UNIVERSITY OF BARCELONAUnlocking brown fat: cellular autophagy mechanism holds key to age-related metabolic decline
Researchers have identified chaperone-mediated autophagy as a critical regulator of brown adipose tissue thermogenic activity, revealing that age-related decline in this selective protein degradation pathway drives metabolic dysfunction. The findings, published in Science Advances, demonstrate that pharmacological activation of this mechanism can restore brown fat function in aged mice, opening therapeutic avenues for obesity and […]
