A multiple myeloma patient whose cancer had stopped responding after nine different treatment regimens experienced a complete remission after receiving an investigational personalized cellular therapy known as CTL019 developed by a team at the University of Pennsylvania. The investigational treatment was combined with chemotherapy and an autologous stem cell transplant
The probiotic Lactobacillus rhamnosus GG was no more effective than regular medical care in preventing the colonization of superbugs in the gastrointestinal tracts of critically ill patients, according to a pilot study by Washington University researchers.
Compared with routine medical care, probiotics administered to critically ill patients in intensive care units showed no benefit in preventing the colonization of drug-resistant microbes in the intestinal tract, according to new research at Washington University School of Medicine in St. Louis.
Probiotics
Adenomas are rare liver tumours, a certain percentage of which can become malignant. Using a new MR (magnetic resonance) technique at MedUni Vienna, it is now possible to classify adenomas without subjecting patients to invasive tissue sampling procedures.
Hitherto patients have had to undergo biopsy to take tissue samples for histological examination in order to determine whether a hepatocellular adenoma is benign or potentially malignant. Using a new imaging technique at the University Department of Radiology and Nuclear Medicine at MedUni Vienna (Christian Herold), this type of tumour can now be clearly classified by means of a liver-specific MR contrast agent.
Adenomas of the liver are relatively rare. They can develop in different ways. Hence there are three subtypes (benign, inflammatory, pre-malignant) and a fourth unclassifiable subgroup with different clinical courses and potential progression. It is now possible to determine which group a particular adenoma belongs to using a new MR imaging technique.
The liver-specific contrast agent, gadoxetic acid, targets the bile transporters OATP (organic anion-transporting polypeptide) and MRP (Multidrug Resistance-Related Protein) in adenoma cells and normal liver cells. These will either absorb the agent or re-excrete it. The tumours can then be classified on the basis of the relative proportion of these surface transporters as compared to normal liver cells, as shown in the MR image.
Researchers at USC and Wake Forest Baptist Medical Center have developed a brain prosthesis that is designed to help individuals suffering from memory loss.
The prosthesis, which includes a small array of electrodes implanted into the brain, has performed well in laboratory testing in animals and is currently being evaluated in human patients.
Designed originally at USC and tested at Wake Forest Baptist, the device builds on decades of research by Ted Berger and relies on a new algorithm created by Dong Song, both of the USC Viterbi School of Engineering. The development also builds on more than a decade of collaboration with Sam Deadwyler and Robert Hampson of the Department of Physiology & Pharmacology of Wake Forest Baptist who have collected the neural data used to construct the models and algorithms.
When your brain receives the sensory input, it creates a memory in the form of a complex electrical signal that travels through multiple regions of the hippocampus, the memory centre of the brain. At each region, the signal is re-encoded until it reaches the final region as a wholly different signal that is sent off for long-term storage.
If there
Pediatric patients who listened to 30 minutes of songs by Taylor Swift , Rihanna and other singers of their choosing — or audio books — had a significant reduction in pain aft er major surgery, according to a new Northwestern Medicine study.
The children, ages nine to 14, chose from a playlist of top music in different genres including pop, country, rock and classical. Short audio books were another option in the study.
A strategy to control post-surgical pain without medication is important because opioid analgesics — most commonly used to control post-surgical pain — can cause breathing problems in children. Thus, caregivers usually limit the amount of opiods prescribed, and children
The results of a study indicate that Magnetic Resonance Imaging (MRI) Diffusion-Tensor Imaging (DTI) could be used for the prognosis and treatment of sports injuries in athletes. The researchers obtained DTI Three-dimensional (3-D) measurements of the upper leg from the hip to the knee, including the hamstring and other susceptible muscles, in a single imaging session. The technique revealed changes that qualitative T2-weighted MR imaging with fat suppression was not able to show, and could be used to help clinicians detect long-term changes in the upper leg from sports-related muscle injuries.
The researchers evaluated five male amateur long-distance runners using a 3-T MR examination of both upper legs at three points in time. The exams took place one week before, two days after, and three weeks aft er the runners took part in a marathon. A musculoskeletal radiologist used three grades to evaluate the level of muscle injury using T2-weighted images with fat suppression. The radiologist noted the specific muscle and its location, the craniocaudal, and axial length of the hemorrhage and/or edema, and manually segmented six muscles in both upper legs based on T1- and T2-weighted images.
Lead author of the study, Martijn Froeling, PhD, at the University Medical Centre Utrecht (Utrecht, Netherlands), said,
In the future, TAVIs can only be carried out in German hospitals with cardiac surgery departments and cardiac wards, as decided by the German Government
Results from an interim analysis of the Guinea Phase III efficacy vaccine trial show that VSV-EBOV (Merck, Sharp & Dohme) is highly effective against Ebola. The independent body of international experts – the Data and Safety Monitoring Board
Scientists from Nanyang Technological University (NTU Singapore) have successfully used dead bacteria to kill colorectal cancer cells.
Harvesting the Clostridium sporogenes bacteria found commonly in soil, the NTU team was able to harness the bacteria in its dead form, and its secretions, to destroy colon tumours cells effectively.
Colorectal cancer is the number one cancer in Singapore and the foremost cancer amongst males as stated by Singapore
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