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Archive for category: E-News

E-News

Radiological method identifies hip patients who may need to be re-operated

, 26 August 2020/in E-News /by 3wmedia

Between 5 and 30 per cent of those who receive a new hip prosthesis will require a re-operation during their lifetime. New research shows that a high-resolution X-ray method can predict which patients have the greatest risk of re-operation.
In Sweden, around 16,000 hip prosthesis operations are done annually, and about an additional 1,100 re-operations are done where part or all of the prosthetic must be replaced or removed.
The risk of re-operation varies with the patient’s age: around 30 per cent of patients under 50 undergo a re-operation within 15 years, while the corresponding percentage for patients older than 75 is 5-10 per cent.
The risk of re-operations also increases after each new operation on the hip joint.
Over 30 years, researchers at Sahlgrenska Academy at the University of Gothenburg have developed a special examination method that makes it possible to measure the prosthesis movement relative to the bone using high-resolution X-rays (called radiostereometry). The method, which has now been evaluated in a doctoral thesis, can be used to predict which patients are at risk of re-operation.
‘With the radiostereometric method, we can discover movements in the artificial joint socket. Since these movements increase the risk that the prosthesis will loosen on the long term, the information can be used to predict re-operation,’ says Maziar Mohaddes, who is presenting the studies in his doctoral thesis.
According to the researchers, the radiostereometric method can predict at an early stage if new prosthetic models and surgical techniques are safe, and if they can be expected to improve the outcome in patients.
The technique in question is so specialized that it is primarily used in research.
According to Maziar Mohaddes, broader clinical use could both identify and to some extent reduce the scope of complications in hip operations.

University of Gothenburghttp://tinyurl.com/hx4pmgf

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Stem cells regenerate human lens

, 26 August 2020/in E-News /by 3wmedia

Researchers at University of California, San Diego School of Medicine and Shiley Eye Institute, with colleagues in China, have developed a new, regenerative medicine approach to remove congenital cataracts in infants, permitting remaining stem cells to regrow functional lenses.
The treatment, which has been tested in animals and in a small, human clinical trial, produced much fewer surgical complications than the current standard-of-care and resulted in regenerated lenses with superior visual function in all 12 of the paediatric cataract patients who received the new surgery.
In subsequent tests in animals with cataracts and in a small human trial, they found the new surgical technique allowed pre-existing LECs to regenerate functional lenses. In particular, the human trial involved 12 infants under the age of 2 treated with the new method and 25 similar infants receiving current standard surgical care. The latter control group experienced a higher incidence of post-surgery inflammation, early-onset ocular hypertension and increased lens clouding.

https://interhospi.com/wp-content/uploads/sites/3/2020/06/logo-footer.png 44 200 3wmedia https://interhospi.com/wp-content/uploads/sites/3/2020/06/Component-6-–-1.png 3wmedia2020-08-26 14:38:292020-08-26 14:38:40Stem cells regenerate human lens

Fighting prescription painkiller abuse among baby boomers

, 26 August 2020/in E-News /by 3wmedia

Prescription opioid abuse has reached epidemic proportions, with more than half of patients being treated for chronic pain reportedly misusing their medication at some point.

However, new research led by University at Buffalo psychiatric nursing researcher Yu-Ping Chang found motivational interviewing, a form of behavioural counselling, is an effective tool at curbing the abuse.

Prescription opioids, which includes pain medications such as morphine and codeine

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Wearable sweat sensor thanks to battery-free ?water pump? inspired by plants

, 26 August 2020/in E-News /by 3wmedia

Plants and trees soak up water in the soil by letting it vaporize through pores in the leaves. Scientists have now taken this principle to develop a sweat sensor through which the sweat itself flows at a steady rate and is analysed.
Using laser micro-manufacturing, they made minuscule structures in flexible plastic and integrated a small analytic chip. Their work overcomes an important hurdle towards the development of flexible sweat sensors that can be stuck on the skin.

The substances in our sweat say much about our health, so sportsmen and women stand to gain quite alot as do medical applications. For instance, the saline concentration in sweat can tells us about cystic fibrosis while the acidity level is a decisive factor in certain skin diseases. To be able to monitor the development of this over time,

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MEDICAL FAIR ASIA to host inaugural Asian edition of Medicine + Sports Conference in 2016

, 26 August 2020/in E-News /by 3wmedia

The MEDICAL FAIR ASIA, Southeast Asia

https://interhospi.com/wp-content/uploads/sites/3/2020/06/logo-footer.png 44 200 3wmedia https://interhospi.com/wp-content/uploads/sites/3/2020/06/Component-6-–-1.png 3wmedia2020-08-26 14:38:292020-08-26 14:38:42MEDICAL FAIR ASIA to host inaugural Asian edition of Medicine + Sports Conference in 2016

New finding offers hope for diabetic wound healing

, 26 August 2020/in E-News /by 3wmedia

Non-healing chronic wounds are a major complication of diabetes, which result in more than 70,000 lower-limb amputations in the United States alone each year. The reasons why diabetic wounds are resistant to healing are not fully understood, and there are limited therapeutic agents that could accelerate or facilitate their repair.

University of Notre Dame researchers have discovered a compound that accelerates diabetic wound healing, which may open the door to new treatment strategies.

A team of researchers from Notre Dame

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New study reviews methods to induce labour on effectiveness and cost

, 26 August 2020/in E-News /by 3wmedia

Researchers from the University

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For young patients with spina bifida, Smartphone app improves self-management

, 26 August 2020/in E-News /by 3wmedia

A system incorporating a smartphone app may help adolescents and young adults with spina bifida to improve their daily selfmanagement skills, suggests a paper.
With features including mobile reminders and messaging with healthcare providers, the

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SCHILLER Americas Inc. now serves the whole American continent

, 26 August 2020/in E-News /by 3wmedia

As of the 1st of October 2015, SCHILLER Latin America merged with SCHILLER America to form the subsidiary SCHILLER Americas. This entity has responsibility over the entire American continent, with cardiologist Francesco Iacona, former General Manager of SCHILLER Latin America, in the role of CEO. Consolidation of both territories comes with many advantages: all processes are being optimized, reaction time is further reduced. Customers will benefit from increased efficiency thanks to resource sharing, from office space to personnel and services, including inventory management, purchasing and logistics. This merger is the starting point for an even stronger representation of SCHILLER in America.

www.schiller.ch
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Pumpkin-shaped molecule enables 100-fold improved MRI contrast

, 26 August 2020/in E-News /by 3wmedia

Assuming that we could visualize pathological processes such as cancer at a very early stage and additionally distinguish the various different cell types, this would represent a giant step for personalized medicine. Xenon magnetic resonance imaging has the potential to fulfill this promise – if suitable contrast media are found that react sensitively enough to the ‘exposure’. Researchers at the Leibniz-Institut fur Molekulare Pharmakologie in Berlin have now found that a class of pumpkin-shaped molecules called cucurbiturils together with the inert gas xenon, enables particularly good image contrast – namely around 100 times better than has been possible up to now. This finding points the way to the tailoring of new contrast agents to different cell types and has the potential to enable molecular diagnostics even without tissue samples in the future.
Personalized medicine instead of one treatment for all – especially in cancer medicine, this approach has led to a paradigm shift. Molecular diagnostics is the key that will give patients access to tailor-made therapy. However, if tumours are located in poorly accessible areas of the body or several tumour foci are already present, this often fails due to a lack of sufficient sensitivity of the diagnostic imaging. But such sensitivity is needed to determine the different cell types, which differ considerably even within a tumour. Although even the smallest of tumour foci and other pathological changes can be detected using the PET-CT, a differentiation according to cell type is usually not possible.
Scientists from the FMP are therefore focusing on xenon magnetic resonance imaging: The further development of standard magnetic resonance imaging makes use of the ‘illuminating power’ of the inert gas xenon, which can provide a 10,000-fold enhanced signal in the MRI. To do this, it must be temporarily captured by so-called ‘cage molecules’ in the diseased tissue. This has been more or less successful with the molecules used to date, but the experimental approach is still far from a medical application.
The research group led by Dr. Leif Schroder at the Leibniz-Institut fur Molekulare Pharmakologie (FMP) has now discovered a molecule class for this purpose that eclipses all of the molecules used to date. Cucurbituril exchanges around 100 times more xenon per unit of time than its fellow molecules, which leads to a much better image contrast. ‘It very quickly became clear that cucurbituril might be suitable as a contrast medium,’ reports Leif Schroder. ‘However, it was surprising that areas marked with it were imaged with a much better contrast than previously.’ The explanation is to be found in the speed. Upon exposure, so to speak, cucurbituril generates contrast more rapidly than all molecules used to date, as it only binds the xenon very briefly and thus transmits the radio waves to detect the inert gas to very many xenon atoms within a fraction of a second. In this way, the inert gas is passed through the molecule much more efficiently.
In the study the world’s first MRI images with cucurbituril have been achieved. With the aid of a powerful laser and a vaporized alkali metal, the researchers initially greatly strengthened the magnetic properties of normal xenon. The hyperpolarized gas was then introduced into a test solution with the cage molecules. A subsequent MRI image showed the distribution of the xenon in the object. In a second image, the curcurbituril together with radio waves destroyed the magnetization of the xenon, leading to dark spots on the images.
‘Comparison of the two images demonstrates that only the xenon in the cages has the right resonance frequency to produce a dark area,’ explains Schroder. ‘This blackening is possible to a much better degree with cucurbituril than with previous cage molecules, for it works like a very light-sensitive photographic paper. The contrast is around 100 times stronger.’
Initial tests were performed with cell material in which cucurbituril is also able to detect a certain enzyme that commonly occurs in cancer cells. On the basis of the enzyme reaction, it is possible to conclude the malignancy of the cells. What is special about this is that relatively little cell material is then sufficient to image the tumour cells in the MRI. The researchers believe that it may be possible to detect even very small tumour foci using this new method in the future. However, there is still a long way to go. To begin with, animal studies must be conducted to determine whether it is possible to transfer the test results obtained to date to the living organism. If so, they can be used to develop highly sensitive contrast media that are able to mark further enzymes and thus a range of different cell types.

Leibniz-Institut fur Molekulare Pharmakologiehttp://tinyurl.com/h2bn6go

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