A baby boy has been born to a couple in the USA by IVF involving the use of a new embryo screening approach. The method uses the latest DNA sequencing techniques and aims to increase IVF success rates while being more affordable for more couples. The work was a collaborative effort. It received significant support from the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, a partnership between Oxford University Hospitals NHS Trust and the University of Oxford. The collaboration also involved industrial partners, in particular the medical diagnostic company Reprogenetics UK. The new approach can identify embryos with the correct number of chromosomes, and may cut hundreds of pounds off the cost of embryo screening test, Dr Wells says, which currently adds
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A more precise method for determining bone marrow involvement in patients with diffuse large B-cell lymphoma (DLBCL)
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Although as many as 25 percent of patients undergoing surgery suffer from sleep apnea, few hospitals have policies to help manage the risks of this condition during surgery, and there is little evidence to help guide anesthesiologists and surgeons caring for these patients. In a new editorial in the New England Journal of Medicine, Stavros Memtsoudis, M.D., Ph.D., director of Critical Care Services at Hospital for Special Surgery, New York City, calls for a new research initiative to identify the safest and most effective ways to manage patients with sleep apnea.
Sleep apnea, a disorder in which a person frequently stops breathing for short periods during sleep, not only makes for a restless night but also puts the person at increased risk of high blood pressure, diabetes, heart attack and stroke. But although the condition is more common than diabetes, and poses particular hazards during surgery, relatively little research has been done to help guide clinicians.
‘Patients with sleep apnea may be at risk for many complications during surgery, including airway blockage and intubation problems,’ said Dr. Memtsoudis. ‘But that’s not all: we know that apnea affects many other organ systems as well. The American Society of Anesthesiologists published guidelines in 2006 to help us take better care of patients with sleep apnea, but there was
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Pre-term infants appear to mature better if they are shielded from most wavelengths of visible light, from violet to orange. But it has been a challenge to develop a controllable light filter for pre-term incubators that can switch between blocking out all light–for sleeping–and all but red light to allows medical staff and parents to check up on the kids when they’re awake. Now researchers describe a proof-of-concept mirror that switches between reflective and red-transparent states when a small voltage is applied.
The research team had previously identified a magnesium-iridium reflective thin film that transforms into a red-transparent state when it incorporates protons. Providing those protons in a way that is practical for pre-term incubators, however, was the challenge. The typical method–using dilute hydrogen gas–is unacceptable in a hospital setting. So the team created a stack of thin films that includes both an ion storage layer and the magnesium-iridium layer: a voltage drives protons from the ion storage layer to the magnesium-iridium layer, transforming it into its red-transparent state. Reversing the voltage transforms it back into a reflective mirror.
The researchers report that the device still allows some undesirable light wavelengths through, but a force of just 5 V changes the device’s state in as little as 10 seconds. The researchers are now looking at other materials to improve colour filtering and switching speed.
EurekAlert
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Clostridium difficile (‘C. diff’) infection is a leading cause of hospital-associated diarrhoea, and the frequency and severity of infections are on the rise.
D. Borden Lacy, Ph.D., associate professor of Pathology, Microbiology and Immunology, and colleagues recently demonstrated that the C. difficile toxin, TcdB, induces rapid cell death of human colon cell lines and pig colonic tissue. The investigators now report that TcdB-induced cell death requires the assembly of a host epithelial enzyme complex (NOX) and the production of reactive oxygen species (ROS).
Treatments that reduced expression of parts of the NOX complex, inhibited NOX component function, or ‘scavenged’ ROS all protected colon cells against the C. difficile toxin. Likewise, treatment of colon explants with an inhibitor of the NOX enzyme core or with the antioxidant NAC protected against TcdB-induced tissue damage.
The findings support the concept of using compounds to block ROS or reduce their generation as a strategy for protecting the colonic lining of patients with C. difficile infection.
Vanderbilt University
Retinal (or fundus) photography is an essential part of any ophthalmology practice. Commercial fundus cameras can cost tens to hundreds of thousands of dollars, making the technology out of reach for smaller ophthalmic practices and to physicians in third-world countries. In a recent study now on line, Massachusetts Eye and Ear researchers describe the relatively simple technique of fundus photography in human and rabbit eyes using a smartphone, an inexpensive app for the smartphone, and instruments that are readily available in an ophthalmic practice.
Smartphones are now being used more routinely in ophthalmology to document patients
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Getting a second urine sample and blood pressure measure as patients head out of the doctor
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Brain infarction, or stroke, is caused by a blood clot blocking a blood vessel in the brain, which leads to interruption of blood flow and shortage of oxygen. Now a research group at Lund University, Sweden, has taken an important step towards a treatment for stroke using stem cells.
The group shows in a new study that induced pluripotent stem cells have developed to mature nerve cells at two months after transplantation into the stroke-injured cerebral cortex of rats. These nerve cells have established contact with other important structures in the brain. The transplantation gave rise to improvement of the animals
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Whole-body MRI may serve as a valuable non-invasive tool for assessing the risk of heart attack and stroke in diabetic patients, according to a new study.
Diabetes is a metabolic disease characterised by an increased concentration of glucose in the blood. There are 347 million diabetic patients worldwide, and the World Health Organization projects that diabetes will be the seventh leading cause of death by 2030.
Patients with diabetes are known to develop atherosclerosis, or thickening of the arterial walls, at an accelerated rate, resulting in a higher incidence of major adverse cardiac and cerebrovascular events (MACCE), such as a heart attack or stroke. However, there are wide variations in the degree of risk for adverse events among diabetic patients.
In recent years, whole-body MRI has emerged as a promising means to assess the cardiovascular systems of people with diabetes.
‘One of the major advantages of whole-body MRI in this population is that the technique itself is not associated with radiation exposure, and larger body areas can be covered without increased risk, especially in younger patients,’ said Fabian Bamberg, M.D., M.P.H., from the Department of Radiology at Ludwig-Maximilians University in Munich, Germany. ‘As such, MRI can be used to evaluate the whole-body degree of disease burden that is not clinically apparent yet.’
Dr. Bamberg and colleagues studied the predictive value of whole-body MRI for the occurrence of MACCE in 65 patients with diabetes. The patients underwent a contrast-enhanced whole-body MRI protocol, including brain, cardiac and vascular sequences. The researchers then conducted follow-up inquiries to assess the rate of MACCE in the study group.
Follow-up information was available for 61 patients. After a median of 5.8 years, 14 patients had experienced MACCE. Patients who had detectable vascular changes on whole-body MRI faced a cumulative MACCE risk rate of 20 percent at three years, and 35 percent at six years. None of the patients with a normal whole-body MRI went on to experience MACCE.
The findings point to a role for whole-body MRI as an accurate prognostic tool for diabetic patients that could speed effective treatments to those at risk, Dr. Bamberg said.
Radiological Society of North America
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