An international research team has mapped distinct molecular “fingerprints” in blood proteins across 59 diseases, creating a comprehensive resource that could revolutionise how clinicians distinguish between different conditions and identify early warning signs of illness.
Researchers have developed a pioneering 3D bioceramic scaffold embedded with silver-gallium liquid metal nanoparticles that simultaneously prevents bacterial infections and promotes bone regeneration. The breakthrough technology offers a non-antibiotic solution to one of orthopaedic surgery’s most persistent challenges, with potential to transform outcomes for high-risk patients.
Scientists at the University of Cambridge have created three-dimensional embryo-like structures that produce blood stem cells through a naturally occurring developmental process, eliminating the need for supplementary growth factors. The innovation, termed ‘hematoids’, mimics human embryonic blood development and could transform approaches to regenerative medicine and disease modelling.
A tailored, multi-faceted intervention has achieved substantial reductions in wasteful pre-surgery testing across Michigan hospitals, demonstrating that education, teamwork and site-specific adaptation can eliminate low-value care whilst preserving patient safety. The RITE-Size programme reduced unnecessary testing rates from 68% to 40% over six months across three hospital settings.
Cambridge-based breath diagnostics specialist Owlstone Medical has been awarded up to $49.1 million by ARPA-H to develop at-home multi-cancer early detection tests. The POSEIDON programme aims to detect 30+ solid tumours at Stage I using synthetic biosensors analysed through breath and urine samples, addressing critical gaps in accessible cancer screening.
A landmark case published in the Journal of Hepatology describes the world’s first auxiliary liver xenotransplant from a genetically engineered pig to a living human recipient, with the patient surviving 171 days. The procedure demonstrates that genetically modified porcine livers can support essential hepatic functions in humans, whilst highlighting significant complications that must be addressed […]
COMBINEDBrain and the Medical University of South Carolina have announced a strategic collaboration to establish what they describe as the first biorepository dedicated to paediatric central nervous system tissue and cerebrospinal fluid from neurotypical donors, addressing a significant gap in neurological disease research infrastructure.
Researchers have identified dendritic nanotubes – ultrathin connections between neurons that can transport disease-related proteins. The structures, distinct from conventional synapses, may accelerate toxic protein accumulation in specific brain cells during early Alzheimer’s pathology, offering potential new therapeutic targets.
Researchers have identified GPR133/ADGRD1, a mechanosensitive adhesion G protein-coupled receptor, as a promising therapeutic target for osteoporosis. The receptor responds to both mechanical forces and molecular signals, enhancing bone formation through cAMP-dependent activation of β-catenin signalling. A novel small-molecule agonist significantly alleviated osteoporosis in preclinical models, suggesting potential for clinical development.
A systematic review of patient perspectives reveals that cancer patients prioritise emotional support, optimistic demeanour, and realistic expectation-setting from their surgical oncologists alongside clinical expertise. The research identifies six distinct communication domains that shape patient satisfaction and treatment adherence.
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© Journal of Hepatology / Zhang et al.