44 per cent of patients being treated for high blood pressure and who took part in the study either suffered vascular disease or died over a 10-year period
In January a research team from the Peninsula College of Medicine and Dentistry reported the first systematic review of findings related to the risk factors associated with a difference in blood pressure between arms.
The first study, which was published in The Lancet, suggested that a difference of more than 10mmHg or 15mmHg in systolic blood pressure (the
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Though pacemakers require only small amounts of energy (about 1 millionth of a Watt), their batteries have to be replaced periodically, which means multiple surgeries for patients. Researchers have searched for ways to prolong battery life — trying to generate energy to power a pacemaker using blood sugar, or the motion of the hands and legs — but these methods either interfere with metabolism or require a more drastic surgery, such as passing a wire from the limbs to the chest area.
Aerospace engineers M. Amin Karami and Daniel J. Inman, from the University of Michigan in Ann Arbor, have developed a prototype device that could power a pacemaker using a source that is surprisingly close to the heart of the matter: vibrations in the chest cavity that are due mainly to heartbeats.
In their method, vibrations in the chest cavity deform a layer of piezoelectric material, which is able to convert mechanical stress into electrical current. Tests indicate that the device could perform at heart rates from 7 to 700 beats per minute (well below and above the normal range), and that it could deliver eight times the energy required for a pacemaker. Furthermore, the authors write, the amount of energy generated is always larger than the amount required to run a pacemaker, regardless of heart rate.
Though the team has yet to develop a prototype that is biocompatible, they say that the potential to package this energy harvester with pacemakers gives it an advantage over competing methods.
U-M Department of Aerospace Engineering
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Why do so many postmenopausal women who are treated for oestrogen-sensitive breast cancer stop using aromatase inhibitors that help prevent the disease from recurring? The first study to actually ask the women themselves, as well as the largest, most scientifically rigorous study to examine the question, carried out at Northwestern University, USA reports that 36 percent of women stop treatment early because of the medications
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A new study testing the benefits of a virtual exercise partner shows the presence of a moderately more capable cycling partner can significantly boost the motivation
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New research finds a strong link between healthcare-associated infections (HAIs) and patient readmission after an initial hospital stay. The finding suggest that reducing such infections could help reduce readmissions, considered to be a major driver of unnecessary healthcare spending and increased patient morbidity and mortality.
‘Although much attention has been directed toward hospital readmissions and healthcare-associated infections as potentially preventable conditions and targets to reduce healthcare spending, to our knowledge, no studies have directly assessed the association between the two,’ write the study’s authors, from the University of Maryland and Oregon State University.
The researchers, led by Jon Furuno, PhD, tracked 136,513 patients admitted to the University of Maryland Medical Center over 8 years (2001-2008). The study reviewed the number of patients readmitted within one year after discharge, as well as the number of patients with positive cultures for one of three major HAIs: methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), or Clostridium difficile (C. difficile) more than 48 hours after admission, considered a proxy for an HAI.
The researchers identified 4,737 patients with positive clinical cultures for MRSA, VRE or C. difficile after more than 48 hours following hospital admission. These patients were 40 percent more likely to readmitted to the hospital within a year and 60 percent more likely to be readmitted within 30 days than patients with negative or no clinical cultures. This disparity was evident even after controlling for variables, including age, sex, length of hospital stay, and severity of illness.
‘The potential to reduce readmissions along with other known benefits
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Attitude may play an important role in how exercise affects menopausal women, according to Penn State researchers, who identified two types of women — one experiences more hot flashes after physical activity, while the other experiences fewer.
‘The most consistent factor that seemed to differentiate the two groups was perceived control over hot flashes,’ said Steriani Elavsky, assistant professor of kinesiology. ‘These women have ways of dealing with (hot flashes) and they believe they can control or cope with them in an effective way on a daily basis.’
Women who experienced fewer hot flashes the day after participating in vigorous to moderate physical activity were more likely to be part of the group that felt they had control over their hot flashes. Women who had more hot flashes following exercise were likely to be those who felt they had very few ways of coping with their hot flashes, Elavsky and her colleagues report in a recent issue of Maturitas.
Elavsky suggested that cognitive behavioural therapy may help some women feel they have more control over their bodies and reactions to hot flashes.
The participants with fewer hot flashes the day after vigorous exercising were also less likely to experience anxiety and depression. However, women who had fewer hot flashes the day after only light or moderate physical activity had higher levels of pessimism and depression than others.
‘The bottom line for research is that people need to look at individual differences,’ said Elavsky. ‘It’s not enough anymore to do a study and look at overall impact of an exercise program on symptoms. It’s very clear that we need to look at the different responses that women might have, and try to understand these individual differences more.’
Elavsky and her colleagues followed 24 menopausal women for the length of one menstrual cycle, or for 30 days if they were no longer menstruating. Each woman used a personal digital assistant to record hot flashes and wore an accelerometer at the hip to track physical activity. The women in the study regularly had hot flashes before the start of the study, experiencing from five to 20 a day.
‘The real-time reporting of symptoms and the objective measurement is a strength of the study,’ said Elavsky. ‘There aren’t any studies out there that use both of these approaches.
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Aberdeen researchers have discovered how a controversial but effective treatment in psychiatry acts on the brain in people who are severely depressed.
Electroconvulsive therapy or ECT – which involves anaesthetising a patient and electrically inducing a seizure – is the most potent treatment option for patients with serious mood disorder.
Despite being used successfully in clinical practice around the world for more than 70 years, the underlying mechanisms of ECT have so far remained unclear.
Now a multidisciplinary team of clinicians and scientists at the University of Aberdeen, Scotland, has shown for the first time that ECT affects the way different parts of the brain involved in depression
A recent report in The Lancet has concluded that blood pressure should be measured in both arms as the difference between left and right could indicate underlying health problems such as vascular disease.
Dr Christopher Clark and colleagues, from the Peninsula College of Medicine and Dentistry at the University of Exeter, reviewed 28 previous study papers on this subject.
According to the study, the difference between arms is important, although the arm with the higher pressure can vary between individuals. Most people in the study had an elevated blood pressure risk and about one-third had a normal level of risk.
The study concluded that a difference in systolic blood pressure of 10 millimetres of mercury (mm Hg) between arms could identify patients at high risk of asymptomatic peripheral vascular disease. A difference of 15 mm Hg would also indicate an increased risk of cerebrovascular disease, a 70% increased risk of cardiovascular mortality and 60% increased risk of death from all causes, the authors said.
Peripheral vascular disease (PVD) is the narrowing and hardening of the arteries that supply blood to the legs and feet. There are often no symptoms. Early detection of PVD is important because these patients could then benefit from stopping smoking, lowering their blood pressure or being offered statin therapy.
Writing in The Lancet, Prof Richard J McManus, department of primary care health sciences at the University of Oxford and Prof Jonathan Mant, from the department of public health and primary care at the University of Cambridge, said the review supports existing guidelines.
Prof Bryan Williams, from the Blood Pressure Association and the University of Leicester, said the study reinforced the message already in the guidelines from health watchdog NICE.
www.lancet.com
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According to the WHO, antibiotic-resistant bacteria are one of the top three threats to human health; patients in hospitals are especially at risk. Now researchers at Tel Aviv University
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Among women with gestational diabetes mellitus, referral to a telephone-based nurse management program was associated with lower risk of high baby birth weight and increased postpartum glucose testing, according to Kaiser Permanente researchers.
Investigators for the Kaiser Permanente Northern California Division of Research examined the associations between referral to telephone-based nurse consultation and outcomes in 12 Kaiser Permanente medical centres with variation in the percent of patients referred to telephonic nurse management.
‘Compared with women from Kaiser Permanente medical centres where the annual proportions of referral to nurse management at the Kaiser Permanente Regional Perinatal Service Center was less than 30 percent, women who delivered in medical centres with an annual referral proportion of greater than 70 percent were less likely to have a high birth weight infant without increasing the risk or having a low birth weight infant,’ said Assiamira Ferrara, MD, PhD, a research scientist with the Kaiser Permanente Northern California Division of Research and the lead author of the study. ‘In addition, they were more likely to have postpartum glucose testing, which leads to earlier identification and management of postpartum glucose intolerance or diabetes.’
Investigators used data from the Kaiser Permanente Northern California GDM registry to identify women who had pregnancy complicated by GDM from 1997 through 2006. They restricted their cohort to women with GDM according to the National Diabetes Data Group criteria. During the study period, 96 percent of all pregnant women without pre-existing diabetes who delivered an infant were screened for GDM. Researchers excluded women who delivered multiple births due to their increased risk of perinatal complications. Overall, researchers identified 11,435 women with GDM at the 12 medical centres, of whom 44.5 percent were referred to the perinatal service centre.
‘The Kaiser Permanente Regional Perinatal Service Center is a nurse-based management program for women with GDM that offers supplemental care via telephone counselling to women with high-risk pregnancies, including those complicated by GDM,’ explained co-author Monique Hedderson, PhD, a research scientist with the Kaiser Permanente Northern California Division of Research.
The program includes a call center with 32 registered nurses and two registered dieticians who offer phone counselling seven days a week and address glucose monitoring and control, diet and physical activity. Nurses are available 24 hours a day, seven days a week, while dieticians are available to patients during the week from 8 a.m. to 5 p.m. In addition to care provided by obstetricians, women referred to the centre receive one to two counselling calls per week to help them manage their blood glucose levels during pregnancy. The centre also sends a laboratory slip for postpartum glucose testing and a reminder telephone call if the screening test was not performed.
EurekAlert
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