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Archive for category: E-News

E-News

Hot nanoparticles for cancer treatments

, 26 August 2020/in E-News /by 3wmedia

Nanoparticles have a great deal of potential in medicine: for diagnostics, as a vehicle for active substances or a tool to kill off tumours using heat. ETH Zurich researchers have now developed particles that are relatively easy to produce and have a wide range of applications.
If you put your hand over a switched-on torch in the dark, it appears to glow red. This is because long-wavelength red light beams penetrate human tissue more effectively than short-wavelength blue light. ETH Zurich researchers exploit this fact in a new kind of nanoparticles: so-called plasmonic particles, which heat up when they absorb near-infrared light. This could enable them to kill tumour tissue with heat, for instance.

Gold is a popular material for nanoparticles used therapeutically, as it is well tolerated and does not usually trigger any undesirable reactions. In the characteristic ball or sphere shape of nanoparticles, however, gold does not have the necessary properties to work as a plasmonic particle that absorbs sufficiently in the near-infrared spectrum of light to heat up. To do so, it needs to be moulded into a special shape, such as a rod or shell, so that the gold atoms adopt a configuration that starts absorbing near-infrared light, thereby generating heat. Producing such nanorods or nanoshells in sufficient amounts, however, is complex and expensive.
A team of researchers headed by Sotiris Pratsinis, Professor of Particle Technology at ETH Zurich, has now discovered a trick to manufacture plasmonic gold particles in large amounts. They used their existing know-how on plasmonic nanoparticles and made sphere-shaped gold nanoparticles that display the desired near-infrared plasmonic properties by allowing them to be aggregated. Each particle is coated with a silicon dioxide layer beforehand, which acts as a placeholder between the individual spheres in the aggregate. Through the precisely defined distance between several gold particles, the researchers transform the particles into a configuration that absorbs near-infrared light and thus generates heat.

‘The silicon dioxide shell has another advantage’, explains Georgios Sotiriou, first author on the study and, until recently, a postdoc in Pratsinis

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Computerised checklist reduces type of hospital infection

, 26 August 2020/in E-News /by 3wmedia

Christopher Longhurst was part of a team that found a way to pull information from hospital patients’ electronic medical records to reduce the rate of one type of infection.
A computerised safety checklist that automatically pulls information from patients’ electronic medical records was associated with a threefold drop in rates of one serious type of hospital-acquired infection, according to a study by researchers at the Stanford University School of Medicine and Lucile Packard Children’s Hospital Stanford.
The study, conducted in the hospital’s pediatric intensive care unit, targeted bloodstream infections that begin in central lines

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Endoscope with an oxygen sensor detects pancreatic cancer

, 26 August 2020/in E-News /by 3wmedia

An optical blood oxygen sensor attached to an endoscope is able to identify pancreatic cancer in patients via a simple endoscopic procedure, according to researchers at Mayo Clinic in Florida.

The study shows that the device, which acts like the well-known clothespin-type finger clip used to measure blood oxygen in patients, has a sensitivity of 92 percent and a specificity of 86 percent.

That means, of 100 patients with pancreatic cancer, this sensor would detect 92 of them, based on the findings. And of 100 patients who don

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?Beneficial inflammation? may promote healing in pulmonary fibrosis

, 26 August 2020/in E-News /by 3wmedia

Inflammation has long been considered an integral part of the biological process that leads to deadly scarring in idiopathic pulmonary fibrosis. New research at National Jewish Health, however, suggests that a little inflammation may also be crucial to the healing and repair processes in the lungs. Elizabeth Redente, PhD, assistant professor of cell biology at National Jewish Health, and her colleagues report that the pro-inflammatory cytokine TNF-α can speed recovery of injured lungs and accelerate the resolution of established fibrosis in a mouse model.

‘The role of inflammation in the development of scarring has been hotly debated in recent years,’ said D
‘Idiopathic pulmonary fibrosis is a relentless, progressive scarring of the lungs for which there is no approved medical therapy. The disease has no known cause and patients generally die within three years of diagnosis. Approximately 40,000 Americans die of idiopathic pulmonary fibrosis every year.
Inflammation was long believed to be a precursor and cause of scarring in the lungs. However, anti-inflammatory treatments have shown no positive effect on the progress of the disease. In recent years, some researchers have thought that inflammation may be part of the healing process as well as the scarring of the lungs.

r. Redente.

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New approach to prostate cancer screening needed

, 26 August 2020/in E-News /by 3wmedia

The UK needs to invest in testing for those men most at risk of prostate cancer rather than follow a cast-the-net-wide approach targeting the whole population, a leading scientist from The University of Manchester – part of Manchester Cancer Research Centre – has argued at an international conference.
Men in the UK are currently entitled to PSA blood test for prostate cancer once they reach the age of 50 and will be recommended to have a prostate biopsy if their PSA level is greater than their age-specific threshold. This practice leaves around 50,000 men in the UK having an unnecessary prostate biopsy every year which is painful, can cause bleeding and infection and rarely even death.
Professor Ken Muir, from The University of Manchester, is proposing the UK moves to a risk-based approach in the community

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Medications can help adults with alcohol use disorders reduce drinking

, 26 August 2020/in E-News /by 3wmedia

Several medications can help people with alcohol use disorders maintain abstinence or reduce drinking, according to research from the University of North Carolina at Chapel Hill.
The work provides additional options for clinicians to effectively address this global concern.
Although alcohol use disorders are associated with many health problems, including cancers, stroke and depression, fewer than one-third of people with the disorders receive any treatment and less than 10 percent receive medications to help reduce alcohol consumption.
‘There are many studies that have tried to show whether certain medications can help with alcohol use disorders, but it is a lot of information to digest and many providers do not know what works or doesn

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Off the shelf, on the skin: Stick-on electronic patches for health monitoring

, 26 August 2020/in E-News /by 3wmedia

Wearing a fitness tracker on your wrist or clipped to your belt is so 2013.
Engineers at the University of Illinois at Urbana-Champaign and Northwestern University have demonstrated thin, soft stick-on patches that stretch and move with the skin and incorporate commercial, off-the-shelf chip-based electronics for sophisticated wireless health monitoring.
The patches stick to the skin like a temporary tattoo and incorporate a unique microfluidic construction with wires folded like origami to allow the patch to bend and flex without being constrained by the rigid electronics components. The patches could be used for everyday health tracking

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Largest study of critical care telemedicine reveals improvements in patient outcomes and reductions in healthcare costs

, 26 August 2020/in E-News /by 3wmedia

With critical care costs in the U.S. totalling roughly $80-100 billion per year, new research highlights Intensive Care Unit (ICU) telemedicine as key to enabling hospitals and health systems to improve patient care at lower cost. The study, which examined the impact of Philips’ remote Intensive Care Unit (eICU) program on 118,990 critical care patients, across 56 ICUs, 32 hospitals and 19 health systems over a five-year period, demonstrated reductions in both mortality and length of stay. The results were statistically significant on both an unadjusted and severity-adjusted basis. The key findings were that, compared to patients receiving usual ICU care, patients who received their ICU care from a hospital that utilized the eICU program were:
    

  • 26% more likely to survive the ICU;
  • Discharged from the ICU 20% faster;
  • 16% more likely to survive hospitalisation and be discharged;
  • Discharged from the hospital 15% faster.

    
“This is the first large-scale study that ties ICU telemedicine to both the improvement of patient outcomes and cost reduction through shorter length of stays in the ICU and hospital, and identifies the processes that achieved greater efficiency,” said Dr. Lilly. “These results point to a significant opportunity to better manage and treat our critical patients in this time of increasing pressure from healthcare reform to deliver high quality and cost-effective care.”  Hospitals and health systems that saw the largest reduction in length of stay and mortality rates were those that excelled in certain components of the program – involving people, technology and processes. As a result, the study revealed the following program design elements common to the most successful ICU telemedicine programs:
    

  • Having an intensivist physician perform a remote review of the patient and care plan within one hour of ICU admission;
  • Frequent collaborative review and use of performance data provided by the ICU telemedicine program;
  • Faster response times to technology-based alerts and alarms for physiological and laboratory value instability;
  • Increased rates of adherence to ICU best practices for those that are supported by the ICU telemedicine team;
  • Interdisciplinary rounds;
  • Institutional ICU committee effectiveness.

Philips Healthcarehttp://tinyurl.com/nbpqnez

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New surgical glue could provide alternative for heart procedures

, 26 August 2020/in E-News /by 3wmedia

People who need multiple surgeries for congenital heart defects undergo procedures that are invasive and challenging partly due to an inability to quickly and safely secure devices inside the heart. Sutures take too much time to stitch and can stress fragile heart tissue, and available clinical adhesives are sub-par.
 The creation of a safe and effective adhesive that can be used internally in the body would help these patients, but researchers trying to develop a glue like this have faced hurdles such as ensuring that it is non-toxic and capable of repelling fluids. Now, a study published by Harvard Medical School offers a potential breakthrough.

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Variations in eye structure and function may reveal features of early-stage Alzheimer’s Disease

, 26 August 2020/in E-News /by 3wmedia

Investigators at the Cedars-Sinai Regenerative Medicine Institute have discovered eye abnormalities that may help reveal features of early-stage Alzheimer’s disease. Using a novel laboratory rat model of Alzheimer’s disease and high-resolution imaging techniques, researchers correlated variations of the eye structure, to identify initial indicators of the disease.
Alzheimer’s disease is the leading cause of dementia, which is characterised by loss of memory and a progressive decline in cognitive function. To date, more than 26 million people are estimated to suffer from the disease and the number is expected to quadruple by 2050. Despite the disease being described over a century ago, treatment and understanding of the disease remain rather limited.
‘Detecting changes in the brain that indicate Alzheimer’s disease can be an extremely challenging task,’ said Shaomei Wang, MD, PhD, lead author of the study and an associate professor in the Regenerative Medicine Institute and Department of Biomedical Sciences. ‘By using the eye as a window to brain activity and function, we may be able to diagnose patients sooner and give them more time to prepare for the future. Options may include earlier enrolment in clinical trials, developing support networks and dealing with any financial and legal matters.’
Using both animal models and post-mortem human retinas from donors with Alzheimer’s disease, researchers found changes in the retinal pigment epithelial layer, which harbours the supportive cells located in the back of the eye, and in the thickness of the choroidal layer that has blood vessels providing nutrients to the retina. Changes in these two regions were detected using sophisticated, state-of-the-art imaging and immunological techniques.
With high-resolution, microscopic imaging and visual acuity measurements, investigators were able to monitor tissue degeneration in the cell layer and vascular layer at the back of the eye, as well as decline in visual function, that were strongly associated with Alzheimer’s disease.
‘Greater magnitude in these eye abnormalities may mean a greater chance of a patient having Alzheimer’s disease,’ said Alexander Ljubimov, PhD, director of the Eye Program within the Regenerative Medicine Institute and co-author of the study. ‘We found that a rat model showed similar signs to the human ailment in the eye. If true in a larger number of humans, these findings may be used to study Alzheimer’s disease mechanisms and test potential drugs.’
Though additional research is needed to investigate the mechanisms of these ocular changes in relation to changes in the brain, investigators hope to ultimately aid early diagnosis of Alzheimer’s disease by studying the most approachable part of the central nervous system: the eye. Cedars-Sinai has been at the cutting edge of studies on the eye and Alzheimer’s disease with a previous report showing amyloid plaques, a hallmark of Alzheimer’s disease, also build up in the eye using a similar animal model of the disease.
‘It is fascinating that the eye may provide such a window to the brain and eventually predict diseases such as Alzheimer’s, although more human studies are now needed to confirm this animal work,’ said Clive Svendsen, PhD, director of the Cedars-Sinai Regenerative Medicine Institute and a co-author on the study. Other members of the Regenerative Medicine Institute Eye Program, include Yu Chun Tsai, PhD, a post-doctoral fellow; and Bin Lu, MD, PhD, and Sergey Girman, PhD, both project scientists. Cedars-Sinai Medical Center

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