey. “We are carrying out further research on the underlying mechanisms of neuroprotection and applying this research to other diseases with similar issues of mitochondrial dysfunction and protein quality control, such as Parkinson’s disease, Alzheimer’s disease, and ALS.”
Duke University School Of Medicinehttps://tinyurl.com/y73s5wfd

https://interhospi.com/wp-content/uploads/sites/3/2020/06/logo-footer.png 44 200 3wmedia https://interhospi.com/wp-content/uploads/sites/3/2020/06/Component-6-–-1.png 3wmedia2020-08-26 14:36:192020-08-26 14:36:42Existing cancer medication offers potential to treat Huntington’s disease

2019 International Hospital Federation Awards now open

, 26 August 2020/in E-News /by 3wmedia

Entry submissions for the 2019 International Hospital Federation Awards is now open. Hospitals and health service providers can nominate their outstanding and innovative projects and programs for a chance to be recognized internationally in one of the four awards.
The IHF/Dr Kwang Tae Kim Grand Award is open only to IHF Full and Associate Members and their members. This recognizes excellence and achievements at health system or facility level in multiple areas including quality and patient safety, corporate social responsibility, innovations in service delivery at affordable costs, and healthcare leadership and management practices.
The Excellence Awards are open to both IHF Member and non-member public and private healthcare providers.
The IHF/Bionexo Excellence Award for Corporate Social Responsibility is for excellent projects that provide quality healthcare services at affordable costs, promote volunteer contribution to community care, uphold sustainable environment, energy and green initiatives, reduce inequalities in healthcare service delivery to the community and advance healthcare for emerging and developing nations.
The IHF/EOH Excellence Award for Leadership and Management in Healthcare recognizes outstanding projects that enhance governance, leadership, management policies and practices, foster new culture of service, effectively manage finance and resources, and for major breakthroughs in productivity improvements or innovations in healthcare delivery or process management.
The IHF/Austco Excellence Award for Quality & Safety and Patient-centered Care recognizes exceptional programs that promote quality and safety, enhances patient education, engagement and empowerment, and promote ethical approaches and evidence-based practices.
Winning an IHF Award is a prestigious accolade in the industry and all public and private healthcare service providers are encouraged to join. Submitting an entry is the first step in an extensive process to determine this year’s award winners, who will be announced at the Awards Ceremony during the 43rd World Hospital Congress in Muscat, Oman on 6-9 November.
Entries can be submitted online through the IHF Awards submission website: https://congress.ihf-fih.org/ihf_awardsDeadline of entries is on 17 May 2019.
 https://worldhospitalcongress.org/

https://interhospi.com/wp-content/uploads/sites/3/2020/06/logo-footer.png 44 200 3wmedia https://interhospi.com/wp-content/uploads/sites/3/2020/06/Component-6-–-1.png 3wmedia2020-08-26 14:35:552020-08-26 14:35:582019 International Hospital Federation Awards now open

How to evaluate medical device warranties

, 26 August 2020/in E-News /by 3wmedia

FUJIFILM SonoSite is helping ultrasound users to assess the total cost of ownership for imaging equipment. Medical device warranties: Fine print, major total cost implications – a recently published report by the company’s Chief Operating Officer Rich Fabian – tackles the intricate details of warranties head-on, helping to clarify key considerations and unpack some of the hidden costs, for both patient care and financial planning. 
Warranties are intended to mitigate the risks related to ownership by allowing hospitals to control expenditure on training, servicing, repairs, replacement parts and software updates over the course of an instrument’s useful lifecycle. The two-page article is essential reading for procurement departments, helpfully examining how the appeal of generous multi-year warranties may be undermined by taking into account the exceptions mentioned in the fine print. For example, limitations on replacement parts can sometimes result in hospitals spending more on transducers than the cost of the original system. A key aim for buyers is to choose equipment in which the quality and durability are commensurate with the warranty offered. The mean time between instrument failures and the frequency of repairs is a critical factor to consider as downtime is costly, both in terms of patient care and delayed procedures. Raising awareness of these considerations will help ultrasound users to get the best value for money when purchasing a new clinical imaging system.
www.beckershospitalreview.com/finance/medical-device-warranties-fine-print-major-total-cost-implications.html

https://interhospi.com/wp-content/uploads/sites/3/2020/06/logo-footer.png 44 200 3wmedia https://interhospi.com/wp-content/uploads/sites/3/2020/06/Component-6-–-1.png 3wmedia2020-08-26 14:35:552020-08-26 14:36:06How to evaluate medical device warranties

New device for assisting accurate hemodialysis catheter placement

, 26 August 2020/in E-News /by 3wmedia

Researchers at Okayama University report in The Journal of Vascular Access a supporting device for accurately placing hemodialysis catheters on kidney patients.  The device was successfully used on a group of 10 patients and is expected to become an essential tool in situations where other, catheter-free hemodialysis approaches are not possible.
Patients with improperly functioning kidneys often need to undergo hemodialysis — the procedure of purifying blood in an artificial kidney outside the body — on a regular basis.  Hemodialysis requires access to blood vessels, for the collection of blood and its re-introduction after purification.  In this context, vascular access is commonly achieved with a so-called tunneled cuffed catheter (TCC).  Accurate TCC placement is important; incorrect positioning can lead to blood clots and induce central vein thrombosis.  Assistant Professor Toshiaki Ohara from Okayama University and colleagues have now developed a device enabling accurate TCC placement.  The researchers’ insertion support device accommodates for individual body shape differences and is expected to decrease the rate of TCC replacements — typically ranging between 8.9% and 56%.
The device was made from a material called expanded polytetrafluoroethylene (ePTFE), having the property of maintained plasticity.  It can be described as a bendable ribbon with holes (eyelets) spaced 1 cm apart; the holes allow making markings on the patient’s body with a felt-tip pen.
The insertion support device was tested on 10 Japanese adult hemodialysis patients (6 men and 4 women with a mean age of 71.3 years) treated at Shigei Medical Research Hospital.  Placement of the device on the body took place with the help of X-ray imaging: the tip of the device, for marking the TCC entry site, was laid so that it overlaps with the right heart border.  With the help of the markings made on the patient’s body, the physician could insert the TCC within an error of about 1 cm.  The patients were observed for 2 months, during which there was no catheter replacement needed.
The device of Dr.Ohara and colleagues helps to reduce catheter waste and the overall cost of hemodialysis.  In addition, as the attachment of a catheter requires exposure to X-rays, it reduces accumulated radiation doses for both patients and physicians.  Although the study was only carried out for 10 patients in a short observation period, the scientists “anticipate that this new device … can be used for catheter intervention in many fields”.

http://www.okayama-u.ac.jp/index_e.html
https://interhospi.com/wp-content/uploads/sites/3/2020/06/logo-footer.png 44 200 3wmedia https://interhospi.com/wp-content/uploads/sites/3/2020/06/Component-6-–-1.png 3wmedia2020-08-26 14:35:552020-08-26 14:36:13New device for assisting accurate hemodialysis catheter placement

Over half of former intensive care patients in the UK report symptoms of psychological disorders

, 26 August 2020/in E-News /by 3wmedia

Patients in the UK who have survived critical illnesses requiring care in an intensive care unit (ICU) frequently report symptoms of anxiety, PTSD and/or depression, according to a study. Those reporting symptoms of depression after critical illness appear to be at a greater risk of death.
Researchers in our department led by Peter Watkinson investigated psychological disorders in a cohort of 4,943 of former ICU patients. They found that 46% of patients reported symptoms of anxiety, 40% reported symptoms of depression and 22% reported symptoms of PTSD, while 18% of patients in the study reported symptoms of all three psychological conditions.
To investigate possible links between treatment in an ICU and symptoms of psychological disorders, the authors asked a total of 4,943 patients who received treatment in one of 26 ICUs in the UK between 2006 and 2013, to complete a questionnaire on their symptoms of anxiety, depression and PTSD three months after discharge from ICU and again 12 months after discharge.
The authors found that patients who reported symptoms of depression were 47% more likely to die from any cause (all-cause mortality) during the first two years after discharge from the ICU than those who did not report these symptoms.
Dr Peter Watkinson said: ‘Our findings suggest that depression following care of a critical illness in the ICU may be a marker of declining health and clinicians should consider this when following up with former ICU patients.’
The authors caution that the generalisability of the results outside of the UK may be limited as the data was only collected from UK based patients. Furthermore, the observational nature of the study and its reliance of self-reported data mean that it does not allow for conclusions about cause and effect between ICU care and symptoms of psychological disorders.

Nuffield Department of Clinical Neuroscience
www.ndcn.ox.ac.uk/news/over-half-of-former-intensive-care-patients-in-the-uk-report-symptoms-of-psychological-disorders

https://interhospi.com/wp-content/uploads/sites/3/2020/06/logo-footer.png 44 200 3wmedia https://interhospi.com/wp-content/uploads/sites/3/2020/06/Component-6-–-1.png 3wmedia2020-08-26 14:35:552020-08-26 14:36:01Over half of former intensive care patients in the UK report symptoms of psychological disorders

Nano-CT device successfully tested

, 26 August 2020/in E-News /by 3wmedia

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. A team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional X-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analysed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is X-rayed and a detector measures the respective amount of radiation absorbed from various angles. Three-dimensional images of the inside of the object can be constructed based on several such measurements. Up until now, however, the technology reached its limits when it came to objects as small as the tiny, 0.4 millimeter long legs of the velvet worm (Onychophora).
High-resolution images of this magnitude required radiation from particle accelerators, yet there are only a few dozen such facilities in Europe. Approaches suitable for the typical laboratory still had to struggle with low resolutions, or the samples investigated had to be made of certain materials and could not exceed a certain size. The reason was often the use of X-ray optics. Put simply, X-ray optics focus X-ray radiation similar to the way optical lenses focus light – but they also have several limitations.
The TUM Nano-CT system is based on a newly developed X-ray source, which generates a particularly focused beam, without relying on X-ray optics. In combination with an extremely low-noise detector, the device produces images that approach the resolution possible with a scanning electron microscope, while also capturing structures under the surface of the object under investigation.
“Our system has decisive advantages compared to CTs using X-ray optics,” says TUM scientist Mark Müller, lead author of the PNAS article. “We can make tomographies of significantly larger samples and we are more flexible in terms of the materials that can be investigated.”
Like so many other imaging instruments, the Nano-CT system was developed and installed at the Munich School of BioEngineering (MSB). This TUM interdisciplinary research centre is Europe’s thematically most comprehensive university facility for the intersection of medicine, engineering sciences and natural sciences. “Our goal in the development of the Nano-CT system is not only to be able to investigate biological samples, such as the leg of the velvet worm,” says Franz Pfeiffer, TUM Professor for Biomedical Physics, Director of the MSB, and a Fellow at the TUM Institute for Advanced Study (TUM-IAS).
“In the future, this technology will also make biomedical investigations possible. Thus, for example, we will be able to examine tissue samples to clarify whether or not a tumour is malignant. A non-destructive and three-dimensional image of the tissue with a resolution like that of the Nano-CT can also provide new insights into the microscopic development of widespread illnesses such as cancer.”

TUMhttps://tinyurl.com/y9x4jycu

https://interhospi.com/wp-content/uploads/sites/3/2020/06/logo-footer.png 44 200 3wmedia https://interhospi.com/wp-content/uploads/sites/3/2020/06/Component-6-–-1.png 3wmedia2020-08-26 14:35:552020-08-26 14:36:08Nano-CT device successfully tested

Novel PET imaging noninvasively pinpoints colitis inflammation sites

, 26 August 2020/in E-News /by 3wmedia

A novel positron emission tomography (PET) imaging method shows promise for noninvasively pinpointing sites of inflammation in people with inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn’s disease.
Amanda C. Freise, PhD, first author of the study and a lecturer at UCLA, explains the research and its significance.
The U.S. Centers for Disease Control states that approximately three million Americans reported being diagnosed with IBD in 2015 (latest data). Managing patients with chronic bowel inflammation can be challenging, relying on symptoms and invasive procedures such as colonoscopy and biopsy.
In a mouse model of colitis, this study uses PET imaging with antibody fragment probes (immunoPET) to target a specific subset of immune cells, the CD4+ T cells, which are characteristic of IBD.
“CD4 immunoPET could provide a non-invasive means to detect and localize sites of inflammation in the bowel and also provide image guidance for biopsies if needed,” explains Anna M. Wu, PhD, professor of Molecular and Medical Pharmacology at UCLA and director of the UCLA Jonsson Comprehensive Cancer Center’s Cancer Molecular Imaging Program, who headed the project and collaborated with Jonathan Braun, MD, and Arion Chatziioannou, PhD, also of UCLA. She adds, “Assessment of CD4 infiltration could also potentially provide a means for detection of subclinical disease, before symptoms occur, and provide a readout as to the efficacy of therapeutic interventions.”
A zirconium-89 (89Zr)-labe7lled anti-CD4 engineered antibody fragment [GK1.5 cDb] was used for non-invasive imaging of the distribution of CD4+ T cells in the mice with induced colitis, and it successfully detected CD4+ T cells in the colon, ceca and mesenteric lymph nodes. The study demonstrates that CD4 immunoPET of IBD warrants further investigation and has the potential to guide development of antibody-based imaging in humans with IBD.
Wu points out that the ability to directly image immune responses could have wide applications, saying, “It could unlock our ability to assess inflammation in a broad spectrum of disease areas, including oncology and immune-oncology, auto-immunity, cardiovascular disease, neuroinflammation, and more. ImmunoPET is a robust and general platform for visualization of highly specific molecular targets.”

Society of Nuclear Medicine and Molecular Imaging
www.snmmi.org/NewsPublications/NewsDetail.aspx?ItemNumber=29170

https://interhospi.com/wp-content/uploads/sites/3/2020/06/logo-footer.png 44 200 3wmedia https://interhospi.com/wp-content/uploads/sites/3/2020/06/Component-6-–-1.png 3wmedia2020-08-26 14:35:552020-08-26 14:36:15Novel PET imaging noninvasively pinpoints colitis inflammation sites
Page 214 of 234«‹212213214215216›»

Latest issue of International Hospital

April 2024

15 August 2025

International Hospital Federation announces 81 finalists across eight award categories

15 August 2025

COVID-19 vaccines prevented 2.5 million deaths worldwide, study finds

11 August 2025

Mayo Clinic unveils breakthrough tool for hidden cancer DNA analysis

Digital edition
All articles Archived issues

Free subscription

View more product news

Get our e-alert

The medical devices information portal connecting healthcare professionals to global vendors

Sign in for our newsletter
  • News
    • Featured Articles
    • Product News
    • E-News
  • Magazine
    • About us
    • Archived issues
    • Media kit
    • Submit Press Release

Beukenlaan 137
5616 VD Eindhoven
The Netherlands
+31 85064 55 82
info@interhospi.com

PanGlobal Media IS not responsible for any error or omission that might occur in the electronic display of product or company data.

Scroll to top

This site uses cookies. By continuing to browse the site, you are agreeing to our use of cookies.

Accept settingsHide notification onlyCookie settings

Cookie and Privacy Settings



How we use cookies

We may ask you to place cookies on your device. We use cookies to let us know when you visit our websites, how you interact with us, to enrich your user experience and to customise your relationship with our website.

Click on the different sections for more information. You can also change some of your preferences. Please note that blocking some types of cookies may affect your experience on our websites and the services we can provide.

Essential Website Cookies

These cookies are strictly necessary to provide you with services available through our website and to use some of its features.

Because these cookies are strictly necessary to provide the website, refusing them will affect the functioning of our site. You can always block or delete cookies by changing your browser settings and block all cookies on this website forcibly. But this will always ask you to accept/refuse cookies when you visit our site again.

We fully respect if you want to refuse cookies, but to avoid asking you each time again to kindly allow us to store a cookie for that purpose. You are always free to unsubscribe or other cookies to get a better experience. If you refuse cookies, we will delete all cookies set in our domain.

We provide you with a list of cookies stored on your computer in our domain, so that you can check what we have stored. For security reasons, we cannot display or modify cookies from other domains. You can check these in your browser's security settings.

.

Google Analytics Cookies

These cookies collect information that is used in aggregate form to help us understand how our website is used or how effective our marketing campaigns are, or to help us customise our website and application for you to improve your experience.

If you do not want us to track your visit to our site, you can disable this in your browser here:

.

Other external services

We also use various external services such as Google Webfonts, Google Maps and external video providers. Since these providers may collect personal data such as your IP address, you can block them here. Please note that this may significantly reduce the functionality and appearance of our site. Changes will only be effective once you reload the page

Google Webfont Settings:

Google Maps Settings:

Google reCaptcha settings:

Vimeo and Youtube videos embedding:

.

Privacy Beleid

U kunt meer lezen over onze cookies en privacy-instellingen op onze Privacybeleid-pagina.

Privacy policy
Accept settingsHide notification only

Sign in for our newsletter

Free subscription