Archive for category: E-News

E-News

Prof. Jeanette Leusen, PhDEd van Rijswijk

Novel first-in-class antibodies block inflammation pathway in autoimmune diseases

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Researchers at UMC Utrecht have developed two novel antibodies that specifically target the high-affinity IgG receptor FcγRI, offering a potential therapeutic approach for autoimmune diseases including rheumatoid arthritis, systemic lupus erythematosus, and immune thrombocytopenia. The antibodies, designated C01 and C04, effectively block immune complex binding without triggering receptor activation, addressing a key limitation of previous […]

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Schematic illustration of the noninvasive closed-loop spinal interface.© TMIMS

Non-invasive spinal stimulation restores stepping control in paraplegic patients

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Researchers in Japan have developed a breakthrough non-invasive closed-loop spinal stimulation system that enables individuals with paraplegia to regain control of leg stepping movements. The hand-controlled magnetic stimulation technique bypasses spinal cord lesions and strengthens preserved neural circuits, offering a surgical-free alternative for gait rehabilitation after spinal cord injury.

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UK government commits £74 million to life sciences innovation

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The UK government has announced over £74 million in combined government and industry funding to support eight research and development projects focused on transforming pharmaceutical manufacturing and addressing critical healthcare challenges.

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CAR T cells reduce atherosclerosis by 70% in mouse study

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Scientists at the University of Pennsylvania’s Perelman School of Medicine have demonstrated that chimeric antigen receptor (CAR) T cell therapy could offer a novel approach to treating atherosclerosis.

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rare diseases, sickle cell disease

UK’s MHRA signals major regulatory overhaul for rare disease therapies

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The Medicines and Healthcare products Regulatory Agency has committed to a fundamental restructuring of the UK’s rare disease therapy regulatory framework, with detailed guidelines scheduled for publication in 2026. The announcement represents the most significant shift in rare disease treatment pathways undertaken by the regulator and forms part of the Government’s broader life sciences strategy.

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UNIVERSITY OF BARCELONA

Unlocking brown fat: cellular autophagy mechanism holds key to age-related metabolic decline

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Researchers have identified chaperone-mediated autophagy as a critical regulator of brown adipose tissue thermogenic activity, revealing that age-related decline in this selective protein degradation pathway drives metabolic dysfunction. The findings, published in Science Advances, demonstrate that pharmacological activation of this mechanism can restore brown fat function in aged mice, opening therapeutic avenues for obesity and […]

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NHS gig doctor

Thousands of UK doctors trapped in NHS gig economy contracts, investigation reveals

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A BMJ investigation reveals almost nine in 10 NHS acute trusts use local employment contracts that trap thousands of doctors – predominantly international medical graduates and ethnic minorities – in roles lacking training opportunities, career progression, and nationally agreed safeguards. Some doctors remain in these precarious positions for over a decade.

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Siemens Healthineers announces strategic restructuring with new Precision Therapy segment

Siemens Healthineers unveils restructuring plan with new precision therapy segment

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Siemens Healthineers has announced a comprehensive strategic restructuring at its Capital Markets Day in London, introducing a new reporting framework centred on three distinct segments and targeting annual revenue growth of 5-7% through fiscal year 2030.

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tirzepatide food cravings

Research shows first direct evidence of weight-loss drug influence on brain signals linked to food cravings

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A pioneering study tracking brain activity in patients taking the weight-loss drug tirzepatide has uncovered distinctive neural patterns associated with food preoccupation, offering the first direct evidence of how incretin-based therapies modulate reward circuitry in humans. The research reveals a specific low-frequency brain signal that precedes intense food cravings and demonstrates how pharmacological intervention may […]

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Clinicians urged to revitalise bedside strategies as technology reshapes patient care

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A new report in the New England Journal of Medicine outlines six practical strategies to strengthen fundamental clinical skills and restore the doctor-patient relationship in an increasingly technology-driven healthcare environment.

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April 2024

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