One in eight women in the United States will develop breast cancer. Of those, many will undergo surgery to remove the tumour and will require some kind of breast reconstruction afterward, often involving implants. Cancer is an elusive target, though, and malignant cells return for as many as one-fifth of women originally diagnosed, according to the American Cancer Society.
Would it be possible to engineer implant materials that might drive down that rate of relapse? Brown University biomedical scientists report some promising advances. The team has created an implant with a ‘bed-of-nails’ surface at the nanoscale (dimensions one-billionth of a meter, or 1/50,000th the width of a human hair) that deters cancer cells from dwelling and thriving. Made out of a common federally approved polymer, the implant is the first of its kind, based on a review of the literature, with modifications at the nanoscale that cause a reduction in the blood-vessel architecture on which breast cancer tumours depend
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According to a new report* by business intelligence expert GBI Research patient care is improving at home and in remote areas, as rising rates of chronic disease, a growing elderly population, and advancements in wireless and sensor technologies continue to drive the global patient monitoring market.
The new report shows that efficient patient management through the use of wireless technology will help to reduce the rising healthcare burden which now affects many developed and developing countries, as large elderly populations who have increased life expectancy further add to the global patient pool.
Wireless technology has a wide range of applications in remote patient monitoring. Remote monitoring enables a patient to undergo hospital visits of reduced length, and have constant monitoring at home. This not only improves the quality of life for elderly and chronically ill patients, but also leads to a significant reduction in healthcare expenditure.
Wireless remote patient monitoring can also provide continuous and real time data to physicians from remote locations such as the home, hospice, ambulance, or other outpatient settings, thereby offering the advantage of convenience to both physicians and patients, while hospitalization costs are massively reduced.
Over the past few years, the number of cases of chronic diseases such as Cardiovascular Disease (CVDs), diabetes and chronic respiratory diseases has increased, due to the growing population in developing nations. According to the World Diabetes Foundation (WDF), 80% of the diabetic population is expected to come from low and middle income countries by 2025.
Emerging economies such as India and China, with huge patient bases and an under-served market, are expected to act as potentially lucrative markets for remote patient monitoring devices. The global patient monitoring devices market is expected to grow at a Compound Annual Growth Rate (CAGR) of 4% to reach $8 billion in 2017 from $6.1 billion in 2010.
*Patient Monitoring Devices Market to 2017 – Increasing Use of Wireless Remote Patient Monitoring to be the Key Technology Trend
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Contract negotiations have been finalized between Maquet the global leader in OR complete solutions and Siemens Healthcare Sector. The companies will now collaborate closely to introduce a combined system for diagnostics and surgical procedures. The very first systems will be delivered and installed starting in May 2012.
The heart of the joint solution is the angiography system Artis zeego [1] (Siemens) and the Magnus operating table system (Maquet) [2]. The application is primarily intended for the hybrid operating room. A decisive benefit of the combined solution for hospitals is its versatile range of application in the OR: in future, the solution will be used for angiographic imaging as well as for open surgery. Both companies see considerable growth potential for the hybrid OR in this joint development, in particular for the fields of cardiovascular surgery, neurosurgery, orthopedics, traumatology and urology.
The agreement shall apply worldwide and be implemented by the subsidiaries of both companies individually and at a national level. In future, Siemens Healthcare Sector and Maquet will mutually advise customers on issues pertaining to the hybrid OR.
‘We look forward to developing new global business portfolios with Siemens Healthcare and to show our customers the benefits of our combined system’, says Michael Rieder, Executive Vice President Sales & Marketing, Getinge Medical Systems.
With this new joint effort, Maquet is further expanding its longstanding position as a global leader for the hybrid OR. Besides the Magnus operating table system, the product range encompasses all essential components of the hybrid OR
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Patients who have had metal-on-metal hip replacements are no more likely to develop cancer in the first seven years after surgery than the general population, although a longer-term study is required, a study led by the University of Bristol claims.
A recent BMJ and BBC Newsnight investigation looked into the potentially high level of toxic metals from failing hip implants which may, in future, affect thousands of people around the world. The investigation also looked at why these hip replacements were allowed despite the risks being known and documented for decades. The BMJ has a large collection of articles about the safety of medical devices which can be found here.
This study, commissioned by the National joint Registry of England and Wales and carried out by authors from the Universities of Bristol and Exeter, looks at whether these concerns are valid. The registry contains records of over one million procedures from at least 97 per cent of orthopaedic units. Every year registry data and hospital episode statistics are linked up to check how patients who have had joint replacements are faring.
Ashley Blom, Professor of Orthopaedic Surgery in the School of Clinical Sciences at the University of Bristol, who led the team that undertook the study, said: ‘This research shows that there is no increased risk of cancer with metal-on-metal hip replacements in the first seven years after surgery. Although this is very reassuring, we do not know what are the long-term risks and thus further studies will be necessary in the future.’
In this study cancer rates in patients with metal-on-metal hip replacements were compared with both a group of patients who had other hip bearing surfaces implanted and the general population. Overall, 14 per cent (40,576) of registered patients had some type of metal-on-metal bearing surface: seven per cent (21,264) had a stemmed metal-on-metal prosthesis and seven per cent (19,312) had a resurfacing procedure. The researchers compared patients’ outcomes using mathematical modelling. The models included the age and sex of the patient as well as three measures of general health at the time of hip surgery (the American Society of Anaesthesiologists grade that scores the patient’s other serious illnesses, the number of distinct diagnostic codes recorded at time of surgery, and the number of NHS funded admissions to hospital in the previous five years). The authors do say, however, that comparison with the general population is not straightforward as hip replacement patients ‘tend to be healthier than others of the same gender and age group’.
Results show that the chance of a 60-year-old man with moderate health and a metal-on-metal stemmed hip replacement being diagnosed with cancer in the five years following surgery is 6.2 per cent, compared to 6.7 per cent chance with hip replacement using other bearing surfaces. For women, these figures were 4.0 per cent for metal-on-metal stemmed hip replacement and 4.4 per cent for other bearing surfaces. Further results show that the incidence of cancer diagnosis is low after hip replacement and lower than that predicted for the age and sex matched general population.
The authors hope that this study will help clinicians reassure patients that the ‘risk of cancer for hip replacement patients is relatively low’ with no evidence of an increase in cancer associated with metal-on-metal hips. They add though that this only shows results for up to seven years following surgery and the analysis of long-term data is required over the next few decades as some cancers take many years to develop.
University of Bristol
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A cheap medical device can dramatically reduce the number of premature births in some at-risk women, according to a team of doctors in Spain. Being born before 34 weeks of pregnancy is linked to a host of health problems.
The study showed that using a ‘cervical pessary’ reduced the rate in the at-risk group. Doctors said more studies were needed before the technique was used routinely.
The authors said 13 million babies were born prematurely every year.
In the trial, doctors were looking at women who had a cervix – part of the lower section of the uterus – which was shorter than 25mm. These pregnant women are thought to be at a higher risk of an early delivery.
The cervix was measured between 18 and 22 weeks into the pregnancy by an ultrasound scan. Of the 11,875 women who took part in the trial, 726 had a cervical length less than 25mm. Half of these women had a pessary, a small ring of silicone, inserted into their cervix.
In the group of women without the pessary, 27% of babies were born prematurely. The rate was six per cent among those fitted with a pessary.
Maria Goya, one of the researchers at the Vall d’Hebron Hospital, said: ‘Placement of a pessary is an affordable procedure, non-invasive, and easy to insert and remove as required.’
The study concluded the pessary was a ‘reliable alternative for prevention of preterm birth’ in a group of at-risk women.
Prof Steve Thornton of the University of Exeter, a spokesman for the Royal College of Obstetricians and Gynaecologists, said: ‘The difference in the two groups is pretty amazing.’
He said more research was needed to prove that it worked, and to find out if it could help other women at risk of a premature birth.
‘If this is borne out it could make a big difference,’ he added.
BBC
Dr. Fritz EilberResearchers from UCLA’s Jonsson Comprehensive Cancer Center have found that by administering a PET scan to individuals with soft-tissue sarcomas after just a single cycle of neoadjuvant chemotherapy, they can predict increased survival in these patients.
Prior research by this multidisciplinary team of physician-scientists had shown that a combined PET/CT scan using a glucose uptake probe called FDG allowed them to determine the pathologic response of patients’ tumours after the first dose of chemotherapy drugs. They then wondered if the patients who showed a significant PET response after the first round of chemotherapy also were surviving longer.
‘We did find that patients who experienced an early PET response to treatment had significantly increased survival,’ said the study’s senior author, Dr. Fritz Eilber, an associate professor of surgical oncology and director of the Jonsson Cancer Center’s sarcoma program. ‘This is vital because patients want to know if the drugs are working and what that says about their ultimate outcome.’
In the study, 39 patients with soft-tissue sarcoma underwent a PET scan to measure their tumour
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Allison Kurian was a developer of the online tool that helps people with BRCA mutations make preventive care decisions.
At age 47, Melanie Lemons has already had her ovaries removed. With a few clicks of her computer
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Stroke patients receiving in-patient rehabilitation are more likely to land back in the hospital within three months if they are functioning poorly, show signs of depression and lack social support according to researchers at the University of Texas Medical Branch (UTMB) at Galveston. Hospital readmission for older adults within 30 days of discharge costs Medicare roughly $18 billion annually.
Among the first of such research to explore the risk of re-hospitalisation among this patient segment, the study is available online at The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. The findings are timely as effective this October hospitals will be held accountable for high short-turnaround readmission rates.
According to Dr. Kenneth Ottenbacher, Director, Center for Rehabilitation Sciences, and Associate Director, UTMB Sealy Center on Ageing, ‘by identifying clear demographic, clinical and environmental factors that lead to re-hospitalisation, we can develop meaningful quality indicators for post-acute care that target ways to improve patients’ health and contain costs by reducing the likelihood of readmission.’
Currently, more than 30 percent of stroke patients receive in-patient rehabilitation after release from acute care, he said.
‘Though we intuitively know that these patients are at highest risk for being re-hospitalised
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More than 30% of the one million heart attack victims in the United States each year die before seeking medical attention. Although widespread education campaigns describe the warning signs of a heart attack, the average time from the onset of symptoms to arrival at the hospital has remained at 3 hours for more than 10 years. In their upcoming article,’This is your heart speaking. Call 911,
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Assessing the mental health of eight-year-olds is a way of identifying those children with the greatest potential need for psychiatric care in later life. This is one of the findings in David Gyllenberg
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