By Samuel Boova, Director Alliance Development, High Burden HIV Global Markets, Beckman Coulter Life Sciences Despite significant progress in its prevention and treatment, human immunodeficiency virus (HIV) remains a serious public health threat across the globe. The United Nations programme UNAIDS has led the global effort to address the HIV/AIDS crisis and has set out […]

The MedTech company Hologic, with a primary focus on women’s health, has acquired SOMATEX Medical Technologies, a leader in biopsy site markers and localization technologies, for approximately $64 million. The company was previously owned by E-Med Solutions, Berlin, a group of investors led by German private equity company Westlake Partners.

Proton therapy, a type of external beam radiation therapy, is a safe and effective treatment for prostate cancer, according to two new studies.
In the first study, researchers at the University of Florida in Jacksonville, Fla., prospectively studied 211 men with low-, intermediate-, and high-risk prostate cancer. The men were treated with proton therapy, a specialised type of external beam radiation therapy that uses protons instead of X-rays. After a two year follow-up, the research team led by Nancy Mendenhall, MD, of the University of Florida Proton Therapy Institute, reported that the treatment was effective and that the gastrointestinal and genitourinary side effects were generally minimal.
‘This study is important because it will help set normal tissue guidelines in future trials,’ Dr. Mendenhall, said.
In the second study, researchers from Massachusetts General Hospital in Boston, Loma Linda University Medical Center in Loma Linda, Calif., and the Radiation Therapy Oncology Group in Philadelphia performed a case-matched analysis comparing high-dose external beam radiation therapy using a combination of photons (X-rays) and protons with brachytherapy (radioactive seed implants).
Over three years, 196 patients received the external beam treatments. Their data was compared to 203 men of similar stages who received brachytherapy over the same time period. Researchers then compared the biochemical failure rates (a statistical measure of whether the cancer relapses) and determined that men who received the proton/photon therapy had the same rate of recurrence as the men who received brachytherapy.
‘For men with prostate cancer, brachytherapy and external beam radiation therapy using photons and protons are both highly effective treatments with similar relapse rates,’ John J. Coen, MD, a radiation oncologist at Massachusetts General Hospital in Boston, said. ‘Based on this data, it is our belief that men with prostate cancer can reasonably choose either treatment for localised prostate cancer based on their own concerns about quality of life without fearing they are compromising their chance for a cure.’ EurekAlert

Thousands more American senior citizens with kidney disease are good candidates for transplants and could get them if physicians would get past outdated medical biases and put them on transplant waiting lists, according to a new study by Johns Hopkins researchers.
The Hopkins investigators estimate that between 1999 and 2006, roughly 9,000 adults over 65 would have been ‘excellent’ transplant candidates and approximately 40,000 more older adults would have been ‘good’ candidates for new kidneys. None, however, were given the chance.
‘Doctors routinely believe and tell older people they are not good candidates for kidney transplant, but many of them are if they are carefully selected and if factors that really predict outcomes are fully accounted for,’ says transplant surgeon Dorry L. Segev, M.D., Ph.D., an associate professor of surgery at the Johns Hopkins University School of Medicine and leader of the study. ‘Many older adults can enjoy excellent transplant outcomes in this day and age,’ he says, and should ‘be given consideration for this lifesaving treatment.’
Those ages 65 and older make up over one-half of people with end-stage renal disease in the United States, and appropriately selected patients in this age group will live longer if they get new kidneys as opposed to remaining on dialysis, Segev says. The trouble is, he adds, that very few older adults are even put on transplant waiting lists. In 2007, only 10.4 percent of dialysis patients between the ages of 65 and 74 were on waiting lists, compared to 33.5 percent of 18- to 44-year-old dialysis patients and 21.9 percent of 45- to 64-year-old dialysis patients.
Segev cautions that some older kidney disease patients are indeed poor transplant prospects, because they have other age-related health problems. But he says his team’s new findings, in addition to other recent research, show that new organs can greatly improve survival even in this age group.
Segev and his team constructed a statistical model for predicting how well older adults would be expected to do after kidney transplantation by taking into account age, smoking, diabetes and 16 other health-related variables. Using those data to define an ‘excellent’ candidate, the information was then applied to every person 65 and older on dialysis during the seven-year study period. The researchers also determined whether these candidates were already on the waiting list.
‘We have this regressive attitude toward transplantation in older adults,’ Segev says, ‘one based on historical poor outcomes in older patients, which no longer hold up. Anyone who can benefit from kidney transplantation should at least be given a chance. They should at least be put on the list.’ Johns Hopkins Medical Institutions