The Medicines and Healthcare products Regulatory Agency has committed to a fundamental restructuring of the UK’s rare disease therapy regulatory framework, with detailed guidelines scheduled for publication in 2026. The announcement represents the most significant shift in rare disease treatment pathways undertaken by the regulator and forms part of the Government’s broader life sciences strategy.
Researchers have identified chaperone-mediated autophagy as a critical regulator of brown adipose tissue thermogenic activity, revealing that age-related decline in this selective protein degradation pathway drives metabolic dysfunction. The findings, published in Science Advances, demonstrate that pharmacological activation of this mechanism can restore brown fat function in aged mice, opening therapeutic avenues for obesity and […]
A BMJ investigation reveals almost nine in 10 NHS acute trusts use local employment contracts that trap thousands of doctors – predominantly international medical graduates and ethnic minorities – in roles lacking training opportunities, career progression, and nationally agreed safeguards. Some doctors remain in these precarious positions for over a decade.
Siemens Healthineers has announced a comprehensive strategic restructuring at its Capital Markets Day in London, introducing a new reporting framework centred on three distinct segments and targeting annual revenue growth of 5-7% through fiscal year 2030.
A pioneering study tracking brain activity in patients taking the weight-loss drug tirzepatide has uncovered distinctive neural patterns associated with food preoccupation, offering the first direct evidence of how incretin-based therapies modulate reward circuitry in humans. The research reveals a specific low-frequency brain signal that precedes intense food cravings and demonstrates how pharmacological intervention may […]
A new report in the New England Journal of Medicine outlines six practical strategies to strengthen fundamental clinical skills and restore the doctor-patient relationship in an increasingly technology-driven healthcare environment.
MIT engineers have developed a flexible drug-delivery patch that can be placed on the heart after a heart attack, delivering therapeutics on a programmed schedule to promote healing and regeneration. In rat studies, the patch reduced damaged tissue by 50% and significantly improved cardiac function, offering a potential breakthrough for post-myocardial infarction treatment.
Researchers present a comprehensive framework linking Arctic and Antarctic transformations to worldwide disease burden, from vector-borne illnesses to cardiovascular mortality, urging urgent interdisciplinary action to integrate polar tipping points into health impact assessments and clinical preparedness strategies.
The European Association for the Study of Obesity has released comprehensive guidance positioning semaglutide and tirzepatide as primary treatments for obesity and most complications. The framework, published in Nature Medicine, represents a paradigm shift towards complication-focused prescribing rather than weight loss alone, with recommendations based on systematic meta-analysis of randomised controlled trials.
A simple nursing assessment of patient-reported breathlessness during hospitalisation can identify those at dramatically elevated risk of death, with post-admission dyspnoea linked to a sixfold increase in mortality compared with patients reporting no breathing difficulty, according to research published in ERJ Open Research.
April 2024
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