A unified computational framework developed at Carnegie Mellon University enables clinicians to analyse all major epileptic biomarkers within a single system, potentially transforming presurgical evaluation for drug-resistant epilepsy patients. The spatial-temporal-spectral imaging approach achieves localisation accuracy within millimetres of invasive monitoring whilst eliminating the need for separate analysis pipelines.
Researchers in Japan have developed a breakthrough non-invasive closed-loop spinal stimulation system that enables individuals with paraplegia to regain control of leg stepping movements. The hand-controlled magnetic stimulation technique bypasses spinal cord lesions and strengthens preserved neural circuits, offering a surgical-free alternative for gait rehabilitation after spinal cord injury.
Researchers at University College London have developed NextBrain, a probabilistic histological atlas of the entire human brain that enables automated segmentation of magnetic resonance imaging scans into 333 distinct regions of interest. Built from approximately 10,000 histological sections across five brain hemispheres, the atlas combines artificial intelligence-enabled registration techniques with Bayesian segmentation methods to provide […]
COMBINEDBrain and the Medical University of South Carolina have announced a strategic collaboration to establish what they describe as the first biorepository dedicated to paediatric central nervous system tissue and cerebrospinal fluid from neurotypical donors, addressing a significant gap in neurological disease research infrastructure.
Researchers have identified dendritic nanotubes – ultrathin connections between neurons that can transport disease-related proteins. The structures, distinct from conventional synapses, may accelerate toxic protein accumulation in specific brain cells during early Alzheimer’s pathology, offering potential new therapeutic targets.
Researchers have engineered sophisticated human brain organoids that faithfully model myelin production and repair processes. The groundbreaking model integrates immune cells called microglia, revealing their essential role in remyelination and providing a powerful new platform for testing potential multiple sclerosis therapies.
Researchers from the International Brain Laboratory have unveiled the first brain-wide activity map showing how decision-making unfolds across the entire brain in mice at single-cell resolution. The comprehensive study recorded from over 621,000 neurons across 279 brain areas, revealing that decision-making is distributed across many regions in a highly coordinated way.
A groundbreaking diagnostic test measuring brain blood flow dynamics has demonstrated superior accuracy in detecting Alzheimer’s disease compared to traditional markers, achieving a 96% diagnostic performance rate. The non-invasive cerebrovascular test offers hope for earlier, more accessible dementia screening whilst challenging conventional amyloid-focused diagnostic approaches.
Researchers at the University of Minnesota Twin Cities have demonstrated a groundbreaking process that combines 3D printing, stem cell biology, and lab-grown tissues for spinal cord injury recovery. The innovative approach uses microscopic channels to guide neural regeneration, offering new hope for treating complete spinal cord injuries.
Washington University researchers have developed a quantitative technique measuring leg movement variability to accurately diagnose dystonia in paediatric cerebral palsy patients. The breakthrough identifies brain mechanisms underlying the condition, which could enable early intervention strategies to prevent this painful complication.
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Lange et al., Sci. Trans. Med. 17, eadp7047 (2025)
Dan Birman, International Brain Laboratory
McAlpine Research Group, University of Minnesota
Matt Miller/ Washington University School of Medicine