COMBINEDBrain and the Medical University of South Carolina have announced a strategic collaboration to establish what they describe as the first biorepository dedicated to paediatric central nervous system tissue and cerebrospinal fluid from neurotypical donors, addressing a significant gap in neurological disease research infrastructure.
Researchers have identified dendritic nanotubes – ultrathin connections between neurons that can transport disease-related proteins. The structures, distinct from conventional synapses, may accelerate toxic protein accumulation in specific brain cells during early Alzheimer’s pathology, offering potential new therapeutic targets.
Researchers have engineered sophisticated human brain organoids that faithfully model myelin production and repair processes. The groundbreaking model integrates immune cells called microglia, revealing their essential role in remyelination and providing a powerful new platform for testing potential multiple sclerosis therapies.
Researchers from the International Brain Laboratory have unveiled the first brain-wide activity map showing how decision-making unfolds across the entire brain in mice at single-cell resolution. The comprehensive study recorded from over 621,000 neurons across 279 brain areas, revealing that decision-making is distributed across many regions in a highly coordinated way.
A groundbreaking diagnostic test measuring brain blood flow dynamics has demonstrated superior accuracy in detecting Alzheimer’s disease compared to traditional markers, achieving a 96% diagnostic performance rate. The non-invasive cerebrovascular test offers hope for earlier, more accessible dementia screening whilst challenging conventional amyloid-focused diagnostic approaches.
Researchers at the University of Minnesota Twin Cities have demonstrated a groundbreaking process that combines 3D printing, stem cell biology, and lab-grown tissues for spinal cord injury recovery. The innovative approach uses microscopic channels to guide neural regeneration, offering new hope for treating complete spinal cord injuries.
Washington University researchers have developed a quantitative technique measuring leg movement variability to accurately diagnose dystonia in paediatric cerebral palsy patients. The breakthrough identifies brain mechanisms underlying the condition, which could enable early intervention strategies to prevent this painful complication.
A revolutionary digital assessment that measures brain chemistry in just three minutes has been validated against direct neuroimaging for the first time, offering new possibilities for early detection of cognitive decline and dementia. The breakthrough research demonstrates that a self-administered computerised test can accurately reflect levels of acetylcholine, a crucial neurotransmitter whose decline signals cognitive […]
Researchers at UC Davis have demonstrated the first brain-computer interface that directly translates neural activity into synthesised speech in real-time, allowing a man with severe ALS to communicate naturally with immediate audio feedback rather than text-based approaches.
Scientists have discovered a novel mechanism by which immune cells targeting gut bacteria can infiltrate the brain and cause neuroinflammation through molecular mimicry. The research reveals how intestinal inflammation promotes the migration of microbiota-specific T cells into the central nervous system, where they mistakenly attack brain proteins.
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Lange et al., Sci. Trans. Med. 17, eadp7047 (2025)
Dan Birman, International Brain Laboratory
McAlpine Research Group, University of Minnesota
Matt Miller/ Washington University School of Medicine
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