Archive for category: pharmacology

Salk Institute

New comprehensive genomic atlas of cannabis reveals therapeutic applications amid genetic diversity

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Researchers have assembled the most comprehensive genetic atlas of cannabis to date, revealing unprecedented molecular diversity that could revolutionise medicinal applications and unlock novel therapeutic compounds. The landmark study, published in Nature on 28 May 2025, analysed 193 cannabis genomes and identified surprising genetic variation that may hold the key to developing new cannabinoid-based treatments.

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Antibiotics in infancy linked to higher asthma and food allergy risk

Antibiotics in infancy linked to higher asthma and food allergy risk

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A large-scale study from Rutgers Health has found that repeated antibiotic exposure in children under two years of age is associated with a significantly higher risk of developing asthma, food allergies and hay fever later in childhood. The research, involving over one million children, demonstrates that antibiotics may disrupt the digestive microbiome during a critical […]

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AI system designs peptides to target previously ‘undruggable’ proteins

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Biomedical engineers at Duke University have developed an artificial intelligence platform that can design short proteins capable of binding to and destroying previously untreatable disease-causing proteins. The breakthrough could revolutionise drug development for currently intractable diseases.  

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MIT Microjet

Novel squid-inspired gastrointestinal capsule enables macromolecular drug delivery

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MIT and Novo Nordisk researchers have developed an ingestible capsule system that could enable oral delivery of medications typically requiring injection, such as insulin and therapeutic proteins. The needle-free device uses a biomimetic jet propulsion mechanism inspired by cephalopod physiology.  

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CAR-T therapy

New research reveals severe non-inflammatory neurological complications in young patients following CAR-T therapy

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A study from Children’s Hospital of Philadelphia has uncovered rare but severe neurological side effects in children, adolescents, and young adults receiving CAR-T cell therapy for leukaemia, highlighting the need for further investigation into the complex mechanisms underlying these complications.  

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donanemab Kinsula

FDA under fire: Controversial Alzheimer’s drug donanemab approved amid excess death concerns and conflicts of interest

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A new investigation of FDA-approved Alzheimer’s drug donanemab highlights concerns about excess deaths, missing safety data, and financial conflicts of interest among FDA advisory panel members who recommended approval.  

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Alzheimer’s disease

New Alzheimer’s drugs may have limited population-level impact, researchers warn

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Cambridge scientists question whether recently approved amyloid immunotherapy treatments for Alzheimer’s disease will significantly reduce the condition’s burden, citing concerns about efficacy, safety, and health system challenges.  

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