{"id":19505,"date":"2025-02-21T06:00:13","date_gmt":"2025-02-21T06:00:13","guid":{"rendered":"https:\/\/interhospi.com\/?p=19505"},"modified":"2025-02-17T06:06:01","modified_gmt":"2025-02-17T06:06:01","slug":"new-cell-atlas-reveals-why-some-obese-people-stay-metabolically-healthy","status":"publish","type":"post","link":"https:\/\/interhospi.com\/new-cell-atlas-reveals-why-some-obese-people-stay-metabolically-healthy\/","title":{"rendered":"New cell atlas reveals why some obese people stay metabolically healthy"},"content":{"rendered":"
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New cell atlas reveals why some obese people stay metabolically healthy<\/h1>\/ in E-News<\/a>, Lifestyle Diseases<\/a>, Research<\/a> <\/span><\/span><\/header>\n<\/div><\/section>
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A groundbreaking study by ETH Zurich and Leipzig researchers has created the first comprehensive cellular atlas of adipose tissue in obese individuals, revealing crucial differences between those who maintain metabolic health and those who develop conditions like diabetes and hypertension. The findings, published in Cell Metabolism<\/em>, could revolutionise how we identify and treat obesity-related metabolic disorders.<\/strong><\/p>\n

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Using samples from the Leipzig Obesity Biobank, researchers conducted an extensive cell-by-cell analysis of both subcutaneous and visceral adipose tissue from 70 obese volunteers. This unprecedented mapping effort revealed significant functional variations between metabolically healthy and unhealthy individuals, particularly in visceral fat tissue surrounding internal organs.<\/p>\n

Visceral fat remodelling in disease<\/strong><\/h3>\n

The research team, led by Professor Christian Wolfrum, identified substantial cellular remodelling in the visceral adipose tissue of individuals with metabolic diseases. \u201cThese substances trigger an immune response in the visceral fat of obese people,\u201d explains study co-lead author Isabel Reinisch, suggesting this response could be instrumental in metabolic disease development.<\/p>\n

Mesothelial cells emerge as key players<\/strong><\/h3>\n

One of the study\u2019s most striking discoveries involved mesothelial cells, which form the outer boundary of visceral adipose tissue. Metabolically healthy obese individuals showed higher proportions of these cells, which demonstrated remarkable functional flexibility, including the ability to transform into different cell types.<\/p>\n

Gender differences uncovered<\/strong><\/h3>\n

The atlas revealed notable sex-specific variations in adipose tissue composition, with researchers identifying a unique progenitor cell type present exclusively in women\u2019s visceral fat. This finding could help explain the well-documented gender differences in metabolic disease development and progression.<\/p>\n

Implications for personalised medicine<\/strong><\/h3>\n

The comprehensive cellular atlas provides a foundation for identifying new biomarkers that could predict metabolic disease risk. This could prove particularly valuable for prioritising treatment with new appetite-suppressing medications that also promote insulin release, which are currently in limited supply.<\/p>\n

Future directions<\/strong><\/h3>\n

The researchers have made their data publicly accessible through a web application, facilitating further investigation by the broader scientific community. While the current study cannot definitively establish causality between cellular differences and metabolic health, it provides crucial groundwork for future research into obesity-related metabolic disorders.<\/p>\n

The findings could have significant implications for developing targeted therapies and improving patient stratification in obesity treatment. The researchers suggest that their work might help identify those most likely to benefit from specific interventions, potentially revolutionising the approach to obesity-related metabolic disease management.<\/p>\n

Reference<\/strong><\/h5>\n

Reinisch, I., Ghosh, A., No\u00e9, F., et. al. (2024). Unveiling adipose populations linked to metabolic health in obesity. Cell Metabolism<\/em>. https:\/\/doi.org\/10.1016\/j.cmet.2024.11.006<\/a><\/p>\n<\/div><\/section>
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