Health monitoring? There’s an app for that

Researchers in New Zealand have developed a prototype Bluetooth-enabled medical monitoring device that can be connected wirelessly to your smart phone and keep track of various physiological parameters, such as body temperature, heart rate, blood pressure and movements. The prototype could be extended to include sensors for other factors such as blood glucose as well as markers for specific diseases. The connectivity would allow patients to send data directly to their healthcare provider and receive timely advice and medication suggestions.

Helen Zhou and Tim Roberts of the School of Electrical Engineering at Manukau Institute of Technology explain how they have developed a microcontroller-based personal health monitoring unit that can carry medical sensors and a positioning device. The unit can connect to other devices via the short-range wireless networking system known as Bluetooth and so could be readily connected to software on a smart mobile phone for health monitoring.

The team adds that the mobile phone can be used as a gateway to further relay patient health data to a remote database via the mobile network for remote diagnoses. ‘Any medical instructions can be sent back instantly to the mobile users,’ the team says. ‘The use of standard development tools makes it possible for patients to easily use everyday mobile devices for their personal health monitoring and assessment anytime anywhere.’ They add that, ‘Bluetooth and mobile networks enable wireless communications among mobile users, medical professionals and other healthcare givers in an easy, secure and efficient manner.’

The device software is based on the familiar cross-platform Java system and provides user with an easy to use graphical user interface (GUI) on their smart phone that uses the standard navigation buttons on mobile devices.

EurekAlert

Radiation oncologists are discussing infertility risks with young cancer patients

More than 80 percent of radiation oncologists discuss the impact of cancer treatments on fertility with their patients of childbearing age, which can lead to improved quality of life for young cancer patients who are living much longer after their original diagnosis thanks to modern treatment options, according to a study.

In the past, the clinical focus for young cancer patients was strictly survival. With the success of today

Could a NOSH-Aspirin-a-Day keep cancer away?

The humble aspirin may soon have a new role. Scientists from The City College of New York have developed a new aspirin compound that has great promise to be not only an extremely potent cancer-fighter, but even safer than the classic medicine cabinet staple.

The new designer aspirin curbed the growth of 11 different types of human cancer cells in culture without harming normal cells, reported a team from the Sophie Davis School of Biomedical Education of The City College of New York in a paper published this month in the journal ACS Medicinal Chemistry Letters. The cancers controlled included colon, pancreatic, lung, prostate, breast, and leukaemia. ‘The key components of this new compound are that it is very, very potent and yet it has minimal toxicity to the cells,’ said Associate Professor Khosrow Kashfi, the principal investigator.

The aspirin compound also shrank human colon cancer tumours by 85 percent in live animals, again without adverse effects, according to a second paper in press by the City College researchers and colleague Kenneth Olson of Indiana University School of Medicine, South Bend. ‘If what we have seen in animals can be translated to humans,’ said Professor Kashfi, ‘it could be used in conjunction with other drugs to shrink tumours before chemotherapy or surgery.’

Long the go-to drug for minor aches and pains, aspirin and other so-called non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen, are known primarily for their ability to calm inflammation. Studies in the 1980

Closing hole in the heart is no better than drugs in preventing strokes

Loyola University Medical Center is one of the major enrollers in a landmark clinical trial that found that plugging a hole in the heart works no better than drugs in preventing strokes.
Loyola enrolled 24 patients, one of the highest patient enrollments in the multi-centre trial and more than any other Chicago-area hospital. Principal investigators at the Loyola site were stroke specialist Dr. Michael Schneck and interventional cardiologist Dr. Fred Leya.
About 1 in 4 adults has a small hole in the wall that separates the top two chambers of the heart. It’s called a patent foramen ovale (PFO). For most people, a PFO poses no problems. But in some cases, a clot can pass through the hole, migrate to the brain and trigger a stroke.
The standard treatment is medication to prevent blood clots, typically aspirin or Coumadin. A newer treatment is to plug the hole with a device delivered by a catheter. The catheter is inserted into a blood vessel at the top of the leg and guided up to the heart. When the catheter reaches the PFO, the device is deployed, opening like an umbrella to plug the hole.
The clinical trial included 909 patients who had PFOs and had previously suffered strokes or mini strokes called transient ischemic attacks (TIAs). They were randomly assigned to receive a PFO closure device plus blood thinners or drug therapy alone.
The closure device worked no better than drugs alone in preventing recurrent strokes or TIAs. Moreover, major vascular complications occurred in 3.2 percent of the closure group.
Loyola University Health System

Study determines critical skills for primary care providers to safely and effectively manage opioid risk in chronic pain patients

Primary care physicians are faced with treating a large proportion of chronic pain patients, but many do not often have specific training in the assessment and management of chronic pain, including the use of opioid medications for chronic pain management. Recognising the significant role prescribers can play in reducing the risk of addiction, unintentional overdose, and death from the misuse and abuse of opioids, the U.S. Food and Drug Administration (FDA) has made prescriber education a central part of its Risk Evaluation and Mitigation Strategy (REMS) requirements for manufacturers of long-acting and extended-release (LA/ER) opioids.
With this in mind, Inflexxion

Checking off symptoms online affects our perceptions of risk

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A new method for more accurate assessment of osteoporosis

Laser-based measurements are proving to be a promising method for the assessment of osteoporosis. The team led by Professor Jussi Timonen has developed an ultrasound technique that use laser beams for a rapid and accurate assessment of osteoporosis. The research is part of the Photonics and Modern Imaging Techniques Research Programme of the Academy of Finland and involves input by researchers from the Universities of Jyv

Nano rescues skin

Nanoparticles containing chitosan have been shown to have effective anti-microbial activity against Staphylococcus saprophyticus and Escherichia coli. The materials could be used as a protective wound-healing material to avoid opportunistic infection as well as working to facilitate wound healing.

Chitosan is a natural, non-toxic and biodegradable, polysaccharide readily obtained from chitin, the main component of the shells of shrimp, lobster and the beak of the octopus and squid. Its anti-microbial activity is well known and has been exploited in dentistry to prevent caries and as preservative applications in food packaging. It has even been tested as an additive for anti-microbial textiles used in clothing for healthcare and other workers.

Now, Mihaela Leonida of Fairleigh Dickinson University, in Teaneck, New Jersey and colleagues describe how they have prepared nanoparticles of chitosan that could have potential in preventing infection in wounds as well as enhancing the wound-healing process itself by stimulating skin cell growth.

The team made their chitosan nanoparticles (CNP) using an ionic gelation process with sodium tripolyphosphate. This process involves the formation of bonds between polymers strands, a so-called cross-linking process. Conducted in these conditions it precludes the need for complex preparative chemistry or toxic solvents. CNP can also be made in the presence of copper and silver ions, known antimicrobial agents. The researchers’ preliminary tests show the composite materials to have enhanced activity against two representative types of bacteria.

Understanding the mechanism of inhibition of bacteria by these particles may lead to the preparation of more effective antibacterial agents. The team has also demonstrated that the CNP have skin regenerative properties in tests on skin cell fibroblasts and keratinocytes, in the laboratory, which might even have implications for anti-ageing skin care products.

EurekAlert

How ECT helps severely depressed

Aberdeen researchers have discovered how a controversial but effective treatment in psychiatry acts on the brain in people who are severely depressed.
Electroconvulsive therapy or ECT – which involves anaesthetising a patient and electrically inducing a seizure – is the most potent treatment option for patients with serious mood disorder.
Despite being used successfully in clinical practice around the world for more than 70 years, the underlying mechanisms of ECT have so far remained unclear.
Now a multidisciplinary team of clinicians and scientists at the University of Aberdeen, Scotland, has shown for the first time that ECT affects the way different parts of the brain involved in depression

Second study investigates two-arm blood pressure difference

44 per cent of patients being treated for high blood pressure and who took part in the study either suffered vascular disease or died over a 10-year period
In January a research team from the Peninsula College of Medicine and Dentistry reported the first systematic review of findings related to the risk factors associated with a difference in blood pressure between arms.
The first study, which was published in The Lancet, suggested that a difference of more than 10mmHg or 15mmHg in systolic blood pressure (the