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In a study of nearly 2,000 adults, researchers found that a buildup of plaque in the body’s major arteries was associated with mild cognitive impairment.

‘It is well established that plaque buildup in the arteries is a predictor of heart disease, but the relationship between atherosclerosis and brain health is less clear,’ said Christopher D. Maroules, M.D., radiology resident at UT Southwestern Medical Center in Dallas. ‘Our findings suggest that atherosclerosis not only affects the heart but also brain health.’

Atherosclerosis is a condition in which fat, cholesterol and other substances collect in the arteries, forming a substance called plaque that can build up, limiting blood flow. It can occur in any artery of the body, including the carotid, which supplies blood to the brain, coronary arteries and the aorta, which carries oxygenated blood from the heart through the abdomen to the rest of body.

In the study, researchers analysed the test results of 1,903 participants (mean age, 44 years) in the Dallas Heart Study, a multiethnic population-based study of adults from Dallas County, Texas. The participants included both men and women who had no symptoms of cardiovascular disease.

Study participants completed the Montreal Cognitive Assessment (MoCA), a 30-point standardized test for detecting mild cognitive impairment, and underwent magnetic resonance imaging (MRI) of the brain to identify white matter hyperintensity (WMH) volume. Bright white spots known as high signal intensity areas on a brain MR images indicate abnormal changes within the white matter.

‘Increased white matter hyperintensity volume is part of the normal aging process,’ Dr. Maroules explained. ‘But excessive WMH volume is a marker for cognitive impairment.’

Study participants also underwent imaging exams to measure the buildup of plaque in the arteries in three distinct vascular areas of the body: MRI to measure wall thickness in the carotid arteries and the abdominal aorta, and computed tomography (CT) to measure coronary artery calcium, or the amount of calcified plaque in the arteries of the heart.

Using the results, researchers performed a statistical regression to correlate the incidence of atherosclerosis and mild cognitive impairment. After adjusting for traditional risk factors for atherosclerosis

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