Safer radiologic imaging of otolaryngologic disease in children

Advances in diagnostic imaging have benefited children with otolaryngologic disease, allowing shorter hospital stays, fewer invasive procedures, more targeted surgical procedures, and earlier and more precise diagnoses. However, despite improved technology, concerns about exposure of children to ionising radiation have recently come to the forefront, according to a commentary in the July 2012 issue of Otolaryngology

Progress in quest to reduce use of radiation in treatment of pediatric Hodgkin lymphoma

A multicenter trial showed that nearly half of young patients with early-stage Hodgkin lymphoma can be cured without undergoing either irradiation or intensive chemotherapy that would leave them at risk for second cancers, infertility, heart and other problems later.
St. Jude Children

Multiple perspectives improve laparoscopy

What makes laparoscopic surgery ‘minimally invasive’

Electrical brain stimulation can alleviate swallowing disorders after stroke

After stroke, patients often suffer from dysphagia, a swallowing disorder that results in greater healthcare costs and higher rates of complications such as dehydration, malnutrition, and pneumonia. In a new study, researchers have found that transcranial direct current stimulation (tDCS), which applies weak electrical currents to the affected area of the brain, can enhance the outcome of swallowing therapy for post-stroke dysphagia.
‘Our pilot study demonstrated that ten daily sessions of tDCS over the affected oesophageal motor cortex of the brain hemisphere affected by the stroke, combined with swallowing training, improved post-stroke dysphagia. We observed long-lasting effects of anodal tDCS over three months,’ reports lead investigator Nam-Jong Paik, MD, PhD, of the Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Sixteen patients with acute post-stroke dysphagia were enrolled in the trial. They showed signs of swallowing difficulties such as reduced tongue movements, coughing and choking during eating, and vocal cord palsy. Patients underwent ten 30-minute sessions of swallowing therapy and were randomly assigned to a treatment or control group. Both groups were fitted with an electrode on the scalp, on the side of the brain affected by the stroke, and in the region associated with swallowing. For the first 20 minutes of their sessions, tDCS was administered to the treatment group and then swallowing training alone continued for the remaining 10 minutes. In the control group, the direct current was tapered down and turned off after thirty seconds. Outcomes were measured before the experiment, just after the experiment, and again three months after the experiment. A patient from each group underwent a PET scan at before and just after the treatment to view the effect of the treatment on metabolism.
All patients underwent interventions without any discomfort or fatigue. There were no significant differences in age, sex, stroke lesion site, or extent of brain damage. Evaluation just after the conclusion of the sessions found that dysphagia improved for all patients, without much difference between the two groups. However, at the three month follow-up, the treatment group showed significantly greater improvement than the control group.
In the PET study, there were significant differences in cerebral metabolism between the first PET scan and the second PET scan in the patient who had received tDCS. Increased glucose metabolism was observed in the unaffected hemisphere, although tDCS was only applied to the affected hemisphere, indicating that tDCS might activate a large area of the cortical network engaged in swallowing recovery rather than just the areas stimulated under the electrode.
‘The results indicate that tDCS can enhance the outcome of swallowing therapy in post-stroke dysphagia,’ notes Dr. Paik. ‘As is always the case in exploratory research, further investigation involving a greater number of patients is needed to confirm our results. It will be important to determine the optimal intensity and duration of the treatment to maximise the long-term benefits.’ EurekAlert

Man and robot linked by brain scanner

Robot avatars have got a step closer to being the real world doubles of those who are paralysed or have locked-in-syndrome. Scientists have made a robot move on a human’s behalf by monitoring thoughts about movement.
The man-machine link joined a man in a brain scanner in Israel and a robot wandering a laboratory in France. The person controlling the robot could also see through the eyes of his electronic surrogate. The researchers are now working on ways to make the man-machine link more sensitive and to let people speak via the robot.
The research project connected a robot to a man having his brain scanned using fMRI (Functional Magnetic Resonance Imaging). This monitors blood flowing through the brain and can spot when areas associated with certain actions, such as movement, are in use.
Using brain scanners is a step beyond current efforts to link up men and machines. Much recent work involved teleoperated robots in which humans manipulate controls, such as joysticks, to make a robot move.
By contrast, the scanning approach is more subtle and attempts to fool the human subject into thinking that they are embodied in the robot.
Eventually the small robot will be swapped for one the size of an average human The experiment helping to prove the technology works linked up student Tirosh Shapira who was in a lab at Bar-Ilan University, Israel, with a small two-legged robot thousands of kilometres away at Beziers Technology Institute in France.
Prior to connecting the two, researchers made Mr Shapira think about different sorts of movements and developed software that could quickly spot his intention.
The result was that he could control the robot in almost real time.
The illusion of embodiment was tested by surprising Mr Shapira with a mirror so he could see his robot self – a test that convinced him he was present in the French lab.
The next step for the research is to refine it to use a different type of scanning that can work using a skull cap rather than an fMRI machine that a person has to lie in. The robot used to represent a human is to be upgraded to a version that has a similar stature and gait to a real person.
The research is part of an international project called Virtual Embodiment and Robotic Re-Embodiment that aims to refine ways to link people and surrogates in both virtual environments and the real world.
Work is being done on medical applications of the technology but the researchers warned that it was a long way from being able to help anyone yet. BBC

‘Desperate Debra’: making caesareans safer

A new caesarean simulator called Desperate Debra is being launched by the Trust, in collaboration with NHS Fife and Adam,Rouilly Ltd. Desperate Debra is the first simulator used to train doctors in dealing with late-stage (emergency) caesareans, which affect around 20,000 births per year in the UK and can be life-threatening for both mother and baby.
During emergency caesareans, the baby

Researchers develop secure protocol for linking data registries for HPV surveillance

Monitoring the effectiveness of the HPV vaccine in Canada requires that data from multiple registries and other data sources be combined. Linking registries can be problematic, however, since they are often managed by unrelated organisations. Privacy legislation may also restrict the sharing of data for such linkages. To address these challenges, Dr. Khaled El Emam and his team at the CHEO Research Institute have developed a secure protocol that allows the linking of individual patient records without revealing personal information.
According to Dr. El Emam, previous protocols were not secure or did not protect privacy; this new evidence-based protocol, however, is the strongest on record. It can be generalised for use in monitoring other conditions or diseases, or vaccination programs.
‘There is a need to do long-term evaluations of vaccines, and to monitor vaccination rates and how they vary by individual and family characteristics. Access to data to perform such surveillance is often challenging because of legitimate privacy concerns. Our protocol addresses these concerns directly and facilitates rapid data sharing,’ explained Dr. El Emam.
HPV, or the human papillomavirus, is one of the most prevalent sexually transmitted viral infections in the world, causing symptoms that range from genital warts to increased risk of cervical cancer. An effective preventative quadrivalent vaccine has been available in Canada since 2007 (and a second, bivalent vaccine was approved for use in 2010) and is regularly administered to girls through publicly funded school-based programs. The vaccine can potentially reduce health care costs and HPV-related illnesses and death, but the long-term effectiveness of the vaccine is not yet known. Further research is required to gauge the vaccine’s lasting impact on health and to inform policy decisions concerning the allocation of health resources.
The new protocol uses a number of cryptographic techniques, including a commutative hash function and homomorphic cryptosystem. The secure computation allows registries to match records on identifiers such as SIN, health card number and date of birth without revealing these values to anyone, and then perform analytics on the linked data without that linked data being disclosed. The protocol provides end-to-end privacy protection for surveillance programs and eliminates many concerns about sharing data.
‘We set out to assess the impact of the HPV vaccine by creating a secure protocol to link simulated databases on cancer, cervical screening, health care services and immunisation. Such linkage can only be done in an environment that is responsive to patient privacy concerns,’ explained Dr. El Emam. ‘The protocol we created would allow any public health unit to link databases from multiple sources and compute relevant statistics from linked data without revealing personal information, and hence, still provide strong patient privacy guarantees.’ Children’s Hospital of Eastern Ontario Research Institute

Pre-clinical studies use specialised ultrasound to detect presence of cancer

From the air, the twists and turns of rivers can easily be seen. In the body, however, tracing the twists and turns of blood vessels is difficult, but important. Vessel ‘bendiness’ can indicate the presence and progression of cancer.
This principle led UNC scientists to a new method of using a high-resolution ultrasound to identify early tumours in pre-clinical studies. The method, based on vessel bendiness or ‘tortuosity,’ potentially offers an inexpensive, non-invasive and fast method to detect cancer that could someday help doctors identify cancers when tumours are less than a centimetre in size.
Paul Dayton, PhD, associate professor of biomedical engineering explains, ‘The correlation between vessel tortuosity and cancer is well-established. What’s new about our finding is that we can visualise these vessels in minutes with a very quick scan, using very inexpensive imaging methods.’ Dr. Dayton is a member of UNC Lineberger Comprehensive Cancer Center.
The UNC team used a new high-resolution ultrasound method, called ‘acoustic angiography,’ with an intravascular contrast agent that allowed them to acquire images of only the blood vessels. ‘Unlike current clinical ‘grayscale’ ultrasound, this method filters out all tissue signals, so we can see small blood vessels clearly.’ says Dayton.
‘Our results showed a definitive difference between vessels within and surrounding tumours versus those associated with normal healthy vasculature. The limitation that we must now address is that our method works only for tumours at a shallow depth into tissue, such as melanomas or thyroid cancer. Our next studies will focus on this imaging-depth issue as well as evaluating the ability of this technology to determine a tumour

Study suggests new screening method for sudden death in athletes

A new study suggests that echocardiography be included as part of screenings to help identify student athletes with heart problems that could lead to sudden death.
The Cincinnati Children

Mayo Clinic creates tool to track real-time chemical changes in brain

Mayo Clinic researchers have found a novel way to monitor real-time chemical changes in the brains of patients undergoing deep brain stimulation (DBS). The groundbreaking insight will help physicians more effectively use DBS to treat brain disorders such as Parkinson’s disease, depression and Tourette syndrome.
Researchers hope to use the discovery to create a DBS system that can instantly respond to chemical changes in the brain. Parkinson’s, Tourette syndrome and depression all involve a surplus or deficiency of neurochemicals in the brain. The idea is to monitor those neurochemicals and adjust them to appropriate levels.
 
‘We can learn what neurochemicals can be released by DBS, neurochemical stimulation, or other stimulation. We can basically learn how the brain works,’ says author Su-Youne Chang, Ph.D., of the Mayo Clinic Neurosurgery Department. As researchers better understand how the brain works, they can predict changes, and respond before those changes disrupt brain functioning.
Researchers observed the real-time changes of the neurotransmitter adenosine in the brains of tremor patients undergoing deep brain stimulation. Neurotransmitters such as dopamine and serotonin are chemicals that transmit signals from a neuron to a target cell across a synapse.
The team used fast scan cyclic voltammetry (FSCV) to quantify concentrations of adenosine released in patients during deep brain stimulation. The data was recorded using Wireless Instantaneous Neurotransmitter Concentration Sensing, a small wireless neurochemical sensor implanted in the patient’s brain. The sensor, combined with FSCV, scans for the neurotransmitter and translates that information onto a laptop in the operating room. The sensor has previously identified neurotransmitters serotonin and dopamine in tests in brain tissue. This was the first time researchers used this technique in patients.
Tremors are a visual cue that the technique is working; researchers suspect adenosine plays a role in reducing tremors.
Researchers also hope to learn more about conditions without such external manifestations.
‘We can’t watch pain as we do tremors,’ says Kendall Lee, M.D., Ph.D., a Mayo Clinic neurosurgeon. ‘What is exciting about this electrochemical feedback is that we can monitor the brain without external feedback. So now, we can monitor neurochemicals in the brain and learn about brain processes like pain.’
DBS has been used successfully worldwide to treat patients with tremors. However, physicians do not fully understand why DBS works in patients. They know that when DBS electrodes are inserted before electrical stimulation, there is an immediate tremor reduction. Known as the microthalamotomy effect, it is reported in up to 53 percent of patients and known to last as long as a year.
Researchers hope to use the study findings to create a self-contained ‘smart’ DBS system. Mayo Clinic