Archive for category: Neurology

© Martina Bocchetta, Dorit Kliemann and Juan Eugenio Iglesias

New NextBrain atlas enables unprecedented granularity in human brain imaging analysis

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Researchers at University College London have developed NextBrain, a probabilistic histological atlas of the entire human brain that enables automated segmentation of magnetic resonance imaging scans into 333 distinct regions of interest. Built from approximately 10,000 histological sections across five brain hemispheres, the atlas combines artificial intelligence-enabled registration techniques with Bayesian segmentation methods to provide […]

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paediatric CNS biorepository established in US partnership

Novel paediatric CNS biorepository established in US partnership

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COMBINEDBrain and the Medical University of South Carolina have announced a strategic collaboration to establish what they describe as the first biorepository dedicated to paediatric central nervous system tissue and cerebrospinal fluid from neurotypical donors, addressing a significant gap in neurological disease research infrastructure.

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dendritic nanotubes in the brain

Scientists discover hidden neural network that may drive early Alzheimer’s disease

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Researchers have identified dendritic nanotubes – ultrathin connections between neurons that can transport disease-related proteins. The structures, distinct from conventional synapses, may accelerate toxic protein accumulation in specific brain cells during early Alzheimer’s pathology, offering potential new therapeutic targets.

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Microglia integrated in human brain organoids respond to toxin-induced demyelination with morphological changes. Representative immunofluorescence images show microglia (IBA1, green) in a human brain organoid model. Panels show the response to control conditions, demyelination (induced by toxin), and remyelination, respectively. Magnified insets an the right highlight the detailed morphological changes of microglia in each condition.Lange et al., Sci. Trans. Med. 17, eadp7047 (2025)

Newly engineered human brain organoids reveal myelin production and repair processes

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Researchers have engineered sophisticated human brain organoids that faithfully model myelin production and repair processes. The groundbreaking model integrates immune cells called microglia, revealing their essential role in remyelination and providing a powerful new platform for testing potential multiple sclerosis therapies.

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Brain-wide map showing 75,000 analysed neurons, each dot is linearly scaled according to the raw average firing rate of that neuron up to a maximum size.Dan Birman, International Brain Laboratory

Scientists create first complete brain-wide activity map during decision-making

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Researchers from the International Brain Laboratory have unveiled the first brain-wide activity map showing how decision-making unfolds across the entire brain in mice at single-cell resolution. The comprehensive study recorded from over 621,000 neurons across 279 brain areas, revealing that decision-making is distributed across many regions in a highly coordinated way.

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Advanced blood flow test achieves 96% accuracy diagnosing Alzheimer’s

New non-invasive blood flow test outperforms standard Alzheimer’s diagnostic markers

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A groundbreaking diagnostic test measuring brain blood flow dynamics has demonstrated superior accuracy in detecting Alzheimer’s disease compared to traditional markers, achieving a 96% diagnostic performance rate. The non-invasive cerebrovascular test offers hope for earlier, more accessible dementia screening whilst challenging conventional amyloid-focused diagnostic approaches.

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New research combines 3D printing, stem cell biology, and lab-grown tissues for possible treatments of spinal cord injuries.McAlpine Research Group, University of Minnesota

3D-printed spinal cord scaffolds restore function in paralysed rats

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Researchers at the University of Minnesota Twin Cities have demonstrated a groundbreaking process that combines 3D printing, stem cell biology, and lab-grown tissues for spinal cord injury recovery. The innovative approach uses microscopic channels to guide neural regeneration, offering new hope for treating complete spinal cord injuries.

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Bhooma Aravamuthan, MD, DPhil, a paediatric movement disorders specialist at WashU MedicineMatt Miller/ Washington University School of Medicine

New objective method set to transform dystonia assessment in cerebral palsy children

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Washington University researchers have developed a quantitative technique measuring leg movement variability to accurately diagnose dystonia in paediatric cerebral palsy patients. The breakthrough identifies brain mechanisms underlying the condition, which could enable early intervention strategies to prevent this painful complication.

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Brain

Digital test breakthrough links brain chemistry to cognitive health

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A revolutionary digital assessment that measures brain chemistry in just three minutes has been validated against direct neuroimaging for the first time, offering new possibilities for early detection of cognitive decline and dementia. The breakthrough research demonstrates that a self-administered computerised test can accurately reflect levels of acetylcholine, a crucial neurotransmitter whose decline signals cognitive […]

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The BCI study participantUC Regents

Neuroprosthetics breakthrough: brain implant enables real-time speech synthesis for ALS patient

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Researchers at UC Davis have demonstrated the first brain-computer interface that directly translates neural activity into synthesised speech in real-time, allowing a man with severe ALS to communicate naturally with immediate audio feedback rather than text-based approaches.

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