{"id":1016,"date":"2020-08-26T14:36:44","date_gmt":"2020-08-26T14:36:44","guid":{"rendered":"https:\/\/interhospi.3wstaging.nl\/proton-therapy-lowers-treatment-side-effects-in-paediatric-head-and-neck-cancer-patients\/"},"modified":"2020-08-26T14:36:53","modified_gmt":"2020-08-26T14:36:53","slug":"proton-therapy-lowers-treatment-side-effects-in-paediatric-head-and-neck-cancer-patients","status":"publish","type":"post","link":"https:\/\/interhospi.com\/proton-therapy-lowers-treatment-side-effects-in-paediatric-head-and-neck-cancer-patients\/","title":{"rendered":"Proton therapy lowers treatment side effects in paediatric head and neck cancer patients"},"content":{"rendered":"<p><span lang=\"EN-GB\">Paediatric patients with head and neck cancer can be treated with proton beam therapy (PBT) instead of traditional photon radiation, and it will result in similar outcomes with less impact on quality of life. Researchers from the Perelman School of Medicine at the University of Pennsylvania as well as Children\u2019s Hospital of Philadelphia analysed cases of paediatric head and neck cancer treated with PBT between 2010 and 2016 and found similar rates of tumour control and lower rates of toxicity than what is historically expected from photon radiation. <\/span><br \/>\n<span lang=\"EN-GB\">Cancers of the head and neck account for about 12 percent of all paediatric cancers, and they are generally different tumour types than those that affect adults. For solid tumours like neuroblastoma, thyroid cancer, and soft tissue sarcomas, treatment usually involves a combination of therapies including chemotherapy, radiation, and surgery. Post-operative radiation can be critical, since surgeons may not be able to completely remove all cancer given the complexity of the head and neck region.<\/span><br \/>\n<span lang=\"EN-GB\">The area\u2019s sensitivity also means the effects of treatment can lower patient quality of life due to symptoms including loss of appetite, difficulty swallowing, or mucositis \u2013 in which ulcers form in the digestive tract, usually in reaction to chemotherapy or radiation.<\/span><br \/>\n<span lang=\"EN-GB\">\u201cThese concerns are especially important to address in paediatric patients, since they\u2019re still developing and may need to deal with any adverse effects for the rest of their lives. This study shows that protons may be an important tool in improving quality of life both during treatment and for years after for these young patients,\u201d said the study\u2019s senior author Christine Hill-Kayser, MD, chief of the Paediatric Radiation Oncology Service at Penn and an attending physician at CHOP. CHOP cancer patients who need radiation therapy are treated at Penn, including proton therapy through the Roberts Proton Therapy Center.<\/span><br \/>\n<span lang=\"EN-GB\">Jennifer Vogel, MD, a resident in Radiation Oncology at Penn, is the study\u2019s lead author.<\/span><br \/>\n<span lang=\"EN-GB\">Researchers looked at 69 Paediatric head and neck cancer patients treated with PBT at Penn and CHOP between 2010 and 2016. Thirty-five (50 percent) of those patients had rhabdomyosarcoma, a cancer of the cells that make up skeletal muscles. Ten (7 percent) were treated for Ewing sarcoma, a cancer most commonly found in the bone or soft tissue. The other 24 were treated for a variety of other cancers affecting the head and neck regions.<\/span><br \/>\n<span lang=\"EN-GB\">One year after treatment, 93 percent of patients were still alive, and 92 percent did not experience recurrence at their primary disease site.<\/span><br \/>\n<span lang=\"EN-GB\">Toxicities, or side effects, are measured on a scale from 1 to 5 with 5 being the most severe. In this study, no patients were above grade 3, and the most severe toxicities at that level were mucositis (4 percent), loss of appetite (22 percent), and difficulty swallowing (7 percent).<\/span><br \/>\n<span lang=\"EN-GB\">\u201cDifferent disease sites required different dosage levels, and we specifically found the severity of muscositis was associated with higher doses of radiation,\u201d Vogel said.<\/span><br \/>\n<span lang=\"EN-GB\">Those numbers are still well below what is typically associated with photon radiation. In rhabdomyosarcoma, for example, 46 percent of patients historically report grade 3 or 4 mucositis.<\/span><br \/>\n<span lang=\"EN-GB\">&nbsp;<\/span>\u201cThese data show proton therapy is not only effective, it is also more tolerable for patients,\u201d Hill-Kayser said. \u201cThis study shows this treatment is safe and offers practice guidelines for delivering head and neck proton therapy in the Paediatric population.\u201d<br \/>\n<span lang=\"EN-GB\">Penn Medicine<\/span><br \/>\n<span lang=\"EN-GB\"><link https:\/\/www.pennmedicine.org\/news\/news-releases\/2017\/october\/proton-therapy-lowers-treatment-side-effects-in-pediatric-head-and-neck-cancer-patients _blank external-link-new-window \"Opens external link in new window\">www.pennmedicine.org\/news\/news-releases\/2017\/october\/proton-therapy-lowers-treatment-side-effects-in-Paediatric-head-and-neck-cancer-patients<\/link><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Paediatric patients with head and neck cancer can be treated with proton beam therapy (PBT) instead of traditional photon radiation, and it will result in similar outcomes with less impact on quality of life. Researchers from the Perelman School of Medicine at the University of Pennsylvania as well as Children\u2019s Hospital of Philadelphia analysed cases [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":638,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-1016","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-e-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Proton therapy lowers treatment side effects in paediatric head and neck cancer patients - International Hospital<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/interhospi.com\/proton-therapy-lowers-treatment-side-effects-in-paediatric-head-and-neck-cancer-patients\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Proton therapy lowers treatment side effects in paediatric head and neck cancer patients - International Hospital\" \/>\n<meta property=\"og:description\" content=\"Paediatric patients with head and neck cancer can be treated with proton beam therapy (PBT) instead of traditional photon radiation, and it will result in similar outcomes with less impact on quality of life. 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