{"id":17547,"date":"2023-05-02T17:50:34","date_gmt":"2023-05-02T17:50:34","guid":{"rendered":"https:\/\/interhospi.com\/?p=17547"},"modified":"2023-05-02T17:52:01","modified_gmt":"2023-05-02T17:52:01","slug":"researchers-develop-safe-bioink-for-3d-printing-artificial-organs","status":"publish","type":"post","link":"https:\/\/interhospi.com\/researchers-develop-safe-bioink-for-3d-printing-artificial-organs\/","title":{"rendered":"Researchers develop safe bioink for 3D printing artificial organs"},"content":{"rendered":"
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Researchers develop safe bioink for 3D printing artificial organs<\/h1>3D printing<\/a><\/span>, artificial<\/a><\/span>, bioink<\/a><\/span>, develop<\/a><\/span>, organs<\/a><\/span>, Researchers<\/a><\/span>, safe<\/a><\/span>, Featured Articles<\/a> <\/span><\/span><\/header>\n<\/div><\/section>
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The Korea Institute of Science and Technology (KIST) has developed a new type of bioink material for 3D bioprinting that can be used to create artificial tissues and organs. The new bioink is based on a temperature-sensitive poly(organophosphazene) hydrogel.<\/h3>\n

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Tuning mechanical properties of bioink according to temperature and 3d scaffold printing<\/div><\/div><\/div>
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Tuning mechanical properties of bioink according to temperature and 3d scaffold printing<\/em><\/p>\n<\/div><\/section>
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The hydrogel exists in a liquid form at low temperatures and changes to a hard gel at body temperature. This enables the regeneration of tissues by temperature control only, without chemical crosslinking agents or UV irradiation and the manufacture of a three-dimensional scaffold with a physically stable structure, which minimizes the possibility of immune adverse effects in the human body.<\/p>\n

The bioink can also interact with growth factors to enhance tissue regeneration, and it can be tailored to different types of tissues and organs.<\/p>\n

The research team fabricated the 3D scaffold by printing it with a 3D bioprinter using bioink containing transforming growth factor beta 1 (TGF-\u03b21) and bone morphogenetic protein-2 (BMP-2), which are required for cell infiltration and bone regeneration. They conducted an experiment by implanting it into a damaged bone in a rat. This resulted in cells from the surrounding tissue migrating into the scaffold and regenerating the damaged bone to a normal tissue level.The implanted 3D scaffold slowly biodegraded in the body over 42 days.<\/p>\n

The development of this new bioink is significant because commonly used hydrogel-based bioinks can cause cytotoxicity due to the chemical crosslinking agent and ultraviolet light used to connect the molecular structure of photocuring 3D-printed bioink. The new bioink developed by KIST eliminates this risk and allows for the creation of a three-dimensional scaffold with a physically stable structure that minimizes the possibility of immune adverse effects in the human body.<\/p>\n

The technology has already been transferred to NexGel Biotech Co., Ltd. for commercial development, and the team is conducting follow-up research to apply it to the regeneration of other types of tissues and organs.<\/p>\n

Overall, this new bioink technology has great potential for use in the development of artificial organs and tissues for patients suffering from accidental injuries and chronic diseases.<\/p>\n<\/div><\/section>
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