{"id":788,"date":"2020-08-26T14:35:55","date_gmt":"2020-08-26T14:35:55","guid":{"rendered":"https:\/\/interhospi.3wstaging.nl\/advanced-imaging-technology-measures-magnetite-levels-in-the-living-brain\/"},"modified":"2020-08-26T14:35:55","modified_gmt":"2020-08-26T14:35:55","slug":"advanced-imaging-technology-measures-magnetite-levels-in-the-living-brain","status":"publish","type":"post","link":"https:\/\/interhospi.com\/advanced-imaging-technology-measures-magnetite-levels-in-the-living-brain\/","title":{"rendered":"Advanced imaging technology measures magnetite levels in the living brain"},"content":{"rendered":"

Investigators at the Martinos Center for Biomedical Imaging at Massachusetts General Hospital (MGH) have used magnetoencephalography (MEG) \u2013 a technology that measures brain activity by detecting the weak magnetic fields produced by the brain\u2019s normal electrical currents \u2013 to measure levels of the iron-based mineral called magnetite in the human brain. While magnetite is known to be present in the normal brain and to accumulate with age, evidence has also suggested it may play a role in neurodegenerative disorders like Alzheimer\u2019s disease. <\/span>
\n\u201cThe ability to measure and localize magnetite in the living brain will allow new studies of its role in both the normal brain and in neurodegenerative disease,\u201d says David Cohen, PhD, of the Martinos Center, corresponding author of the report published in Human Brain Mapping. \u201cStudies could investigate whether the amount of magnetite in the hippocampal region could predict the development of Alzheimer\u2019s disease and whether treatments that influence magnetite could alter disease progression.\u201d
\nCohen was the first to measure the magnetic fields generated by currents within the brain when he was at the University of Illinois in 1968. After he moved to the Massachusetts Institute of Technology in 1969, the development of highly sensitive magnetic detectors \u2013 along with the availability of a room well shielded from external magnetic fields \u2013 significantly improved detection of the magnetic fields produced by the brain, as well as the heart and lungs. Since then, MEG has developed into a valuable tool for research \u2013 particularly for its ability to precisely measure when a brain signal occurs, in contrast to functional MRI that can reveal where it takes place \u2013 and to guide surgical treatment of brain tumours and epilepsy. <\/span>
\nWhile magnetite particles were first reported in the human brain in 1992, until now their presence could only be studied in post-mortem brains. Previous studies found higher levels of magnetite in the brains of older individuals \u2013 implying age-associated accumulation of the particles \u2013 and suggested that magnetite may play a role in neurodegenerative diseases. For example, magnetite particles have been associated with the characteristic plaques and tangles in the brains of patients with Alzheimer\u2019s disease. The current study came out of Cohen\u2019s investigation of MEG signals produced by direct current (dc) magnetic fields, rather than the better understood alternating current fields. <\/span>
\nThe earliest dcMEG mapping studies found only a single source of dc magnetic fields of the head, produced when healthy hair follicles over the scalp were lightly pressed. The availability of an advanced dcMEG system at the Martinos Center has allowed the detection of new phenomena, including for the first time, fields produced by magnetic material within the head. This observation led Cohen, who joined the Martinos Center in 2001, and lead author Sheraz Khan, PhD, to investigate the ability of dcMEG to measure the amount and the location of magnetite in the brains of healthy volunteers. <\/span>
\nThe study enrolled 11 male participants aged 19 to 89 \u2013 all with little or no hair, to avoid interference from the hair-follicle signal \u2013 who underwent an initial baseline dcMEG scan before being placed in a powerful MRI scanner, both to acquire an MR image and to magnetize any magnetite particles within their brains. A second dcMEG scan taken several minutes later revealed changes in the magnetic field that reflect the size and shape of magnetite particles, as well as other factors. Alignment of the MEG and MRI images allowed precise localization of the magnetic signals.<\/span>
\nThe results found greater accumulation of magnetite in the brains of the oldest volunteers, primarily in and around the hippocampus \u2013 the structure in which memories are encoded \u2013 replicating the findings of post-mortem studies. The rate at which the magnetic signal dissipated, which could reflect the size of magnetite particles, was measured by subsequent dcMEG scans taken from hours to several days later. The authors note that this new tool will be valuable for determining whether and how magnetite can be used in the diagnosis and potentially the treatment of Alzheimer\u2019s disease and other disorders. <\/span>
\nMassachusetts General Hospital<\/span>
\nwww.massgeneral.org\/about\/pressrelease.aspx?id=2315<\/link><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Investigators at the Martinos Center for Biomedical Imaging at Massachusetts General Hospital (MGH) have used magnetoencephalography (MEG) \u2013 a technology that measures brain activity by detecting the weak magnetic fields produced by the brain\u2019s normal electrical currents \u2013 to measure levels of the iron-based mineral called magnetite in the human brain. While magnetite is known […]<\/p>\n","protected":false},"author":2,"featured_media":638,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-788","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-e-news"],"_links":{"self":[{"href":"https:\/\/interhospi.com\/wp-json\/wp\/v2\/posts\/788"}],"collection":[{"href":"https:\/\/interhospi.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/interhospi.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/interhospi.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/interhospi.com\/wp-json\/wp\/v2\/comments?post=788"}],"version-history":[{"count":1,"href":"https:\/\/interhospi.com\/wp-json\/wp\/v2\/posts\/788\/revisions"}],"predecessor-version":[{"id":10756,"href":"https:\/\/interhospi.com\/wp-json\/wp\/v2\/posts\/788\/revisions\/10756"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/interhospi.com\/wp-json\/wp\/v2\/media\/638"}],"wp:attachment":[{"href":"https:\/\/interhospi.com\/wp-json\/wp\/v2\/media?parent=788"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/interhospi.com\/wp-json\/wp\/v2\/categories?post=788"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/interhospi.com\/wp-json\/wp\/v2\/tags?post=788"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}