Researchers have developed PathoPlex, a new multiplexed imaging technology capable of mapping over 140 proteins within cells at subcellular resolution. The framework identified kidney stress-related protein patterns in people with type 2 diabetes before clinical signs of disease appeared, potentially accelerating both diagnosis and treatment timelines.
Researchers have achieved a milestone in xenotransplantation by successfully transplanting a genetically modified pig lung into a brain-dead human recipient, where it remained viable and functional for nine days without hyperacute rejection or infection, according to research published in Nature Medicine.
A comprehensive investigation reveals sophisticated networks of editors, authors, and brokers systematically scamming the scientific publishing system at unprecedented scale. The research exposes coordinated fraud operations that have infiltrated major journals and publishers, with fraudulent publications growing exponentially faster than legitimate science.
OHSU scientists have developed OmicsTweezer, a powerful machine learning tool that uses advanced deep learning and optimal transport techniques to analyse cell type composition in human tissues. The breakthrough technology addresses long-standing batch effect challenges in cancer research, potentially improving therapeutic target identification and patient outcomes across multiple cancer types.
Researchers have developed a third-generation CRISPR technique that modifies gene expression by removing methylation marks rather than cutting DNA sequences. The approach uses catalytically dead Cas9 proteins fused to demethylating enzymes, offering a potentially safer alternative to conventional gene editing for treating inherited blood disorders including sickle cell disease and β-thalassemia.
Washington University researchers have developed a quantitative technique measuring leg movement variability to accurately diagnose dystonia in paediatric cerebral palsy patients. The breakthrough identifies brain mechanisms underlying the condition, which could enable early intervention strategies to prevent this painful complication.
The International Hospital Federation has revealed finalists for its 2025 awards programme, with 81 healthcare organisations from 38 countries competing across eight categories. Winners will be announced at the World Hospital Congress in Geneva in November, recognising excellence in clinical quality, sustainability, and operational performance. A full list of finalists is listed below.
A comprehensive analysis spanning four years of global vaccination campaigns reveals that COVID-19 vaccines prevented 2.5 million deaths worldwide between 2020 and 2024. The landmark study, which examined vaccination impact across all age groups and pandemic phases, found that one life was saved for every 5,400 vaccine doses administered, with the vast majority of benefits […]
Mayo Clinic researchers have developed BACDAC, a computational tool that exposes elusive genomic patterns in cancer samples with low DNA coverage, with the aim of transforming how clinicians predict tumour behaviour and guide personalised treatment decisions through enhanced detection of chromosomal instability markers.
China’s National Medical Products Administration has approved expanded production capacity for NEFECON®, the only etiological treatment for IgA nephropathy. The regulatory milestone addresses growing clinical demand across Asia, where over 5 million patients live with this progressive kidney disease requiring targeted therapeutic intervention.
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