How well a woman recovers from a concussion may depend on that time of the month. Researchers found that women injured during the two weeks leading up to their period (the pre-menstrual phase) had a slower recovery and poorer health one month after injury compared to women injured during the two weeks directly after their period or women taking birth control pills. If confirmed in subsequent research, the findings could alter the treatment and prognosis of women who suffer head injuries from sports, falls, car accidents or combat. Several recent studies have confirmed what women and their physicians anecdotally have known for years: Women experience greater cognitive decline, poorer reaction times, more headaches, extended periods of depression, longer hospital stays and delayed return-to-work compared to men following head injury. Such results are particularly pronounced in women of childbearing age; girls who have not started their period and post-menopausal women have outcomes similar to men. Few studies have explored why such differences occur, but senior author Jeffrey J. Bazarian, M.D., M.P.H. says it stands to reason that sex hormones such as estrogen and progesterone, which are highest in women of childbearing age, may play a role.
The use of permanent brachytherapy, a procedure where radioactive sources are placed inside the prostate, into or near to the tumour, preserves erectile function in approximately 50% of patients with prostate cancer.
Brachytherapy works by giving a high dose of radiotherapy directly to the tumour, but only a very low dose to the surrounding normal tissues. Since erectile dysfunction (ED) can occur in up to 68% of patients who receive external beam radiotherapy for the condition, this is a significant improvement and the treatment should be offered to all patients, particularly those who are sexually active, the researchers say.
Dr Ren
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East Kent Hospitals University NHS Foundation Trust, serving a local population of over 750,000, recently installed 224 wireless-enabled Roche Accu-Chek Inform II blood glucose meters in 130 point of care (POC) locations across seven hospital sites. Linked to the cobas IT 1000 POC data management package, this fully connected glucose testing solution from Roche enhances patient safety by helping to ensure appropriate use of the meters and by providing a full audit trail for every test performed.
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Measuring variability of heart rate may identify premature infants at risk of developing narcotising enterocolitis, a serious inflammatory condition that can lead to death, according to Penn State College of Medicine researchers.
Narcotising enterocolitis, or NEC, may lead to destruction of the intestinal wall and vital organ failure. It affects 6 to 10 percent of premature infants within the first two weeks of life.
‘NEC is currently diagnosed by a combination of laboratory and radiology tests, usually done when the disease is already significant,’ said Kim Doheny, director of clinical research in newborn medicine and assistant professor of pediatrics. ‘Since NEC progresses so rapidly and the symptoms develop suddenly, a non-invasive biomarker that allows early detection of patients at risk is required as a matter of urgency.’
Heart rate fluctuates in the intervals between beats, and contributors to this fluctuation are measured through mathematical analysis. One of these contributors is the parasympathetic nervous system — the system that controls digestive responses and regulates the organs during rest — represented through measurement of high-frequency energy distribution. The researchers studied 70 infants born at 28 to 35 weeks within the first five to eight days of life. The babies were stable with no sign of illness.
The researchers then measured heart rate variability in the infants to test whether measuring the high-frequency component of heart rate variability may be used as a way to predict an infant’s NEC risk before disease onset.
Of the 70 infants studied, nine who later developed NEC had decreased high frequency in the heart rate variability, suggesting reduced parasympathetic nervous system activity. Of all the infants with a decreased high-frequency heart rate variability, 50 percent developed the disease. In contrast, 98 percent of those with a higher high-frequency value did not get the disease.
‘This shows that measuring high-frequency variability during this early critical window of postnatal development has value for identifying NEC risk at a time when symptoms are not evident and interventions to improve the parasympathetic nervous system activity can be given,’ said researcher R. Alberto Travagli, professor of neural and behavioral sciences. ‘This relatively simple, economical, and non-invasive method offers the opportunity to monitor at-risk infants more closely and to test the efficacy of emerging treatments.’
The researchers say future investigations should include a larger sample that also includes measurement of inflammation at the time heart rate variability is measured.
Penn State College of Medicine
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For the millions of people forced to rely on a plastic tube to eliminate their urine, developing an infection is nearly a 100 percent guarantee after just four weeks. But with the help of a little bubble-blowing, biomedical engineers hope to bring relief to urethras everywhere.
About half of the time, the interior of long-term urinary catheters become plagued by biofilms
Surgical implants are widely used in modern medicine but their effectiveness is often compromised by how our bodies react to them. Now, scientists at the University of Cambridge have discovered that implant stiffness is a major cause of this so-called foreign body reaction. An obvious difference between electrodes and brain tissue is stiffness. Brain tissue is as soft as cream cheese, it is one of the softest tissues in the body, and electrodes are orders of magnitude stiffer Dr Kristian Franze This is the first time that stiffness of implant materials has been shown to be involved in foreign body reactions.
The findings could lead to major improvements in surgical implants and the quality of life of patients whose lives depend on them. Foreign bodies often trigger a process that begins with inflammation and ends with the foreign body being encapsulated with scar tissue. When this happens after an accident or injury, the process is usually vital to healing, but when the same occurs around, for example, electrodes implanted in the brain to alleviate tremor in Parkinson
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Researchers at the University of British Columbia have identified a small molecule that prevents bacteria from forming into biofilms, a frequent cause of infections. The anti-biofilm peptide works on a range of bacteria including many that cannot be treated by antibiotics.
‘Currently there is a severe problem with antibiotic-resistant organisms,’ says Bob Hancock, a professor in UBC
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By discovering a new mechanism that allows blood to enter the brain immediately after a stroke, researchers at UC Irvine and the Salk Institute have opened the door to new therapies that may limit or prevent stroke-induced brain damage.
A complex and devastating neurological condition, stroke is the fourth-leading cause of death and primary reason for disability in the U.S. The blood-brain barrier is severely damaged in a stroke and lets blood-borne material into the brain, causing the permanent deficits in movement and cognition seen in stroke patients.
Dritan Agalliu, assistant professor of developmental & cell biology at UC Irvine, and Axel Nimmerjahn of the Salk Institute for Biological Studies developed a novel transgenic mouse strain in which they use a fluorescent tag to see the tight, barrier-forming junctions between the cells that make up blood vessels in the central nervous system. This allows them to perceive dynamic changes in the barrier during and after strokes in living animals.
While observing that barrier function is rapidly impaired after a stroke (within six hours), they unexpectedly found that this early barrier failure is not due to the breakdown of tight junctions between blood vessel cells, as had previously been suspected. In fact, junction deterioration did not occur until two days after the event.
Instead, the scientists reported dramatic increases in carrier proteins called serum albumin flowing directly into brain tissue. These proteins travel through the cells composing blood vessels
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When a person suffers a broken bone, treatment calls for the surgeon to insert screws and plates to help bond the broken sections and enable the fracture to heal. These ‘fixation devices’ are usually made of metal alloys.
But metal devices may have disadvantages: Because they are stiff and unyielding, they can cause stress to underlying bone. They also pose an increased risk of infection and poor wound healing. In some cases, the metal implants must be removed following fracture healing, necessitating a second surgery. Resorbable fixation devices, made of synthetic polymers, avoid some of these problems but may pose a risk of inflammatory reactions and are difficult to implant.
Now, using pure silk protein derived from silkworm cocoons, a team of investigators from Tufts University School of Engineering and Beth Israel Deaconess Medical Center (BIDMC) has developed surgical plates and screws that may not only offer improved bone remodelling following injury, but importantly, can also be absorbed by the body over time, eliminating the need for surgical removal of the devices.
‘Unlike metal, the composition of silk protein may be similar to bone composition,’ says co-senior author Samuel Lin, MD, of the Division of Plastic and Reconstructive Surgery at BIDMC and Associate Professor of Surgery at Harvard Medical School. ‘Silk materials are extremely robust. They maintain structural stability under very high temperatures and withstand other extreme conditions, and they can be readily sterilised.’
Collaborating with Lin were co-senior author and Tufts chair of biomedical engineering David Kaplan, PhD, a leader in the use of silk for biomedical applications, and a team of biomedical and mechanical engineers.
‘One of the other big advantages of silk is that it can stabilise and deliver bioactive components, so that plates and screws made of silk could actually deliver antibiotics to prevent infection, pharmaceuticals to enhance bone regrowth and other therapeutics to support healing,’ says Kaplan.
Kaplan and his team have previously developed silk-based sponges, fibres and foams for use in the operating room and in clinical settings. But until now, silk hadn
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