After a diving accident left Jason DiSanto paralysed from the neck down in 2009, he had to learn how to navigate life from a powered wheelchair, which he controls with a sip-and-puff system. Users sip or puff air into a straw mounted on their wheelchair to execute four basic commands that drive the chair. But results from a new clinical study offer hope that sip-and-puff users like DiSanto could gain a higher level of independence than offered by this common assistive technology.
In the study, individuals with paralysis were able to use a tongue-controlled technology to access computers and execute commands for their wheelchairs at speeds that were significantly faster than those recorded in sip-and-puff wheelchairs, but with equal accuracy. This study is the first to show that the wireless and wearable Tongue Drive System outperforms sip-and-puff in controlling wheelchairs. Sip-and-puff is the most popular assistive technology for controlling a wheelchair.
The Tongue Drive System is controlled by the position of the user
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Sea coral could soon be used more extensively in bone grafting procedures thanks to new research from Swansea University that has refined the material
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Current laser therapy approaches are effective for treating excessive scars resulting from abnormal wound healing.
The review by Dr. Qingfeng Li and colleagues of Shanghai Ninth People’s Hospital in Shanghai, China, provides strong support for laser treatment of hypertrophic scars
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Nuclear Magnetic Resonance (NMR) Spectroscopy is an extremely powerful non-destructive technique for the characterization of molecules. Widely used by chemists from its origin, it is now essential in the synthesis and analysis laboratories and sees its scope extended in biological laboratories.
Coupled with NMR, Dynamic Nuclear Polarization (DNP) allows, thanks to polarizing agents, the enhancement of NMR signals from a wide range of molecules resulting in the significant reduction of the NMR acquisition time. It shows therefore strong advantages over ‘classical’ NMR and possibly over X-ray diffraction techniques used to characterize proteins on synchrotron type equipments.
NMR has also known an impressive development in the medicine with the development of Magnetic Resonance Imaging (MRI).
Up to now, the DNP has been efficiently applied to MRI for the early diagnosis of cancers in small animals (rats and porks) in pre-clinical studies and more recently to 30 human patients having prostate cancers. However, MRI using DNP can not be generalized to human diagnosis as polarizing agents used to activate biological tracers/contrast agents need to be quantitatively separated from the polarized solution before human injection and image acquisition. This technical hurdle is now fixed.
In this context, an innovative powder for the easy polarization of many molecules, including biological tracers, was developed in the frame of a European collaboration involving the Laboratory of Chemistry, Catalysis, Polymers and Processes (UMR 5265-LC2P2), the European Center for high field NMR (UMR 5280, CRMN-Lyon) and ETH Zurich. These innovative ‘powders’ open perspectives for the fast characterization of complex systems by means of solid state NMR using DNP but also in the field of medical imaging for early cancer diagnosis using MRI. In this latter field, the aforementioned materials can deliver a solution of polarized biological tracers /contrast agents free from any impurity and therefore injectable to humans.
EurekAlert
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Widely used treatments for type 2 diabetes have different effects on the hearts of men and women, even as the drugs control blood sugar equally well in both sexes, according to researchers at Washington University School of Medicine in St. Louis.
In particular, the commonly prescribed diabetes drug metformin had positive effects on heart function in women but not in men, who experienced a shift in metabolism thought to increase the risk of heart failure.
‘We saw dramatic sex differences in how the heart responds to the different therapies,’ said senior author Robert J. Gropler, MD, professor of radiology. ‘Our study suggests that we need to better define which therapies are optimal for women with diabetes and which ones are optimal for men.’
To the researchers
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A new individualised systems medicine strategy enables a selection of potentially effective cancer therapies for individual patients. The promising results achieved by applying this strategy to chemoresistant adult acute myeloid leukaemia patients have been recently published
A multi-disciplinary team of researchers at the Institute for Molecular Medicine Finland, FIMM, and the Helsinki University Central Hospital has developed a novel individualised systems medicine (ISM) strategy which enables selection of potentially effective cancer therapies for individual patients.
Results achieved by applying this strategy to 28 patient samples have been recently published.
Most of the patients studied had chemoresistant adult acute myeloid leukaemia (AML), a disease characterised by poor prognosis.
AML is today largely treated by the same chemotherapeutic agents as applied 30-50 years ago. Here, the researchers measured the response of patients
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The Journal of Hospital Infection (JHI) has just released the awaited epic3 guidelines on infection prevention and control for a range of healthcare professionals. They are freely available online on ScienceDirect and on the journal’s website.
The guidelines were commissioned by the UK Department of Health and have been developed after a systematic and expert review of all the available scientific evidence. They update and supersede the previous guidelines on this topic published in 2007.
Infection prevention and control came to the public awareness after the rise of MRSA and C. difficile in particular in the middle of the last decade. Since the publication of the 2007 guidelines, more resistant organisms have emerged, some of which are now almost untreatable by antimicrobials. This is actually no great surprise, as the development of resistance to antibiotics is an inevitable consequence of evolution- microbes have been producing chemical weapons to destroy each other since the dawn of life on earth. Resistance means survival. There are no really new antimicrobial agents under development, and for the first time, we are facing a world where more bacterial infections may be untreatable. Contrary to popular belief, we always had several treatment options available to treat MRSA.
Microbiologist Dr Jenny Child, Editor in Chief of The Journal of Hospital Infection, said ‘It is difficult to stop the rise of increasingly resistant organisms. What we can do however is prevent them spreading between patients and becoming established among the resident microbial flora- the bacterial population in our hospitals. Infection prevention and control has never been more important than it is now.’
It is no coincidence that the very first of the seven key action points outlined in the UK 5-year Antimicrobial Resistance Strategy 2013-1018, produced earlier this year by the DoH and DEFRA, is about improving infection prevention and control.
In her Forward to the epic3 Guidelines, which will accompany the January 2014 printed issue of The Journal of Hospital Infection, Professor Dame Sally Davies, NHS England’s Chief Medical Officer, said, ‘In March 2013, my Annual Report on ‘Infection and the rise of antimicrobial resistance’ highlighted the need for healthcare professionals to understand and put into practice the principles of infection prevention and control in order to improve patient outcomes. These updated guidelines underpin and provide the knowledge base to inform this understanding’.
‘The guidelines provide the evidence base for many elements of clinical practice that are essential in minimizing the spread of antimicrobial-resistant organisms, and maintaining high standards of infection prevention and control that can be adapted for use locally by all healthcare practitioners. The principles set out in these guidelines also provide the evidence base to support elements of the implementation of the 5-year UK Antimicrobial Resistance Strategy,’ Davies added.
EurekAlert
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Diabetes Mellitus, a metabolic disorder that affects nearly 170 million people worldwide, is characterised by chronic hyperglycaemia that disrupts carbohydrate fat and protein metabolism resulting from defects in insulin secretion, insulin action or both. DM can cause long-term damage, dysfunction and even failure of various organs.
Patients with DM may develop corneal complications and delayed wound healing. This slow wound healing contributes to increased infections and the formation of bed sores and ulcers. Corneal complications include diabetic neuropathies and ocular complications that often lead to reduced vision or blindness.
A team of Wayne State University researchers recently developed several diabetic models to study impaired wound healing in diabetic corneas. Using a genome-wide cDNA array analysis, the group identified genes, their associated pathways and the networks affected by DM in corneal epithelial cells and their roles in wound closure. The findings may bring scientists one step closer to developing new treatments that may slow or thwart DM
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