The 43rd World Hospital Congress of the International Hospital Federation will bring health leaders from around the globe together in Oman in November to discuss the importance of people-centered health services in times of peace and crisis. The World Hospital Congress is a unique global forum where leaders of national and international hospital and healthcare organizations convene to share knowledge, expertise, experiences and best practices in leadership in hospital and healthcare management and service delivery. Hosted this year by the Ministry of Health of the Sultanate of Oman, the event will be held on 6-9 November in Muscat with the theme ”People at the heart of health services in peace and crisis”. To respond to peoples’ expectations, health services must be supported by investments contributing to the prosperity of the nation, resilience to all possible issues, and innovation to increase health gain. The Congress will explore how health services can be more responsive through better resilience, supportive through appropriate health investments and prospective through health impactful innovations. More than 100 health leaders and professionals from over 40 countries will be sharing insights, best practices and experiences in a diverse program. Keynote topics will include:
How hospitals and health services can protect people in situation of crisis like outbreaks, conflicts and natural disasters
How hospitals and health services contribute locally and nationally to prosperity
How health services can support better well-being
How to identify real innovation that will effectively support healthcare
The role of patients in time of peace and crisis from self-empowerment to social mobilization
The congress will provide an amazing opportunity to learn from some of the best in the industry, broaden their network, plus explore the hidden beauty of Oman. Early bird registration is now open and will end on 15 August 2019. Delegates can already secure their slots at the best rates by registering online.
www.worldhospitalcongress.org
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A team of Massachusetts General Hospital (MGH) researchers has developed a potential alternative to gadolinium-based contrast agents (GBCAs) for magnetic resonance imaging (MRI). In their report, the team describes experiments showing in a primate model that the manganese-based agent Mn-PyC3A produced contrast enhancement of blood vessels equivalent to that of gadolinium-based agents, which carry significant health risks for some patients. “About 40 percent of MRI procedures use a contrast agent to produce a signal that can detect cancers, diagnose aneurysms or arterial narrowing, or identify the area of a heart damaged by a heart attack,” says Peter Caravan, PhD, of the Martinos Center for Biomedical Imaging and co-director of the Institute for Innovation in Imaging at MGH, corresponding author of the Radiology paper. “All current FDA-approved MR contrast agents contain gadolinium, which in 2006 was associated with a devastating condition called nephrogenic systemic fibrosis in patients with impaired kidney function. We estimate that around 2 million contrast-enhanced scans are not performed in the U.S. every year because of the inability to use GBCAs in patients with poor renal function.” More recent reports finding gadolinium deposits in the brains and other organs of patients have added to concerns about the safety of GBCAs, leading the U.S. FDA to reiterate the need for caution and restraint in the use of the agents and the European Medical Association to remove three of seven previously approved agents from the market and restrict the use of others earlier this year. Caravan and his colleague Eric Gale, PhD, of the Martinos Center developed their manganese-based agent Mn-PyC3A based on two properties of the element: its ability to produce an MR signal comparable to that of GBCAs and the fact that that – in contrast to gadolinium, which is not naturally found in the human body – manganese is an essential element, and intake of small amounts is required for vital bodily functions. The body has natural mechanisms to process and excrete excess manganese, but any gadolinium that is released from GBCAs is likely to be retained in the body indefinitely. Previous studies conducted by the team in mouse models showed that Mn-PyC3A was very resistant to the release of manganese ions; that it provided good enhancement of blood vessels, liver and kidneys; that more than 99 percent was excreted from the body within 24 hours, and that it was eliminated by both the liver and the kidneys, reducing the likelihood of prolonged retention in subjects with poor kidney function. For the current study, the researchers compared the use of Mn-PyC3A to a commonly used GBCA in a baboon model. Each animal underwent two MR imaging sessions, one with Mn-PyC3A and one with the GBCA. The scans were performed under identical conditions – the scanner used, the dosages and imaging protocols were the same as would be used for human patients – and the enhanced images of major arteries, kidneys, livers and specific muscles produced by both agents were comparable. As in the mouse study, Mn-PyC3A was quickly excreted though both kidney and liver clearance, and there was no evidence of the release of free manganese. Gale explains, “While we did not test it here, we believe that having an alternative route of elimination through the liver will provide an efficient mechanism for elimination of Mn-PyC3A in patients with kidney disease and prevent any retention of the contrast agent in the body. Our next steps are to manufacture Mn-PyC3A on a larger scale and conduct additional preclinical safety studies before we can begin testing in human patients.”
Massachusetts General Hospitalhttps://tinyurl.com/y8oq4r8q
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Membranous nephropathy (MN) is a progressive kidney disease which is characterized by the accumulation of immune complexes within the kidney. It often leads to a so-called nephrotic syndrome with proteinuria, hypoalbuminemia, and edema, it can even result in kidney failure. MN can occur without any known causes (primary MN), but can also be acquired via other diseases. Antibodies against phospholipase A2 receptor (PLA2R) are highly specific for the primary form of the disease, but do not occur in secondary forms. An Indian working group published five cases of nephrotic syndrome caused by MN with evidence of chronic mercury poisoning due to consumption of traditional Indian medicines such as Siddha and Ayurveda. The article was published in “Clinical Kidney Journal” (ckj), an official journal of the ERA-EDTA, in June 2018, and is the first report of its kind showing that traditional Indian medicines can cause MN, proven by renal biopsy. All patients received this kind of medicine and the index patients were seronegative for antibodies against phospholipase A2 receptor (PLA2R), giving evidence that they did not suffer from the primary form of the disease. Very few cases of mercury-induced MN have been reported in the literature so far and most known cases have developed due to traditional Chinese medicine, skin-lightening creams, inhalation containing mercury and hair dye containing mercury. Traditional Indian medicines have so far not been “on the radar”, although mercury has been an ingredient in several traditional medicines such as Ayurveda, Unani, Siddha, Tibetan and Chinese medicines. Traditional Indian medicines are sold over the Internet and have found a global market. However, these drugs sold by some traditional medicine manufacturers may not be rigorously tested for the contents and their sale is not regulated. However, despite the widespread consumption of traditional Indian medicines, no renal toxicity has been reported so far. According to the authors of this case report, it might be possible that it is underreported due to a lack of awareness among physicians and nephrologists or to a lack of knowledge: very often, patients do not even mention that they are taking traditional medicines in addition to what their family doctor or nephrologist prescribes. The authors suggest that mercury poisoning should be considered in patients with anti-PLA2R antibody-negative MN, and that these patients should be asked, if they had taken traditional Indian medicines. “The publication of these case reports is important. It shows that seemingly harmless traditional medicine can harm people a lot and that it is high time that controls and regulations concerning the ingredients of any medicine are needed”, explains ckj editor-in-chief, Professor Alberto Ortiz. “As long as there are no quality controls for substances used in traditional medicine, we have to warn our patients: Mercury poisoning can lead to MN as well as to many other severe health problems, because it is affecting the brain, the gut and the kidneys.”
www.era-edta.org
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Cardiovascular disease pervades Appalachia, yet many Appalachians live far from any heart and vascular specialist. Follow-up doctor’s visits in the weeks after cardiovascular surgery can involve hours-long drives down narrow, winding roads. A recent study led by Albeir Mousa, a professor in the West Virginia University School of Medicine, suggests telemedicine may improve these patients’ satisfaction with their postoperative care as well as their quality of life. With telemedicine, a healthcare provider can use a computer, tablet or other electronic device to remotely evaluate their patients’ symptoms, diagnose illnesses or injuries, and prescribe treatments. They can also field their patients’ questions. The 30 participants in Mousa’s study were recovering from vascular surgery. In each case, the surgeon made an incision in the patient’s groin to access the arteries that needed rebuilding or rerouting. Whether the incisions healed without complications was the study’s focus. Sixteen patients received tablets with Enform—a telemedicine app developed by TeleMed 2020 Inc.—that facilitated communication with nurses managing their care. As part of an in-home monitoring kit, patients also received thermometers, blood pressure cuffs, scales and devices to measure blood oxygen saturation levels. Each day, patients who had been discharged from the hospital weighed themselves, took their temperature, measured their pulse and blood pressure, and determined their blood oxygen levels using the Enform app. They completed a wellness and symptom tracking quiz that included questions like “How is your pain today?” Each week they answered satisfaction and emotional wellness questions as well. These data, along with photos of the surgical incision sites that patients captured with the app—were made available to the patients’ care team. Care managers, in turn, logged into the telemedicine platform daily to review the information patients had submitted from their homes. Cares managers received notifications of abnormalities, such as blood pressure spikes and fevers. Based on the information they gathered, the care managers intervened, answered patients’ questions about symptoms or wound care, called in prescriptions, scheduled appointments with physicians, and modified care plans based on consultations with the medical director. Meanwhile, the other 14 participants had standard-of-care treatment. They received no monitoring equipment, tablet or telemedicine app. After 30 days, the researchers made a number of comparisons between the two groups. For example, were wound infections more common in one group than the other? Did one group require more hospital readmissions? How did members of each group rate their own well-being? Were they happy with the postoperative care they received? Hospital-readmission and wound-infection rates did not differ significantly between groups. The researchers attribute this fact to the study’s small sample size. But patients in the telemedicine group scored better on measures of their physical function, mental health and role limitations due to physical health problems. In addition, the vast majority of patients who used the app found it intuitive to use. Using a five-point scale to measure ease of use, 91 percent of patients gave it a score of 4 or 5. A similar percentage of patients said the app enriched the quality of care they received. Likewise, the telemedicine patients’ scores on quality-of-life assessments surged more dramatically between the study’s beginning and end. Patients assigned to the telemedicine group lived an average of 60 miles from their vascular care center. Almost a third of them lived more than 77 miles away and had to drive for two to three hours to get there. “Telemedicine would save a lot of headache in Appalachia—in areas where people don’t even have the money to get in the car to get to the hospital,” said Mousa, who teaches surgery at the WVU Health Sciences Charleston Campus. He envisions that, one day, patients will be able to download a cell phone app that provides these telemedicine services. That way, they won’t even need a tablet. “Each household has at least one cell phone, and most likely, it’s a smartphone.” “You’re getting the same service,” he said, “but with a very minor hassle for the patient and the physician.”
West Virginia University medicine.hsc.wvu.edu/News/Story?headline=wvu-researchers-find-telemedicine-may-increase-patients-satisfaction-with-their-medical-care
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The International Day of Radiology (IDoR) will be celebrated for the seventh time on November 8, this year focusing on cardiac imaging.
Cardiac imaging is a fast-growing subspecialty of diagnostic radiology that plays a huge part in the assessment and management of heart patients throughout the world. Cardiac radiologists – the experts in charge – supervise or perform imaging examinations, using technology such as computed tomography (CT) and magnetic resonance imaging (MRI), and then interpret the resulting images to diagnose and monitor a wide range of diseases of the heart.
For IDoR 2018, we are highlighting the increasingly important role of radiologists in cardiac care, contributing to the diagnosis, pre-procedural work-up and follow-up of patients with a wide variety of cardiac pathology, from coronary artery disease and leaky heart valves to defects in the size and shape of the heart.
To underline the significance of cardiac imaging in various regions of the world and to show its current place in today’s medical healthcare spectrum, the ESR has conducted numerous interviews with experts throughout Europe, Latin America and Asia, as well as with individuals from Canada, South Africa and Egypt.
The stunning IDoR 2018 poster can again be downloaded on the IDoR website; this year it is available in 30 languages, covering a great variety from Icelandic to Nepalese.
A publication on this year’s main theme is currently in the making; books from previous years on emergency radiology, breast imaging, pediatric imaging, brain imaging and thoracic imaging are still available for download on the IDoR website.
As in previous years, more than 160 radiology-related professional societies from around the world will participate in the International Day of Radiology, holding a range of different events to celebrate, such as public lectures, department open days, conferences, and press events.
The International Day of Radiology was launched in 2012 and is a joint initiative of the European Society of Radiology (ESR), the Radiological Society of North America (RSNA) and the American College of Radiology (ACR). It is an annual event held with the aim of building greater awareness of the value that radiology contributes to safe patient care, and improving understanding of the vital role radiologists play in the healthcare continuum.
November 8, the day that Wilhelm Conrad Röntgen discovered the existence of x-rays in 1895, was chosen as a day of action and awareness. The organizers hope to alert the world to the stunning medical, scientific and even artistic possibilities of medical imaging, the essential role of the radiologist as a part of the healthcare team in countless medical scenarios, and the high educational and professional standards required of all staff working in medical imaging.
idor2018.com
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Nowadays, tumours inside the complex central nervous system remain one of the most challenging cancers to diagnose. Different from conventional brain-imaging techniques, nearinfrared (NIR) fluorescence imaging demonstrates particular merits including being non-hazardous, offering fast feedback, and having higher sensitivity. A research team led by Prof. ZHENG Hairong from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences, in collaboration with Prof. LIU Bin from the University of Singapore, reported the first NIR-II fluorescent molecule with aggregation-induced-emission (AIE) characteristics for dual fluorescence and photoacoustic imaging. Fluorescence imaging in the second NIR window (NIR-II), compared with the first NIR window (NIR-I), exhibits salient advantages of deeper penetration and higher spatiotemporal resolution, owing to further reduced photon scattering, absorption, and tissue autofluorescence in biological tissues. Scientists designed a new donor-acceptor (D-A)-tailored NIR-II emissive AIE molecule, and formulated dots showed a high NIR-II fluorescence quantum yield up to 6.2%, owing to the intrinsic aggregation-induced emission nature of the designed molecule. The AIE dots have been successfully used for dual NIR-II fluorescence and NIR-I photoacoustic imaging for precise non-invasive brain-tumour diagnosis. Based on the same dots, the experiments revealed that NIR-II fluorescence imaging showed a high resolution. Meanwhile, NIR-I PA imaging intrinsically exhibited higher penetration depth than that of NIR-II fluorescence imaging, which allowed clear delineation of tumour depth in the brain. The synergetic bimodal imaging with targeting c-RGD-decorated bright AIE nanoparticles showed precise brain-tumour diagnosis with good specificity and high sensitivity, which yielded a high S/B of 4.4 and accurately assessed the depth of tumour location inside brain tissue. The study demonstrates the promise of NIR-II AIE molecules and their dots in dual NIR-II fluorescence and NIR-I photoacoustic imaging for precise brain cancer diagnostics.
Machine learning – a field of artificial intelligence that uses statistical techniques to enable computer systems to ‘learn’ from data – can be used to analyse electronic health records and predict the risk of emergency hospital admissions, a new study from The George Institute for Global Health at the University of Oxford has found. The research suggests that using these techniques could help health practitioners accurately monitor the risks faced by patients and put in place measures to avoid unplanned admissions, which are a major source of healthcare spending. ‘There were over 5.9 million recorded emergency hospital admissions in the UK in 2017, and a large proportion of them were avoidable,’ said Fatemeh Rahimian, former data scientist at The George Institute UK, who led the research. ‘We wanted to provide a tool that would enable healthcare workers to accurately monitor the risks faced by their patients, and as a result make better decisions around patient screening and proactive care that could help reduce the burden of emergency admissions.’ The study, of 4.6 million patients from 1985 to 2015, was conducted using linked electronic health records from the UK’s Clinical Practice Research Datalink. A wide range of factors was taken into account, including age, sex, ethnicity, socioeconomic status, family history, lifestyle factors, comorbidities, medication and marital status, as well as the time since first diagnosis, last use of the health system and latest laboratory tests. Using more variables combined with information about their timing, machine learning models were found to provide a more robust prediction of the risk of emergency hospital admission than any models used previously. ‘Our findings show that with large datasets which contain rich information about individuals, machine learning models outperform one of the best conventional statistical models,’ Rahimian said. ‘We think this is because machine learning models automatically capture and ‘learn’ from interactions between the data that we were not previously aware of.’ Whether machine learning models can lead to similarly strong improvements in risk prediction in other areas of medicine requires further research.
University of Oxford
www.ox.ac.uk/news/2018-11-21-machine-learning-can-be-used-predict-which-patients-require-emergency-admission
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Testing women for the presence of sexually transmitted infections (STIs) only at the urogenital site will miss approximately 20% of STIs in women who report having receptive anal intercourse, a STD surveillance network study indicates. “As an obstetrician-gynecologist, I thought it would be interesting to analyse data from women who report having receptive anal intercourse and see what the rates of chlamydia and gonorrhea might be,” Eloisa Llata, MD, MPH, Centers for Disease Control and Prevention, Atlanta, Georgia, said in podcast prepared by the journal, Obstetrics & Gynecology. “We found that about one in five women who reported having receptive anal intercourse will only be infected at the rectal site, so if we only screen women with a urine-based approach, we are going to miss these women and the opportunity to stop transmission,” she added. “So this study underscores the need to ascertain a comprehensive sexual history for all patients, male and female, in order to identify risky behaviours and to test accordingly,” Llata emphasized. The researchers collected and analysed data from the STD Surveillance Network involving 10 state and local health jurisdictions for all visits between January 2015 and December 2016. The researchers included 94,094 visits made to STD clinics in five jurisdictions in the analysis. A total of 7.4% of women presenting for care during a 2-year interlude reported having receptive anal intercourse. Some 94.1% of women were tested for Chlamydia trachomatis at the urogenital site, whereas 94.5% were tested for Neisseria gonorrhea at the same site. Fewer women, at 76.9%, were tested for the same two STIs at the rectal site. C trachomatis positivity was 9.1%, and N gonorrhea positivity was 5.4% among women tested only at the genital site. Results differed among women who were tested only at the rectal site. In this subgroup of women, C trachomatis was detected in 26.7% of samples and N gonorrhea in 6.1% of them. Investigators then identified infection rates for each of the two STIs separately in women who were tested at both the genital and rectal sites. Analysis of this subgroup of women found that 10.4% of women tested positive for C trachomatis; of these, 20.9% of women were positive for the infection at the genital site only, whereas 58.6% of women tested positive at both the genital and rectal sites. Another 20.5% of women were positive for C trachomatis only at the rectal site. For women who were tested at both the genital and rectal site for N gonorrhea, 4.5% of women had been infected with the STI.
MedScapehttps://tinyurl.com/y7hayez8
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The evidence is clear: Cervical cancer is best treated with brachytherapy, a form of radiation therapy. Yet the use of this potentially lifesaving treatment has been declining, and a new study from the University of Virginia School of Medicine may explain why. UVA researchers have determined that offering brachytherapy for locally advanced cervical cancer ends up costing hospitals money. After accounting for the costs and time involved, the researchers found that Medicare reimburses four times more per minute required for a less effective alternative than it does for brachytherapy. Ultimately, providing brachytherapy results in a net loss for the providing healthcare facility, the researchers determined. This can leave hospitals – particularly smaller hospitals that don’t do a lot of brachytherapy – in the lurch. “Studies have time and time again shown that brachytherapy is the most important part of cervical cancer treatment, because it is essential to eradicating the tumour,” said Timothy Showalter, MD, a radiation oncologist at UVA Cancer Center. “A decline in brachytherapy utilization is associated with a higher rate of mortality in cervical cancer, so there’s a direct relationship.” The problem stems partly from the amount of physician time brachytherapy requires: It takes 80+ percent more personnel time to administer brachytherapy than it does to deliver the increasingly popular alternative, external beam radiation. Both methods deliver radiation to the tumour, but brachytherapy delivers much greater doses in a much more targeted manner. Another key difference, the researchers found: Medicare reimbursement makes external beam radiation profitable, while brachytherapy is not. Overall, the researchers determined that it costs hospitals more than twice as much to provide brachytherapy as it does to provide external-beam radiation. But the reimbursement doesn’t reflect that. “Brachytherapy requires a lot of physician effort and expertise and reimburses poorly for that effort,” Showalter said. “I can certainly imagine how the comparatively poor reimbursement rates compared to external beam radiation could contribute in some environments to not establishing a service for brachytherapy or just not committing physician time to it.” He noted that healthcare providers face a cold, hard truth when deciding whether to offer brachytherapy, or any other treatment: “If practices don’t run at least a profit greater than zero,” he said, “then they fold.” The researchers concluded that hospitals that see a high volume of patients, such as UVA, are best equipped to provide brachytherapy – and to absorb the major resource commitment that comes with it. “My job specifically involves brachytherapy,” Showalter said. “We’re at this big hospital with all the equipment we need at the ready and a wonderful streamlined process that enhances the patient experience and reduces patients’ time on the table. That makes it easier to provide efficient and effective care.”
EurekAlerthttps://tinyurl.com/y9oqfbe4
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An innovative technique that uses mammography to determine the biological tissue composition of a tumour could help reduce unnecessary breast biopsies, according to a new study. Mammography has been effective at reducing deaths from breast cancer by detecting cancers in their earliest, most treatable stages. However, many women are called back for additional diagnostic imaging and, in many cases, biopsies, for abnormal findings that are ultimately proven benign. Research estimates this recall rate to be more than 10 percent in the United States. “The callback rate with mammography is much higher than ideal,” said the study’s first author, Karen Drukker, PhD, research associate professor from the Department of Radiology at the University of Chicago. “There are costs and anxiety associated with recalls, and our goal is to reduce these costs but not miss anything that should be biopsied.” Dr. Drukker and colleagues recently studied a new technique called three-compartment breast (3CB) imaging. John Shepherd, PhD, currently at the University of Hawaii in Honolulu, and his team developed 3CB while he was at the University of California in San Francisco. By measuring the water, lipid and protein tissue composition throughout the breast, 3CB might provide a biological signature for a tumour. For instance, more water in the tumour tissue might indicate angiogenesis. For the study, the researchers acquired dual-energy mammograms from 109 women with breast masses that were suspicious or highly suggestive of a malignancy immediately prior to biopsy. The ensuing biopsies showed 35 masses to be invasive cancers, while the remaining 74 were benign. 3CB images were derived from the dual-energy mammograms and analysed along with mammography radiomics developed by Maryellen L. Giger, PhD, and her team at the University of Chicago for use in computer-aided diagnosis on breast images. The combination of 3CB image analysis and radiomics improved the positive predictive value in breast masses deemed suspicious. The combined method improved positive predictive value from 32 percent for visual interpretation alone to almost 50 percent, with an almost 36 percent reduction in biopsies. The 3CB-radiomics method missed one of the 35 cancers, for a 97 percent sensitivity rate. “These results are very promising,” Dr. Drukker said. “Combining 3CB image analysis with mammography radiomics, the reduction in recalls was substantial.” Dr. Drukker said the combined 3CB-radiomics approach has the potential to play an increasingly prominent role in breast cancer diagnosis and perhaps also screening. She noted that 3CB can easily be added to mammography without requiring extensive modifications of existing equipment. “The patient is already getting the mammography, plus we get all this extra information with only a 10 percent additional dose of radiation,” she said.
Radiological Society of North Americahttps://tinyurl.com/ychyg9wa
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