A study involving nearly 27,000 older adults on five continents found that nearly 1 in 10 met criteria for pre-dementia based on a simple test that measures how fast people walk and whether they have cognitive complaints. People who tested positive for pre-dementia were twice as likely as others to develop dementia within 12 years. Scientists at Albert Einstein College of Medicine of Yeshiva University and Montefiore Medical Center led the study.
The new test diagnoses motoric cognitive risk syndrome (MCR). Testing for the newly described syndrome relies on measuring gait speed (our manner of walking) and asking a few simple questions about a patient
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Population Council scientists and their partners have found that their proprietary microbicide gel is safe, stable, and can prevent the transmission of multiple sexually transmitted infections (STIs) in both the vagina and rectum in animals: HIV, herpes simplex virus 2 (HSV-2), and human papillomavirus (HPV). The USAID-funded study also provides the first data that the gel is effective against multiple strains of HIV, and has a window of efficacy in the vagina against all three viruses of at least eight hours prior to exposure. A Phase 1 safety trial of the gel started enrollment in May 2014. The gel, known as MZC, contains two potent antiviral agents: MIV-150 and zinc acetate. MIV-150 is an enzyme inhibitor that prevents HIV-infected cells from producing new virus, and zinc acetate is an antiviral agent with known activity against HIV and HSV-2. These compounds are mixed in a base of carrageenan, a compound derived from seaweed that has also been shown to have potent activity against HPV. Infection with HSV-2 or HPV is associated with increased risk of HIV infection. Microbicides that target HIV, HSV-2, and HPV may more effectively limit HIV transmission than those that target HIV alone. In this study, Council scientists and their partners used macaque and mouse models to examine whether MZC gel could prevent the vaginal and rectal transmission of SHIV-RT, HSV-2, and HPV. SHIV-RT is a human/simian immunodeficiency chimeric virus combining the HIV reverse transcriptase (RT) within SIV (the monkey version of HIV). MIV-150 and zinc acetate inhibit HIV-RT via different mechanisms of action. Pre-clinical testing in animals is required by the FDA and is important to ensure the highest level of safety and to build the evidence base for potential efficacy in humans.
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Using heart-lung support technology, the University of Michigan
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The benefits of medical imaging far outweigh the risks when children receive The Right Exam, ordered The Right Way, with The Right Radiation Dose. However, overuse and misuse of imaging change the benefit-risk ratio and Mayo Clinic is leading a collaborative effort to ensure a national protocol is put into action. The commentary calls for the American College of Radiology, the Joint Commission, the Intersociety Accreditation Commission, and the Centers for Medicare & Medicaid Services to require three safety practices for accreditation of all American hospitals and advanced diagnostic imaging facilities.
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For the first time, robotic prostheses controlled via implanted neuromuscular interfaces have become a clinical reality. A novel osseointegrated (bone-anchored) implant system gives patients new opportunities in their daily life and professional activities.
In January 2013 a Swedish arm amputee was the first person in the world to receive a prosthesis with a direct connection to bone, nerves and muscles.
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Manchester scientists are working out how to safely increase the radiotherapy dose given to lung cancer patients
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Kessler Foundation researchers published long-term follow-up results of their MEMREHAB trial, which show that in individuals with MS, patterns of brain activity associated with learning were maintained at 6 months post training. The article, A pilot study examining functional brain activity 6 months after memory retraining in MS: the MEMREHAB trial, was published online ahead of print on June 14 by Brain Imaging and Behavior (doi: 10.1007/s11682-014-9309-9).
This pilot study was based on the Foundation
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Certain processes used to sterilise blood products could potentially cause serious health issues in transfusion recipients, according to an international study by Dr. Patrick Provost of Universit
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Lungs from donors whose cause of death was asphyxiation or drowning can be safely transplanted into patients with end-stage lung disease.
Patient survival rates were not affected when lungs from cases involving asphyxiation and drowning were used.
The researchers note that if centres wanted to expand their individual criteria for donation, they could successfully expand their donor pool.
‘For most patients with end-stage lung disease, transplant offers the only hope for survival, but there is a critical organ shortage, especially for patients on the lung transplant list. Increasing the potential donor pool would help reduce the number of patients who die while on the waiting list and help expand this lifesaving treatment to those who need it,’ said Bryan A. Whitson, MD, PhD, from The Ohio State University Wexner Medical Center in Columbus.
Dr. Whitson and colleagues searched the United Network for Organ Sharing (UNOS) Standard Transplant Analysis and Research registry for lung transplants from 1987 to 2010 and assessed the association between donor cause of death and recipient survival, focusing on asphyxiation or drowning as the cause of death. Lungs from donors who died from asphyxiation or drowning are not routinely utilised because of potential damage sustained by the organs.
The researchers found 18,250 adult primary lung transplants, including 309 cases that involved asphyxiation or drowning. They also found that although the hospital stay was slightly longer (0.8 day) for recipients of lungs from asphyxiation or drowning deaths when compared with patients who received lungs from all other causes of donor death, survival rates were the same and there were no differences in treatment for rejection within the first year, post-transplant dialysis, or post-transplant stroke.
Elsevier
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The Siemens Museum for Medical Technology held its grand opening last May in Erlangen. Occupying 400 square meters in all, the Siemens MedMuseum offers an overview of the development of medical technology, a field in which Siemens has played a key role for more than 160 years
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