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Archive for category: E-News

E-News

Study identifies methods for preventing overcrowding in emergency rooms

, 26 August 2020/in E-News /by 3wmedia

No single solution exists for alleviating crowding in emergency rooms, but a new study identifies four key strategies that have reduced the problem.
The study concludes that engaged executive leadership can alleviate the problem when combined with a data-driven approach and coordination across the hospital from housekeepers to the CEO. Crowding in emergency rooms has been associated with decreased patient satisfaction and even death.
“Emergency department crowding can be dangerous for patients,” said senior author Benjamin Sun, M.D., a professor of emergency medicine in the OHSU School of Medicine. “We know, for example, that emergency department crowding can lead to delays in pain medications for patients with broken bones, as well as delays in antibiotics for patients with pneumonia. We know the risk of death is higher when the emergency department is more crowded than when it’s less crowded.”
The study identified groups of hospitals categorized as low, high or highest-improving in terms of lengths of stay and boarding times (the length of time an admitted patient must wait for an inpatient bed), as measured through statistics provided by 2,619 U.S. hospitals to the Centers for Medicare and Medicaid Services. The authors picked a representative sample of four hospitals in each of the three categories of performance, then systematically interviewed a broad range of stakeholders.
The researchers talked to 60 people at the 12 hospitals. Interviewees included nursing staff, emergency department directors, directors of inpatient services, chief medical officers and other executive officers.
The study identified four key strategies:
1) Involvement of executive leadership: The study noted that executive leaders in highperforming hospitals identified hospital crowding as a top priority complete with clear goals and resources to achieve those goals.
“In contrast, low performing hospital executive leadership did not prioritize crowding initiatives, despite acknowledging the causes,” the authors wrote. “Emergency department leadership often felt isolated in their struggle with significant boarding and lengths of stay.”
2) Hospital-wide coordinated strategies: High-performing hospitals performed as a cohesive system across departments to alleviate crowding, in contrast to low-performing hospitals that operated in silos. For example, one executive at a high-performing hospital developed strategies for improving bed turnaround times on inpatient rooms.
“Instead of waiting for the room to go from dirty to clean and then to book transportation for a patient to come, we started doing things in parallel so that we would cut down on waiting time,” the executive said in the report.
3) Data-driven management: High-performing hospitals gathered and used data to adjust operations in real time, provided immediate feedback to key personnel, and predicted patterns of flow in the emergency department and hospital, matching resources to meet expected demand.
“In contrast, at low-performing hospitals, data were most often available only retrospectively, and, if the data were used, they were discussed by executive leadership at monthly or quarterly meetings,” the authors wrote.
4) Performance accountability: High-performing hospitals held staff accountable and problems were addressed immediately to reduce crowding.
Sun described a typical scenario in one high-performing hospital: “If boarding in the ED exceeded the acceptable limit, the chief medical officer would physically get out of the office, go onto the ward floors, and start reviewing charts and asking, ‘What can we do to fix the problem?’” he said.
OHSU School of Medicine
http://tinyurl.com/y8bq3gvg

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Obese heart surgery patients require significantly more ICU resources

, 26 August 2020/in E-News /by 3wmedia

After heart surgery, obese patients tend to require additional intensive care unit (ICU) services and longer recovery times when compared to non-obese patients. This results in more expensive, more labour-intensive care, according to a study.
"Obesity is a growing problem for society that has reached epidemic proportions," said lead author Brandon R. Rosvall, BSc, of Dalhousie Medicine New Brunswick in Canada. "In our study, we saw that as patients became more obese, the hospital resources required to care for them after heart surgery also increased."
Rosvall, along with senior author Ansar Hassan, MD, and other colleagues, used data from the New Brunswick Heart Centre Cardiac Surgery Database to identify patients who underwent cardiac surgery at the New Brunswick Heart Centre between January 2006 and December 2013. The authors also examined data specific to the patients’ ICU stays, which were obtained from logbooks and individual charts.
Of the 5,365 patients included in the final analysis, 1,948 (36%) were classified as obese. The patients were grouped into the following weight categories, as defined by the World Health Organization: Obese Class I (BMI 30.00-34.99), n=1,363 (25%); Obese Class II (BMI 35.00-39.99), n=441 (8%); and Obese Class III (BMI greater than 40.00), n=144 (3%). Body mass index (BMI) is a measure of body fat based on weight in relation to height. In general, the higher the BMI number, the more body fat a person has.
The study showed that following surgery, patients with higher levels of obesity were four times more likely to require extra time in the ICU, three times more likely to need additional time on mechanical ventilation, and three times more likely to be readmitted to the ICU. Researchers also learned that these patients experienced longer overall hospital lengths of stay and discharges with home care.
"The consistent relationship we have shown between increased BMI and these primary adverse outcomes confirms the robust nature of our findings," said Rosvall.
According to the Centers for Disease Control and Prevention (CDC), more than one-third (36.5%) of American adults are obese. The estimated yearly medical cost of obesity in the US reached $147 billion in 2008 (the latest data available), which translates to $1,429 more for each obese patient than a patient of normal weight.
"The ICU provides a number of highly specialized services to care for patients who are seriously ill," said Rosvall. "Expensive resources including staff, medical equipment, and medication are needed to provide these services. Health care is costly, so by more efficiently using ICU resources, we can save the health care system money, while also improving overall patient care."
Researchers said that strategies should be developed that improve ICU resource utilization among patients with increased BMI. For example, knowing that obese patients spend more time in the ICU after their operations enables health care providers to better predict ICU bed vacancies and be more thoughtful when scheduling staff and surgeries. Rosvall explained that efficient booking allows more patients to be treated while preventing overworked staff and cancelled procedures. In addition, there are pre-emptive actions that doctors should put into practice, such as closer monitoring of obese patients and preoperative discussions about the unique surgical risks that they may face.
"Patients should be aware that obesity may negatively impact recovery from heart surgery," said Rosvall. "More in-depth conversations regarding surgical risks and alternatives to surgery should take place with obese patients so that they are aware of the true impact of increased obesity. While obesity has become a social issue, it is one that can be addressed on a personal level. By working with their health care providers, patients can learn how to achieve and maintain a healthy body weight."
According to Rosvall, this research group is currently conducting research on biomarkers (specific molecules in the blood) that will help doctors predict how obese patients will recover from cardiac surgery.

EurekAlert
www.eurekalert.org/pub_releases/2017-08/e-ohs081017.php

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When a common cold may trigger early supportive care

, 26 August 2020/in E-News /by 3wmedia

Human rhinovirus (HRV), the culprit behind most colds, is the leading cause of hospitalization for premature babies. However, in very preterm children, exactly how HRV causes severe respiratory disease — and which patients may need more intensive observation and treatment — is less well understood.
A new study led by Children’s National Health System research clinicians showed that in children who were born severely premature, HRV infections seem to trigger an airway hyper-reactivity (AHR) type of disease, which leads to wheezing and air-trapping (hyperinflation) and more severe respiratory disease. This, in turn, increases the risk for hospitalization.
The study found that other signs of respiratory distress, such as low arterial blood oxygen or rapid shallow breathing, were no more common in severely premature children (less than 32 weeks of gestational age) than in kids born preterm or full-term. The findings have implications for administering supportive care sooner or more intensively for severely premature children than for other infants.
“When it comes to how they respond to such infections, severely premature children are quite different,” says Geovanny Perez, M.D., a specialist in pulmonary medicine at Children’s National and lead study author. “We’ve known they are more susceptible to human rhinovirus infection and have more severe disease. However, our study findings suggest that severely premature kids have an ‘asthma’ type of clinical picture and perhaps should be treated differently.”
The study team sought to identify clinical phenotypes of HRV infections in young children hospitalized for such infections. The team theorized that severely premature babies would respond differently to these infections and that their response might resemble symptoms experienced by patients with asthma.
“For a number of years, our team has studied responses to viruses and prematurity, especially HRV and asthma,” Dr. Perez says. “We know that premature babies have an immune response to HRV from the epithelial cells, similar to that seen in older patients with asthma. But we wanted to address a gap in the research to better understand which children may need closer monitoring and more supportive care during their first HRV infection.”
In a retrospective cross-sectional analysis, the study looked at 205 children aged 3 years or younger who were hospitalized at Children’s National in 2014 with confirmed HRV infections. Of these, 71 percent were born full-term (more than 37 gestational weeks), 10 percent were preterm (32 to 37 gestational weeks) and 19 percent were severely premature (less than 32 gestational weeks).
Dr. Perez and his team developed a special respiratory distress scoring system based on physical findings in the children’s electronic medical records to assess the degree of lower-airway obstruction or AHR (as occurs in asthma) and of parenchymal lung disease. The physical findings included:

  • Wheezing;
  • Subcostal retraction (a sign of air-trapping/hyperinflation of the lungs), as can occur in pneumonia;
  • Reduced oxygen levels (hypoxemia); and
  • Increased respiratory rate (tachypnea).

The research team assigned each case an overall score. The severely premature children had worse overall scores — and significantly worse scores for AHR and hyperinflated lungs relative to children born late preterm or full-term.
“What surprised us, though, in this study was that the phenotypical characterization using individual parameters for parenchymal lung disease, such as hypoxemia or tachypnea, were not different in severe preterm children and preterm or full term,” says Dr. Perez. “On the other hand, our study found that severely preterm children had a lower airway obstruction phenotype associated with retractions and wheezing. Moreover there was a ‘dose effect’ of prematurity: children who were born more premature had a higher risk of wheezing and retractions.”
Among the implications of this study, Dr. Perez sees the potential to use phenotypical (clinical markers, such as retractions and wheezing) and biological biomarkers to better personalize patients’ treatments. Dr. Perez and his team have identified biological biomarkers in nasal secretions of children with rhinovirus infection that they plan to combine with clinical biomarkers to identify which patients with viral infections will benefit from early supportive care, chronic treatments or long-term monitoring.
ScienceDailyhttps://tinyurl.com/yd3mz3eu

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Misleading biopsies may cause viable, donated kidneys to be discarded

, 26 August 2020/in E-News /by 3wmedia

Based on biopsy results, thousands of donated kidneys each year are discarded instead of being transplanted, but a new study from physicians at Columbia University Medical Center and NewYork-Presbyterian suggests that biopsies underestimate organ quality.
“It’s a complex issue, but our findings suggest that biopsy results should be used not to discard organs, but instead used in limited circumstances to guide recipient selection,” says the study’s lead investigator Sumit Mohan, MD, nephrologist at NewYork-Presbyterian and associate professor of medicine and epidemiology at Columbia University Medical Center.
Each year, nearly 20 percent of deceased-donor kidneys recovered with the intent to transplant are instead discarded. The most common reason cited for rejecting a kidney is a poor biopsy result. Biopsies allow physicians to look for any abnormalities in the microanatomy of the organ, Dr. Mohan says, but it’s unclear how well biopsy results predict the long-term health of a transplanted kidney.
The new study looked at nearly 1,000 kidney biopsies that were processed by pathologists at NewYork-Presbyterian/Columbia University Medical Center from 2005 through 2009 and the subsequent long-term function of the organ in the recipients.
For living-donor transplantation, biopsy results did not help predict long-term outcomes.
Our study raises serious questions about transplant centres using biopsy findings to make decisions about whether to use an available kidney for their patients. For deceased-donor kidneys, long-term outcomes did correlate with biopsy findings, but the researchers also found that 73 percent of deceased-donor kidneys with even suboptimal biopsy results were still functioning five years later.
Transplantation with even suboptimal kidneys provides a significant survival advantage compared to remaining on dialysis, Dr. Mohan says.

Columbia University Medical Centerhttp://tinyurl.com/yc4y5p8o

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Guidelines promote more family engagement in intensive care units

, 26 August 2020/in E-News /by 3wmedia

Having a loved one go through a critical illness is a stressful and traumatic experience that may have lasting effects months after the patient is discharged from the intensive care unit (ICU). To improve the well-being of both patients and family during this vulnerable time, a set of new guidelines has been released, providing physicians with evidence-based strategies to optimize outcomes for the critically ill and those at their bedside.
“There is increasing awareness that support for family can also improve patient outcomes,” said Judy Davidson, lead author of the guidelines and a nurse at UC San Diego Health. “Families in the ICU aren’t visitors — they are an integral part of the care and the care team.”
Based on an analysis of more than 450 qualitative and quantitative studies, a multidisciplinary, international panel of 29 health care experts developed a series of recommendations for family-centred care, defined as an approach to healthcare that is respectful of and responsive to individual families’ needs and values. The experiences and perspectives of former ICU patients and family members from UC San Diego Health, the University of Maryland (UOM) School of Medicine, patient advocacy organizations and the LGBTQ community were used to develop the new guidelines.
The 23 recommendations grouped into five categories include: space for loved ones to sleep; educational programmes to teach family how to assist with care; encouraging family members to be part of the decision-making process; implementing ICU diaries to reduce a family’s anxiety and post-traumatic stress; and involving a multi-disciplinary team, such as psychologists, social workers and spiritual advisors. UC San Diego Health is among the first hospitals in the nation to embrace the concept of implementing a family diary in the ICUs.
“Structured interventions and approaches to support family members of critically ill patients are needed both to mitigate the impact of the crisis of critical illness and to prepare family members for decisionmaking and caregiving demands,” said Davidson. “Up to half of families with a critically ill loved one experience psychological symptoms. A robust programme built around family-centred care may decrease the negative impact surrounding critical illness. It is a matter of public health.”
The guidelines suggest that clinicians and institutions need to decide which intervention or combination of interventions are likely to be the most successful in specific circumstances.
“We have developed a self-analysis tool that ICUs can use to build a customized family-centered plan that will bring change,” said Robert El-Kareh, MD, MPH, hospitalist at UC San Diego Health and associate professor at UC San Diego of Medicine, who was instrumental in building translational tools to help ICUs move recommendations into practice.

University of California – San Diego http://tinyurl.com/y732jdfk

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Poop pill’ capsule research paves the way for simpler C. difficile treatment

, 26 August 2020/in E-News /by 3wmedia

An Alberta-led clinical trial has shown Faecal Microbiota Transplant (FMT) is effective in treating clostridium difficile (C. difficile) infections whether delivered by colonoscopy or by swallowing capsules. The finding could revolutionize and broaden the use of FMT, which restores the healthy balance of bacteria living in the intestine by transferring a healthy donor’s stool to the gut of a person with C. difficile.
Dr. Thomas Louie, clinical professor at the Cumming School of Medicine and the Calgary FMT study co-lead and senior author, pioneered the development of the FMT pill in 2013. “Recurrent C. difficile infection is such a miserable experience and patients are so distraught that many ask for faecal transplantation because they’ve heard of its success,” says Louie. “Many people might find the idea of faecal transplantation off-putting, but those with recurrent infection are thankful to have a treatment that works.”
“This will transform the way people think about how we deliver Faecal Microbiota Transplant,” says Dr. Dina Kao, an associate professor with the University of Alberta’s Faculty of Medicine and Dentistry and lead author of the study. “Capsules have numerous advantages over colonoscopy. They are non-invasive, they’re less expensive, they don’t have any of the risks associated with sedation and they can be administered in a doctor’s office.”
Capsules containing frozen donor bacteria taken orally were shown to be 96-per-cent effective in treating C. difficile, the same success rate as those receiving transplant by colonoscopy. The pills have no scent or taste. They are made by processing faeces until it contains only bacteria, then encapsulating the bacteria concentrate inside three layers of gelatin capsule. “The pills are a one-shot deal, not a continuing treatment,” says Louie. “They are easier for patients and are well tolerated.”
Humans are host to hundreds of different species of gut bacteria, which together help the digestive and immune systems to function properly. However, when a harmful infection requires treatment with antibiotics, those same antibiotics can disrupt the healthy balance of the gut bacteria, allowing opportunistic microorganisms such as C. difficile to cause illness.
People with C. difficile infections suffer from diarrhoea, cramping and other gastrointestinal difficulties. In advanced cases, it may be necessary to remove the large intestine. Although rare, C. difficile can be extremely debilitating and resistant to treatment by antibiotics. In some cases, it can be fatal. In Alberta, there are about 200 C. difficile cases every year, of which between 20 and 40 are fatal.
University of Calgary
www.ucalgary.ca/utoday/issue/2017-11-29/poop-pill-capsule-research-paves-way-simpler-c-difficile-treatment

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Fewer lab tests for hospitalized patients

, 26 August 2020/in E-News /by 3wmedia

In a review article, physicians at Johns Hopkins, along with experts from several other institutions across north America, compiled published evidence and crafted an experience-based quality improvement blueprint to reduce repetitive lab testing for hospitalised patients.
Repeated blood draws for such tests can lead to hospital-acquired anaemia and other complications. This is the second paper co-authored by residents and faculty from the High Value Practice Academic Alliance, a consortium of nearly 90 academic medical centres collaborating to improve health care quality and safety by reducing unnecessary components of practice that do not add value to patient care.
“Excessive blood draws can deplete a patient’s haemoglobin count, which often leads to repeat testing,” says Kevin Eaton, M.D., a third-year internal medicine resident at The Johns Hopkins Hospital. Others have estimated that nearly 20 percent of hospitalised patients can develop moderate to severe hospital-acquired anaemia. This spiral, he and his co-authors assert, can generate additional unnecessary tests, interventions and costs for the patient. Moreover, says the authors, published studies show that decreasing repetitive daily laboratory testing did not result in missed diagnoses or increase the number of readmissions to the hospital.
Citing individual studies where front-line health care workers reduced the number of orders for lab tests by anywhere between 8 percent and 19 percent, the authors reported that cost savings have ranged from $600,000 to more than $2 million per year. Says Eaton, while many professional societies have recommended reducing repetitive lab tests, recommendations alone typically do not change behaviour. The most successful efforts to reduce daily lab testing in this review included a combination of educating health care providers about charges, obtaining feedback by showing providers’ ordering habits and changing clinical workflow to restrict automated repeat ordering of tests.
 
The recommendations are as follows:
Design hospital-wide educational initiatives backed by data to collectively outline and standardize best practice.
Establish target numbers by which to reduce lab test ordering and provide instant feedback to those ordering tests to show their personal ordering patterns, so they are aware of their own behavior with respect to agreed-upon standards.
Reprogram the electronic systems used to order tests to restrict the number of “pre-ordered” tests with an eye on having better reasons to order tests than just doing so daily.
“Reducing unnecessary daily inpatient laboratory testing is only one small improvement, but doing so successfully can help change the culture of health care providers to be more keenly focused on thoughtful ordering and prescribing for their patients,” says Pam Johnson, M.D., associate professor of radiology, who was not involved in this study. Says Johnson, who leads the High Value Practice Academic Alliance, “improving patient safety and patient outcomes are the goals here, and an additional benefit to reducing the number of unnecessary diagnostics is also a reduction in the financial burden to the patient.”

John Hopkins Hospital
www.hopkinsmedicine.org/news/media/releases/experts_recommend_fewer_lab_tests_for_hospitalized_patients

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New app uses smartphone selfies to screen for pancreatic cancer

, 26 August 2020/in E-News /by 3wmedia

Pancreatic cancer has one of the worst prognoses — with a five-year survival rate of 9 percent — in part because there are no telltale symptoms or non-invasive screening tools to catch a tumour before it spreads.
Now, University of Washington researchers have developed an app that could allow people to easily screen for pancreatic cancer and other diseases — by snapping a smartphone selfie.
BiliScreen uses a smartphone camera, computer vision algorithms and machine learning tools to detect increased bilirubin levels in a person’s sclera, or the white part of the eye.
One of the earliest symptoms of pancreatic cancer, as well as other diseases, is jaundice, a yellow discoloration of the skin and eyes caused by a buildup of bilirubin in the blood. The ability to detect signs of jaundice when bilirubin levels are minimally elevated — but before they’re visible to the naked eye — could enable an entirely new screening program for at-risk individuals.
In an initial clinical study of 70 people, the BiliScreen app — used in conjunction with a 3-D printed box that controls the eye’s exposure to light — correctly identified cases of concern 89.7 percent of the time, compared to the blood test currently used.
“The problem with pancreatic cancer is that by the time you’re symptomatic, it’s frequently too late,” said lead author Alex Mariakakis, a doctoral student at the Paul G. Allen School of Computer Science & Engineering. “The hope is that if people can do this simple test once a month — in the privacy of their own homes — some might catch the disease early enough to undergo treatment that could save their lives.”
BiliScreen builds on earlier work from the UW’s Ubiquitous Computing Lab, which previously developed BiliCam, a smartphone app that screens for newborn jaundice by taking a picture of a baby’s skin. A recent study showed BiliCam provided accurate estimates of bilirubin levels in 530 infants.
BiliScreen is designed to be an easy-to-use, non-invasive tool that could help determine whether someone ought to consult a doctor for further testing. Beyond diagnosis, BiliScreen could also potentially ease the burden on patients with pancreatic cancer who require frequent bilirubin monitoring.

University of Washington
www.washington.edu/news/2017/08/28/new-app-uses-smartphone-selfies-to-screen-for-pancreatic-cancer/

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Eliminating opioids from anaesthesia decreases post-surgery nausea

, 26 August 2020/in E-News /by 3wmedia

Opioid-free general anaesthesia is safe, effective and dramatically decreases postoperative nausea, according to a single-centre study of more than 1,000 patients.
Using opioid alternatives during general anaesthesia is part of an effort by TEAMHealth Anesthesia at Select Physicians Surgery Center in Tampa, Florida to reduce the use of opioids during and after surgery. The study findings suggest physician anaesthesiologists are helping pave the way to promote pain management alternatives to opioids, and making headway in reducing the use of the addictive medications.
“Opioids crept into general anaesthesia over the years because they don’t cause problems with the cardiovascular system, but our research suggests we can use alternatives safely and effectively,” said David Samuels, M.D., lead author of the study and medical director of anaesthesia at Select Physicians Surgery Center and medical director for TEAMHealth Anesthesia, Tampa. “By avoiding the use of opioids intraoperatively and helping surgeons understand the value and importance of offering patients different options for pain after surgery, physician anaesthesiologists can be agents of change in addressing the opioid dependency crisis.”
Opioids – usually fentanyl, an opioid 50 times more powerful than heroin – are typically included in the combination of medications given to patients for general anaesthesia during surgery. In the study, 1,009 patients having head and neck surgery (including laryngoscopy, complex facial plastic surgery, middle ear surgery and nasal or sinus surgery) received general anaesthesia without opioids. Instead, patients received various combinations of magnesium, sub-anaesthetic ketamine, lidocaine and ketorolac, depending on the patient’s age and health. Surgeons and patients expressed a high degree of satisfaction with the new anaesthesia protocol and postoperative pain management.
After surgery, 11 percent of patients experienced nausea, whereas 50 to 80 percent of patients typically suffer from nausea after surgery. Additionally, 64 percent of patients did not require any pain medication in the PACU.
The traditional use of fentanyl in general anaesthesia can cause hyperalgesia, or increased sensitivity to pain, Dr. Samuels said.
“Hyperalgesia leads to increased pain, so patients request more opioids in the recovery area, and then go home with an excessive number of pills,” said Enrico M. Camporesi, M.D., co-author of the study and professor emeritus at the University of South Florida and director of research for TEAMHealth Anesthesia Research Institute, Tampa. “We believe that not using fentanyl during surgical anaesthesia, as well as not providing patients too many pills after surgery, may help decrease the likelihood of opioid abuse. Studies show that 1 in 15 patients who has surgery is still taking prescription opioids 90 days afterwards,” he said.
Three of the 19 surgeons who participated in the study now prescribe patients daily oral magnesium, gabapentin and ibuprofen for pain management after surgery. They also prescribe five hydrocodone pills for any breakthrough pain. Previously, these surgeons prescribed 50 hydrocodone pills. The change to five pills will lead to 27,000 fewer prescribed hydrocodone pills in one year’s time for these surgeons at their practice.
American Society of Anesthesiologists (ASA) www.asahq.org/about-asa/newsroom/news-releases/2017/10/eliminating-opioids-from-anesthesia-decreases-post-surgery-nausea

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Catheter ablation better than traditional drug therapies for treating atrial fibrillation

, 26 August 2020/in E-News /by 3wmedia

Every year millions of people around the world are diagnosed with heart failure, a chronic, progressive condition where the heart is unable to pump enough oxygenated blood throughout the body. Researchers at the University of Utah Health and Klinikum Coburg, Germany co-led a clinical trial that showed radiofrequency catheter ablation lowered hospitalization and mortality rates by 47 and 44 percent respectively in patients with atrial fibrillation (AF), a contributing factor to heart failure.
“None of the traditional drug therapies are improving the patient’s condition, a major medical dilemma when we see these patients in our clinics,” said Nassir F. Marrouche, M.D., professor in Internal Medicine and Executive Director of the Comprehensive Arrhythmia Research and Management (CARMA) Center at U of U Health.
The medical community has long debated the ideal treatment for AF, especially for patients who suffer from left ventricular dysfunction, a weakening of the left ventricle that supplies most of the heart’s pumping power. Until now, no clinical studies have been conducted that support one definitive treatment.
Marrouche and Johannes Brachmann from the Klinikum Coburg conducted the eight-year CASTLE-AF clinical trial to compare catheter ablation to conventional drug therapies recommended by the American Heart Association and European Heart Society to control the heart’s rate.
“The CASTLE-AF clinical trial represents a landmark in the history of cardiovascular medicine because of its potential impact on our patients who are suffering from heart failure,” said James Fang, M.D., Chief of Cardiovascular Medicine at the University of Utah Health. “For the first time in a randomized study, the strategy of catheter ablation for atrial fibrillation may be better than the current approach for these patients. It is also one of the many landmark contributions to cardiovascular medicine that the University of Utah has made over the past five decades.”
After evaluating more than 3,000 patients from North America, Europe and Australia, researchers selected 363 participants with temporary or persistent AF and heart failure, characterized by heart function at less than 35 percent capacity, for the clinical trial. The patients were separated into two groups, receiving either radiofrequency catheter ablation (179) or a conventional drug therapy (184).
The clinical trial’s end point was set at all-cause mortality and worsening of heart failure, resulting in an unplanned overnight hospitalization. Patients in the ablation group experienced lower overall mortality (28%; 51/179) compared to the medication group (46%; 82/184). In addition, catheter ablation resulted in lower cardiovascular mortality (13%; 24/179) compared to the medication group (25%; 46/184).
Special heart cells create electrical signals that cause the heart’s upper and lower chambers to beat in the proper sequence to pump blood through the body. Abnormal cells can cause the heart to beat faster or irregularly, resulting in AF.
“Atrial fibrillation prevents the heart from filling and pumping properly,” said Marrouche. “When the heart is not synchronized, it hastens heart failure and increases the risk of stroke.”
During the ablation process, a catheter is snaked through the patient’s body to the site of abnormal heart cells. The doctor delivers a dose of radiofrequency energy, similar to microwaves, to destroy the abnormal cells, which restores the heart’s regular rhythm.
All of the participants included in the CASTLE-AF trial had previously received an implantable cardioverter defibrillator (ICD), which allowed for continuous monitoring of heartrate. The ICD may have improved mortality, which Marrouche believes is the primary limitation in this study that may have affected death rates in both groups.
“This clinical trial is the first time we can show with hard data that ablation is saving more lives than arrhythmia medications,” said Marrouche. “It also lowers the cost of treating patients by keeping them out of hospital due to lower incidence of worsening heart failure.”
University of Utah Health http://tinyurl.com/y7fmfm2s

https://interhospi.com/wp-content/uploads/sites/3/2020/06/logo-footer.png 44 200 3wmedia https://interhospi.com/wp-content/uploads/sites/3/2020/06/Component-6-–-1.png 3wmedia2020-08-26 14:36:442020-08-26 14:37:00Catheter ablation better than traditional drug therapies for treating atrial fibrillation
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