Patients whose colorectal cancer (CRC) is detected during a screening colonoscopy are likely to survive longer than those who wait until they have symptoms before having the test, according to a study.
The study looked at 312 patients in 10 gastroenterology practices in Germany, all aged 55 or older, who were diagnosed with CRC in 2003-2005. Of those, 60 patients were diagnosed during a screening colonoscopy, meaning they had no symptoms and/or only a negative faecal occult blood test (FOBT). The other 252 patients had their cancers detected during a diagnostic colonoscopy,
following a positive FOBT and/or symptoms including abdominal pain, iron deficiency anaemia, weight loss, changes in bowel habits, or rectal bleeding. None of the patients had had a previous colonoscopy, and all received endoscopic follow-up care. The patients were followed for as long as 10 years after diagnosis.
Patients whose cancer was detected during screening colonoscopy lived 20.2 months longer, on average, than those who had the test after noticing symptoms or having a positive FOBT (diagnostic colonoscopy). The latter group tended to have more advanced stage tumors; as expected, those whose cancer was in a more advanced stage had shorter survival times. About 55 percent of the patients with diagnostic colonoscopy, and about 77 percent of the screening
colonoscopy patients, survived beyond the time period of the study.
According to the lead author, Kilian Friedrich, MD,
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Patients with worsening chronic obstructive pulmonary disease spend less time in hospital when their doctors manage their care by using a checklist of steps called order sets.
Order sets help doctors and other clinicians choose the most appropriate care for a patient and can help improve care across several diseases. A new study is the first to examine the impact of order sets on patients with worsening COPD.
COPD, a lung disease that includes chronic bronchitis and emphysema, is the fourth leading cause of death globally and is the leading cause of hospitalisation in Canada.
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Patients undergoing colorectal operations who participated in an enhanced recovery program left the hospital sooner and had significantly lower hospital costs than patients who had the traditional approach to their care, according to a new study, which also found further postoperative improvements after adding an infection prevention protocol.
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UT Southwestern Medical Center pediatric diabetes researchers found that incorporating routine pet care into a child
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The International Exhibition on Hospital, Diagnostic, Pharmaceutical, Medical & Rehabilitation Equipment & Supplies will take place from 10 to 12 September 2015 at the Queen Sirikit National Convention Center (QSNCC) in Bangkok.
MEDICAL FAIR THAILAND is part of the globally recognized and leading medical and healthcare trade event under the Messe D
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A novel breast arterial calcification (BAC) score that uses findings from standard digital mammography is predictive of underlying coronary calcification and cardiovascular disease risk, a new study shows.
‘This is almost the ‘perfect storm’ because the age range for people who are having mammograms is the same as the age range for those who might benefit the most from preventive cardiology,’ said Laurie Margolies, MD, from the Icahn School of Medicine at Mount Sinai in New York City.
‘If breast arterial calcification is a surrogate for coronary artery calcium, or if it could augment documented risk-factor analysis, mammography could play a part in cardiovascular disease prevention and early intervention,’ she pointed out.
‘We found that the BAC score significantly predicts the presence of coronary artery calcium with an overall accuracy of 69%,’ she reported here at the American Roentgen Ray Society 2015 Annual Meeting
The study involved 325 women who had a non-contrast chest CT and a traditional mammogram within 1 year of each other.
If calcified vessels were identified on the mammogram, the investigators calculated the BAC score by evaluating the number of vessels involved, the length of the vessel involved, and the density of calcium involvement in the lumen.
They determined that breast arterial calcification was present in 45.5% of the cohort.
For each patient, they then compared the BAC score with the Coronary Artery Calcium Score. A calcium score of 4 or higher indicates significant risk for cardiovascular disease.
Agreement between the two scores was ‘highly significant,’ Dr Margolies reported.
For patients with a calcium score of 0, 76% also had a BAC score of 0, whereas 11% had a BAC score of 1 to 3 and 13% had a BAC score of 4 to 12.
For patients with a calcium score of 4 to 12, 55% also had a BAC score of 4 to 12, whereas 29% had a BAC score of 0 and 16% had a BAC score of 1 to 3.
The mechanisms of breast arterial calcification and coronary artery calcification are different. Breast calcification is medial in location, whereas coronary calcification is located in the intima, Dr Margolies explained.
In addition, mammary arteries are branches of several different arterial systems that are considered to be unsusceptible to conventional atherosclerosis.
‘Each of the individual variables we had in the BAC were all significantly predictive of the calcium score (P < .0001),' Dr Margolies pointed out.
Calcification in the breast is in the media, which is a different kind of calcification than occurs in the coronaries.
Predictably, BAC-positive patients were significantly older than BAC-negative patients (66.8 vs 58.2 years; P <.0001). There was also more hypertension in BAC-positive than in BAC-negative women (78% vs 55%; P = .0002).
Paradoxically, fewer BAC-positive than BAC-negative patients were smokers (11% vs 23%; P < .0087).
'Right now, I'm putting this information in the mammography report, but whether the primary care physician who ordered the mammography is picking it up or acting on it, I don't know,' Dr Margolies told Medscape Medical News.
'But cardiologists are extremely interested in this research. They are looking to prevent strokes and heart attacks, so anything that encourages women to be more proactive about their cardiovascular health is greatly welcomed,' she said.
Medscape
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Surgical robots allow doctors to improve recovery time and minimise scarring. A study into the safety of surgical robots has linked the machines’ use to at least 144 deaths and more than 1,000 injuries over a 14-year period in the US.
The events included broken instruments falling into patients’ bodies, electrical sparks causing tissue burns and system errors making surgery take longer than planned. The report notes that the figures represent a small proportion of the total number of robotic procedures.
But it calls for fresh safety measures. ‘Despite widespread adoption of robotic systems for minimally invasive surgery, a non-negligible number of technical difficulties and complications are still being experienced during procedures,’ the study states. ‘Adoption of advanced techniques in design and operation of robotic surgical systems may reduce these preventable incidents in the future.’
Robotic surgery can reduce the risk of infections and help patients heal more quickly.
The work was carried out by researchers at the University of Illinois at Urbana-Champaign, the Massachusetts Institute of Technology and Chicago’s Rush University Medical Center.
Their paper says 144 deaths, 1,391 injuries and 8,061 device malfunctions were recorded out of a total of more than 1.7 million robotic procedures carried out between January 2000 and December 2013. This was based on reports submitted by hospitals, patients, device manufacturers and others to the US Food and Drug Administration, and the study notes that the true number could be higher.
Surgeons face the risk of broken parts causing injury or lengthening procedures
Its authors say the number of injuries and deaths per procedure has remained relatively constant since 2007. But due to the fact that the use of robotic systems is increasing ‘exponentially’, they add, this means that the number of accidents is increasing every year.
They highlight that when problems do occur, people are several times more likely to die if the surgery involves their heart, lungs, head and/or neck rather than gynaecological and urological procedures.
They acknowledge that the data does not pinpoint why, but suggest it is because the former are more complex types of operations for which robots are less commonly used, so there is less experience and expertise available.
The researchers did not, however, compare accident rates with similar operations in which robots were not used. Their study has not been peer reviewed.
Surgical robotic devices are typically expensive – costing millions of pounds – but offer advantages.
They can allow surgeons to use smaller instruments, letting them make smaller and more nimble cuts. That can mean patients recover faster, with less risk of infection and the promise of smaller scars.
In addition, the development of remote surgery means that doctors do not always need to be in the same room as their patients, allowing specialists who are in demand to treat more people.
The report acknowledges that the ‘vast majority of procedures’ involving robots were successful
BBC
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A team of biomedical engineers have developed a prototype of a low-cost portable device that can detect bacterial meningitis in babies replacing the existing painful and difficult lumbar puncture puncture test.
The innovative procedure consists of a simple, non-invasive, high-resolution ultrasound scan of part of the brain, called the fontanelle, through an opening between the cranial bones of babies under 12 months of age. The researchers created algorithms that analyse the image and can indicate, within seconds, whether cellularity, a sign of infection, exists in the cerebrospinal fluid.
The economical procedure, aims to revolutionize the detection of this illness, especially in developing countries where hospitals do not have the facilities to carry out the lumbar puncture. Without the test many children die or suffer serious complications as a result of bacterial meningitis. The procedure can be used without specialized training, and has already been tested on a small number of babies at the La Paz University Hospital (Madrid, Spain).
The research was carried out by the Madrid-MIT M+Visi
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New evidence has been gained for the success of faecal microbial transplantation in treating severe Clostridium difficile infection, a growing problem worldwide that leads to thousands of fatalities every year. The findings have important implications for a range of diseases associated with microbial imbalance, or dysbiosis, researchers say.
Research led by Michael Sadowsky, Alex Khoruts, and colleagues at the University of Minnesota in collaboration with the Rob Knight Lab at the University of Colorado, Boulder, reveals that healthy changes to a patient’s microbiome are sustained for up to 21 weeks after transplant, and has implications for the regulation of the treatment. Findings also demonstrate the dynamic nature of faecal microbiota in FMT donors and recipients.
In FMT, faecal matter is collected from a donor, purified, mixed with a saline solution and placed in a patient, usually by colonoscopy. In contrast to standard antibiotic therapies, which further disrupt intestinal microflora and may contribute to the recurrence of CDI, FMT restores the intestinal microbiome and healthy gut function.
Using DNA samples of healthy individuals from the Human Microbiome Project (HMP) as a baseline, Sadowsky and his team compared changes in faecal microbial communities of recipients over time to the changes observed within samples from the donor. Significantly, the composition of gut microbes in the both donor and recipient groups varied over the course of the study, but remained within the normal range when compared to hundreds of samples collected by the HMP.
According to Sadowsky, the findings have important implications for a range of diseases associated with microbial imbalance, or dysbiosis, and could influence the regulatory regime surrounding FMT, currently treated as a drug by the U.S. Food and Drug Administration (USFDA).
‘The dynamic nature of fecal microbiota in both the donor and recipients suggests that the current framework of regulation, requiring consistent composition, may need to be re-examined for faecal transplantations,’ says Michael Sadowsky. ‘Change in faecal microbial composition is consistent with normal responsiveness to shifts in the diet and other environment factors. Variability should be taken into account when comparing microbial composition in normal individuals to those with dysbiosis characteristic of disease states, especially when assessing clinical interventions and outcomes.
Also discovered in the research, the performance of frozen and fresh preparations of faecal material was indistinguishable. Though the sample was limited and warrants further study with a larger cohort, it has several implications for the widespread adoption of FMT. The frozen preparation greatly simplifies the standardization and distribution of the faecal material. It also facilitates long-term storage of donor material for future study and makes FMT accessible to a greater number of physicians and patients. Finally, it offers advantages over fresh material in the testing of faecal samples for pathogens, which in some cases can take several weeks to complete.
ScienceDaily
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