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Archive for category: E-News

E-News

Body cooling cuts in-hospital cardiac arrest patient deaths nearly 12 percent

, 26 August 2020/in E-News /by 3wmedia

Forced body cooling known as therapeutic hypothermia has reduced in-hospital deaths among sudden cardiac arrest patients nearly 12 percent between 2001 and 2009, according to a Mayo Clinic study being presented at the upcoming American Academy of Neurology 2012 Annual Meeting in New Orleans. The research is among several Mayo abstracts that will be discussed at the conference.

The goal of therapeutic cooling is slowing the body’s metabolism and preventing brain damage or death. It is believed that mild therapeutic hypothermia suppresses harmful chemical reactions in the brain and preserves cells. Two key studies published in 2002 found therapeutic hypothermia more effective for sudden cardiac arrest patients than traditional therapies. Mayo researchers analysed a database covering more than 1 million patients and found mortality rates among in-hospital sudden cardiac arrest patients dropped from 69.6 percent in 2001 — the year before the studies appeared — to 57.8 percent in 2009, the most recent data available.

‘Because we reviewed such a large number of cases, we are confident that the reduction in mortality among in-hospital sudden cardiac arrest patients is significant and sustained,’ says co-author Alejandro Rabinstein, M.D., a Mayo Clinic neurologist. ‘We continue to seek answers to the questions: Why did this trend develop, and how can we accelerate it,’ says co-author Jennifer Fugate, D.O.

These measures are important because disease accumulates in the cortex over time, and inflammation in the cortex is a sign the disease has progressed.

EurekAlert
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Moffitt Cancer Center researchers find sarcoma tumour immune response with combination therapy

, 26 August 2020/in E-News /by 3wmedia

A team of 18 researchers at Moffitt Cancer Center in Tampa have found that treating high-risk, soft tissue sarcoma patients with a combination of implanted dendritic cells (immune system cells) and fractionated external beam radiation (EBRT) provided more than 50 percent of their trial patients with tumour-specific immune responses lasting from 11 to 42 weeks.
‘Sarcomas are relatively rare forms of cancer with about 10,000 new cases in the U.S. annually,’ said study co-author Dmitry Gabrilovich, M.D., Ph.D., senior member of the Moffitt Department of Immunology.
The authors note that because 50 percent of patients with large, high-grade soft tissue sarcomas develop distant metastasis, new, effective treatments are needed.
‘Unfortunately, conventional therapy for large, high-grade tumours is frequently systematically ineffective, making this a very deadly problem,’ Gabrilovich said.
According to the researchers, administration of dendritic cells has been found to be a promising method for producing an immune response because dendritic cells process antigen material and present it to other immune cells. Dendritic cells act as immune system messengers.
‘Many studies have shown that preoperative radiotherapy and surgery is effective in treating many soft tissue sarcomas with high-risk features,’ said Gabrilovich. ‘We designed our study to investigate the effect of combining the administration of dendritic cells and EBRT for patients with soft tissue, high-risk sarcomas.’
The researchers hypothesised that if dendritic cell implants were combined with EBRT (the most common kind of radiotherapy treatment that not only can kill tumour cells but release tumour antigens) the combination therapy might be complimentary when the dendritic cells helped process tumour antigens released by the EBRT treatment.
‘The combination treatment resulted in dramatic increases in immune T cells in the tumours,’ explained Gabrilovich. ‘The presence of T cells in the tumours positively correlated with the development of tumour-specific immune responses.’
An important finding in this study was that no patient had significant tumour specific immune responses before the combined therapy. After the combination treatment, tumour specific responses were observed in 52.9 percent of trial patients.
The researchers reported that the combination treatment was ‘well tolerated’ and that 12 of the 17 patients in the clinical trial were ‘progression free’ after one year.
The authors concluded that given that the combination therapy proved effective in creating a potent anti-tumor response and was safe, producing no adverse side effects, larger trials with greater numbers of patients were warranted. Moffitt Cancer Center

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Musical pacifier invention to help premature babies one lullaby at a time

, 26 August 2020/in E-News /by 3wmedia

PAL brings the healing power of music to premature infants.
Many premature babies enter the world with a mountain of challenges in front of them. Even after they overcome any life-threatening issues, they face ongoing, and typically unpleasant, medical procedures, long hospital stays and increased chances of chronic health issues throughout their lives.
To help address one of their biggest problems

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Online tool helps those with BRCA mutations understand options

, 26 August 2020/in E-News /by 3wmedia

Allison Kurian was a developer of the online tool that helps people with BRCA mutations make preventive care decisions.
At age 47, Melanie Lemons has already had her ovaries removed. With a few clicks of her computer

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Autism redefined: Yale researchers study impact of proposed diagnostic criteria

, 26 August 2020/in E-News /by 3wmedia

Getting an autism diagnosis could be more difficult in 2013 when a revised diagnostic definition goes into effect. The proposed changes may affect the proportion of individuals who qualify for a diagnosis of autism spectrum disorder, according to preliminary data presented by Yale School of Medicine researchers at a meeting of the Icelandic Medical Association.
The proposed changes to the diagnostic definition would be published in the fifth edition of the American Psychiatric Association

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UGA study finds anxiety linked to chest pain in children

, 26 August 2020/in E-News /by 3wmedia

Psychological factors can have as much-or more-impact on pediatric chest pain as physical ones, a University of Georgia study found recently. UGA psychologists discovered pediatric patients diagnosed with non-cardiac chest pain have higher levels of anxiety and depression than patients diagnosed with innocent heart murmurs-the noise of normal turbulent blood flow in a structurally normal heart.
The UGA research was done in collaboration with Children’s Healthcare of Atlanta and Emory University.
‘The fact that these psychological symptoms are higher in non-cardiac chest pain patients suggests the psychological symptoms may be playing a role in the presentation of chest pain,’ said Jennifer Lee, a doctoral candidate in the UGA Franklin College of Arts and Sciences and the study’s lead author.
The results of the study show a statistically significant increase in anxiety and depression among patients who are later diagnosed with non-cardiac chest pain when compared to patients diagnosed with innocent heart murmurs. Lee said it is not clear if the anxiety is a cause of the pain or if pain caused the anxiety in the sample group.
‘The higher levels weren’t so high as to cause a clinical diagnosis on their own, but when you contrast the two groups, there were statistically significant differences,’ said study co-author Ronald Blount, a psychology professor in the Franklin College.
The study included 129 patients ages 8 to 18. The group completed surveys prior to diagnosis. All patients were essentially in the same situation-sitting in a cardiology office awaiting their unknown medical diagnosis.
‘We are highlighting that psychology has a part in these symptoms,’ Blount said, ‘and screening for psychological, as well as medical factors, is one implication we foresee coming from this investigation.’
Chest pain can indicate serious medical conditions that require a doctor’s evaluation. In adults, pain in the chest is often linked to a cardiac problem. In children, however, less than 2 percent of patients receive a cardiac diagnosis for their pain.
The Sibley Heart Center at Children’s Healthcare of Atlanta is one of the largest pediatric heart centres in the world, seeing an average of 2,500 new patients with acute chest pain each year.
‘We know up front that 99 percent of these patients will not have a heart complication at all. The trick is, it is not zero, and I cannot miss the one patient with heart disease because the consequences could be catastrophic,’ said Dr. Robert Campbell, chief of the Sibley Heart Center and division director of the department of pediatrics at the Emory University School of Medicine.
The study also observed that non-cardiac chest pain patients have a higher level of functional disability-or the inability to participate in everyday activities like running across a football field or making it through a day without a nap. They also spent less time at school and were less involved in extra-curricular activities.
‘These kids also report greater levels of physical symptoms with unclear causes, like joint pain, stomach aches, head aches,’ Lee said. ‘These symptoms are believed to be psychological manifestations of stress. Sometimes your brain doesn’t tell you that you are stressed out, but your body does, so you will experience symptoms like these.’
Pediatric patients with non-cardiac chest pain also reported higher levels of anxiety sensitivity, a fear of experiencing physical symptoms and additionally fearing that those symptoms are related to a catastrophic health issue.
‘Psychological functioning is heavily related to pain,’ Blount said. ‘Pain is a sensory experience, but your attention to one thing or another and your emotions can impact your experience of pain. And how debilitating the pain is for you can be determined by psychological and social factors. That is what we were interested in looking at.’
Previous studies have shown reducing emotional symptoms can lead to better coping ability with pain, Lee said. ‘A goal with these patients would be to create a clearer, more comprehensive picture of what is going on and determine a better way to help these kids and adolescents.’
Campbell said the UGA research helps him serve the majority of his patients who leave his office with a clean bill of health but unexplained chest pain.
‘Most importantly what we’ve learned is that after a physical evaluation of the patient, we take the time to sit down with the family and find out what they are most worried about so we can address their psychological issues,’ Campbell said. ‘We’ve learned to pay attention and to be confident and reassuring. I need to make it clear to my patients and their parents that I’m not saying you are not having pain, but that the pain is not caused by your heart.’ University of Georgia

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Plasma jet gives ?cold? shoulder to superbugs

, 26 August 2020/in E-News /by 3wmedia

Scientists at Queen

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Study allays concerns about endoscopic vein harvesting during heart surgery

Cardiology, 26 August 2020/in E-News /by 3wmedia

Using an endoscope to guide the removal of leg veins used in heart surgery is as safe as using large, ankle-to-groin incisions, according to a study by Duke University Medical Center researchers.

The data shows the two procedures have similar mortality rates after three years. The endoscopic method has lower rates of infection and wound complications. Today

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Discovery helps mice beat urinary tract infections

, 26 August 2020/in E-News /by 3wmedia

Scientists at Washington University School of Medicine in St. Louis have found new clues to why some urinary tract infections recur persistently after multiple rounds of treatment.
Their research, conducted in mice, suggests that the bacteria that cause urinary tract infections take advantage of a cellular waste disposal system that normally helps fight invaders. In a counterintuitive finding, they learned that when the disposal system was disabled, the mice cleared urinary tract infections much more quickly and thoroughly.
‘This could be the beginning of a paradigm shift in how we think about the relationship between this waste disposal system, known as autophagy, and disease-causing organisms,’ says senior author Indira Mysorekar, PhD, assistant professor of obstetrics and gynaecology and of pathology and immunology. ‘There may be other persistent pathogens that have found ways to exploit autophagy, and that information will be very useful for identifying new treatments.’
Urinary tract infections are very common, particularly in women. In the United States alone, annual treatment costs are estimated to run as high as $1.6 billion. Scientists believe 80 percent to 90 percent of these infections are caused by the bacterium Escherichia coli (E. coli).
Data from the new study and earlier results have led Mysorekar and her colleagues to speculate that E. coli that cause recurrent urinary tract infections may hide in garbage-bin-like compartments within the cells that line the urinary tract.
These compartments, found in nearly all cells, are called autophagosomes. They sweep up debris within the cell, including harmful bacteria and worn-out cell parts. Then, they merge with other compartments in the cell that are filled with enzymes that break down the contents of autophagosomes.
‘We think, but can

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Early treatment sparks striking brain changes in autism

, 26 August 2020/in E-News /by 3wmedia

When given early treatment, children with autism spectrum disorders (ASD) made significant improvements in behaviour, communication, and most strikingly, brain function, Yale School of Medicine researchers report in a new study.
The study was published by Yale Child Study Center researchers Dr. Fred Volkmar, Kevin A. Pelphrey, and their colleagues.
The results suggest that brain systems supporting social perception respond well to an early intervention behavioural program called pivotal response treatment. This treatment includes parent training, and employs play in its methods.
ASDs are complex neurobiological disorders that inhibit a person

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