Columbia University Medical Center (CUMC) researchers have created a way to develop personalized gene therapies for patients with retinitis pigmentosa (RP), a leading cause of vision loss. The approach, the first of its kind, takes advantage of induced pluripotent stem (iPS) cell technology to transform skin cells into retinal cells, which are then used as a patient-specific model for disease study and preclinical testing.
Using this approach, researchers led by Stephen H. Tsang, MD, PhD, showed that a form of RP caused by mutations to the gene MFRP (membrane frizzled-related protein) disrupts the protein that gives retinal cells their structural integrity. They also showed that the effects of these mutations can be reversed with gene therapy. The approach could potentially be used to create personalized therapies for other forms of RP, as well as other genetic diseases.
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Pushing new frontiers in dementia research, Nanyang Technological University, Singapore (NTU Singapore) scientists have found a new way to treat dementia by sending electrical impulses to specific areas of the brain to enhance the growth of new brain cells.
Known as deep brain stimulation, it is a therapeutic procedure that is already used in some parts of the world to treat various neurological conditions such as tremors or Dystonia, which is characterised by involuntary muscle contractions and spasms.
NTU scientists have discovered that deep brain stimulation could also be used to enhance the growth of brain cells which mitigates the harmful effects of dementia-related conditions and improves short and long-term memory.
Their research has shown that new brain cells, or neurons, can be formed by stimulating the front part of the brain which is involved in memory retention using minute amounts of electricity.
The increase in brain cells reduces anxiety and depression, and promotes improved learning, and boosts overall memory formation and retention.
The research findings open new opportunities for developing novel treatment solutions for patients suffering from memory loss due to dementia-related conditions such as Alzheimer
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Rice University scientists have found the balance necessary to aid healing with high-tech hydrogel.
Rice chemist Jeffrey Hartgerink, lead author Vivek Kumar and their colleagues have created a new version of the hydrogel that can be injected into an internal wound and help it heal while slowly degrading as it is replaced by natural tissue.
Hydrogels are used as a scaffold upon which cells can build tissue. The new hydrogel overcomes a host of issues that have kept them from reaching their potential to treat injuries and forming new vasculature to treat heart attack, stroke and ischemic tissue diseases.
The Rice lab
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Testosterone (T) therapy is routinely used in men with hypogonadism, a condition in which diminished function of the gonads occurs. Although there is no evidence that T therapy increases the risk of prostate cancer (PCa), there are still concerns and a paucity of long-term data. In a new study, investigators examined three parallel, prospective, ongoing, cumulative registry studies of over 1,000 men. Their analysis showed that long-term T therapy in hypogonadal men is safe and does not increase the risk of PCa.
Lead investigator Ahmad Haider, MD, PhD, urologist, Bremerhaven, Germany, states, ‘Although considerable evidence exists indicating no relationship between testosterone and increased risk of developing PCa, decades of physician training with the notion that testosterone is fuel for PCa made it difficult to dispel such fallacy and the myth continued to persist. Nevertheless, in the absence of long-term follow-up data demonstrating reduced risk of PCa in hypogonadal men who are receiving T therapy, considerable skepticism remains throughout the medical community and this is an expected natural and acceptable path of medical and scientific discourse. In view of the current evidence, clinicians are compelled to think this over and cannot justify withholding T therapy in hypogonadal men, also in men who have been successfully treated for PCa.’
EurekAlert
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Undescended testis is commonly found in new-born boys and usually normalizes spontaneously by the age of six months. In one in a hundred boys, however, at least one testis remains undescended
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The Critical Care Recovery Center care model — the USA
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A simple point-of-care testing device for anemia could provide more rapid diagnosis of the common blood disorder and allow inexpensive at-home self-monitoring of persons with chronic forms of the disease. The disposable self-testing device analyses a single droplet of blood using a chemical reagent that produces visible colour changes corresponding to different levels of anemia. The basic test produces results in about 60 seconds and requires no electrical power. A companion smartphone application can automatically correlate the visual results to specific blood hemoglobin levels. By allowing rapid diagnosis and more convenient monitoring of patients with chronic anemia, the device could help patients receive treatment before the disease becomes severe, potentially heading off emergency room visits and hospitalizations. Anemia, which affects two billion people worldwide, is now diagnosed and monitored using blood tests done with costly test equipment maintained in hospitals, clinics or commercial laboratories. Because of its simplicity and ability to deliver results without electricity, the device could also be used in resource-poor nations. Using a two-piece prototype device, the test works this way: a patient sticks a finger with a lance similar to those used by diabetics to produce a droplet of blood. The device
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Survey of Swedish anesthesia personnel reveals the need to improve knowledge, particularly in elderly and fragile patients. Postsurgical cognitive side effects can have major implications for the level of care, length of hospital stay, and the patient
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No methods currently exist for the early detection of Alzheimer
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The Perioperative Surgical Home (PSH) model consistently and significantly improves quality of care for patients and reduces health care costs, reports a first-of-its-kind, large-scale literature review of the PSH in the United States and abroad. The review provides further evidence to support the benefits, and encourage the adoption, of the PSH model.
‘There is a global push for more rigorously coordinated and integrated management of surgical patients to enhance patient satisfaction and improve quality of care and outcomes, while cutting costs,’ said Thomas R. Miller, Ph.D., M.B.A., co-author of the review and director of health policy research at the American Society of Anesthesiologists, Schaumburg, Ill. ‘Whether in the U.S. or overseas, our review found that the PSH model of care is highly effective at achieving these measures by reducing cancellations and surgical delays, lowering complication rates and readmissions, and shortening hospital stays.’
The PSH is a patient-centred, physician-led, multidisciplinary team-based model of coordinated care. In a PSH, a patient’s entire surgical experience – preoperative, intraoperative, postoperative and post-discharge – is fully coordinated and treated as one continuum of care. The PSH model emphasizes the cost-efficient use of resources as well as lead physician, multi-specialty team and patient-shared decision-making.
Interestingly, both U.S. and international studies stressed the importance of the role of physician anaesthesiologists in perioperative patient management and PSH models of care.
‘This literature review provides still more evidence that physician anaesthesiologist-led anaesthesia care teams are associated with better patient outcomes, fewer complications, less pain, earlier return to functionality and home, and lower costs,’ said J.P. Abenstein, ASA president. ‘The Perioperative Surgical Home will advance our goals of improved patient safety, quality of care and cost-effectiveness. Every patient undergoing an invasive procedure deserves the involvement of a physician anaesthesiologist in their care.’
Researchers from Texas A&M University and the ASA performed a comprehensive analysis of 152 peer-reviewed studies published between 1980 and 2013. They compared PSH models in the U.S. and other countries and summarized the findings related to clinical outcomes and efficiencies/cost of surgery in various surgical homes. All studies were categorized as preoperative, intraoperative or postoperative in scope.
According to the review, 82 percent of preoperative studies analysed found that the PSH model had a significant positive impact on preoperative clinical outcomes (32 studies) and reduced costs (23 studies). Studies cited preoperative patient education as a component of the PSH model that significantly reduced length of stays and readmission rates. Additionally, studies cited that minimizing the number of unnecessary preoperative tests was found to reduce costs. In fact, one study found eliminating unneeded tests reduced costs by as much $112 per patient, for a total of $1.01 million over the course of the study.
Eighty-two percent of intraoperative studies analysed found that the PSH model had a significant positive impact on intraoperative clinical outcomes (29 studies) and reduced costs (17 studies). Studies cited design and process flow initiatives such as real-time patient-routing systems (real-time electronic dashboards that ensure access to medical records) as one of the intraoperative components of the PSH model that led to a reduction in O.R. delays, surgical cancellations and improved efficiencies.
Last, 90 percent of postoperative studies analysed found that the PSH model had a significant positive impact on clinical outcomes (71 studies) and reduced costs (23 studies). Studies cited enhanced recovery after surgery programs as a component of the PSH model that significantly helped reduce complications, length of stays and costs by encouraging quicker recovery and earlier discharges.
‘We would like to see the PSH model of care be adopted nationwide,’ said Miller. ‘Large reviews such as this show just how successful this model of care can be at raising the quality of care for patients, while meeting the increasing demands of health care reform.’
EurekAlert
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