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Archive for category: E-News

E-News

Improving ICU care and communication through technology Use

, 26 August 2020/in E-News /by 3wmedia

Hospitalization in an intensive care unit (ICU) can be a frightening and sometimes traumatizing experience for patients. Although engaging the patient and improving communication among the clinical team can positively impact care and the patient experience, the ICU environment can be a challenging place to engage patients. In new research, led by Brigham and Women’s Hospital, researchers tested a structured and technology-centred program that was focused on team communication and patient engagement. They found that this approach was associated with a lower rate of adverse events and improved patient satisfaction. Results of this project, named PROSPECT (Promoting Respect and Ongoing Safety through Patient Engagement Communication and Technology), have recently been published.
“Our goal was to shift our clinical thinking from ‘What is the matter?’ to discovering ‘What matters to you?’” said Patricia Dykes, PhD, RN, a senior nurse scientist in the Center for Patient Safety, Research and Practice at BWH and lead author of the paper. “If we can effectively collaborate with our patients and their care partners and engage them in their care, then we have the potential to enhance the care, improve adherence to care plans, positively impact satisfaction rates and reduce healthcare costs.”
Researchers developed an intervention to support integrated, multidisciplinary patient-centred communication characterized by shared checklists, health information, and goals of care articulated by both clinicians and patients. The aim of the intervention, which was tested in two medical ICUs at BWH and included 1,075 patients and their care partners, was to reduce adverse events defined as falls, pressure ulcers, catheter-associated urinary tract infections and ventilator-associated events. Secondarily, the team also sought to improve patient and care partners’ satisfaction rates, agreement on care plans between patient and providers, and healthcare utilization.
The specific interventions were systems-based and included a 60-min training session for all clinicians involved in the study. The training introduced a standard model for care meant to enhance clinicians’ responsiveness to the needs, concerns and expectations of the patients and their care partners as well as training on a web-based toolkit to facilitate team communication and patient engagement. The web-based toolkit included an ICU safety checklist that populated with real-time data from the patient’s electronic health record (EHR). The toolkit also included shared care planning and messaging tools accessed by clinicians through the EHR and by patients and care partners through a bedside portal on an iPad. Eighteen percent of patients and care partners used the portal to document their goals of care, their preferences, and to directly communicate.
When compared to a similar group of ICU patients, researchers found that the intervention was associated with a 29 percent reduction in adverse events. The reduction was determined by the drop in adverse events per 1,000 patient days. Patient days are the total number of days for all patients who were admitted for an episode of care, for example, 20 patients in a hospital for 1 day would represent 20 patient days. The rate fell from 59 per 1,000 patient days in the baseline period to 41.9 per 1,000 patient days in the intervention period, driven by a drop in the number of catheter-associated urinary tract infections and pressure ulcers. While researchers are unable to determine which specific component of the intervention drove this reduction, they suspect it is due largely to implementation of the electronic check list, as only a small percentage of patients or care partners participated through the portal.
“We took the paper checklist that is widely used in ICUs across the country and enhanced it with technology. This allowed more patient-specific information to be available to the multidisciplinary group of clinicians that were making daily decisions about a patient’s care while they executed the checklist,” said Dykes. “For example, if you’re deciding whether or not to remove a catheter or a central line, it is extremely helpful to know the type of catheter and when it was put in. When using a paper check list, that information is not available, but if you transition that checklist to a web-based tool that pulls data from a patient’s electronic health record, then you can make a much more informed decision.”
Researchers also found an improvement in patient satisfaction scores, which were captured through a survey of a subsample of patients and care partners. Ninety-three percent of patients in the intervention who responded to the survey assigned a top score to their overall hospital rating score compared to 71.8 percent of patients in the baseline group. Care partner satisfaction also improved, from 84.3 to 90 percent. Changes in concordance of the care plan between the care team and patients was not observed and resource utilization did not significantly change between the intervention and baseline groups.


Brigham and Women’s Hospital
www.brighamandwomens.org/about_bwh/publicaffairs/news/pressreleases/PressRelease.aspx?sub=0&PageID=2782

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Germ-zapping robots put to the test to combat hospital-acquired infections

, 26 August 2020/in E-News /by 3wmedia

Michigan researchers will look at the ability of high intensity ultraviolet light delivered by Xenex Germ-Zapping Robots to protect patients from deadly superbugs, such as Clostridium difficile, found on surfaces.
Patients are vulnerable to hospital-acquired infections – infections they can get while staying at a medical facility. Significant progress has been made in preventing some infection types, but they continue to be a major threat nationwide.
At the end of two years, researchers will report on rates of hospital-acquired infections in units where pulsed xenon UV light (PX-UV) was added to cleaning routines compared to units where a sham UV disinfection system was added to standard cleaning.
They’ll measure if cleaning plus PX-UV reduced the number of infections from drug-resistant organisms including C.difficile, vancomycin-resistant enterococci (VRE), Klebsiella pneumonia, Escherichiae coli producing extended-spectrum betalactamases (ESBLs), methicillin-resistant Staphylococcus aureus (MRSA) and Acinetobacter baumannii.
Hospital cleanliness is recognized as a critically important process to help prevent hospital-acquired infections. It involves extensive cleaning and disinfection after a patient has been discharged and before the next patient has been admitted to the room.
PX-UV lamps in the robot produce a flash of germicidal light in millisecond pulses, damaging the cell structure and stopping the DNA repair mechanisms for most pathogens.
The unique design of the study, which is double-blinded and sham-controlled, makes it the first to examine the clinical impact of adding PX-UV to hospital cleaning routines.

Michigan Medicine http://tinyurl.com/yblkwdge

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Immune discovery points to stroke therapy

, 26 August 2020/in E-News /by 3wmedia

Having a stroke damages immune cells as well as affecting the brain, research has found. The findings help explain why patients have a greater risk of catching life-threatening infections, such as pneumonia, after having a stroke.

Therapies that boost survival of the affected immune cells or compensate for their damage could help improve the recovery of stroke patients, the researchers say.

The study found that patients have reduced levels of protective antibodies in their blood after having a stroke, which might explain why they are more susceptible to infections. Tests with mice revealed those which experienced a stroke had fewer numbers of specialised immune cells called marginal zone B cells, which produce antibodies. Affected mice were more susceptible to bacterial lung infections, the researchers found. Loss of the B cells was caused by a chemical called noradrenaline produced by nerves activated during stroke.

Researchers, led by the University of Edinburgh’s Roslin Institute, found they could protect the mice from infections using a therapy to block the effects of noradrenaline.

We now plan to build on our findings by developing and testing new treatments that can block or bypass these immune deficits with B cells a particular target.

Noradrenaline is part of the body’s fight or flight response. It helps to prepare the body for action and has a range of effects, such as raising heart rate, boosting blood supply and triggering the release of energy from stores.

Blocking noradrenaline would probably be too dangerous in stroke patients, the researchers caution.

They say development of other therapies that block or bypass the damage to the immune system could offer new approaches to help cut the risk of infection after stroke.

University of Edinburgh www.ed.ac.uk/news/2017/immune-discovery-points-to-stroke-therapy

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Clinics cut pregnancy risks for obese women

, 26 August 2020/in E-News /by 3wmedia

Specialist antenatal clinics for severely obese mums-to-be can help cut rates of pregnancy complications, research has found.
Women who received the specialist care were eight times less likely to have a stillbirth.
Health experts say the clinic helps them to spot signs of complications sooner, so that women can be given appropriate treatment. It also helps them to pinpoint those who need to be induced early or undergo an elective caesarean to avoid problems during labour.
The team tracked more than 1000 pregnant women classed as being severely obese during pregnancy because they had a body mass index (BMI) of 40 or above.
Around half of the women attended a specialist obesity clinic while the others received standard antenatal care.
Those that attended the obesity clinic were treated by a team that included obstetricians, specialist midwives, dieticians and other clinical experts.  They were given tailored advice about healthy eating and weight management during pregnancy, and were tested for diseases such as gestational diabetes.
Women who developed a complication could be treated in one visit, rather than being referred to a separate specialist clinic at a later date.
Around one in five pregnant women in the UK is obese and one in 50 is classed as severely obese.

University of Edinburgh
www.ed.ac.uk/news/2017/clinics-cut-pregnancy-risks-for-obese-women

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PET imaging of atherosclerosis reveals risk of plaque rupture

, 26 August 2020/in E-News /by 3wmedia

A new study shows that a hybrid molecular imaging system unites three imaging modalities to map the composition of dangerous arterial plaques before they rupture and induce a major cardiac event.
Certain types of plaques associated with atherosclerosis are prone to instability and tend to break apart, which can lead to embolism and sudden death, if left untreated. Lesions called thin-cap fibro atheroma (TCFA) are especially prone to rupture. Stanford University researchers have developed a scanner that unites optical, radioluminescence, and photoacoustic imaging to evaluate for TCFA.
“This is the first clinical imaging system able to detect vulnerable plaque in their earliest stages,” said Raiyan T. Zaman, PhD, instructor of cardiovascular medicine at Stanford University School of Medicine in Stanford, Calif. “Our novel imaging system can detect these vulnerable plaques despite their small size, complex biochemistry and morphology. This could lead to a paradigm shift in the way coronary artery disease is diagnosed and assessed.”
Early diagnosis and treatment could save lives by preventing the progression, and subsequent rupture, of these plaques. That is precisely why researchers designed the Circumferential-Intravascular-Radioluminescence-Photoacoustic-Imaging (CIRPI) system, which allows not just high-acuity optical imaging via beta-sensitive probe, but also radioluminescent marking inside the artery to determine the extent of inflammation. Photoacoustic imaging also provides information about the often-complex biological makeup of the plaques (how much is calcified or comprised of cholesterol or triglycerides).
“This is an important and potentially life-saving tool that could one day be used by interventional cardiologists to identify the appropriate treatment plan for patients at risk of future TCFA rupture,” explained Zaman.
For this study, researchers focused on atherosclerotic samples of both human and mouse carotid arteries and performed CIRPI following injection of fluorine-18 fluorodeoxyglucose (18F-FDG). Photoacoustic lasers were used at different wavelengths to delineate plaque composition. The result was a never-before-seen 360-degree perspective of arterial plaque burden, confirmed effective by follow-up radiography, ultrasound and histology.

Society of Nuclear Medicine and Molecular Imaging www.snmmi.org/NewsPublications/NewsDetail.aspx?ItemNumber=24263

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Medication history for patients on blood thinners is critical to EMS

, 26 August 2020/in E-News /by 3wmedia

One change to field triage guidelines for emergency medical services (EMS) responding to older adults with head trauma could make a ‘clinically important improvement over usual care,’ according to a study and accompanying editorial published earlier this month.

‘Adding a question about the use of blood thinners in older adults to our field triage criteria could save lives,’ said the editorial’s writer, Craig Newgard, MD, MPH, of Oregon Health & Science University in Portland, Ore. ‘Older patients suffering head trauma who are taking blood thinners are more likely to suffer from bleeding in the brain that requires time-sensitive surgery at a major trauma centre. Current EMS triage criteria do not include that question but this study suggests that maybe they should.’

Researchers analysed charts for 2,100 patients who were 55 or older with head trauma who were transported to the hospital by EMS. Using standard field triage criteria, 19.8 percent of those patients were correctly identified as suffering traumatic intracranial haemorrhage, or bleeding in the brain. Adding a fourth question – whether the patient is on anti-coagulant therapy – improved the sensitivity for intracranial haemorrhage to 59.5 percent.

‘Use of steps one to three triage criteria is not sufficient for identifying intracranial haemorrhage and death or neurosurgery for older patients who suffer head trauma,’ said the lead author of the study, Daniel K. Nishijima, MD, MAS, of the University of California Davis School of Medicine in Sacramento, Calif. ‘While we wait for other studies to confirm our research, we strongly urge patients to make their medication history available and known to their families and EMS providers, especially for situations that may arise where they cannot speak for themselves. Knowledge of their use of blood thinners may help in getting these patients to the right hospital.’

American College of Emergency Physicians newsroom.acep.org/news_releases?item=122825

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MRI scans for suspected prostate cancer could improve diagnosis

, 26 August 2020/in E-News /by 3wmedia

A researcher from Hull York Medical School (HYMS) has helped design and set up a study which has been hailed as the biggest leap in diagnosing prostate cancer in decades.  The study was led by researchers from University College London, with collaboration from a multi-disciplinary team including Dr Rhian Gabe from HYMS. Prostate cancer is the most common cancer in British men. If men have high prostate specific antigen (PSA) levels in the blood, they are referred for a biopsy.
Researchers revealed that an advanced MRI technique can pick up 93 per cent of aggressive cancers, compared with 48 per cent for a standard biopsy. The study on 576 men showed more than a quarter could be spared invasive biopsies.
The current standard technique for prostate biopsy can miss a cancer that is there, fail to spot whether it is aggressive, and biopsies can cause side-effects including bleeding, serious infections and erectile dysfunction.
Around 100,000 to 120,000 men go through this every year in the UK.
The trial, at 11 hospitals in the UK, used multi-parametric MRI on men with high PSA levels.
Dr Gabe said: “The study is ground-breaking because of the implications for future recommendations regarding diagnostic tests for prostate cancer and the potential benefit derived by the vast numbers of men referred for prostate biopsies on the basis of elevated PSA levels.
“The study has highlighted inadequacies with standard biopsies with only half the clinically significant cancers being detected in a cohort of men with elevated PSA.
“The results also suggest that advanced MRI prior to biopsy could identify about a quarter of men who could safely avoid unnecessary biopsies and in future, could be used to guide prostate biopsy to greatly improve detection of clinically significant cancer.”
For this strategy to be implemented across the NHS, a number of important capacity issues such as training of radiologists would be need to be addressed, Dr Gabe added.

Hull York Medical Schoolhttp://tinyurl.com/yd9cmrqz

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New material could save time and money in medical imaging

, 26 August 2020/in E-News /by 3wmedia

Chemists at The University of Texas at Austin have developed a material that holds the key to cheap, fast and portable new sensors for a wide range of chemicals that right now cost government and industries large sums to detect. The innovation could lead to major public health gains, as it holds the potential to drastically reduce the costs associated with cleaning-up accidental chemical spills, remediating old industrial sites, detecting radioactive contamination in drinking water, and operating medical and research imaging devices.

‘A company with an abandoned chemical plant that has barrels of unlabelled solvents or a public utility concerned its water supply has been contaminated today face a cumbersome process of identifying the chemicals before they can start clean-up,’ said Simon Humphrey, associate professor of chemistry who led the research. ‘It’s costly and can take two or three days. We can now do that with a rapid, on-site method – and that difference could improve people’s health and reduce pollution a lot more efficiently.’

Humphrey envisions disposable paper dipsticks coated with the new material. A user would dip one into an uncharacterized substance and stick it into an ultraviolet (UV) reader. Based on the colours of light emitted, the device would indicate what components, such as organic solvents, fluoride, mercury and heavy metals, are in the substance.

The material, called PCM-22 is a crystal made of lanthanide ions and triphenylphosphine. When a chemical bonds to the material and a UV light shines on it, the material emits specific colours of visible light. Each chemical produces a unique eight-factor signature of colour and brightness that can be used to identify and quantify it in an uncharacterized sample.

Once scientists calibrate the sensor on known samples to create a catalogue of fingerprints that can be used to identify the components of uncharacterized samples, the dipstick-type sensors would be relatively simple to produce, Humphrey said. He and UT Austin share joint patents on the sensor material and on the process of analysing results, and UT Austin’s Office of Technology Commercialization has already begun work to license the technology to companies.

Another beneficial feature of PCM-22 is that it can distinguish between two types of water -the ordinary water (H2O) that we experience in everyday life and so-called heavy water (D2O), used in the operation of medical and research imaging.

With D2O, hydrogen atoms are replaced by deuterium atoms, but the two types of water are notoriously hard to tell apart because they look and, in most cases, behave the same chemically. It normally requires a costly test with a sophisticated piece of laboratory equipment called a laser spectrometer to tell the two apart.

Because the new material makes distinguishing between the two types of water simpler, it could become much easier for government agencies to detect the presence of radioactive contamination in drinking water or other bodies of water such as lakes and rivers. When ordinary water interacts with radioactive material, such as uranium, some of it is converted to heavy water, so elevated levels of heavy water give an early warning of contamination with radioactive material.

The ability to detect and quantify the two forms of water quickly, cheaply and at the point of need also would pave the way for more affordable and reliable medical and research imaging, such as nuclear magnetic resonance spectroscopy (NMR), which requires heavy water to operate. For NMR to function properly, this heavy water has to be very pure, but it is easily contaminated with ordinary water from moisture in the atmosphere.

‘When you buy heavy water from a manufacturer it starts out ultrapure,’ Humphrey said. ‘But as soon as you unscrew the bottle, hydrogen atoms from the air start swapping with deuterium atoms. A week later, all of the H’s have become scrambled with the D’s and it effectively ruins the heavy water. It’s an exchange that you can’t stop.’

The new material, which is sensitive enough to detect concentrations of ordinary water as low as 10 parts per million in a solution of heavy water, could make it cheaper and faster to verify the purity of this important reagent.

University of Texas at Austin news.utexas.edu/2017/04/13/universal-chemical-sensor-could-help-boost-public-health

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Controversial test could be leading to unnecessary open heart operations

, 26 August 2020/in E-News /by 3wmedia

An approved international test to check whether people need open-heart surgery could be sending twice as many people under the knife unnecessarily, at a cost of nearly GBP 75m, research by the University of Leicester has suggested.

Since 2012 doctors have been using exercise testing on people with a condition called aortic stenosis (AS) to determine whether they need an operation to save their life.

However, a study, led by Gerry McCann, Professor of Cardiac Imaging and Honorary Consultant Cardiologist from the University of Leicester Department of Cardiovascular Sciences, who conducted the research as part of a NIHR Fellowship, has shown the current approach is ‘highly inaccurate’ and if followed may send thousands of patients to surgery before it is needed.

The exercise test, which involves cycling on a stationary bike, is used to determine whether surgery is needed for people with the condition – but it only has a 60 per cent accuracy rate, the study found.

AS, which is the narrowing of the aortic heart valve, affects predominantly older people and affects up to three per cent of people over 75 years of age. Symptoms, such as chest pain, breathlessness and feeling faint, can take years to develop. However, when they do it means the person is seriously ill and could die from heart failure or sudden death.

If exercise test participants become breathless, they are recommended to have valve replacement therapy. About 10,000 aortic valve replacements are performed every year at a cost of up to GBP 15,000. Hospital recuperation then takes between seven and 10 days.

Professor McCann, who is also a consultant cardiologist from the NIHR Leicester Cardiovascular Biomedical Research Unit (BRU), said: ‘There is no doubt that valve replacement therapy is highly effective for patients with symptoms, however there are risks involved. It’s a major operation and there’s a one per cent chance of people dying or having a stroke during or after. There’s also the chance they could develop an infection.

‘It can often take six months to recover, but if they survive they tend to do very well afterwards. However, if we know a patient has AS and no symptoms and we do nothing there’s also a one per cent chance they will die so there’s a fine line between whether we should intervene or not.

‘Our findings showed that this exercise test, which has been approved by the American Heart Association/American College of Cardiology and the European Society of Cardiology, was highly inaccurate as almost twice the number of people who became breathless during the test did not develop symptoms within a year.’

Professor McCann now wants to conduct further research to find a more accurate way to determine whether doctors should wait for symptoms to develop or to intervene beforehand. Ultimately a clinical study comparing early surgery versus waiting for symptoms to develop is needed.

University of Leicester www2.le.ac.uk/offices/press/press-releases/2017/february/controversial-test-could-be-leading-to-unnecessary-open-heart-operations

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Significance of plaque burden using 3D vascular ultrasound in estimating cardiovascular risk

, 26 August 2020/in E-News /by 3wmedia

In a large population study that was the first of its kind, researchers found that an experimental technique known as three-dimensional vascular ultrasound (3DVUS) estimated the quantification of plaque burden (in cubic millimeters) as an important addition to conventional risk factor profile in addressing patient risk stratification.
At an average age of 45 years, they found that the plaque burden in subjects was more than twice as high in men as in women (63.4 cubic millimeters vs. 25.7), and higher in the femoral arteries, and with increasing age.
Researchers explored the bilateral carotid and femoral arteries of 3,860 middle aged participants without prior cardiovascular disease who were employees of the Banco de Santander in Madrid, Spain.  This is an ongoing observational prospective cohort study where participants are being followed up for 10 years. The 3DVUS examinations were performed using a new Phillips iU22 ultrasound system equipped with a VL13-5 3D volume–linear array transducer. This equipment will be available in the near future for routine patient care.
The clinical application of 3DVUS techniques is still at the research and development stage, but there are now a number of clinically promising areas including the measurement of plaque. Direct quantification of atherosclerotic plaque volume by 3DVUS is more reproducible than two-dimensional techniques.
“3DVUS is a feasible, reproducible, and novel imaging technique for quantifying early carotid and femoral atherosclerotic burden in large populations,” said the study’s lead author, Valentin Fuster, MD, PhD, Director of Mount Sinai Heart and Physician-in-Chief of The Mount Sinai Hospital. “This novel method is valid for imaging superficial peripheral atherosclerosis burden from early to advanced stages of disease and can be applied to identification of individuals at risk, targeting or monitoring treatment. Further studies are needed, however, to assess the cost utility of this method compared with others when used in large-scale practice settings and population-based epidemiological studies.”


Icahn School of Medicine at Mount Sinai
icahn.mssm.edu/about-us/news-and-events/mount-sinai-researchers-find-the-significance-of-plaque-burden-using-3d-vascular-ultrasound-in-estimating-cardiovascular-risk

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