A new transformative point-of-care diagnostic which gives instant results for the detection of genetic material from the HIV virus is being rolled out across Africa. The small, highly portable machine – known as SAMBA II – will help transform the lives of millions, especially HIV exposed infants who have a one in two chance of early death if HIV infection is not diagnosed within the first six weeks of life and if they are not immediately initiated on treatment.

Already available in Uganda and Malawi, SAMBA II has just received product approval in Kenya, making available for the first time rapid, accurate and cost-effective DNA point-of-care diagnosis in even the most environmentally challenging and resource-limited settings.

Developed by Diagnostics for the Real World, a spin-out company from the University of Cambridge, the new SAMBA II instrument and chemistry has been a decade in the making.

SAMBA II makes use of innovative technology to offer an effective sample-in-results-out test without the need for centralised laboratories or specialist technicians. It integrates the whole testing process within a single instrument using ready-made disposable cartridges. Easy to read results are obtained in less than two hours and indicated by a simple blue line similar to a pregnancy test.

Until now nucleic acid based HIV tests have taken many hours to perform and required specialist facilities and highly-trained personnel. The necessity of transporting samples over long distances to centralised laboratories creates numerous logistical problems including long delays. In the meantime, many patients may be lost before they can be initiated on treatment. By bringing rapid testing to the point-of-care, SAMBA II solves these difficulties.

Dr Helen Lee, Director of Research at the Department of Haematology, University of Cambridge and CEO of Diagnostics for the Real World said:

For the first time, a minimally invasive transcatheter valve – tested by Baylor Research Institute in Dallas (BRI) – has been shown to save more lives than open-heart surgery, according to new research revealed at the American College of Cardiology

Physical therapy after total hip (THR) or total knee replacement (TKR) surgery is standard care for all patients. A new study also found that physical therapy before joint replacement surgery, or

A stroke therapy using stem cells extracted from patients’ bone marrow has shown promising results in the first trial of its kind in humans.

Five patients received the treatment in a pilot study conducted by doctors at Imperial College Healthcare NHS Trust and scientists at Imperial College London.

The therapy was found to be safe, and all the patients showed improvements in clinical measures of disability. It is the first UK human trial of a stem cell treatment for acute stroke to be published.

The therapy uses a type of cell called CD34+ cells, a set of stem cells in the bone marrow that give rise to blood cells and blood vessel lining cells. Previous research has shown that treatment using these cells can significantly improve recovery from stroke in animals. Rather than developing into brain cells themselves, the cells are thought to release chemicals that trigger the growth of new brain tissue and new blood vessels in the area damaged by stroke.

The patients were treated within seven days of a severe stroke, in contrast to several other stem cell trials, most of which have treated patients after six months or later. The Imperial researchers believe early treatment may improve the chances of a better recovery.

A bone marrow sample was taken from each patient. The CD34+ cells were isolated from the sample and then infused into an artery that supplies the brain. No previous trial has selectively used CD34+ cells, so early after the stroke, until now.

Although the trial was mainly designed to assess the safety and tolerability of the treatment, the patients all showed improvements in their condition in clinical tests over a six-month follow-up period.

Four out of five patients had the most severe type of stroke: only four per cent of people who experience this kind of stroke are expected to be alive and independent six months later. In the trial, all four of these patients were alive and three were independent after six months.

Dr Soma Banerjee, a lead author and Consultant in Stroke Medicine at Imperial College Healthcare NHS Trust, said:

New therapies are on the horizon for individuals paralyzed following spinal cord injury. The e-Dura implant developed by EPFL scientists can be applied directly to the spinal cord without causing damage and inflammation.

EPFL scientists have managed to get rats walking on their own again using a combination of electrical and chemical stimulation. But applying this method to humans would require multifunctional implants that could be installed for long periods of time on the spinal cord without causing any tissue damage. This is precisely what the teams of professors St