Archive for category: Research

osteoporosis

Mechanosensitive receptor offers new approach to osteoporosis treatment

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Researchers have identified GPR133/ADGRD1, a mechanosensitive adhesion G protein-coupled receptor, as a promising therapeutic target for osteoporosis. The receptor responds to both mechanical forces and molecular signals, enhancing bone formation through cAMP-dependent activation of β-catenin signalling. A novel small-molecule agonist significantly alleviated osteoporosis in preclinical models, suggesting potential for clinical development.

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patient perspectives

Patients identify six key areas for surgeon communication

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A systematic review of patient perspectives reveals that cancer patients prioritise emotional support, optimistic demeanour, and realistic expectation-setting from their surgical oncologists alongside clinical expertise. The research identifies six distinct communication domains that shape patient satisfaction and treatment adherence.

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Mayo Clinic

Mayo Clinic launches AI-powered clinical development platform leveraging international partner ecosystem

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Mayo Clinic has launched Mayo Clinic Platform_Orchestrate, a comprehensive programme designed to accelerate clinical development by providing biopharma and medical device companies with streamlined access to de-identified clinical data, artificial intelligence tools, and international research networks.

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AI designed bacteriophage

Synthetic biology breakthrough: Scientists use AI to create viable bacteriophages from scratch

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Researchers have successfully used genome language models to design complete, functional bacteriophage genomes, marking the first generative design of whole living organisms. The breakthrough demonstrates AI’s capacity to access novel evolutionary spaces and create phage cocktails that rapidly overcome bacterial resistance.

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hospital food

Strategic menu swaps for hospital food could prompt patients to choose healthier options

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New research has shown hospital patients could reduce the carbon footprint and saturated fat content of their selected meals by up to almost a third through strategic reorganisation of weekly menus without removing any dishes, according to a University of Bristol study published in Philosophical Transactions of the Royal Society B.

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Soft Robotic Intubation System (SRIS)David Haggerty, Marvin Wayne, and James Cazzoli

New soft robotic device achieves 96% success rate in emergency intubation with minimal training

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A novel soft robotic device has enabled emergency medical personnel to achieve intubation success rates as high as 96% with only five minutes of training, according to new research published in Science Translational Medicine. The vine-like device could dramatically expand access to life-saving airway management in emergency situations and resource-limited settings.

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COVID-19 virus

COVID-19 vaccines prevented 2.5 million deaths worldwide, study finds

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A comprehensive analysis spanning four years of global vaccination campaigns reveals that COVID-19 vaccines prevented 2.5 million deaths worldwide between 2020 and 2024. The landmark study, which examined vaccination impact across all age groups and pandemic phases, found that one life was saved for every 5,400 vaccine doses administered, with the vast majority of benefits […]

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scientist at Northwestern University holds a donated SuperAger brain in Chicago, ILShane Collins, Northwestern University

25-year study reveals how SuperAgers defy cognitive decline

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Twenty-five years of Northwestern University research reveals that adults over 80 with exceptional memory possess unique brain structures, greater resistance to Alzheimer’s pathology, and enhanced cellular characteristics that challenge traditional assumptions about cognitive decline during normal ageing processes in humans.

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Non-autoimmune diabetes discovered in African children challenges type 1 classification

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A landmark multi-country study has uncovered compelling evidence that the majority of children and young adults clinically diagnosed with type 1 diabetes across sub-Saharan Africa actually have a previously unrecognised non-autoimmune form of insulin-deficient diabetes. The research fundamentally challenges current diabetes classification systems and could change treatment approaches for young people with diabetes in Africa […]

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Schematic illustration of the iPSC cell-derived airway and alveolus chips.Ryuji Yokokawa, et. al. Kyoto University, Nature Biomedical Engineering https://doi.org/10.1038/s41551-025-01444-2

New lung-on-chip technology with iPS cells reveals distinct immune responses for flu and COVID-19

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Scientists have developed groundbreaking airway and alveolus chip models using induced pluripotent stem cells, revealing how SARS-CoV-2 and influenza trigger dramatically different immune responses in upper versus lower respiratory regions. The research offers new insights into COVID-19 pathology and potential therapeutic targets.

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