Genesis Digital Imaging, Inc. (Los Angeles, CA), a privately-held imaging software developer and distributor of diagnostic imaging systems, has been acquired by Carestream Health.
This acquisition enables Carestream to expand its customer base by leveraging the expertise Genesis has in serving U.S. dealers that primarily call on the value tier market and specialty medical practices. Carestream offers a proven portfolio of products and services designed specifically for these types of healthcare customers.
With this acquisition, Carestream is uniquely positioned to serve customers across the U.S. With its direct sales force offering large hospital customers the latest high-end digital radiography systems and healthcare IT solutions, its Quantum Medical Imaging organisation serving customers in the mid-tier hospital, orthopedic and imaging centre segments, and Genesis focusing on customers in the value tier segment, Carestream has innovative products and services and attractive pricing for customers in all areas of the U.S. market.
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An injection of banked sperm-producing stem cells can restore fertility to male primates who become sterile due to cancer drug side effects, according to researchers at the University of Pittsburgh School of Medicine and Magee-Womens Research Institute. In their animal study previously frozen stem cells restored production of sperm that successfully fertilised eggs to produce early embryos.
Some cancer drugs work by destroying rapidly dividing cells. As it is not possible to discriminate between cancer cells and other rapidly dividing cells in the body, the precursor cells involved in making sperm can be inadvertently wiped out leaving the patient infertile, said senior investigator Kyle Orwig, Ph.D., associate professor, Department of Obstetrics, Gynecology and Reproductive Medicine, Pitt School of Medicine, and an investigator at Magee-Womens Research Institute.
‘Men can bank sperm before they have cancer treatment if they hope to have biological children later in their lives,’ he said. ‘But that is not an option for young boys who haven
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Currently repeated operations are needed to replace batteries in pacemakers, but according to US researchers a device which could harness energy from a beating heart can produce enough electricity to keep a pacemaker running.
Piezoelectric materials generate an electric charge when their shape is changed. They are used in some microphones to convert vibrations into an electrical signal. Researchers at the University of Michigan are trying to use the movement of the heart as a source of electricity.
In tests designed to simulate a range of heartbeats, enough electricity was generated to power a pacemaker. Tests suggested the device could produce 10 times the amount of energy needed. The designers now want to test the device on a real heart and build it into a commercial pacemaker.
The British Heart Foundation said clinical trials were needed to show it would be safe for patients.
Dr Amin Karami told a meeting of the American Heart Association that pacemaker batteries needed to be replaced approximately every seven years. ‘Many of the patients are children who live with pacemakers for many years. You can imagine how many operations they are spared if this new technology is implemented.’
Prof Peter Weissberg, the medical director at the British Heart Foundation, said: ‘Advancing technology over recent years has meant people with pacemakers need to change their battery less often. This device could be another step forward along this path. ‘If researchers can refine the technology and it proves robust in clinical trials, it would further reduce the need for battery changes.’
BBC
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Scientists have identified a group of small molecules that interfere with the activity of a compound that initiates multiple steps in blood clotting, including those that lead to the obstruction of veins or arteries, a condition called thrombosis. Blocking the activity of this compound, polyphosphate, could treat thrombosis with fewer bleeding side effects than the drugs that are currently on the market.
Blood clots are formed at the site of an injured blood vessel to prevent blood loss. Sometimes, however, blood clots completely clog an artery or vein and the surrounding tissues are damaged. The U.S. Centers for Disease Control and Prevention reports that annually, 300,000 to 600,000 Americans are afflicted with deep vein thrombosis or pulmonary embolism, a blocked lung artery that often results from thrombosis, and 60,000 to 100,000 people die each year as a result of these conditions.
There are two pathways that trigger blood clotting. The tissue factor pathway helps stop bleeding if a person is injured. If any of the proteins of this pathway are missing, a bleeding problem will develop. In contrast, the contact pathway is activated when blood comes into contact with some artificial substances. Although this pathway can cause pathological blood clots, humans who lack proteins in this pathway do not have bleeding problems. These two pathways eventually converge to form a common pathway.
In 2006, the researchers found that compounds called polyphosphates can, when released from cell fragments called platelets, activate the contact pathway, said University of Illinois biochemistry professor James H. Morrissey, who led that study and the new analysis.
Because the contact pathway is not essential for normal blood clotting after an injury, interrupting polyphosphate ‘wouldn
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When given early treatment, children with autism spectrum disorders (ASD) made significant improvements in behaviour, communication, and most strikingly, brain function, Yale School of Medicine researchers report in a new study.
The study was published by Yale Child Study Center researchers Dr. Fred Volkmar, Kevin A. Pelphrey, and their colleagues.
The results suggest that brain systems supporting social perception respond well to an early intervention behavioural program called pivotal response treatment. This treatment includes parent training, and employs play in its methods.
ASDs are complex neurobiological disorders that inhibit a person
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Using a combination of surgical procedures developed over the last 11 years, surgeons at Boston Children’s Hospital have established a new approach for rebuilding the heart in children born with a severe heart defect called hypoplastic left heart syndrome (HLHS). This ‘staged left ventricle recruitment’ (SLVR) strategy uses the existing standard single-ventricle treatment for HLHS and additional procedures to spur the body’s capacity for healing and growth and encourage the small left ventricle in these children to grow and function.
Members of Boston Children’s Departments of Cardiac Surgery and Cardiology
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A ‘chemo-bath’ which delivers toxic cancer drugs to just one organ in the body has been used on patients in the UK for the first time, say doctors. Chemotherapy drugs kill rapidly growing cells such as cancers, but they also attack healthy parts of the body.
Doctors at Southampton General Hospital believe targeting just one organ can prevent side effects. They also say it means they can give higher doses without causing damage to the patient.
Chemotherapy drugs are normally injected into the veins of patients. However, the whole body, rather than just the tumour, is exposed. It results in side effects such as fatigue, feeling sick, hair loss and damage to fertility.
Two patients in the UK have now received chemotherapy focused on just their liver. Both had a rare eye cancer which had spread to the liver. The operation works by inflating balloons inside blood vessels on either side of the liver to isolate it from the rest of the body. The liver is then pumped full of chemotherapy drugs, which are filtered out before the liver is reconnected to the main blood supply.
It means only a tiny fraction of the chemotherapy dose ends up in the body.
Dr Brian Stedman, a consultant interventional radiologist, said: ‘To cut off an organ from the body for 60 minutes, soak it in a high dose of drug and then filter the blood almost completely clean before returning is truly groundbreaking.
‘Previously, the outlook for patients specifically suffering from cancer which has spread to the liver has been poor because standard chemotherapy’s effect is limited by the unwanted damage the drug causes to the rest of the body.’
The surgery took place in the past three months and both patients are said to be doing well and their tumours ‘all look smaller’, he said.
Dr Stedman told the BBC: ‘In 20 years’ time the idea of injecting a drug which poisons the whole body for a cancer in just one small area will seem bonkers.’
He suggested that any organ which could be easily separated from the blood supply, such as the kidney, pancreas and lungs, would be suitable for this kind of approach. However, he said the method was ‘in its infancy’ and he was ‘not sure this is the finished product or the end of the story’.
The technique is also being tested in the US and elsewhere in Europe.
BBC
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Leading clinicians and health researchers from across Europe say much greater emphasis must be placed on the scientific evidence for the effectiveness of treatments and other healthcare interventions to ensure patients receive the best care available. The call is contained in a Science Policy Briefing published by the European Medical Research Councils, which also made ten key recommendations on how to improve the quality of research and healthcare in Europe. The briefing,
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A new three-dimensional (3-D) digital mammography technique has the potential to significantly improve the accuracy of breast cancer screening, according to a study.
Two-dimensional (2-D) x-ray mammography, the current primary screening method for early detection of breast cancer in women, is a valuable tool but has some limitations. Surrounding normal tissue can mask lesions, and 2-D views do not provide direct information about the volumetric appearance
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A tiny medical device no larger than an eyelash may significantly reduce eye pressure in glaucoma patients and allow some to stop using eye-drop medications, according to year-one clinical trial results for the device. Results of the HYDRUS I clinical trial, which indicate successful control of eye pressure in all study participants, will be presented today at the 116th Annual Meeting of the American Academy of Ophthalmology, jointly conducted this year with the Asia-Pacific Academy of Ophthalmology.
The Hydrus stent is one of several promising mini-drainage devices now in clinical trials in the United States and other countries. If future trials confirm micro-stents’ effectiveness, they could someday help protect millions of glaucoma patients from vision loss or blindness.
Open-angle glaucoma, the most common form of the disease, affects nearly three million people in the U.S and 60 million worldwide.[ Though it is a multi-factorial disease, currently the only proven way to prevent vision loss is by reducing intra-ocular pressure (IOP). The treatment choices are effective but less than ideal, as some patients may not use eye drop medications consistently enough to control their IOP, while others simply don’t respond to the drugs. Surgical procedures to open blocked drainage channels or implant larger stents, which are used only for patients with advanced glaucoma, carry risks of infection, bleeding, deterioration of other parts of the eye, and vision loss.
In this particular study of 69 patients suffering from mild to moderate open-angle glaucoma, IOP was reduced to acceptable levels in 100 percent of participants after they received minimally invasive stent implant surgery. In 40 patients the stent was placed during cataract surgery, a procedure that also reduces IOP. Twenty-nine patients had the Hydrus stent placed without cataract surgery to assess whether the stent would be effective on its own. No significant complications occurred in either patient group. At the six-month follow up, 85 percent of combined surgery and 70 percent of stent-only patients no longer needed eye drop medications to control their IOP. Reductions in IOP were consistent among all patients and remained stable at the one year follow up.
‘So far, mini-stents appear to have important advantages in that they allow us to treat open-angle glaucoma at earlier stages and with lower complication risk,’ said Thomas W. Samuelson, M.D., a glaucoma specialist with Minnesota Eye Consultants, who served as the HYDRUS I trial’s medical monitor. ‘If the devices can effectively control IOP over many years, it would be a real breakthrough in combating this blinding disease.’
Dr. Samuelson cited the experience of an 81-year-old retired neurosurgeon who had tried multiple glaucoma medications, then had a drainage procedure called a trabeculoplasty, but couldn’t achieve safe IOP levels. In 2010, the Hydrus was implanted in his right eye during cataract surgery, followed by the same surgery in his left eye a year later. A follow-up exam two months ago, confirmed that his IOP levels remained acceptably low in both eyes, without the use of eye drops.
American Academy of Ophthalmology
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