Probiotics prevent deadly complications of liver disease

Probiotics are effective in preventing hepatic encephalopathy in patients with cirrhosis of the liver, according to a new study. Hepatic encephalopathy is a deterioration of brain function that is a serious complication of liver disease.

‘This rigorous new research finds that probiotics modify the gut microbiota to prevent hepatic encephalopathy in patients with cirrhosis of the liver,’ said David W. Victor III, MD. ‘These results offer a safe, well-tolerated and perhaps cheaper alternative to current treatments.’

Investigators from Govind Ballabh Pant Hospital, New Delhi, India, conducted a single-centre, prospective, open-label, randomised trial with cirrhosis patients who showed risk factors for hepatic encephalopathy, but had yet to experience an obvious episode. When comparing treatment with probiotics versus placebo, the researchers found that the incidence of hepatic encephalopathy was lower in patients treated with probiotics.

Probiotic supplementation was not associated with any side effects and none of the patients required discontinuation of therapy. These results suggest that probiotics are similar in effectiveness to the current standard of care, lactulose, in the prevention of hepatic encephalopathy, yet they appear to be much better tolerated. The effectiveness of lactulose, a non-absorbable disaccharide, is limited by side effects (diarrhoea, bloating and gas) and a narrow therapeutic window.

‘By virtue of its size, study duration and design, as well as the thorough nature of the baseline and follow-up assessments, this study represents an important contribution to the hepatic encephalopathy literature,’ added Dr. Victor, a practicing hepatologist in the Methodist J.C. Walter Jr. Transplant Center at Houston Methodist Hospital, TX. AGA Institute