A new working party report from the Royal College of Physicians (RCP) says there should be a national system for recognising very sick patients whose condition is deteriorating and who need more intensive medical or nursing care. The working party also developed and piloted a National Early Warning Score for this purpose, which if implemented across the NHS, would result in a step-change upwards in patient safety.
Visit the NEWS pages of the RCP website to download the report and resources.
Speaking at a press conference to launch the National Early Warning Score, Professor Bryan Williams, chair of the working party, estimated that 6,000 lives could be saved by its use.*
The report, National early warning score (NEWS); standardising the assessment of acute-illness severity in the NHS, was produced by a multidisciplinary working group including doctors, nurses and managers. Clinical observation charts and e-learning materials were also produced by the NEWS educational programme, a collaborative project funded by the RCP, the Royal College of Nursing (RCN), the National Outreach Forum, and NHS Training for Innovation.
Each acute hospital bed has a chart that is used to record measurements such as the patient
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In a new study, researchers used mice to identify a combination six naturally occurring bacteria that eradicate a highly contagious form of Clostridium difficile, an infectious bacterium associated with many hospital deaths. Three of the six bacteria have not been described before. This work may have significant implications for future control and treatment approaches.
The researchers found that this strain of C. difficile, known as O27, establishes a persistent, prolonged contagious period, known as super-shedding that is very difficult to treat with antibiotics. These contagious
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According to a recent study, shift work is associated with an increased risk of a heart attack or stroke. Analysing the results of dozens of studies involving more than two million people, researchers looked at the health impact of evening shifts, irregular or unspecified shifts, mixed schedules, night shifts and rotating shifts. They compared the findings with non-shift workers and the general population. It appeared that heart attacks and strokes were more common among shift workers. Shift work was associated with a 23% increased risk of a heart attack and a 5% increased risk of a stroke. Night shifts were associated with the steepest increase in risk for coronary events. Whether you work nights, evenings or regular office hours, eating healthily, getting active and quitting smoking can make a big difference to your heart health irrespective of whether one works nights, evenings or regular office hours. The study was published in the British Medical Journal.
http://tinyurl.com/c223sus
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Robot avatars have got a step closer to being the real world doubles of those who are paralysed or have locked-in-syndrome. Scientists have made a robot move on a human’s behalf by monitoring thoughts about movement.
The man-machine link joined a man in a brain scanner in Israel and a robot wandering a laboratory in France. The person controlling the robot could also see through the eyes of his electronic surrogate. The researchers are now working on ways to make the man-machine link more sensitive and to let people speak via the robot.
The research project connected a robot to a man having his brain scanned using fMRI (Functional Magnetic Resonance Imaging). This monitors blood flowing through the brain and can spot when areas associated with certain actions, such as movement, are in use.
Using brain scanners is a step beyond current efforts to link up men and machines. Much recent work involved teleoperated robots in which humans manipulate controls, such as joysticks, to make a robot move.
By contrast, the scanning approach is more subtle and attempts to fool the human subject into thinking that they are embodied in the robot.
Eventually the small robot will be swapped for one the size of an average human The experiment helping to prove the technology works linked up student Tirosh Shapira who was in a lab at Bar-Ilan University, Israel, with a small two-legged robot thousands of kilometres away at Beziers Technology Institute in France.
Prior to connecting the two, researchers made Mr Shapira think about different sorts of movements and developed software that could quickly spot his intention.
The result was that he could control the robot in almost real time.
The illusion of embodiment was tested by surprising Mr Shapira with a mirror so he could see his robot self – a test that convinced him he was present in the French lab.
The next step for the research is to refine it to use a different type of scanning that can work using a skull cap rather than an fMRI machine that a person has to lie in. The robot used to represent a human is to be upgraded to a version that has a similar stature and gait to a real person.
The research is part of an international project called Virtual Embodiment and Robotic Re-Embodiment that aims to refine ways to link people and surrogates in both virtual environments and the real world.
Work is being done on medical applications of the technology but the researchers warned that it was a long way from being able to help anyone yet.
BBC
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Contrary to popular thought, regular exercise before and during pregnancy could have beneficial effects for women that develop high blood pressure during gestation, human physiology professor Jeff Gilbert said, summarising a new study by his research team.
Gilbert
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Mini-courses designed to increase creative stimulation and variety in physicians’ daily routines can sharpen critical thinking skills, improve job satisfaction and encourage innovative thinking, according to Penn State College of Medicine researchers who piloted a series of such courses.
‘For decades, career development theory has identified a stage that occurs at midlife, characterised by a desire to escape the status quo and pursue new ventures,’ said Kimberly Myers, Ph.D., associate professor of humanities. ‘It is increasingly clear that these mid-career professionals are yearning to explore ways of thinking that are outside of their usual responsibilities.’
The courses are an outgrowth of a pilot initiative called the Penn State Hershey Physician Writers Group, which Myers founded and facilitated. The group met every other week for three months and explored how medically related topics are featured in different literary genres. Participants wrote original pieces, which they discussed and edited with each other and Myers.
‘The process of literary analysis, which is both methodical and intuitive, helps to sharpen the cognitive processes inherent in medical diagnosis and treatment that are so vital in medical practice,’ said Myers. ‘Group discussions also provide a refreshing opportunity for collaboration, which help to form new alliances among colleagues.’
Many physicians’ writings were published in professional journals, and the physicians reported overwhelming satisfaction with the experience. As a result of the pilot program’s success, the researchers and their colleagues in the Department of Humanities developed and conducted eight mini-courses on different topics throughout 2010-2011.
Although each course had its own objectives, the overarching goal of the series was to provide humanities-related, clinically relevant learning opportunities for health care practitioners.
‘The topics covered fell into four general categories: reading, reflection, and discussion; creative expression; technology; and ethics,’ said Daniel George, Ph.D., assistant professor of humanities.
To accommodate busy schedules, the researchers scheduled these courses across an eight-month period and met three to five times total. Each hour of participation earned one Continuing Medical Education credit. Participants included physicians, nurses, administrative and support staff, medical and nursing students and health researchers and scientists.
Post-course surveys proved as favourable as the feedback from the Writers Group. Participants reported a high degree of satisfaction with learning new disciplines outside of biomedicine, using their training in uncustomary ways, forming new camaraderie with their colleagues, and enjoying a respite from the stressful flow of the workday.
‘These courses offer an opportunity for intellectual and social ‘play’ to those who participate, which fosters workplace satisfaction and creative, innovative thinking,’ said George. ‘Efforts that implement programs like these in other medical settings could potentially contribute to reviving the health care system, which would ultimately benefit both practitioners and their patients.’
EurekAlert
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A single-dose vaccine capable of providing immunity against the effects of cocaine offers a novel and groundbreaking strategy for treating cocaine addiction is described.
‘This is a very novel approach for addressing the huge medical problem of cocaine addiction,’ says James M. Wilson, MD, PhD, Editor-in-Chief, and Director of the Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.
In the article ‘AAVrh.10-Mediated Expression of an Anti-Cocaine Antibody Mediates Persistent Passive Immunization That Suppresses Cocaine-Induced Behavior,’ (online.liebertpub.com/doi/pdfplus/10.1089/hum.2011.178) a team of researchers from Weill Cornell Medical College (New York, NY), The Scripps Research Institute (La Jolla, CA), and Cornell University (Ithaca, NY) used a virus-based delivery vehicle in mice to transfer a gene that produces a protein capable of binding to cocaine present in the blood, preventing the cocaine from crossing into the brain. The protein is a monoclonal antibody that sequesters cocaine, making the vaccinated mice resistant to the drug’s effects. Whereas unvaccinated mice exhibited hyperactivity when exposed to intravenous cocaine, the immunized mice showed no effects, according to authors Jonathan Rosenberg, et al.
EurekAlert
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Using a combination of surgical procedures developed over the last 11 years, surgeons at Boston Children’s Hospital have established a new approach for rebuilding the heart in children born with a severe heart defect called hypoplastic left heart syndrome (HLHS). This ‘staged left ventricle recruitment’ (SLVR) strategy uses the existing standard single-ventricle treatment for HLHS and additional procedures to spur the body’s capacity for healing and growth and encourage the small left ventricle in these children to grow and function.
Members of Boston Children’s Departments of Cardiac Surgery and Cardiology
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By including chemotherapy as a conditioning regimen prior to treatment, researchers have developed a refined gene therapy approach that safely and effectively restores the immune system of children with a form of severe combined immunodeficiency (SCID), according to a study.
SCID is a group of rare and debilitating genetic disorders that affect the normal development of the immune system in newborns. Infants with SCID are prone to serious, life-threatening infections within the first few months of life and require extensive treatment for survival beyond infancy.
Adenosine deaminase (ADA) deficiency, which accounts for approximately 15 percent of all SCID cases, develops when a gene mutation prohibits the production of ADA, an enzyme that breaks down toxic molecules that can accumulate to harmful levels and kill lymphocytes, the specialised white blood cells that help make up the immune system. In its absence, infants with ADA-deficient SCID lack almost all immune defenses and their condition is almost always fatal within two years if left untreated. Standard treatment for ADA-deficient SCID is a haematopoietic stem cell transplant (HSCT) from a sibling or related donor; however, finding a matched donor can be difficult and transplants can carry significant risks. An alternate treatment method, enzyme replacement therapy (ERT), involves regular injections of the ADA enzyme to maintain the immune system and can help restore immune function; however, the treatments are extremely expensive and painful for the young patients and the effects are often only temporary.
Given the limitations of HSCT and ERT, in the 1990s researchers began investigating the efficacy of gene therapy for ADA-deficient SCID. They discovered that they could ‘correct’ the function of a mutated gene by adding a healthy copy into the cells of the body that help fight infectious diseases. Since then, there have been significant advances in gene therapy for SCID, yet successful gene therapy in patients with ADA-deficient SCID has been seen in only a small series of children due to the difficulty of introducing a healthy ADA gene into bone marrow stem cells and to engraft these cells back into the patients.
‘Although the basic steps of gene therapy for patients with SCID have been known for a while, technical and clinical challenges still exist and we wanted to find an optimized gene therapy protocol to restore immunity for young children with ADA-deficient SCID,’ said Fabio Candotti, MD, one of the study
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